LAROTRECTINIB

LAROTRECTINIB was reported 379 times

LAROTRECTINIB is most commonly taken among patients reporting these side effects:

# Side effect Count Frequency
0 NTRK GENE FUSION OVEREXPRESSION 1 0.5000
1 NASAL ASPIRATION 1 0.2500
2 FIBROSARCOMA METASTATIC 1 0.2000
3 UPPER AIRWAY NECROSIS 1 0.1111
4 SALIVARY GLAND CANCER RECURRENT 1 0.0909
5 ADENOCARCINOMA OF SALIVARY GLAND 2 0.0769
6 NEUROENDOCRINE CARCINOMA OF PROSTATE 1 0.0556
7 BLADDER TRANSITIONAL CELL CARCINOMA METASTATIC 1 0.0370
8 NEUROENDOCRINE TUMOUR OF THE LUNG METASTATIC 1 0.0333
9 DESMOPLASTIC SMALL ROUND CELL TUMOUR 2 0.0317
10 NERVOUS SYSTEM NEOPLASM 1 0.0244
11 MENINGIOMA MALIGNANT 1 0.0233
12 SALIVARY GLAND ADENOMA 1 0.0208
13 LUNG SQUAMOUS CELL CARCINOMA METASTATIC 1 0.0200
14 ANAPLASTIC THYROID CANCER 1 0.0192
15 UTERINE LEIOMYOSARCOMA 1 0.0154
16 VASCULAR NEOPLASM 1 0.0130
17 OLIGODENDROGLIOMA 1 0.0108
18 ASTROCYTOMA 3 0.0106
19 MALIGNANT GLIOMA 1 0.0103
20 GLIOMA 4 0.0098
21 NON-SMALL CELL LUNG CANCER RECURRENT 1 0.0085
22 SOFT TISSUE SARCOMA 2 0.0080
23 HEAD CIRCUMFERENCE ABNORMAL 1 0.0077
24 TRACHEAL HAEMORRHAGE 2 0.0071
25 DOSE CALCULATION ERROR 2 0.0066
26 SALIVARY GLAND PAIN 1 0.0065
27 CHOLELITHOTOMY 1 0.0063
28 GLIOBLASTOMA 7 0.0062
29 PHARYNGEAL OPERATION 1 0.0056
30 FOOD REFUSAL 2 0.0052
31 SALIVARY GLAND CANCER 2 0.0050
32 ALOPECIA UNIVERSALIS 1 0.0048
33 THORACIC CAVITY DRAINAGE 1 0.0047
34 PELVIC NEOPLASM 1 0.0040
35 HEMIANAESTHESIA 3 0.0038
36 INTRACRANIAL MASS 2 0.0031
37 TUMOUR INVASION 1 0.0029
38 METASTASES TO BONE MARROW 1 0.0028
39 GLIOBLASTOMA MULTIFORME 2 0.0028
40 ORTHOSTATIC HYPERTENSION 1 0.0026
41 NEUROLOGICAL EXAMINATION ABNORMAL 1 0.0026
42 NONINFECTIVE ENCEPHALITIS 1 0.0026
43 REFUSAL OF TREATMENT BY RELATIVE 1 0.0024
44 SARCOMA 2 0.0023
45 LOSS OF THERAPEUTIC RESPONSE 1 0.0023
46 INTERCEPTED PRODUCT ADMINISTRATION ERROR 1 0.0022
47 METASTASES TO MENINGES 3 0.0022
48 ALLODYNIA 1 0.0020
49 TRAUMATIC FRACTURE 1 0.0019
50 EASTERN COOPERATIVE ONCOLOGY GROUP PERFORMANCE STATUS WORSENED 1 0.0018
51 EYELID FUNCTION DISORDER 1 0.0016
52 GENE MUTATION 2 0.0016
53 BRONCHIAL CARCINOMA 1 0.0015
54 EMERGENCY CARE 2 0.0015
55 CARDIAC STRESS TEST ABNORMAL 1 0.0014
56 HYPERVIGILANCE 1 0.0013
