Drug Side Effects

ADALIMUMAB

ADALIMUMAB was reported 695824 times

ADALIMUMAB is most commonly taken among patients reporting these side effects:

# Side effect Count Frequency
0 HUMAN ANTICHIMERIC ANTIBODY POSITIVE 305 0.9187
1 ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE 5774 0.8684
2 ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY 533 0.8367
3 RHEUMATOID FACTOR POSITIVE 4525 0.8242
4 SWOLLEN JOINT COUNT INCREASED 2270 0.8013
5 PEMPHIGUS 8965 0.7680
6 RHEUMATIC FEVER 3049 0.7657
7 LUPUS VULGARIS 779 0.7652
8 DEEP VEIN THROMBOSIS POSTOPERATIVE 1293 0.7410
9 INJECTION SITE PAPULE 3171 0.7369
10 INJECTION SITE BURNING 562 0.7214
11 CARTILAGE ATROPHY 570 0.7143
12 C-REACTIVE PROTEIN 570 0.6917
13 C-REACTIVE PROTEIN ABNORMAL 4158 0.6906
14 DUODENAL ULCER PERFORATION 4663 0.6892
15 GRANULOMA SKIN 536 0.6617
16 HAND DEFORMITY 8207 0.6615
17 SYNOVITIS 11154 0.6446
18 RED BLOOD CELL SEDIMENTATION RATE ABNORMAL 1427 0.6317
19 FACET JOINT SYNDROME 1730 0.6255
20 HIDRADENITIS 4653 0.5986
21 ADJUSTMENT DISORDER WITH DEPRESSED MOOD 1082 0.5939
22 BONE EROSION 1967 0.5823
23 X-RAY ABNORMAL 957 0.5724
24 DISLOCATION OF VERTEBRA 1136 0.5686
25 ADVERSE FOOD REACTION 492 0.5604
26 HELICOBACTER INFECTION 5003 0.5271
27 SURGICAL FAILURE 567 0.5155
28 INTESTINAL STENOSIS 2041 0.5072
29 BODY HEIGHT BELOW NORMAL 322 0.5016
30 SMALL INTESTINAL STENOSIS 506 0.5010
31 POSTOPERATIVE ADHESION 327 0.4932
32 RETINITIS 722 0.4922
33 GASTROINTESTINAL FISTULA 406 0.4805
34 ILEAL STENOSIS 794 0.4735
35 DRUG SPECIFIC ANTIBODY 615 0.4670
36 MUSCLE INJURY 3540 0.4638
37 INTESTINAL FISTULA 619 0.4613
38 RHEUMATOID NODULE 1245 0.4570
39 LARGE INTESTINAL STENOSIS 844 0.4570
40 FOLLICULITIS 4317 0.4505
41 SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE 2669 0.4431
42 BLOOD PARATHYROID HORMONE DECREASED 615 0.4233
43 ENTHESOPATHY 643 0.4205
44 BLOOD IRON ABNORMAL 394 0.4191
45 PERIPHERAL VENOUS DISEASE 1519 0.4151
46 TUBERCULIN TEST POSITIVE 1043 0.4137
47 ABDOMINAL ADHESIONS 1278 0.4136
48 CONTRAINDICATED PRODUCT ADMINISTERED 11863 0.4133
49 GLOSSODYNIA 8516 0.4002
50 ARTHRODESIS 389 0.3986
51 SYSTEMIC LUPUS ERYTHEMATOSUS 13342 0.3981
52 JOINT RANGE OF MOTION DECREASED 5031 0.3965
53 PERICARDITIS 6187 0.3957
54 SERONEGATIVE ARTHRITIS 409 0.3929
55 RHEUMATOID LUNG 365 0.3862
56 FISTULA DISCHARGE 471 0.3845
57 JUVENILE IDIOPATHIC ARTHRITIS 872 0.3734
58 ACCIDENTAL NEEDLE STICK 304 0.3671
59 DRUG TOLERANCE DECREASED 955 0.3634
60 GASTROINTESTINAL INFLAMMATION 2601 0.3511
61 CROHN'S DISEASE 2391 0.3485
62 GASTROINTESTINAL OBSTRUCTION 776 0.3426
63 JOINT DESTRUCTION 510 0.3407
64 RED BLOOD CELL SEDIMENTATION RATE INCREASED 3646 0.3404
65 GRIP STRENGTH DECREASED 2798 0.3374
66 PRURITUS ALLERGIC 371 0.3324
67 POST PROCEDURAL SWELLING 336 0.3288
68 FINGER DEFORMITY 1538 0.3287
69 RHEUMATOID ARTHRITIS 35574 0.3285
70 PUSTULAR PSORIASIS 1086 0.3273
71 ABSCESS INTESTINAL 682 0.3262
72 FEMALE GENITAL TRACT FISTULA 536 0.3252
73 PANNICULITIS 745 0.3222
74 WOUND 8432 0.3192
75 SMALL INTESTINAL RESECTION 339 0.3186
76 PRECANCEROUS CELLS PRESENT 444 0.3183
77 ANAL FISTULA 1600 0.3126
78 DRUG SPECIFIC ANTIBODY PRESENT 1932 0.3112
79 FOOT DEFORMITY 3298 0.3080
80 ADHESION 436 0.2972
81 PYODERMA GANGRENOSUM 995 0.2962
82 TENOSYNOVITIS 789 0.2952
83 THERAPEUTIC PRODUCT EFFECT DECREASED 12295 0.2940
84 LARGE INTESTINAL OBSTRUCTION 601 0.2874
85 PSORIATIC ARTHROPATHY 10754 0.2842
86 LIVE BIRTH 2148 0.2726
87 BURSITIS 3109 0.2725
88 MENISCUS INJURY 1603 0.2710
89 LUPUS-LIKE SYNDROME 2319 0.2699
90 SACROILIITIS 486 0.2675
91 GASTROINTESTINAL WALL THICKENING 366 0.2670
92 EXOSTOSIS 2339 0.2665
93 ANKYLOSING SPONDYLITIS 3296 0.2663
94 INTESTINAL RESECTION 1339 0.2633
95 ONYCHOMADESIS 1014 0.2630
96 ILEOSTOMY 615 0.2604
97 INFLAMMATORY MARKER INCREASED 1191 0.2587
98 OSTEOARTHRITIS 10401 0.2549
99 CARTILAGE INJURY 610 0.2547
100 INTESTINAL POLYP 410 0.2547
101 ARTHROPATHY 13637 0.2538
102 GASTROINTESTINAL STOMA COMPLICATION 377 0.2534
103 ONYCHOMYCOSIS 1018 0.2460
104 SPONDYLITIS 851 0.2452
105 PRECANCEROUS SKIN LESION 348 0.2452
106 JOINT EFFUSION 1642 0.2449
107 FISTULA 2653 0.2447
108 IMMUNODEFICIENCY 3331 0.2418
109 SYNOVIAL CYST 1082 0.2402
