Drug Side Effects

METHOTREXATE

METHOTREXATE was reported 413993 times

METHOTREXATE is most commonly taken among patients reporting these side effects:

# Side effect Count Frequency
0 ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE 3599 0.9004
1 SWOLLEN JOINT COUNT INCREASED 1001 0.8796
2 HUMAN ANTICHIMERIC ANTIBODY POSITIVE 263 0.8738
3 RHEUMATOID FACTOR POSITIVE 2893 0.8104
4 RHEUMATIC FEVER 1164 0.7593
5 PEMPHIGUS 6176 0.7577
6 RED BLOOD CELL SEDIMENTATION RATE ABNORMAL 1534 0.7361
7 SYNOVITIS 9261 0.6877
8 C-REACTIVE PROTEIN ABNORMAL 2754 0.6847
9 HAND DEFORMITY 5888 0.6478
10 DUODENAL ULCER PERFORATION 2365 0.6427
11 GRANULOMA SKIN 448 0.6231
12 DEEP VEIN THROMBOSIS POSTOPERATIVE 296 0.5681
13 RHEUMATOID NODULE 1410 0.5622
14 BONE EROSION 1250 0.4954
15 BODY HEIGHT BELOW NORMAL 303 0.4935
16 CONTRAINDICATED PRODUCT ADMINISTERED 11157 0.4780
17 ENTHESOPATHY 597 0.4682
18 SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE 1697 0.4469
19 DACTYLITIS 326 0.4318
20 HELICOBACTER INFECTION 2597 0.4186
21 MUSCLE INJURY 2043 0.4181
22 RHEUMATOID LUNG 345 0.4142
23 X-RAY ABNORMAL 359 0.4075
24 BLOOD PARATHYROID HORMONE DECREASED 512 0.3948
25 DRUG TOLERANCE DECREASED 740 0.3878
26 SERONEGATIVE ARTHRITIS 246 0.3844
27 FOLLICULITIS 2258 0.3841
28 JUVENILE IDIOPATHIC ARTHRITIS 731 0.3788
29 BLOOD PRESSURE DIASTOLIC ABNORMAL 779 0.3765
30 BLOOD PRESSURE SYSTOLIC ABNORMAL 718 0.3759
31 BLOOD IRON ABNORMAL 305 0.3738
32 LYMPHOPROLIFERATIVE DISORDER 875 0.3714
33 RHEUMATOID ARTHRITIS 33481 0.3655
34 HYPOFIBRINOGENAEMIA 280 0.3651
35 TENOSYNOVITIS 878 0.3645
36 DISLOCATION OF VERTEBRA 342 0.3638
37 PERICARDITIS 3884 0.3480
38 DRUG CLEARANCE DECREASED 331 0.3459
39 ACUTE GRAFT VERSUS HOST DISEASE 1317 0.3434
40 JOINT DESTRUCTION 438 0.3349
41 ADJUSTMENT DISORDER WITH DEPRESSED MOOD 271 0.3346
42 ARTHRODESIS 286 0.3329
43 PANNICULITIS 646 0.3326
44 GLOSSODYNIA 5648 0.3305
45 RED BLOOD CELL SEDIMENTATION RATE INCREASED 3020 0.3305
46 CHRONIC GRAFT VERSUS HOST DISEASE 953 0.3294
47 FACET JOINT SYNDROME 303 0.3272
48 EPSTEIN-BARR VIRUS ASSOCIATED LYMPHOPROLIFERATIVE DISORDER 436 0.3169
49 ACUTE GRAFT VERSUS HOST DISEASE IN SKIN 647 0.3052
50 SYSTEMIC LUPUS ERYTHEMATOSUS 7516 0.3028
51 ACUTE GRAFT VERSUS HOST DISEASE IN INTESTINE 323 0.2936
52 HISTOPLASMOSIS DISSEMINATED 279 0.2665
53 THERAPEUTIC PRODUCT EFFECT DECREASED 8116 0.2525
54 WOUND 5103 0.2464
55 FEBRILE BONE MARROW APLASIA 790 0.2398
56 DRUG SPECIFIC ANTIBODY 261 0.2394
57 CENTRAL NERVOUS SYSTEM LYMPHOMA 241 0.2365
58 GRIP STRENGTH DECREASED 1383 0.2338
59 PSORIATIC ARTHROPATHY 6639 0.2332
60 ARTHROPATHY 10661 0.2309
61 FINGER DEFORMITY 852 0.2288
62 GRAFT VERSUS HOST DISEASE IN GASTROINTESTINAL TRACT 365 0.2213
63 DRUG INTOLERANCE 16909 0.2212
64 POLYARTHRITIS 880 0.2206
65 MYELOPATHY 351 0.2202
66 JOINT ARTHROPLASTY 329 0.2177