57 LUNG CANCER METASTATIC 3 0.0013
58 BONE NEOPLASM 1 0.0012
59 COLORECTAL CANCER METASTATIC 1 0.0011
60 ASPARTATE AMINOTRANSFERASE ABNORMAL 1 0.0011
61 PANCREATIC NEOPLASM 1 0.0011
62 TUMOUR PAIN 1 0.0011
63 HAEMOLYTIC URAEMIC SYNDROME 2 0.0010
64 GALLBLADDER CANCER 1 0.0009
65 PANCREATIC CARCINOMA METASTATIC 2 0.0009
66 COLON CANCER METASTATIC 1 0.0008
67 SENSITIVE SKIN 3 0.0008
68 THERAPEUTIC PRODUCT INEFFECTIVE 2 0.0008
69 CARCINOEMBRYONIC ANTIGEN INCREASED 1 0.0008
70 AMYLASE INCREASED 2 0.0008
71 METASTASES TO LUNG 6 0.0008
72 ALANINE AMINOTRANSFERASE ABNORMAL 1 0.0007
73 CELL DEATH 1 0.0007
74 EYELID IRRITATION 1 0.0007
75 AMYOTROPHIC LATERAL SCLEROSIS 1 0.0007
76 EAR HAEMORRHAGE 1 0.0007
77 ENDOMETRIAL CANCER 1 0.0006
78 ACUTE LYMPHOCYTIC LEUKAEMIA RECURRENT 1 0.0006
79 NEUROLOGICAL DECOMPENSATION 1 0.0006
80 METASTASIS 3 0.0006
81 PERIARTHRITIS 1 0.0006
82 INCORRECT DOSAGE ADMINISTERED 2 0.0006
83 JAW FRACTURE 1 0.0006
84 VARICELLA 1 0.0005
85 CEREBELLAR SYNDROME 1 0.0005
86 HEPATIC CYTOLYSIS 1 0.0005
87 EXPOSURE VIA SKIN CONTACT 1 0.0005
88 ABDOMINAL MASS 1 0.0005
89 DRUG RESISTANCE 8 0.0005
90 METASTASES TO LYMPH NODES 2 0.0004
91 ONYCHOMADESIS 1 0.0004
92 SHOULDER OPERATION 1 0.0004
93 FIBROSIS 1 0.0004
94 SUSPECTED COUNTERFEIT PRODUCT 1 0.0004
95 METASTASES TO LIVER 5 0.0004
96 REGURGITATION 1 0.0004
97 MULTIPLE ALLERGIES 2 0.0004
98 THERAPY CHANGE 2 0.0004
99 PRODUCT SUPPLY ISSUE 1 0.0004
100 HALLUCINATIONS, MIXED 1 0.0004
101 METASTASES TO CENTRAL NERVOUS SYSTEM 3 0.0004
102 NAIL DISCOLOURATION 1 0.0004
103 HEPATIC LESION 1 0.0003
104 METASTATIC NEOPLASM 1 0.0003
105 TUMOUR MARKER INCREASED 1 0.0003
106 SELF-INJURIOUS IDEATION 1 0.0003
107 LIVER FUNCTION TEST INCREASED 4 0.0003
108 DISEASE COMPLICATION 1 0.0003
109 COMPRESSION FRACTURE 1 0.0003
110 TRANSAMINASES INCREASED 5 0.0003
111 HEPATIC ENZYME ABNORMAL 1 0.0003
112 HYPERNATRAEMIA 1 0.0003
113 NEUROTOXICITY 3 0.0003
114 FAECALOMA 1 0.0003
115 PULMONARY THROMBOSIS 2 0.0003
116 PULMONARY TOXICITY 1 0.0003
117 ASPERGILLUS INFECTION 1 0.0003
118 CHOLANGITIS 1 0.0002
119 HEPATOCELLULAR INJURY 3 0.0002
120 HYDROCEPHALUS 1 0.0002
121 NEURALGIA 4 0.0002
122 PANCREATIC CARCINOMA 5 0.0002
123 FAILURE TO THRIVE 1 0.0002