110 MYCOBACTERIUM TUBERCULOSIS COMPLEX TEST POSITIVE 544 0.2384
111 STENOSIS 415 0.2384
112 CHONDROPATHY 634 0.2378
113 FIBROMYALGIA 5483 0.2363
114 OBSTRUCTION 900 0.2362
115 JOINT ARTHROPLASTY 404 0.2334
116 IMPAIRED HEALING 7303 0.2321
117 INCISIONAL HERNIA 309 0.2318
118 INTESTINAL ULCER 355 0.2317
119 WOUND INFECTION 2359 0.2308
120 IRRITABLE BOWEL SYNDROME 4670 0.2298
121 BREAST CANCER STAGE III 1387 0.2296
122 FAECAL CALPROTECTIN INCREASED 660 0.2249
123 GASTROINTESTINAL OEDEMA 374 0.2234
124 COLECTOMY 1181 0.2226
125 DEVICE ISSUE 17971 0.2211
126 LIP DRY 1834 0.2196
127 PROCTITIS 584 0.2180
128 ANTIBODY TEST POSITIVE 354 0.2164
129 POLYARTHRITIS 1075 0.2153
130 INJECTION SITE IRRITATION 2567 0.2143
131 INJECTION SITE HAEMORRHAGE 16123 0.2134
132 RECTAL ABSCESS 345 0.2117
133 KNEE ARTHROPLASTY 4147 0.2107
134 HYPERCHOLESTEROLAEMIA 1884 0.2090
135 SHOULDER ARTHROPLASTY 512 0.2069
136 SCLERITIS 314 0.2056
137 RHEUMATIC DISORDER 385 0.2049
138 DRUG DELIVERY SYSTEM MALFUNCTION 979 0.2046
139 LIMB DEFORMITY 314 0.2032
140 JOINT SWELLING 23282 0.2021
141 DERMAL CYST 476 0.2015
142 DERMATITIS PSORIASIFORM 389 0.2013
143 HIP ARTHROPLASTY 2882 0.2012
144 JOINT STIFFNESS 5049 0.2003
145 JOINT LOCK 546 0.1979
146 AUTOIMMUNE DISORDER 1748 0.1972
147 PSORIASIS 24707 0.1969
148 INFLAMMATION 9569 0.1966
149 JOINT DISLOCATION 1954 0.1942
150 UVEITIS 2473 0.1923
151 INTESTINAL OBSTRUCTION 6759 0.1905
152 COLOSTOMY 349 0.1888
153 ROTATOR CUFF SYNDROME 2350 0.1881
154 DRUG INTOLERANCE 17172 0.1874
155 INJECTION SITE VESICLES 1049 0.1860
156 CYST 2211 0.1846
157 WOUND COMPLICATION 609 0.1837
158 LIGAMENT RUPTURE 783 0.1832
159 SMALL INTESTINAL OBSTRUCTION 2133 0.1829
160 CARPAL TUNNEL SYNDROME 2452 0.1816
161 INJECTION SITE HAEMATOMA 2610 0.1813
162 INJECTION SITE DISCHARGE 769 0.1799
163 TRIGGER FINGER 694 0.1791
164 COLITIS ULCERATIVE 7447 0.1783
165 FEAR OF INJECTION 1149 0.1780
166 ABDOMINAL HERNIA 782 0.1777
167 SPINAL STENOSIS 674 0.1776
168 SCIATICA 2667 0.1772
169 DISSEMINATED TUBERCULOSIS 430 0.1772
170 NAIL DISORDER 1442 0.1756
171 FOETAL DEATH 870 0.1739
172 PURULENCE 331 0.1733
173 DEMYELINATION 688 0.1723
174 NASAL SEPTUM DEVIATION 321 0.1708
175 FREQUENT BOWEL MOVEMENTS 4332 0.1702
176 NODULE 2133 0.1695
177 ANAL ABSCESS 848 0.1660
178 C-REACTIVE PROTEIN INCREASED 5765 0.1654
179 INJECTION SITE PAIN 47251 0.1652
180 FURUNCLE 1252 0.1640
181 MUSCULOSKELETAL STIFFNESS 13772 0.1634
182 POST PROCEDURAL INFECTION 1252 0.1629
183 HEPATIC ENZYME INCREASED 10470 0.1616
184 ALANINE AMINOTRANSFERASE ABNORMAL 320 0.1612
185 FOOD INTOLERANCE 555 0.1599
186 PULMONARY FIBROSIS 2906 0.1599
187 BLEPHAROSPASM 911 0.1591
188 LIPOMA 393 0.1577
189 HERNIA 2873 0.1567
190 MOBILITY DECREASED 10705 0.1566
191 NERVE COMPRESSION 1373 0.1556
192 UMBILICAL HERNIA 700 0.1555
193 INTERVERTEBRAL DISC PROTRUSION 3294 0.1551
194 INJECTION SITE URTICARIA 3521 0.1543
195 WOUND SECRETION 584 0.1535
196 RADICULOPATHY 389 0.1531
197 SPINAL FUSION SURGERY 583 0.1530
198 LATENT TUBERCULOSIS 305 0.1530
199 POSTOPERATIVE WOUND INFECTION 983 0.1526
200 INJECTION SITE PRURITUS 9635 0.1526
201 ACCIDENT AT WORK 323 0.1511
202 MELANOCYTIC NAEVUS 637 0.1508
203 LIMB MASS 313 0.1506
204 LARGE INTESTINAL ULCER 390 0.1503
205 ARTHRITIS 11312 0.1495
206 FOOT OPERATION 695 0.1491
207 TREATMENT FAILURE 11536 0.1482
208 ANIMAL BITE 372 0.1481
209 PURULENT DISCHARGE 611 0.1476
210 LARGE INTESTINE POLYP 982 0.1475
211 ANTINUCLEAR ANTIBODY POSITIVE 467 0.1473
212 DEFAECATION URGENCY 961 0.1466
213 SPINAL COLUMN INJURY 312 0.1457
214 POST PROCEDURAL COMPLICATION 2708 0.1456
215 SENSITIVITY TO WEATHER CHANGE 715 0.1455
216 SWELLING 12984 0.1455
217 ABDOMINAL ABSCESS 614 0.1452
218 VOLVULUS 316 0.1446
219 INJECTION SITE NODULE 1520 0.1441
220 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 6466 0.1440
221 GAIT INABILITY 4459 0.1436
222 ABSCESS 2197 0.1434
223 RESPIRATORY TRACT CONGESTION 2167 0.1428
224 LIVER INJURY 3199 0.1422
225 IRITIS 417 0.1415
226 OBESITY 2138 0.1401
227 INJECTION SITE EXTRAVASATION 1715 0.1400
228 SINUSITIS 13694 0.1388
229 PROCEDURAL COMPLICATION 1016 0.1361
230 PARANASAL SINUS HYPERSECRETION 509 0.1360
231 INJECTION SITE BRUISING 10083 0.1354