67 GRAFT VERSUS HOST DISEASE IN SKIN 373 0.2151
68 FOOT DEFORMITY 1902 0.2104
69 LEUKOENCEPHALOPATHY 668 0.2081
70 JOINT RANGE OF MOTION DECREASED 1975 0.2047
71 SCLERITIS 247 0.1990
72 ACUTE LYMPHOCYTIC LEUKAEMIA RECURRENT 380 0.1984
73 JOINT SWELLING 18981 0.1959
74 JOINT EFFUSION 1159 0.1945
75 TREATMENT FAILURE 12050 0.1916
76 VENOOCCLUSIVE LIVER DISEASE 746 0.1910
77 SYNOVIAL CYST 761 0.1891
78 SACROILIITIS 287 0.1875
79 LIMB DEFORMITY 271 0.1874
80 CYTOMEGALOVIRUS CHORIORETINITIS 280 0.1873
81 PSEUDOMONAL SEPSIS 264 0.1867
82 ALANINE AMINOTRANSFERASE ABNORMAL 297 0.1856
83 C-REACTIVE PROTEIN INCREASED 5333 0.1847
84 TUBERCULIN TEST POSITIVE 439 0.1810
85 ANTIBODY TEST POSITIVE 270 0.1800
86 PERIPHERAL VENOUS DISEASE 342 0.1792
87 GRAFT VERSUS HOST DISEASE 1100 0.1786
88 ARTHRITIS BACTERIAL 606 0.1786
89 LATENT TUBERCULOSIS 286 0.1764
90 LEUKAEMIA RECURRENT 251 0.1713
91 SHOULDER ARTHROPLASTY 327 0.1711
92 EPSTEIN-BARR VIRUS INFECTION 842 0.1694
93 ADENOVIRUS INFECTION 356 0.1635
94 DISSEMINATED TUBERCULOSIS 334 0.1628
95 VENOOCCLUSIVE DISEASE 322 0.1624
96 KNEE ARTHROPLASTY 2514 0.1622
97 CYTOMEGALOVIRUS INFECTION REACTIVATION 340 0.1605
98 IRRITABLE BOWEL SYNDROME 2545 0.1600
99 HUMAN HERPESVIRUS 6 INFECTION 260 0.1593
100 HISTOPLASMOSIS 234 0.1578
101 BLOOD PRESSURE DIASTOLIC DECREASED 974 0.1554
102 DIFFUSE LARGE B-CELL LYMPHOMA 834 0.1546
103 OSTEOARTHRITIS 5315 0.1544
104 INFUSION RELATED REACTION 7646 0.1539
105 FIBROMYALGIA 2888 0.1536
106 LOWER RESPIRATORY TRACT INFECTION 5097 0.1527
107 HIP ARTHROPLASTY 1754 0.1524
108 SPINAL STENOSIS 417 0.1522
109 PNEUMOCYSTIS JIROVECI PNEUMONIA 338 0.1514
110 FINE MOTOR SKILL DYSFUNCTION 338 0.1514
111 ANKYLOSING SPONDYLITIS 1389 0.1510
112 ASPERGILLUS INFECTION 725 0.1501
113 HEPATIC ENZYME INCREASED 7969 0.1488
114 MUCOSAL INFLAMMATION 3131 0.1475
115 PULMONARY FIBROSIS 2156 0.1471
116 PULMONARY TUBERCULOSIS 537 0.1468
117 FAECAL CALPROTECTIN INCREASED 313 0.1463
118 IMPAIRED HEALING 3812 0.1458
119 CYTOMEGALOVIRUS VIRAEMIA 447 0.1451
120 MUSCULOSKELETAL STIFFNESS 10571 0.1450
121 NODULE 1557 0.1447
122 CYSTITIS HAEMORRHAGIC 465 0.1444
123 HISTIOCYTOSIS HAEMATOPHAGIC 428 0.1426
124 SENSITIVITY TO WEATHER CHANGE 556 0.1412
125 INFLAMMATORY MARKER INCREASED 506 0.1391
126 JOINT STIFFNESS 3042 0.1391
127 PNEUMOCYSTIS JIROVECII PNEUMONIA 1028 0.1386
128 BASAL CELL CARCINOMA 1776 0.1383
129 SKIN NECROSIS 624 0.1378
130 CHONDROPATHY 339 0.1376
131 DEMYELINATION 476 0.1375
132 PUSTULAR PSORIASIS 379 0.1368
133 BLOOD PRESSURE DIASTOLIC INCREASED 498 0.1361
134 BURSITIS 1155 0.1356
135 ONYCHOMYCOSIS 420 0.1326
136 MYCOBACTERIUM TUBERCULOSIS COMPLEX TEST POSITIVE 262 0.1309
137 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 4402 0.1301
138 B-CELL LYMPHOMA 383 0.1297
139 PULMONARY TOXICITY 661 0.1287
140 FOOT OPERATION 484 0.1276
141 SWELLING 9668 0.1273