124 PRODUCT DOSE OMISSION IN ERROR 1 0.0002
125 DISEASE PROGRESSION 17 0.0002
126 MULTIPLE FRACTURES 3 0.0002
127 FEELING OF BODY TEMPERATURE CHANGE 1 0.0002
128 PRODUCT PRESCRIBING ISSUE 1 0.0002
129 HYPERVENTILATION 1 0.0002
130 DERMATITIS EXFOLIATIVE 1 0.0002
131 POISONING DELIBERATE 1 0.0002
132 THYROID CANCER 2 0.0002
133 BRAIN OEDEMA 2 0.0002
134 NEUROPATHY PERIPHERAL 13 0.0002
135 TROPONIN INCREASED 1 0.0002
136 CYTOKINE RELEASE SYNDROME 1 0.0002
137 METASTASES TO BONE 2 0.0002
138 HAND FRACTURE 1 0.0002
139 EYE MOVEMENT DISORDER 1 0.0002
140 MYELOSUPPRESSION 1 0.0002
141 PRE-EXISTING CONDITION IMPROVED 1 0.0002
142 GAIT INABILITY 3 0.0002
143 PNEUMOTHORAX 2 0.0002
144 ESCHERICHIA INFECTION 1 0.0002
145 HYPOAESTHESIA ORAL 2 0.0002
146 PANIC REACTION 1 0.0002
147 CARDIOMYOPATHY 2 0.0002
148 SCRATCH 1 0.0002
149 HEPATOCELLULAR CARCINOMA 1 0.0002
150 FURUNCLE 1 0.0002
151 PRODUCT USE COMPLAINT 1 0.0002
152 DIZZINESS POSTURAL 1 0.0002
153 PRODUCT AVAILABILITY ISSUE 1 0.0002
154 HEPATIC ENZYME INCREASED 7 0.0002
155 HEPATIC FUNCTION ABNORMAL 4 0.0002
156 MUSCLE STRAIN 1 0.0002
157 EMBOLISM 1 0.0002
158 HYPERAESTHESIA 1 0.0002
159 BLOOD ALKALINE PHOSPHATASE INCREASED 3 0.0001
160 THERAPY CESSATION 5 0.0001
161 HYPERSOMNIA 3 0.0001
162 RESTLESS LEGS SYNDROME 2 0.0001
163 LABELLED DRUG-DRUG INTERACTION MEDICATION ERROR 1 0.0001
164 OVARIAN CANCER 1 0.0001
165 BLOOD THYROID STIMULATING HORMONE INCREASED 1 0.0001
166 HEPATIC ENCEPHALOPATHY 1 0.0001
167 WITHDRAWAL SYNDROME 4 0.0001
168 MOTOR DYSFUNCTION 1 0.0001
169 NEOPLASM PROGRESSION 3 0.0001
170 FEELING JITTERY 2 0.0001
171 JOINT RANGE OF MOTION DECREASED 1 0.0001
172 SPINAL PAIN 1 0.0001
173 HOSPITALISATION 12 0.0001
174 POLYNEUROPATHY 1 0.0001
175 INTESTINAL PERFORATION 1 0.0001
176 MALIGNANT NEOPLASM PROGRESSION 8 0.0001
177 EAR INFECTION 2 0.0001
178 LUNG DISORDER 4 0.0001
179 PARAESTHESIA 13 0.0001
180 SURGERY 4 0.0001
181 TACHYPNOEA 1 0.0001
182 NEOPLASM MALIGNANT 5 0.0001
183 ALANINE AMINOTRANSFERASE INCREASED 5 0.0001
184 PROSTATIC SPECIFIC ANTIGEN INCREASED 1 0.0001
185 SKIN FISSURES 1 0.0001
186 HYPERLIPIDAEMIA 1 0.0001
187 PERIPHERAL COLDNESS 1 0.0001
188 ASPARTATE AMINOTRANSFERASE INCREASED 4 0.0001
189 ORAL DISCOMFORT 1 0.0001