232 GASTROINTESTINAL INFECTION 1144 0.1345
233 INGROWING NAIL 304 0.1340
234 APPARENT DEATH 483 0.1340
235 DISCOMFORT 7644 0.1336
236 PHARYNGITIS STREPTOCOCCAL 1384 0.1332
237 NECK MASS 360 0.1331
238 MACULAR DEGENERATION 1513 0.1330
239 SKIN PAPILLOMA 514 0.1329
240 BRONCHITIS CHRONIC 315 0.1327
241 BACK INJURY 1354 0.1317
242 SKIN NECROSIS 660 0.1309
243 POLYP 825 0.1309
244 WRONG TECHNIQUE IN DRUG USAGE PROCESS 4759 0.1308
245 MUSCULOSKELETAL DISORDER 2420 0.1307
246 DRUG LEVEL DECREASED 1284 0.1299
247 MUCOUS STOOLS 598 0.1294
248 DIARRHOEA HAEMORRHAGIC 1165 0.1293
249 DRUG EFFECT INCOMPLETE 4700 0.1292
250 INJECTION SITE ERYTHEMA 15181 0.1290
251 TYPE 2 DIABETES MELLITUS 4188 0.1288
252 BASAL CELL CARCINOMA 1924 0.1281
253 COELIAC DISEASE 1200 0.1278
254 INGUINAL HERNIA 746 0.1272
255 ENTERITIS 764 0.1271
256 INJECTION SITE WARMTH 2524 0.1268
257 INFUSION SITE REACTION 337 0.1267
258 CORONARY ARTERY OCCLUSION 1693 0.1265
259 INFUSION RELATED REACTION 7912 0.1261
260 MUSCULOSKELETAL PAIN 6431 0.1249
261 ARTHROPOD BITE 885 0.1249
262 WALKING AID USER 791 0.1247
263 EAR INFECTION 3154 0.1246
264 LARYNGITIS 1289 0.1241
265 SARCOIDOSIS 565 0.1240
266 SUBCUTANEOUS ABSCESS 575 0.1240
267 BLOOD IRON DECREASED 1378 0.1237
268 ENDOMETRIOSIS 562 0.1227
269 INJECTION SITE HYPERSENSITIVITY 344 0.1226
270 TUBERCULOSIS 1513 0.1225
271 INJECTION SITE RASH 3464 0.1218
272 ARTHRALGIA 48039 0.1217
273 SINUS CONGESTION 1572 0.1209
274 PROCEDURAL PAIN 3127 0.1208
275 LOWER RESPIRATORY TRACT INFECTION 5136 0.1207
276 LIVER FUNCTION TEST INCREASED 2419 0.1207
277 ARTHRITIS INFECTIVE 536 0.1204
278 GASTROINTESTINAL PAIN 1239 0.1191
279 SPINAL COLUMN STENOSIS 563 0.1190
280 INTESTINAL PERFORATION 1276 0.1190
281 BLOOD CHOLESTEROL INCREASED 5318 0.1188
282 HEPATIC CIRRHOSIS 2104 0.1185
283 INJURY ASSOCIATED WITH DEVICE 2232 0.1179
284 INJECTION SITE INJURY 593 0.1172
285 PLANTAR FASCIITIS 377 0.1171
286 NASOPHARYNGITIS 20605 0.1170
287 ARTHRITIS BACTERIAL 457 0.1168
288 INTERVERTEBRAL DISC DEGENERATION 1056 0.1168
289 CHRONIC SINUSITIS 418 0.1165
290 LIMB OPERATION 518 0.1163
291 SPINAL OSTEOARTHRITIS 989 0.1163
292 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 7805 0.1161
293 THYROID MASS 413 0.1157
294 FINE MOTOR SKILL DYSFUNCTION 314 0.1157
295 TENDON RUPTURE 1385 0.1155
296 IMMUNOSUPPRESSION 930 0.1153
297 BLISTER 6110 0.1143
298 JOINT INJURY 2336 0.1138
299 APPENDICECTOMY 385 0.1136
300 EYE INJURY 322 0.1128
301 PROCTALGIA 692 0.1122
302 LOWER LIMB FRACTURE 2016 0.1116
303 INJECTION SITE REACTION 7270 0.1112
304 PULMONARY MASS 1580 0.1111
305 RASH VESICULAR 508 0.1107
306 MATERNAL EXPOSURE TIMING UNSPECIFIED 384 0.1106
307 DRUG EFFECT DECREASED 5963 0.1106
308 UPPER RESPIRATORY TRACT INFECTION 4872 0.1104
309 WOUND DEHISCENCE 357 0.1097
310 SHOULDER OPERATION 428 0.1094
311 INJECTION SITE SWELLING 7828 0.1094
312 NORMAL NEWBORN 568 0.1091
313 TONSILLITIS 543 0.1082
314 SKIN PLAQUE 874 0.1080
315 GRANULOMA 357 0.1076
316 TOOTH INFECTION 1353 0.1069
317 PNEUMONIA VIRAL 321 0.1060
318 INCORRECT DOSE ADMINISTERED 22332 0.1060
319 RASH PUSTULAR 752 0.1059
320 REHABILITATION THERAPY 387 0.1057
321 ERYTHEMA NODOSUM 356 0.1055
322 ULCER 1614 0.1054
323 COLITIS 3741 0.1052
324 SPINAL PAIN 1182 0.1052
325 IRON DEFICIENCY 439 0.1048
326 ANAL FISSURE 534 0.1048
327 WOUND HAEMORRHAGE 377 0.1047
328 INTERVERTEBRAL DISC DISORDER 433 0.1042
329 FUNGAL SKIN INFECTION 395 0.1042
330 GASTRIC INFECTION 383 0.1042
331 INFECTION 14297 0.1041
332 PERIPHERAL SWELLING 15188 0.1041
333 ULCER HAEMORRHAGE 678 0.1041
334 NIGHT SWEATS 3172 0.1032
335 RASH PAPULAR 2226 0.1028
336 PRODUCT LABEL CONFUSION 566 0.1027
337 LYME DISEASE 326 0.1023
338 SKIN MASS 639 0.1021
339 PULMONARY THROMBOSIS 1060 0.1011
340 SARS-COV-2 TEST POSITIVE 1314 0.1006
341 DRUG TOLERANCE 490 0.1001
342 BREAST MASS 640 0.0991
343 MASS 1332 0.0987
344 PULMONARY TUBERCULOSIS 404 0.0986
345 SPINAL OPERATION 1108 0.0986
346 MATERNAL EXPOSURE DURING PREGNANCY 8185 0.0985
347 HAEMATOCHEZIA 5159 0.0984
348 DISABILITY 1852 0.0983
349 INJECTION SITE INFLAMMATION 460 0.0981
350 THERAPEUTIC RESPONSE SHORTENED 2779 0.0979
351 NECK PAIN 5233 0.0973
352 LOCAL SWELLING 1699 0.0973
353 SINUS HEADACHE 562 0.0973