142 INFLAMMATION 5029 0.1271
143 MOUTH ULCERATION 2133 0.1260
144 HEPATIC FIBROSIS 343 0.1248
145 ARTHRITIS INFECTIVE 469 0.1246
146 CUSHINGOID 312 0.1245
147 UVEITIS 1243 0.1244
148 PNEUMONIA VIRAL 306 0.1240
149 APLASIA 248 0.1236
150 POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME 907 0.1233
151 EXOSTOSIS 906 0.1231
152 INJECTION SITE IRRITATION 1285 0.1226
153 SARCOIDOSIS 472 0.1213
154 LIVER FUNCTION TEST INCREASED 1827 0.1200
155 BLOOD PRESSURE SYSTOLIC INCREASED 1914 0.1183
156 INJECTION SITE HAEMATOMA 1659 0.1183
157 MUCORMYCOSIS 239 0.1181
158 TUBERCULOSIS 1249 0.1164
159 JOINT LOCK 282 0.1152
160 BRONCHITIS CHRONIC 245 0.1136
161 ARTHRITIS 7369 0.1134
162 STOMATITIS 5523 0.1134
163 BLOOD PRESSURE FLUCTUATION 2358 0.1131
164 BLOOD CULTURE POSITIVE 316 0.1128
165 ANTINUCLEAR ANTIBODY POSITIVE 324 0.1122
166 LIVER INJURY 1764 0.1102
167 DISCOMFORT 5026 0.1099
168 HAEMATOTOXICITY 737 0.1099
169 BK VIRUS INFECTION 251 0.1089
170 GASTROINTESTINAL TOXICITY 364 0.1084
171 ACUTE LYMPHOCYTIC LEUKAEMIA 261 0.1079
172 IMMUNOSUPPRESSION 682 0.1075
173 BRONCHIECTASIS 541 0.1074
174 BODY TEMPERATURE DECREASED 928 0.1066
175 IMMUNODEFICIENCY 1114 0.1061
176 STAPHYLOCOCCAL SEPSIS 459 0.1055
177 PULMONARY MASS 1246 0.1050
178 LUPUS-LIKE SYNDROME 729 0.1050
179 JOINT DISLOCATION 881 0.1041
180 GRANULOMA 298 0.1040
181 CREPITATIONS 278 0.1032
182 SKIN ULCER 2235 0.1030
183 APHTHOUS ULCER 575 0.1028
184 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 5284 0.1023
185 HEPATOTOXICITY 1802 0.1021
186 WOUND INFECTION 763 0.1017
187 HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS 407 0.1013
188 SINUSITIS 8553 0.1013
189 PHARYNGITIS 1074 0.1011
190 PANCYTOPENIA 4548 0.1009
191 BRONCHOPULMONARY ASPERGILLOSIS 610 0.1006
192 SCIATICA 1185 0.1002
193 FEBRILE NEUTROPENIA 5181 0.0996
194 FEAR OF INJECTION 480 0.0994
195 TENDERNESS 888 0.0990
196 HEPATIC ENZYME ABNORMAL 397 0.0981
197 CYTOPENIA 779 0.0981
198 APPARENT DEATH 352 0.0981
199 IRITIS 251 0.0980
200 RHINOVIRUS INFECTION 233 0.0977
201 HYPERCHOLESTEROLAEMIA 663 0.0975
202 MOBILITY DECREASED 5613 0.0965
203 PLEURISY 506 0.0962
204 INFECTION 10879 0.0958
205 THYROID NEOPLASM 252 0.0957
206 ANAL FISSURE 375 0.0955
207 ARTHRALGIA 31463 0.0951
208 LUNG ADENOCARCINOMA 231 0.0941
209 HEPATITIS B REACTIVATION 238 0.0931
210 BACTERIAL SEPSIS 245 0.0922
211 IMMOBILE 335 0.0921
212 TONSILLITIS 387 0.0913
213 MUSCULOSKELETAL PAIN 4388 0.0912
214 PYODERMA GANGRENOSUM 231 0.0911
215 WHEELCHAIR USER 335 0.0904
216 SKIN PLAQUE 636 0.0900
217 DIVERTICULITIS 2028 0.0896
218 VIRAL UPPER RESPIRATORY TRACT INFECTION 381 0.0886
219 CYTOMEGALOVIRUS INFECTION 1187 0.0879
220 PERIPHERAL SWELLING 10640 0.0874
221 HERPES SIMPLEX 454 0.0873
222 POSTOPERATIVE WOUND INFECTION 472 0.0865
223 BLISTER 3828 0.0856
224 TOOTH INFECTION 929 0.0855
225 DEFORMITY 723 0.0854