190 FEELING COLD 2 0.0001
191 CARDIOMEGALY 1 0.0001
192 MASS 1 0.0001
193 GENERALISED TONIC-CLONIC SEIZURE 1 0.0001
194 BLOOD BILIRUBIN INCREASED 2 0.0001
195 INFLUENZA LIKE ILLNESS 6 0.0001
196 RESPIRATORY TRACT CONGESTION 1 0.0001
197 ACUTE MYELOID LEUKAEMIA 1 0.0001
198 DELUSION 1 0.0001
199 ASCITES 2 0.0001
200 RESPIRATORY DISORDER 2 0.0001
201 LYMPHOMA 1 0.0001
202 PAIN IN JAW 2 0.0001
203 PRODUCT PRESCRIBING ERROR 1 0.0001
204 EJECTION FRACTION DECREASED 1 0.0001
205 MYALGIA 11 0.0001
206 OSTEOPENIA 1 0.0001
207 THERAPY NON-RESPONDER 2 0.0001
208 COORDINATION ABNORMAL 1 0.0001
209 ERUCTATION 1 0.0001
210 KNEE ARTHROPLASTY 1 0.0001
211 INCREASED APPETITE 1 0.0001
212 HYPOAESTHESIA 9 0.0001
213 MUSCLE TIGHTNESS 1 0.0001
214 FULL BLOOD COUNT DECREASED 1 0.0001
215 ACCIDENTAL OVERDOSE 2 0.0001
216 FLUID RETENTION 3 0.0001
217 BLOOD PRESSURE ABNORMAL 1 0.0001
218 HERNIA 1 0.0001
219 NERVOUS SYSTEM DISORDER 2 0.0001
220 GOUT 1 0.0001
221 ILLNESS 2 0.0001
222 PRODUCT DOSE OMISSION 5 0.0001
223 PSYCHOMOTOR HYPERACTIVITY 1 0.0001
224 DIZZINESS 27 0.0001
225 CHOKING 1 0.0001
226 CHOLESTASIS 1 0.0001
227 SINUS DISORDER 1 0.0001
228 BLOOD URINE PRESENT 1 0.0001
229 HEPATOTOXICITY 1 0.0001
230 SLEEP APNOEA SYNDROME 1 0.0001
231 PLEURAL EFFUSION 3 0.0001
232 UPPER LIMB FRACTURE 1 0.0001
233 MULTIPLE ORGAN DYSFUNCTION SYNDROME 1 0.0001
234 MENTAL DISORDER 2 0.0001
235 PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME 1 0.0001
236 LUNG NEOPLASM MALIGNANT 2 0.0001
237 PERIPHERAL SWELLING 6 0.0001
238 PRODUCT DOSE OMISSION ISSUE 5 0.0001
239 DISEASE RECURRENCE 1 0.0001
240 COGNITIVE DISORDER 2 0.0001
241 WOUND 1 0.0001
242 RESPIRATORY TRACT INFECTION 1 0.0001
243 MELAENA 1 0.0001
244 ENCEPHALOPATHY 1 0.0001
245 CHROMATURIA 1 0.0001
246 PNEUMONITIS 1 0.0001
247 CONSTIPATION 8 0.0001
248 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 2 0.0001
249 BONE MARROW FAILURE 1 0.0001
250 DYSGEUSIA 3 0.0001
251 CONTRAINDICATED PRODUCT ADMINISTERED 1 0.0001
252 PNEUMONIA ASPIRATION 1 0.0001
253 HAEMATOCHEZIA 2 0.0001
254 BREAST CANCER FEMALE 1 0.0001
255 ABDOMINAL DISTENSION 4 0.0001
256 RESPIRATORY FAILURE 3 0.0001
257 DISCOMFORT 2 0.0001
258 HEPATITIS 1 0.0001
259 BLISTER 2 0.0001