354 KNEE OPERATION 885 0.0971
355 LACERATION 913 0.0970
356 ARTERIAL OCCLUSIVE DISEASE 739 0.0968
357 LOCALISED INFECTION 2240 0.0964
358 INTESTINAL HAEMORRHAGE 525 0.0964
359 WHEELCHAIR USER 410 0.0955
360 HERPES ZOSTER 5266 0.0950
361 STOMATITIS 5510 0.0950
362 THERAPY INTERRUPTED 5871 0.0947
363 EYE INFLAMMATION 840 0.0944
364 TENDON INJURY 339 0.0941
365 EXPOSURE DURING BREAST FEEDING 312 0.0940
366 PHARYNGITIS 1129 0.0940
367 UTERINE LEIOMYOMA 668 0.0939
368 GASTROINTESTINAL SOUNDS ABNORMAL 422 0.0939
369 VARICOSE VEIN 469 0.0934
370 MUSCLE RUPTURE 344 0.0930
371 SKIN ULCER 2298 0.0927
372 GASTROINTESTINAL DISORDER 7640 0.0925
373 ROAD TRAFFIC ACCIDENT 3710 0.0922
374 INCREASED TENDENCY TO BRUISE 823 0.0921
375 OVARIAN CYST 898 0.0919
376 ADVERSE REACTION 1167 0.0916
377 B-CELL LYMPHOMA 302 0.0914
378 PRESCRIBED OVERDOSE 1690 0.0909
379 CLOSTRIDIUM DIFFICILE INFECTION 1852 0.0903
380 DERMATITIS ALLERGIC 1052 0.0900
381 STREPTOCOCCAL INFECTION 474 0.0891
382 SKIN INFECTION 947 0.0891
383 STAPHYLOCOCCAL INFECTION 2848 0.0891
384 VITAMIN D DECREASED 731 0.0888
385 ABDOMINAL DISCOMFORT 14112 0.0886
386 GENERAL SYMPTOM 646 0.0884
387 PLEURISY 512 0.0884
388 ALOPECIA 16686 0.0882
389 HIP SURGERY 438 0.0881
390 FOOD ALLERGY 622 0.0881
391 ABSCESS LIMB 359 0.0878
392 PROSTATOMEGALY 330 0.0877
393 HYPOPHAGIA 2104 0.0876
394 LIGAMENT SPRAIN 825 0.0875
395 TOOTH ABSCESS 862 0.0870
396 SPINAL DISORDER 791 0.0865
397 PAPULE 568 0.0865
398 DIVERTICULITIS 2270 0.0861
399 LYMPHOMA 1283 0.0859
400 EAR PAIN 1601 0.0856
401 PAIN IN EXTREMITY 24314 0.0854
402 INJECTION SITE INDURATION 1067 0.0851
403 INTRACRANIAL ANEURYSM 329 0.0849
404 BACK DISORDER 1335 0.0849
405 LUNG DISORDER 3972 0.0848
406 INCREASED UPPER AIRWAY SECRETION 426 0.0846
407 URINARY TRACT DISORDER 362 0.0839
408 BRONCHITIS 6023 0.0838
409 GALLBLADDER OPERATION 319 0.0838
410 BRONCHIECTASIS 525 0.0838
411 SKIN LESION 2163 0.0837
412 RECTAL HAEMORRHAGE 3441 0.0829
413 TENDERNESS 837 0.0829
414 PAIN 49057 0.0828
415 MALIGNANT MELANOMA 1066 0.0826
416 SCOLIOSIS 493 0.0826
417 HEPATIC ENZYME ABNORMAL 390 0.0823
418 RHINITIS 632 0.0821
419 SQUAMOUS CELL CARCINOMA OF SKIN 470 0.0818
420 ACCIDENT 930 0.0815
421 CONTUSION 7494 0.0814
422 LUNG NEOPLASM 341 0.0814
423 HYSTERECTOMY 669 0.0814
424 DRUG ERUPTION 1361 0.0812
425 POOR PERIPHERAL CIRCULATION 335 0.0811
426 OSTEOPOROSIS 3216 0.0810
427 HYPERKERATOSIS 428 0.0809
428 SCAR 1326 0.0802
429 POOR QUALITY DRUG ADMINISTERED 519 0.0801
430 INFLAMMATORY BOWEL DISEASE 763 0.0801
431 CHOLECYSTECTOMY 865 0.0798
432 EXPOSURE DURING PREGNANCY 4753 0.0797
433 SKIN WARM 443 0.0794
434 CONCUSSION 588 0.0794
435 VIRAL UPPER RESPIRATORY TRACT INFECTION 368 0.0792
436 TOOTH FRACTURE 837 0.0784
437 SKIN LACERATION 798 0.0784
438 SPUTUM DISCOLOURED 707 0.0784
439 LARGE INTESTINE PERFORATION 520 0.0781
440 LYMPHADENOPATHY 2643 0.0779
441 HEPATIC STEATOSIS 1377 0.0777
442 INJECTION SITE DISCOLOURATION 917 0.0777
443 IMMUNE SYSTEM DISORDER 969 0.0770
444 ABNORMAL FAECES 602 0.0770
445 TENDONITIS 1157 0.0768
446 SQUAMOUS CELL CARCINOMA 690 0.0766
447 TOOTH EXTRACTION 920 0.0765
448 THERAPY NON-RESPONDER 3182 0.0762
449 KIDNEY INFECTION 1427 0.0759
450 SURGERY 4093 0.0758
451 RASH PRURITIC 3862 0.0753
452 LIMB INJURY 1948 0.0752
453 SECRETION DISCHARGE 866 0.0752
454 SKIN DISORDER 2374 0.0750
455 RETINAL DETACHMENT 658 0.0749
456 STRESS 5117 0.0746
457 LIQUID PRODUCT PHYSICAL ISSUE 476 0.0746
458 GROIN PAIN 631 0.0743
459 UNEVALUABLE EVENT 5426 0.0741
460 LIVER DISORDER 3140 0.0740
461 HIATUS HERNIA 927 0.0740
462 ADVERSE DRUG REACTION 6229 0.0738
463 DEAFNESS UNILATERAL 389 0.0738
464 HYPERSENSITIVITY 13071 0.0736
465 NEPHROLITHIASIS 3201 0.0735
466 GLAUCOMA 1351 0.0730
467 TIBIA FRACTURE 327 0.0724
468 RESPIRATORY DISORDER 2079 0.0723
469 DRUG INEFFECTIVE 90711 0.0719
470 HYPOAESTHESIA 10322 0.0716
471 IMPAIRED WORK ABILITY 1481 0.0715
472 INFLUENZA 7480 0.0713
473 OROPHARYNGEAL PAIN 6321 0.0712
474 DEFORMITY 668 0.0709
475 ABDOMINAL PAIN 15669 0.0706
476 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 5029 0.0706
477 DRUG HYPERSENSITIVITY 13197 0.0703
478 BLINDNESS UNILATERAL 947 0.0703
479 SINUS DISORDER 1328 0.0699
480 GASTROENTERITIS VIRAL 1199 0.0697