226 POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER 312 0.0851
227 ABSCESS LIMB 291 0.0850
228 HEPATIC STEATOSIS 1295 0.0850
229 SPONDYLITIS 233 0.0850
230 HERPES ZOSTER 4086 0.0850
231 ORAL HERPES 1278 0.0845
232 EAR PAIN 1348 0.0842
233 TOOTH ABSCESS 745 0.0839
234 RED CELL DISTRIBUTION WIDTH INCREASED 277 0.0838
235 PNEUMONIA FUNGAL 235 0.0835
236 STAPHYLOCOCCAL BACTERAEMIA 278 0.0835
237 LOCALISED INFECTION 1674 0.0835
238 LYMPHOMA 1098 0.0830
239 POOR VENOUS ACCESS 637 0.0828
240 ENCEPHALITIS 448 0.0825
241 ABDOMINAL DISCOMFORT 11167 0.0825
242 DRUG ERUPTION 1144 0.0821
243 THROMBOTIC MICROANGIOPATHY 594 0.0818
244 SKIN PAPILLOMA 272 0.0807
245 ULCER 1078 0.0807
246 CHRONIC SINUSITIS 235 0.0807
247 ANAL ABSCESS 335 0.0805
248 OESOPHAGEAL CANDIDIASIS 251 0.0803
249 GASTROINTESTINAL DISORDER 4955 0.0800
250 MENISCUS INJURY 411 0.0798
251 LUNG NEOPLASM 311 0.0797
252 AUTOIMMUNE DISORDER 496 0.0793
253 BACTERIAL INFECTION 1154 0.0791
254 NEUROTOXICITY 1044 0.0791
255 SQUAMOUS CELL CARCINOMA 616 0.0791
256 MUSCULOSKELETAL DISORDER 1313 0.0791
257 SPINAL OSTEOARTHRITIS 598 0.0790
258 POST PROCEDURAL INFECTION 500 0.0790
259 JOINT INJURY 1391 0.0789
260 HEPATIC CIRRHOSIS 1154 0.0788
261 BRONCHOPNEUMONIA 270 0.0786
262 BONE MARROW FAILURE 1477 0.0786
263 INJECTION SITE WARMTH 1419 0.0783
264 HYPERTRIGLYCERIDAEMIA 365 0.0783
265 HYPOGAMMAGLOBULINAEMIA 324 0.0778
266 PSORIASIS 8576 0.0777
267 WALKING AID USER 396 0.0775
268 CARPAL TUNNEL SYNDROME 907 0.0773
269 ORGANISING PNEUMONIA 281 0.0772
270 HYPERCALCAEMIA 785 0.0771
271 DRUG LEVEL BELOW THERAPEUTIC 340 0.0766
272 NASOPHARYNGITIS 11147 0.0765
273 INJECTION SITE PAPULE 294 0.0764
274 THERAPY NON-RESPONDER 2385 0.0762
275 SPINAL PAIN 732 0.0761
276 RESPIRATORY TRACT CONGESTION 965 0.0760
277 INTERVERTEBRAL DISC DEGENERATION 630 0.0760
278 SINUS CONGESTION 855 0.0759
279 NAIL DISORDER 482 0.0759
280 DRUG SPECIFIC ANTIBODY PRESENT 379 0.0758
281 INTENTIONAL PRODUCT USE ISSUE 5146 0.0757
282 EAR INFECTION 1543 0.0755
283 TRIGGER FINGER 243 0.0753
284 ANAL FISTULA 323 0.0751
285 PARANASAL SINUS HYPERSECRETION 256 0.0749
286 CYST 773 0.0747
287 BLOOD CHOLESTEROL INCREASED 2835 0.0746
288 LARYNGITIS 637 0.0746
289 THERAPY PARTIAL RESPONDER 557 0.0745
290 VASCULITIS 711 0.0743
291 INTERSTITIAL LUNG DISEASE 2833 0.0740
292 LIMB OPERATION 257 0.0740
293 SKIN INFECTION 645 0.0733
294 ADRENAL INSUFFICIENCY 609 0.0730
295 SUBCUTANEOUS ABSCESS 297 0.0728
296 OBESITY 896 0.0728
297 SEPTIC SHOCK 2487 0.0726
298 GAIT INABILITY 1638 0.0721
299 LIVE BIRTH 423 0.0721
300 SKIN LESION 1586 0.0717
301 NEUTROPENIC SEPSIS 445 0.0717
302 ALOPECIA 11949 0.0717
303 BODY TEMPERATURE INCREASED 1261 0.0715
304 ESCHERICHIA URINARY TRACT INFECTION 254 0.0713
305 COLITIS MICROSCOPIC 243 0.0712
306 ENTEROCOCCAL INFECTION 271 0.0710
307 VAGINAL INFECTION 277 0.0708