260 RENAL IMPAIRMENT 3 0.0001
261 OEDEMA 2 0.0001
262 LOSS OF CONSCIOUSNESS 5 0.0001
263 SYSTEMIC LUPUS ERYTHEMATOSUS 1 0.0001
264 WEIGHT INCREASED 8 0.0001
265 SPEECH DISORDER 2 0.0001
266 PAIN 23 0.0001
267 COVID-19 2 0.0001
268 NECK PAIN 2 0.0000
269 CONFUSIONAL STATE 6 0.0000
270 ANAEMIA 7 0.0000
271 OSTEONECROSIS OF JAW 1 0.0000
272 LABORATORY TEST ABNORMAL 1 0.0000
273 RESPIRATORY DISTRESS 1 0.0000
274 MENTAL STATUS CHANGES 1 0.0000
275 LETHARGY 2 0.0000
276 LIMB DISCOMFORT 1 0.0000
277 DYSSTASIA 1 0.0000
278 JAUNDICE 1 0.0000
279 FATIGUE 24 0.0000
280 HEAD INJURY 1 0.0000
281 APHASIA 1 0.0000
282 GASTROINTESTINAL HAEMORRHAGE 3 0.0000
283 GAIT DISTURBANCE 6 0.0000
284 HEPATIC FAILURE 1 0.0000
285 IRRITABILITY 2 0.0000
286 MOVEMENT DISORDER 1 0.0000
287 URINARY RETENTION 1 0.0000
288 HYPOXIA 1 0.0000
289 FEMUR FRACTURE 1 0.0000
290 PYREXIA 10 0.0000
291 HYPERKALAEMIA 1 0.0000
292 INTESTINAL OBSTRUCTION 1 0.0000
293 LYMPHADENOPATHY 1 0.0000
294 BURNING SENSATION 2 0.0000
295 INTERNATIONAL NORMALISED RATIO INCREASED 1 0.0000
296 STAPHYLOCOCCAL INFECTION 1 0.0000
297 JOINT SWELLING 3 0.0000
298 OFF LABEL USE 17 0.0000
299 HAEMATURIA 1 0.0000
300 ADVERSE DRUG REACTION 2 0.0000
301 NEUTROPENIA 3 0.0000
302 CEREBRAL HAEMORRHAGE 1 0.0000
303 DYSURIA 1 0.0000
304 ABDOMINAL PAIN UPPER 5 0.0000
305 HYPOTENSION 5 0.0000
306 NAUSEA 19 0.0000
307 DEPRESSED LEVEL OF CONSCIOUSNESS 1 0.0000
308 THROMBOSIS 2 0.0000
309 WHITE BLOOD CELL COUNT INCREASED 1 0.0000
310 ARTHRALGIA 9 0.0000
311 MUSCULOSKELETAL STIFFNESS 2 0.0000
312 LIVER DISORDER 1 0.0000
313 VOMITING 11 0.0000
314 THROAT IRRITATION 1 0.0000
315 ROAD TRAFFIC ACCIDENT 1 0.0000
316 PRODUCT STORAGE ERROR 1 0.0000
317 PAIN IN EXTREMITY 7 0.0000
318 OROPHARYNGEAL PAIN 2 0.0000
319 SWELLING 2 0.0000
320 ANGIOEDEMA 1 0.0000
321 BALANCE DISORDER 2 0.0000
322 OEDEMA PERIPHERAL 3 0.0000
323 PULMONARY OEDEMA 1 0.0000
324 DYSPHAGIA 2 0.0000
325 MUSCLE SPASMS 4 0.0000
326 ASTHMA 2 0.0000
327 ABNORMAL BEHAVIOUR 1 0.0000
328 TINNITUS 1 0.0000
329 RENAL DISORDER 1 0.0000
330 DYSPEPSIA 2 0.0000
331 FALL 7 0.0000
332 CARDIAC FAILURE CONGESTIVE 2 0.0000
333 CHEST DISCOMFORT 2 0.0000
334 EYE PAIN 1 0.0000
335 COMA 1 0.0000
336 SEIZURE 2 0.0000