481 AORTIC ANEURYSM 515 0.0694
482 FOOD POISONING 344 0.0685
483 ILL-DEFINED DISORDER 3988 0.0683
484 MALNUTRITION 718 0.0682
485 SCAB 735 0.0681
486 EYE INFECTION 726 0.0678
487 RASH MACULAR 2242 0.0677
488 HAEMORRHOIDS 1264 0.0672
489 CATARACT 3794 0.0672
490 INJECTION SITE DISCOMFORT 639 0.0662
491 GENERAL PHYSICAL HEALTH DETERIORATION 7134 0.0658
492 PHARYNGOLARYNGEAL PAIN 349 0.0656
493 PRESCRIBED UNDERDOSE 1239 0.0655
494 ANEURYSM 313 0.0653
495 CYSTITIS 2006 0.0649
496 BREAST CANCER STAGE II 531 0.0649
497 OVERWEIGHT 332 0.0647
498 NERVE INJURY 694 0.0645
499 IRON DEFICIENCY ANAEMIA 562 0.0642
500 FUNGAL INFECTION 2041 0.0639
501 APHTHOUS ULCER 460 0.0634
502 HYPERCALCAEMIA 744 0.0631
503 DENTAL CARIES 673 0.0629
504 SLEEP DISORDER 4169 0.0628
505 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 12124 0.0627
506 GINGIVITIS 326 0.0627
507 VASCULITIS 693 0.0621
508 GASTRIC DISORDER 2126 0.0618
509 BLOOD TEST ABNORMAL 826 0.0617
510 PULMONARY TOXICITY 411 0.0617
511 MIGRAINE 5553 0.0616
512 WHITE BLOOD CELL COUNT INCREASED 2285 0.0614
513 RASH 25267 0.0614
514 ANAL INCONTINENCE 508 0.0612
515 WHEEZING 3432 0.0612
516 RESPIRATORY TRACT INFECTION 1499 0.0609
517 DEAFNESS 1524 0.0609
518 HAND FRACTURE 414 0.0607
519 FRUSTRATION TOLERANCE DECREASED 461 0.0607
520 BACK PAIN 13518 0.0605
521 HERPES VIRUS INFECTION 334 0.0604
522 MUSCULOSKELETAL DISCOMFORT 994 0.0603
523 GAIT DISTURBANCE 11135 0.0602
524 ORAL HERPES 1114 0.0601
525 SKIN HAEMORRHAGE 801 0.0601
526 ADRENAL INSUFFICIENCY 674 0.0601
527 CELLULITIS 2915 0.0600
528 MUSCLE STRAIN 498 0.0599
529 CARDIAC MURMUR 505 0.0597
530 IMPAIRED QUALITY OF LIFE 824 0.0596
531 VIRAL INFECTION 1876 0.0595
532 BRAIN NEOPLASM 521 0.0593
533 MOUTH ULCERATION 1188 0.0593
534 ORAL CANDIDIASIS 732 0.0592
535 EAR DISCOMFORT 579 0.0591
536 SKIN CANCER 1215 0.0590
537 SPINAL COMPRESSION FRACTURE 490 0.0590
538 CONGENITAL ANOMALY 437 0.0588
539 SKIN ATROPHY 322 0.0588
540 DEVICE MALFUNCTION 3625 0.0588
541 TOOTHACHE 1021 0.0587
542 UPPER LIMB FRACTURE 1130 0.0585
543 BOWEL MOVEMENT IRREGULARITY 421 0.0584
544 ANKLE FRACTURE 871 0.0584
545 HEPATITIS 1429 0.0582
546 BACTERIAL INFECTION 1021 0.0579
547 TONGUE DISORDER 410 0.0579
548 NEOPLASM 636 0.0577
549 UPPER-AIRWAY COUGH SYNDROME 447 0.0576
550 RENAL CYST 441 0.0575
551 VITAMIN D DEFICIENCY 534 0.0575
552 DRUG-INDUCED LIVER INJURY 1639 0.0573
553 FOOT FRACTURE 1050 0.0573
554 CONDITION AGGRAVATED 16339 0.0572
555 PYREXIA 18989 0.0571
556 BLOOD POTASSIUM DECREASED 1650 0.0570
557 INJURY 3875 0.0563
558 GALLBLADDER DISORDER 969 0.0563
559 HYPERTENSION 11421 0.0562
560 TENDON DISORDER 353 0.0560
561 DYSSTASIA 1579 0.0559
562 RHINORRHOEA 3410 0.0557
563 APPENDICITIS 489 0.0556
564 NASAL CONGESTION 3047 0.0549
565 ONYCHOCLASIS 358 0.0549
566 PELVIC FRACTURE 405 0.0547
567 GENERAL PHYSICAL CONDITION ABNORMAL 357 0.0545
568 BLOOD MAGNESIUM DECREASED 447 0.0542
569 OEDEMA 2805 0.0541
570 OCULAR DISCOMFORT 541 0.0541
571 URTICARIA 8530 0.0540
572 COVID-19 9251 0.0539
573 SPINAL FRACTURE 1020 0.0538
574 PRURITUS GENERALISED 1164 0.0537
575 FAECES SOFT 364 0.0536
576 URINARY TRACT INFECTION 8673 0.0534
577 DIVERTICULUM 378 0.0533
578 CHOLELITHIASIS 1664 0.0531
579 PHOTOSENSITIVITY REACTION 840 0.0530
580 SCRATCH 512 0.0530
581 ABORTION SPONTANEOUS 2055 0.0529
582 FATIGUE 39110 0.0527
583 INCORRECT PRODUCT STORAGE 693 0.0527
584 INFARCTION 354 0.0525
585 GINGIVAL PAIN 397 0.0522
586 ESCHERICHIA INFECTION 404 0.0521
587 WRIST FRACTURE 599 0.0520
588 PRE-EXISTING CONDITION IMPROVED 319 0.0516
589 OSTEOMYELITIS 900 0.0515
590 SEASONAL ALLERGY 684 0.0513
591 MENINGITIS 327 0.0512
592 SKIN FISSURES 875 0.0511
593 ABDOMINAL PAIN UPPER 10000 0.0511
594 EYE DISORDER 1600 0.0511
595 ILLNESS 4617 0.0510
596 INTENTIONAL PRODUCT USE ISSUE 4260 0.0509
597 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 790 0.0507
598 ABDOMINAL DISTENSION 5008 0.0507
599 PNEUMONIA 15563 0.0505
600 GENERALISED OEDEMA 592 0.0505
601 SNEEZING 1076 0.0505
602 SKIN REACTION 675 0.0504
603 MALAISE 21342 0.0504
604 MYOSITIS 427 0.0503
605 SKIN DISCOLOURATION 2213 0.0503
606 ILEUS 587 0.0500
607 LUNG INFECTION 777 0.0500
608 BEDRIDDEN 628 0.0498