308 MYELODYSPLASTIC SYNDROME 863 0.0707
309 DRUG EFFECT INCOMPLETE 2573 0.0707
310 HYPERBILIRUBINAEMIA 578 0.0698
311 ABSCESS 915 0.0696
312 MALIGNANT MELANOMA 782 0.0693
313 HERPES VIRUS INFECTION 329 0.0692
314 OSTEOPOROSIS 2423 0.0691
315 INJECTION SITE PRURITUS 3697 0.0681
316 BRONCHITIS 4332 0.0681
317 ROTATOR CUFF SYNDROME 750 0.0680
318 MATERNAL EXPOSURE DURING PREGNANCY 4344 0.0670
319 PHARYNGITIS STREPTOCOCCAL 567 0.0669
320 CONDITION AGGRAVATED 15296 0.0667
321 TIBIA FRACTURE 263 0.0667
322 HEART RATE DECREASED 1998 0.0664
323 INJECTION SITE REACTION 3745 0.0661
324 HYPERKERATOSIS 302 0.0660
325 TENDON DISORDER 365 0.0659
326 THERAPEUTIC RESPONSE DECREASED 3154 0.0658
327 OSTEOMYELITIS 1035 0.0654
328 PURULENT DISCHARGE 242 0.0653
329 SKIN LACERATION 524 0.0653
330 PYELONEPHRITIS 457 0.0652
331 UPPER RESPIRATORY TRACT INFECTION 2433 0.0652
332 ILL-DEFINED DISORDER 3067 0.0644
333 STREPTOCOCCAL INFECTION 278 0.0643
334 LIGAMENT RUPTURE 239 0.0643
335 PSEUDOMONAS INFECTION 421 0.0642
336 CLOSTRIDIUM DIFFICILE COLITIS 558 0.0642
337 BACTERAEMIA 588 0.0640
338 RHINITIS 419 0.0640
339 LIP DRY 360 0.0639
340 INTERVERTEBRAL DISC PROTRUSION 1196 0.0633
341 ARTHROPOD BITE 387 0.0632
342 DERMATITIS ALLERGIC 604 0.0632
343 NECK PAIN 2928 0.0632
344 LUNG DISORDER 2461 0.0630
345 RESPIRATORY TRACT INFECTION 1256 0.0630
346 PHARYNGOLARYNGEAL PAIN 334 0.0628
347 ORAL DISORDER 385 0.0628
348 CELLULITIS 2703 0.0628
349 ERYSIPELAS 264 0.0627
350 HYPOALBUMINAEMIA 378 0.0626
351 CANDIDA INFECTION 800 0.0626
352 LIVER DISORDER 2241 0.0625
353 TYPE 2 DIABETES MELLITUS 1716 0.0623
354 PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY 429 0.0622
355 HYPERSENSITIVITY 9538 0.0622
356 DISABILITY 999 0.0620
357 KLEBSIELLA INFECTION 241 0.0620
358 ESCHERICHIA INFECTION 396 0.0619
359 ACUTE MYELOID LEUKAEMIA 782 0.0619
360 STAPHYLOCOCCAL INFECTION 1758 0.0616
361 BREAST CANCER STAGE III 280 0.0616
362 NIGHT SWEATS 1565 0.0616
363 HEPATITIS 1296 0.0615
364 LIVER FUNCTION TEST ABNORMAL 1627 0.0615
365 DRUG HYPERSENSITIVITY 10218 0.0614
366 DRUG INEFFECTIVE 66720 0.0614
367 GASTROINTESTINAL INFECTION 436 0.0612
368 SPINAL COLUMN STENOSIS 290 0.0612
369 ORAL CANDIDIASIS 621 0.0610
370 LOCAL SWELLING 1065 0.0610
371 ENTERITIS 294 0.0610
372 NEPHROPATHY TOXIC 519 0.0609
373 UMBILICAL HERNIA 236 0.0607
374 TRANSAMINASES INCREASED 1134 0.0607
375 PAIN IN EXTREMITY 15285 0.0606
376 ACUTE RESPIRATORY DISTRESS SYNDROME 888 0.0605
377 SPINAL DISORDER 482 0.0604
378 INJECTION SITE ERYTHEMA 6102 0.0600
379 GASTROINTESTINAL INFLAMMATION 363 0.0598
380 MENINGITIS 327 0.0597
381 PNEUMONITIS 1228 0.0594
382 CYSTITIS 1636 0.0594
383 FOOT FRACTURE 959 0.0593
384 LEUKOPENIA 2408 0.0593
385 INJECTION SITE PAIN 13609 0.0593
386 MYELOSUPPRESSION 761 0.0589
387 ENDOMETRIOSIS 234 0.0589
388 TENDONITIS 791 0.0588