337 GENERAL PHYSICAL HEALTH DETERIORATION 2 0.0000
338 SKIN IRRITATION 1 0.0000
339 MULTIPLE SCLEROSIS 1 0.0000
340 LEUKOPENIA 1 0.0000
341 COUGH 5 0.0000
342 DEPRESSED MOOD 1 0.0000
343 CELLULITIS 1 0.0000
344 PULMONARY EMBOLISM 2 0.0000
345 DECREASED APPETITE 4 0.0000
346 THROMBOCYTOPENIA 2 0.0000
347 PANCYTOPENIA 1 0.0000
348 DRUG WITHDRAWAL SYNDROME 2 0.0000
349 INCORRECT DOSE ADMINISTERED 3 0.0000
350 FLATULENCE 1 0.0000
351 SEPSIS 2 0.0000
352 VISUAL IMPAIRMENT 2 0.0000
353 MUSCULAR WEAKNESS 2 0.0000
354 ABDOMINAL PAIN 4 0.0000
355 DYSPNOEA 10 0.0000
356 DEATH 14 0.0000
357 COLORECTAL CANCER 1 0.0000
358 FEELING HOT 1 0.0000
359 ACCIDENTAL EXPOSURE TO PRODUCT 1 0.0000
360 PRODUCT USE IN UNAPPROVED INDICATION 3 0.0000
361 CEREBROVASCULAR ACCIDENT 3 0.0000
362 MUSCULOSKELETAL PAIN 1 0.0000
363 VERTIGO 1 0.0000
364 SOMNOLENCE 3 0.0000
365 DRUG INEFFECTIVE 19 0.0000
366 HOT FLUSH 1 0.0000
367 INTENTIONAL PRODUCT USE ISSUE 1 0.0000
368 AMNESIA 1 0.0000
369 GASTROINTESTINAL DISORDER 1 0.0000
370 MATERNAL EXPOSURE DURING PREGNANCY 1 0.0000
371 TREATMENT FAILURE 1 0.0000
372 ASTHENIA 5 0.0000
373 DIARRHOEA 8 0.0000
374 SKIN BURNING SENSATION 1 0.0000
375 PNEUMONIA 4 0.0000
376 TOXICITY TO VARIOUS AGENTS 2 0.0000
377 GASTROOESOPHAGEAL REFLUX DISEASE 1 0.0000
378 URTICARIA 2 0.0000
379 UNEVALUABLE EVENT 1 0.0000
380 RASH 5 0.0000
381 CONDITION AGGRAVATED 3 0.0000
382 FEELING ABNORMAL 3 0.0000
383 DRUG INTOLERANCE 1 0.0000
384 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 2 0.0000
385 INTENTIONAL PRODUCT MISUSE 1 0.0000
386 TREMOR 2 0.0000
387 WEIGHT DECREASED 3 0.0000
388 HYPERSENSITIVITY 2 0.0000
389 ADVERSE EVENT 1 0.0000
390 ATRIAL FIBRILLATION 1 0.0000
391 HEART RATE INCREASED 1 0.0000
392 CHEST PAIN 2 0.0000
393 SINUSITIS 1 0.0000
394 ALOPECIA 2 0.0000
395 HAEMORRHAGE 1 0.0000
396 FLUSHING 1 0.0000
397 BREAST CANCER 1 0.0000
398 CHILLS 1 0.0000
399 INFECTION 1 0.0000
400 MEMORY IMPAIRMENT 1 0.0000
401 INSOMNIA 2 0.0000
402 ACUTE KIDNEY INJURY 1 0.0000
403 BLOOD PRESSURE INCREASED 1 0.0000
404 MALAISE 3 0.0000
405 HEADACHE 4 0.0000
406 DRUG INTERACTION 1 0.0000
407 PRODUCT USE ISSUE 1 0.0000
408 MYOCARDIAL INFARCTION 1 0.0000
409 OVERDOSE 1 0.0000
410 BACK PAIN 1 0.0000
411 PRURITUS 1 0.0000