609 DRUG DOSE OMISSION 8215 0.0496
610 RASH GENERALISED 1285 0.0496
611 RASH ERYTHEMATOUS 2147 0.0494
612 MUSCULOSKELETAL CHEST PAIN 731 0.0493
613 RIB FRACTURE 969 0.0493
614 FACIAL PARALYSIS 393 0.0492
615 DYSPEPSIA 4594 0.0492
616 GASTRITIS 1241 0.0492
617 PARAESTHESIA 7417 0.0488
618 AUTOIMMUNE HEPATITIS 320 0.0487
619 BLINDNESS 1892 0.0486
620 POST PROCEDURAL HAEMORRHAGE 542 0.0483
621 WEIGHT INCREASED 10197 0.0481
622 GASTRIC ULCER 882 0.0480
623 HAEMORRHAGIC STROKE 365 0.0480
624 EPILEPSY 1391 0.0479
625 PHOTOPHOBIA 851 0.0476
626 WEIGHT DECREASED 12703 0.0475
627 OEDEMA PERIPHERAL 5586 0.0472
628 HEADACHE 28330 0.0472
629 TASTE DISORDER 872 0.0471
630 LIVER FUNCTION TEST ABNORMAL 1337 0.0471
631 INFLUENZA LIKE ILLNESS 3720 0.0467
632 SLEEP APNOEA SYNDROME 861 0.0466
633 COUGH 12396 0.0465
634 PRODUCTIVE COUGH 2067 0.0463
635 DIABETES MELLITUS 3429 0.0463
636 VAGINAL DISCHARGE 444 0.0458
637 EMPHYSEMA 448 0.0458
638 NEEDLE ISSUE 1215 0.0455
639 MUSCULAR WEAKNESS 4957 0.0455
640 BONE DISORDER 811 0.0454
641 OPTIC NEURITIS 397 0.0451
642 FALL 14261 0.0448
643 FLANK PAIN 399 0.0446
644 PNEUMOTHORAX 674 0.0444
645 ABASIA 1098 0.0444
646 COLON CANCER 632 0.0441
647 PAIN OF SKIN 1143 0.0440
648 FEELING HOT 2598 0.0439
649 CANDIDA INFECTION 688 0.0438
650 INTERNAL HAEMORRHAGE 483 0.0438
651 FEEDING DISORDER 802 0.0436
652 OSTEOPENIA 642 0.0435
653 INJECTION SITE MASS 1527 0.0435
654 PAROSMIA 313 0.0434
655 FACIAL PAIN 368 0.0432
656 DERMATITIS CONTACT 469 0.0432
657 HYPERAESTHESIA 346 0.0430
658 APHONIA 570 0.0428
659 NEURALGIA 986 0.0427
660 HEAD INJURY 1287 0.0427
661 DRY MOUTH 3294 0.0427
662 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 2125 0.0426
663 AMNESIA 2678 0.0426
664 LOSS OF CONSCIOUSNESS 5239 0.0426
665 CHILLS 4802 0.0425
666 MULTIPLE ALLERGIES 320 0.0425
667 THYROID DISORDER 625 0.0424
668 CARDIAC OPERATION 340 0.0424
669 GASTROOESOPHAGEAL REFLUX DISEASE 3229 0.0423
670 PREGNANCY 828 0.0419
671 DIARRHOEA 25415 0.0416
672 CHEST PAIN 7427 0.0416
673 PRODUCT USE ISSUE 7271 0.0412
674 PRURITUS 14484 0.0410
675 BLOOD DISORDER 317 0.0409
676 FLATULENCE 2188 0.0407
677 ASTHMA 4278 0.0405
678 PARAESTHESIA ORAL 554 0.0404
679 SEPSIS 4315 0.0403
680 TOOTH DISORDER 871 0.0403
681 LIMB DISCOMFORT 1194 0.0402
682 BLOOD ALBUMIN DECREASED 305 0.0402
683 MUSCLE SPASMS 7045 0.0401
684 VISUAL IMPAIRMENT 4652 0.0399
685 BLOOD URINE PRESENT 730 0.0398
686 INTRAOCULAR PRESSURE INCREASED 491 0.0397
687 VITREOUS FLOATERS 365 0.0395
688 GOUT 680 0.0395
689 UROSEPSIS 345 0.0394
690 BURNING SENSATION 2623 0.0390
691 BLOOD PRESSURE ABNORMAL 733 0.0389
692 PLATELET COUNT INCREASED 487 0.0389
693 DERMATITIS 750 0.0388
694 DRY EYE 1726 0.0387
695 WEIGHT FLUCTUATION 382 0.0386
696 INTENTIONAL DOSE OMISSION 937 0.0385
697 FEMUR FRACTURE 1149 0.0383
698 HEPATOTOXICITY 806 0.0382
699 DYSURIA 1355 0.0382
700 LABORATORY TEST ABNORMAL 1077 0.0381
701 ABDOMINAL PAIN LOWER 922 0.0380
702 QUALITY OF LIFE DECREASED 491 0.0380
703 THROMBOSIS 2938 0.0378
704 THERAPEUTIC RESPONSE DECREASED 2171 0.0378
705 PANCREATITIS 1914 0.0377
706 ASTHENIA 13565 0.0376
707 HEAD DISCOMFORT 629 0.0376
708 DELIRIUM 1223 0.0371
709 ERYTHEMA 7263 0.0370
710 THERAPY CESSATION 1792 0.0369
711 DEPRESSION 8138 0.0368
712 ACTIVITIES OF DAILY LIVING IMPAIRED 730 0.0368
713 VOMITING 16426 0.0368
714 NEOPLASM MALIGNANT 2343 0.0367
715 EYE HAEMORRHAGE 470 0.0364
716 ECZEMA 1597 0.0361
717 NAUSEA 27101 0.0360
718 PHARYNGEAL OEDEMA 553 0.0360
719 DECREASED APPETITE 7922 0.0359
720 MUSCLE ATROPHY 427 0.0359
721 PULMONARY OEDEMA 1537 0.0357
722 CONFUSIONAL STATE 5528 0.0355
723 INTERSTITIAL LUNG DISEASE 1625 0.0353
724 ABORTION INDUCED 318 0.0351
725 RENAL DISORDER 1575 0.0350
726 BLADDER DISORDER 336 0.0350
727 MEMORY IMPAIRMENT 4596 0.0347
728 CARDIOMEGALY 419 0.0347
729 SENSORY DISTURBANCE 540 0.0346
730 ADVERSE EVENT 3052 0.0345
731 INSOMNIA 8851 0.0345
732 HEPATOMEGALY 329 0.0344
733 VERTIGO 2009 0.0343
734 SWELLING FACE 2134 0.0343
735 CONJUNCTIVITIS 594 0.0342
736 PAIN IN JAW 936 0.0342
737 SPLENOMEGALY 384 0.0342
738 LEUKAEMIA 309 0.0341
739 IMPAIRED GASTRIC EMPTYING 370 0.0339
740 HAEMORRHAGE 3392 0.0338
741 DEHYDRATION 4327 0.0338
742 CLOSTRIDIUM DIFFICILE COLITIS 342 0.0337