389 NERVE COMPRESSION 446 0.0588
390 IMMUNE SYSTEM DISORDER 626 0.0587
391 KIDNEY INFECTION 943 0.0585
392 PAIN 30559 0.0584
393 SQUAMOUS CELL CARCINOMA OF SKIN 273 0.0584
394 INJECTION SITE INFLAMMATION 229 0.0584
395 SKIN MASS 302 0.0583
396 SEPSIS 5398 0.0581
397 INJECTION SITE SWELLING 3432 0.0581
398 VIRAL INFECTION 1495 0.0576
399 PNEUMONIA BACTERIAL 387 0.0576
400 APLASTIC ANAEMIA 248 0.0575
401 FURUNCLE 388 0.0575
402 MUSCULOSKELETAL DISCOMFORT 809 0.0569
403 TUMOUR LYSIS SYNDROME 386 0.0568
404 GASTROENTERITIS 682 0.0566
405 SPUTUM DISCOLOURED 429 0.0566
406 TONGUE DISORDER 367 0.0564
407 SECRETION DISCHARGE 520 0.0563
408 FUNGAL INFECTION 1541 0.0562
409 THERAPEUTIC RESPONSE SHORTENED 948 0.0560
410 CATARACT 2610 0.0560
411 TENDON RUPTURE 599 0.0557
412 DRUG-INDUCED LIVER INJURY 1167 0.0557
413 DRUG EFFECT DECREASED 2996 0.0555
414 EYE INFECTION 481 0.0554
415 OSTEOPENIA 736 0.0554
416 RESPIRATORY DISORDER 1367 0.0553
417 MASS 660 0.0553
418 LUNG INFILTRATION 450 0.0553
419 ADVERSE REACTION 600 0.0551
420 LYMPHADENOPATHY 1618 0.0551
421 MUSCLE SPASTICITY 605 0.0547
422 TOOTH FRACTURE 512 0.0545
423 ALANINE AMINOTRANSFERASE INCREASED 2845 0.0544
424 INJECTION SITE BRUISING 3374 0.0543
425 MATERNAL EXPOSURE BEFORE PREGNANCY 268 0.0542
426 OROPHARYNGEAL PAIN 4090 0.0540
427 FISTULA 487 0.0537
428 ODYNOPHAGIA 252 0.0537
429 VITAMIN D DECREASED 389 0.0534
430 INJECTION SITE INDURATION 601 0.0532
431 GENERAL PHYSICAL HEALTH DETERIORATION 4597 0.0532
432 CONTUSION 4202 0.0531
433 SKIN ATROPHY 246 0.0530
434 IMPAIRED WORK ABILITY 994 0.0529
435 STRESS FRACTURE 256 0.0528
436 LUNG INFECTION 823 0.0528
437 KNEE OPERATION 369 0.0527
438 HEPATOMEGALY 458 0.0526
439 ATELECTASIS 440 0.0525
440 CARDIOTOXICITY 348 0.0524
441 DIVERTICULUM 357 0.0524
442 INJECTION SITE RASH 1215 0.0523
443 SPINAL COMPRESSION FRACTURE 397 0.0519
444 LIGAMENT SPRAIN 410 0.0518
445 INFLUENZA 4381 0.0518
446 GASTROINTESTINAL PAIN 450 0.0518
447 PELVIC FRACTURE 331 0.0518
448 PRODUCTIVE COUGH 1861 0.0514
449 BREAST MASS 289 0.0511
450 SINUS HEADACHE 270 0.0511
451 INCREASED TENDENCY TO BRUISE 412 0.0510
452 PRODUCT USE ISSUE 7422 0.0508
453 DECREASED IMMUNE RESPONSIVENESS 361 0.0505
454 MULTIPLE ORGAN DYSFUNCTION SYNDROME 989 0.0500
455 PNEUMONIA 12949 0.0500
456 RESPIRATORY RATE INCREASED 364 0.0499
457 NEPHROLITHIASIS 1818 0.0498
458 INJECTION SITE URTICARIA 919 0.0498
459 PAPULE 262 0.0496
460 GINGIVITIS 229 0.0494
461 RHINORRHOEA 2520 0.0494
462 LOWER LIMB FRACTURE 721 0.0493
463 INJECTION SITE DISCOLOURATION 492 0.0492
464 BACK INJURY 398 0.0489
465 COLITIS 1387 0.0486
466 UROSEPSIS 367 0.0486
467 PULMONARY HAEMORRHAGE 334 0.0486
468 BONE DISORDER 799 0.0486
469 LYMPHOPENIA 548 0.0485
470 BLOOD IRON DECREASED 430 0.0480
471 TOOTH DISORDER 920 0.0479
472 EMPHYSEMA 418 0.0478
473 RASH PUSTULAR 317 0.0478
474 PYREXIA 13744 0.0478