743 SKIN EXFOLIATION 2637 0.0337
744 RENAL PAIN 341 0.0335
745 GASTRIC HAEMORRHAGE 376 0.0334
746 FAECES DISCOLOURED 689 0.0331
747 PERIPHERAL COLDNESS 432 0.0327
748 POOR QUALITY SLEEP 666 0.0327
749 DIPLOPIA 807 0.0326
750 ANAPHYLACTIC REACTION 1687 0.0325
751 EYE PAIN 1662 0.0318
752 DEVICE RELATED INFECTION 475 0.0318
753 GASTROENTERITIS 441 0.0316
754 EYE SWELLING 1117 0.0316
755 TINNITUS 1395 0.0315
756 HAEMOGLOBIN DECREASED 3124 0.0315
757 HYPERHIDROSIS 3905 0.0314
758 ORAL PAIN 676 0.0312
759 GINGIVAL BLEEDING 410 0.0312
760 FLUID RETENTION 1518 0.0310
761 HAEMATEMESIS 757 0.0309
762 DYSPHONIA 1727 0.0309
763 PRODUCT ADMINISTRATION ERROR 572 0.0308
764 DRUG ADMINISTERED AT INAPPROPRIATE SITE 325 0.0308
765 THYROID CANCER 360 0.0307
766 DIZZINESS 14617 0.0307
767 THROAT IRRITATION 1299 0.0306
768 SEPTIC SHOCK 1256 0.0305
769 CARDIAC DISORDER 2766 0.0305
770 DEPRESSED MOOD 1526 0.0304
771 FOETAL EXPOSURE DURING PREGNANCY 2369 0.0304
772 FEELING COLD 811 0.0302
773 BREAST PAIN 311 0.0302
774 COLD SWEAT 512 0.0301
775 HIP FRACTURE 923 0.0301
776 MUSCLE TIGHTNESS 466 0.0300
777 FEELING ABNORMAL 6927 0.0298
778 HAEMATOCRIT DECREASED 576 0.0297
779 ANAEMIA 5376 0.0293
780 BONE PAIN 1640 0.0292
781 MYALGIA 4736 0.0291
782 ANXIETY 7952 0.0289
783 FEAR 758 0.0288
784 DYSPNOEA 15479 0.0286
785 ORAL DISCOMFORT 381 0.0285
786 RED BLOOD CELL COUNT DECREASED 782 0.0284
787 HOSPITALISATION 4068 0.0283
788 CHOLECYSTITIS 320 0.0283
789 BLOOD SODIUM DECREASED 507 0.0281
790 NERVOUS SYSTEM DISORDER 851 0.0281
791 NERVOUSNESS 1432 0.0281
792 SWOLLEN TONGUE 841 0.0280
793 ALANINE AMINOTRANSFERASE INCREASED 1644 0.0279
794 PULMONARY CONGESTION 352 0.0276
795 ASPARTATE AMINOTRANSFERASE INCREASED 1389 0.0272
796 NO THERAPEUTIC RESPONSE 331 0.0271
797 VISION BLURRED 3506 0.0269
798 THERAPY PARTIAL RESPONDER 362 0.0269
799 MEDICATION ERROR 1409 0.0267
800 TRANSIENT ISCHAEMIC ATTACK 869 0.0266
801 ASCITES 746 0.0264
802 HYPOACUSIS 1078 0.0263
803 PARALYSIS 364 0.0263
804 PULMONARY EMBOLISM 2418 0.0262
805 PLEURAL EFFUSION 1529 0.0261
806 DRUG RESISTANCE 640 0.0260
807 BREAST CANCER FEMALE 679 0.0259
808 MENTAL DISORDER 1086 0.0259
809 POLLAKIURIA 1033 0.0259
810 LACRIMATION INCREASED 729 0.0259
811 PRESYNCOPE 596 0.0259
812 OFF LABEL USE 20956 0.0257
813 BLOOD TRIGLYCERIDES INCREASED 438 0.0256
814 HYPOTHYROIDISM 773 0.0255
815 BODY TEMPERATURE INCREASED 504 0.0255
816 OCULAR HYPERAEMIA 1108 0.0253
817 DRUG DISPENSING ERROR 387 0.0253
818 PANIC ATTACK 887 0.0253
819 HAEMOPTYSIS 675 0.0251
820 RENAL FAILURE 3260 0.0251
821 ACNE 1838 0.0249
822 HYPERSOMNIA 682 0.0249
823 MOVEMENT DISORDER 773 0.0249
824 MYOCARDIAL INFARCTION 4255 0.0249
825 EPISTAXIS 1785 0.0248
826 CONSTIPATION 5069 0.0248
827 MENORRHAGIA 487 0.0248
828 NEUROPATHY PERIPHERAL 2204 0.0246
829 BLOOD PRESSURE INCREASED 3623 0.0246
830 PERICARDIAL EFFUSION 540 0.0246
831 SEIZURE 2646 0.0245
832 LUNG NEOPLASM MALIGNANT 981 0.0245
833 SYNCOPE 2355 0.0245
834 ATRIAL FIBRILLATION 2272 0.0243
835 HEART RATE IRREGULAR 523 0.0237
836 PALLOR 620 0.0235
837 BONE DENSITY DECREASED 724 0.0235
838 HYPOAESTHESIA ORAL 339 0.0234
839 APHASIA 679 0.0233
840 RESTLESS LEGS SYNDROME 409 0.0233
841 TRANSAMINASES INCREASED 494 0.0232
842 TUBULOINTERSTITIAL NEPHRITIS 415 0.0232
843 CHEST DISCOMFORT 2239 0.0231
844 CARDIOVASCULAR DISORDER 574 0.0230
845 CARDIAC FAILURE 1772 0.0230
846 HEART RATE DECREASED 783 0.0230
847 BLOOD PRESSURE FLUCTUATION 533 0.0229
848 RETCHING 465 0.0229
849 CEREBROVASCULAR ACCIDENT 3752 0.0229
850 URINARY INCONTINENCE 650 0.0228
851 DEEP VEIN THROMBOSIS 1435 0.0227
852 DIALYSIS 311 0.0227
853 THERAPEUTIC RESPONSE UNEXPECTED 985 0.0226
854 PELVIC PAIN 386 0.0226
855 HAEMATURIA 746 0.0225
856 HAEMATOMA 566 0.0225
857 DRY SKIN 2760 0.0224
858 LIP SWELLING 711 0.0224
859 HEMIPARESIS 367 0.0224
860 PREMATURE BABY 655 0.0223
861 PERITONITIS 439 0.0221
862 SLEEP DISORDER DUE TO A GENERAL MEDICAL CONDITION 306 0.0218
863 CARDIOMYOPATHY 305 0.0213
864 MULTIPLE FRACTURES 342 0.0212
865 EMOTIONAL DISORDER 633 0.0212
866 PNEUMONITIS 541 0.0212
867 LEUKOPENIA 1008 0.0211
868 PALPITATIONS 2339 0.0209
869 ANGINA PECTORIS 585 0.0209
870 BALANCE DISORDER 1743 0.0209
871 CRYING 738 0.0209