475 PULMONARY THROMBOSIS 421 0.0476
476 SLEEP DISORDER 2602 0.0476
477 HEPATOCELLULAR INJURY 610 0.0475
478 GASTROENTERITIS VIRAL 675 0.0475
479 OXYGEN SATURATION DECREASED 2048 0.0475
480 GLAUCOMA 766 0.0475
481 DIARRHOEA HAEMORRHAGIC 373 0.0475
482 FACIAL PARALYSIS 312 0.0473
483 PHOTOSENSITIVITY REACTION 656 0.0473
484 BLOOD TEST ABNORMAL 520 0.0468
485 DISSEMINATED INTRAVASCULAR COAGULATION 572 0.0468
486 COVID-19 PNEUMONIA 430 0.0467
487 RASH 16063 0.0466
488 LIMB INJURY 997 0.0463
489 RENAL CYST 318 0.0463
490 LIMB DISCOMFORT 1187 0.0463
491 HEPATITIS B 242 0.0463
492 HAND FRACTURE 272 0.0462
493 ORAL PAIN 880 0.0461
494 GROIN PAIN 345 0.0460
495 MOUTH HAEMORRHAGE 272 0.0457
496 SCAB 419 0.0457
497 NASAL CONGESTION 2068 0.0453
498 ASPARTATE AMINOTRANSFERASE INCREASED 2034 0.0450
499 IMPAIRED GASTRIC EMPTYING 282 0.0449
500 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 517 0.0448
501 SKIN CANCER 790 0.0448
502 POLYP 246 0.0448
503 APPENDICITIS 328 0.0447
504 SKIN HAEMORRHAGE 437 0.0446
505 CLOSTRIDIUM DIFFICILE INFECTION 755 0.0446
506 ENCEPHALOPATHY 891 0.0445
507 MULTI-ORGAN FAILURE 771 0.0445
508 HYPERTENSION 7766 0.0445
509 EYE INFLAMMATION 311 0.0444
510 NEUTROPENIA 4694 0.0444
511 DRUG LEVEL DECREASED 362 0.0443
512 WEIGHT INCREASED 8055 0.0442
513 ANKLE FRACTURE 577 0.0441
514 HEMIPARESIS 655 0.0440
515 DENTAL CARIES 413 0.0438
516 SKIN REACTION 497 0.0437
517 MYOSITIS 298 0.0437
518 GAIT DISTURBANCE 7027 0.0433
519 VITAMIN D DEFICIENCY 347 0.0432
520 DYSSTASIA 1078 0.0432
521 TOOTHACHE 646 0.0431
522 GASTRIC DISORDER 1510 0.0431
523 COELIAC DISEASE 331 0.0427
524 POLYNEUROPATHY 395 0.0426
525 HIATUS HERNIA 478 0.0424
526 GASTRIC ULCER 694 0.0424
527 DEVICE RELATED INFECTION 570 0.0423
528 INJECTION SITE HAEMORRHAGE 2662 0.0423
529 URINARY TRACT INFECTION 5759 0.0420
530 FREQUENT BOWEL MOVEMENTS 835 0.0419
531 SCRATCH 302 0.0418
532 ONYCHOCLASIS 234 0.0418
533 MUSCULOSKELETAL CHEST PAIN 535 0.0417
534 IRON DEFICIENCY ANAEMIA 314 0.0416
535 BACK PAIN 8113 0.0416
536 PNEUMOTHORAX 536 0.0416
537 OVARIAN CYST 367 0.0414
538 BEDRIDDEN 459 0.0414
539 COUGH 9245 0.0414
540 RASH PRURITIC 1769 0.0412
541 UTERINE LEIOMYOMA 254 0.0411
542 SPLENOMEGALY 406 0.0410
543 THROMBOCYTOPENIA 3708 0.0410
544 INTESTINAL PERFORATION 376 0.0408
545 OFF LABEL USE 24698 0.0407
546 PULMONARY CONGESTION 436 0.0407
547 HEPATIC FUNCTION ABNORMAL 1188 0.0406
548 ADVERSE DRUG REACTION 2743 0.0405
549 DRY EYE 1347 0.0405
550 HERNIA 625 0.0405
551 CROHN'S DISEASE 277 0.0404
552 PRESCRIBED OVERDOSE 634 0.0403
553 PRODUCT USE IN UNAPPROVED INDICATION 6773 0.0403
554 MUSCLE STRAIN 293 0.0403
555 BLOOD ALBUMIN DECREASED 270 0.0403
556 ANAPHYLACTIC REACTION 1701 0.0402
557 STRESS 2329 0.0401
558 PLEURAL EFFUSION 2055 0.0400
559 LARGE INTESTINE PERFORATION 232 0.0399
560 POST PROCEDURAL COMPLICATION 653 0.0399