872 EATING DISORDER 427 0.0207
873 EYE PRURITUS 632 0.0207
874 VAGINAL HAEMORRHAGE 854 0.0206
875 LETHARGY 1141 0.0206
876 RASH MACULO-PAPULAR 433 0.0205
877 THROAT TIGHTNESS 530 0.0205
878 BLOOD GLUCOSE ABNORMAL 363 0.0204
879 HOT FLUSH 1474 0.0203
880 OXYGEN SATURATION DECREASED 1071 0.0203
881 MIDDLE INSOMNIA 361 0.0202
882 PRODUCT DISPENSING ERROR 407 0.0200
883 FEELING JITTERY 367 0.0199
884 TACHYCARDIA 1692 0.0199
885 RENAL IMPAIRMENT 1583 0.0198
886 INTENTIONAL PRODUCT MISUSE 1647 0.0198
887 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 1057 0.0196
888 FRACTURE 356 0.0195
889 UNDERDOSE 1362 0.0195
890 DYSPHAGIA 1756 0.0195
891 MULTIPLE SCLEROSIS 898 0.0193
892 TOOTH LOSS 390 0.0192
893 DYSPNOEA EXERTIONAL 686 0.0192
894 PRODUCT ADMINISTERED AT INAPPROPRIATE SITE 326 0.0191
895 CHROMATURIA 413 0.0191
896 ANAPHYLACTIC SHOCK 461 0.0190
897 HEART RATE INCREASED 1792 0.0189
898 COMA 863 0.0188
899 DEMENTIA 490 0.0186
900 PULMONARY HYPERTENSION 372 0.0184
901 MOOD ALTERED 474 0.0182
902 URINARY RETENTION 578 0.0182
903 PRODUCT USE IN UNAPPROVED INDICATION 4141 0.0181
904 CARDIAC FAILURE CONGESTIVE 1436 0.0181
905 SPEECH DISORDER 911 0.0181
906 MUSCLE TWITCHING 401 0.0180
907 THIRST 305 0.0180
908 CORONARY ARTERY DISEASE 534 0.0179
909 MOOD SWINGS 550 0.0178
910 TREMOR 2851 0.0178
911 CHOKING 330 0.0178
912 SKIN IRRITATION 784 0.0178
913 INCORRECT ROUTE OF DRUG ADMINISTRATION 635 0.0177
914 LEUKOCYTOSIS 305 0.0177
915 VISUAL ACUITY REDUCED 575 0.0176
916 ARRHYTHMIA 805 0.0176
917 BLOOD CREATININE INCREASED 1099 0.0174
918 DRUG PRESCRIBING ERROR 330 0.0172
919 ALTERED STATE OF CONSCIOUSNESS 348 0.0170
920 HEPATIC FUNCTION ABNORMAL 587 0.0167
921 OSTEONECROSIS 529 0.0163
922 WHITE BLOOD CELL COUNT DECREASED 1694 0.0162
923 CEREBRAL HAEMORRHAGE 552 0.0161
924 HYPOKALAEMIA 688 0.0157
925 SUICIDAL IDEATION 1375 0.0156
926 GASTROINTESTINAL HAEMORRHAGE 1272 0.0156
927 RESPIRATORY FAILURE 1090 0.0156
928 DRUG ADMINISTRATION ERROR 475 0.0155
929 PRODUCT STORAGE ERROR 1231 0.0152
930 BREAST CANCER 1369 0.0149
931 ANGER 488 0.0149
932 RESPIRATORY DISTRESS 393 0.0148
933 SOMNOLENCE 2859 0.0148
934 BLOOD PRESSURE DECREASED 942 0.0148
935 ACUTE MYOCARDIAL INFARCTION 423 0.0148
936 DYSGEUSIA 1059 0.0146
937 DEATH 12028 0.0146
938 JAUNDICE 379 0.0145
939 HEPATIC FAILURE 411 0.0142
940 DISORIENTATION 541 0.0141
941 PRODUCT PRESCRIBING ERROR 311 0.0141
942 CARDIO-RESPIRATORY ARREST 571 0.0141
943 AGEUSIA 335 0.0140
944 MENTAL IMPAIRMENT 324 0.0139
945 TREATMENT NONCOMPLIANCE 711 0.0138
946 HYPOTENSION 2624 0.0137
947 SKIN BURNING SENSATION 909 0.0134
948 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 2178 0.0133
949 DISEASE RECURRENCE 615 0.0133
950 DYSARTHRIA 476 0.0132
951 BLOOD GLUCOSE DECREASED 604 0.0130
952 DEVICE LEAKAGE 501 0.0129
953 EYE IRRITATION 657 0.0129
954 DEVICE USE ERROR 414 0.0129
955 DEVICE BREAKAGE 444 0.0125
956 CHRONIC KIDNEY DISEASE 926 0.0124
957 MENSTRUATION IRREGULAR 316 0.0123
958 IRRITABILITY 707 0.0122
959 BLOOD GLUCOSE INCREASED 2133 0.0117
960 NIGHTMARE 387 0.0115
961 DEVICE DISLOCATION 477 0.0115
962 THROMBOCYTOPENIA 1225 0.0115
963 CARDIAC ARREST 882 0.0111
964 DISTURBANCE IN ATTENTION 566 0.0108
965 PANCYTOPENIA 540 0.0101
966 PRODUCT QUALITY ISSUE 1318 0.0101
967 FLUSHING 990 0.0100
968 ANGIOEDEMA 424 0.0100
969 PLATELET COUNT DECREASED 1005 0.0098
970 DEVICE DIFFICULT TO USE 624 0.0098
971 COGNITIVE DISORDER 426 0.0096
972 PROSTATE CANCER 749 0.0094
973 CONVULSION 531 0.0093
974 ACCIDENTAL EXPOSURE TO PRODUCT 760 0.0083
975 ACUTE KIDNEY INJURY 1172 0.0081
976 DYSKINESIA 309 0.0080
977 RENAL FAILURE ACUTE 331 0.0078
978 RENAL CANCER 363 0.0077
979 HYPOGLYCAEMIA 343 0.0074
980 DRUG INTERACTION 1079 0.0071
981 EMOTIONAL DISTRESS 822 0.0070
982 NEUTROPENIA 880 0.0068
983 SUICIDE ATTEMPT 393 0.0067
984 HALLUCINATION 471 0.0066
985 HYPONATRAEMIA 355 0.0066
986 BLADDER CANCER 371 0.0063
987 DISEASE PROGRESSION 707 0.0063
988 OVERDOSE 1310 0.0062
989 AGITATION 440 0.0062
990 PRODUCT SUBSTITUTION ISSUE 327 0.0059
991 PRODUCT DOSE OMISSION 385 0.0058
992 PRODUCT DOSE OMISSION ISSUE 1159 0.0046
993 TOXICITY TO VARIOUS AGENTS 624 0.0039
994 DRUG DEPENDENCE 620 0.0039
995 NO ADVERSE EVENT 483 0.0029