561 UPPER LIMB FRACTURE 696 0.0399
562 WRIST FRACTURE 398 0.0397
563 INJECTION SITE EXTRAVASATION 467 0.0397
564 SENSORY LOSS 272 0.0397
565 NERVE INJURY 378 0.0394
566 BLOOD LACTATE DEHYDROGENASE INCREASED 556 0.0393
567 CONJUNCTIVITIS 536 0.0392
568 FEMUR FRACTURE 1074 0.0392
569 SKIN DISORDER 1047 0.0391
570 COLITIS ULCERATIVE 1220 0.0390
571 FATIGUE 24552 0.0389
572 COAGULOPATHY 559 0.0388
573 SPINAL OPERATION 316 0.0388
574 GASTRITIS 859 0.0387
575 EYE DISORDER 1031 0.0387
576 UPPER-AIRWAY COUGH SYNDROME 248 0.0387
577 RESPIRATORY FAILURE 2361 0.0385
578 DISEASE RECURRENCE 1345 0.0385
579 NEURALGIA 746 0.0382
580 BLOOD PRESSURE INCREASED 4872 0.0381
581 WEIGHT FLUCTUATION 310 0.0380
582 MOTOR DYSFUNCTION 317 0.0380
583 HYPOPHAGIA 770 0.0379
584 DRUG LEVEL INCREASED 522 0.0379
585 DRUG RESISTANCE 760 0.0375
586 PLATELET COUNT INCREASED 403 0.0373
587 OEDEMA 1623 0.0370
588 PRESCRIBED UNDERDOSE 587 0.0368
589 PAIN IN JAW 902 0.0368
590 LACERATION 347 0.0368
591 HAEMATOCHEZIA 1613 0.0368
592 RIB FRACTURE 627 0.0367
593 CHOLECYSTITIS 358 0.0366
594 GINGIVAL PAIN 242 0.0366
595 SEASONAL ALLERGY 378 0.0365
596 PERICARDIAL EFFUSION 675 0.0362
597 ACCIDENT 346 0.0361
598 CHOLELITHIASIS 992 0.0359
599 WEIGHT DECREASED 8239 0.0356
600 MYOPATHY 256 0.0355
601 SINUS DISORDER 580 0.0354
602 PHOTOPHOBIA 527 0.0354
603 OEDEMA PERIPHERAL 3813 0.0354
604 THYROID DISORDER 446 0.0354
605 HYPOAESTHESIA 4449 0.0354
606 DIABETES MELLITUS 2326 0.0351
607 ABDOMINAL PAIN 6719 0.0351
608 AORTIC ANEURYSM 235 0.0350
609 PROCEDURAL COMPLICATION 242 0.0350
610 FRACTURE 557 0.0350
611 SMALL INTESTINAL OBSTRUCTION 346 0.0349
612 TOOTH EXTRACTION 372 0.0349
613 INJECTION SITE DISCOMFORT 264 0.0349
614 URTICARIA 4605 0.0348
615 BACK DISORDER 472 0.0346
616 BRAIN OEDEMA 362 0.0345
617 FEEDING DISORDER 480 0.0343
618 DERMATITIS 531 0.0343
619 HYPERAESTHESIA 251 0.0343
620 IMPAIRED QUALITY OF LIFE 347 0.0342
621 BLOOD BILIRUBIN INCREASED 795 0.0341
622 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 3801 0.0341
623 SECOND PRIMARY MALIGNANCY 236 0.0339
624 HEART RATE IRREGULAR 680 0.0338
625 COLON CANCER 421 0.0337
626 SPINAL FRACTURE 537 0.0337
627 SKIN FISSURES 398 0.0336
628 FACIAL PAIN 245 0.0334
629 CORONARY ARTERY OCCLUSION 411 0.0333
630 HEADACHE 17305 0.0331
631 CHOLECYSTECTOMY 305 0.0329
632 MALAISE 12324 0.0329
633 OPTIC NEURITIS 256 0.0327
634 FLANK PAIN 256 0.0327
635 DEAFNESS 695 0.0327
636 MUSCULAR WEAKNESS 3065 0.0325
637 RASH ERYTHEMATOUS 1115 0.0324
638 WHEEZING 1450 0.0324
639 SLEEP APNOEA SYNDROME 537 0.0324
640 SNEEZING 566 0.0323
641 ASCITES 797 0.0323
642 HAEMORRHOIDS 532 0.0322
643 INJECTION SITE NODULE 304 0.0322
644 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 1332 0.0322
645 ROAD TRAFFIC ACCIDENT 1109 0.0321
646 RESPIRATORY DISTRESS 747 0.0320
647 WHITE BLOOD CELL COUNT INCREASED 1060 0.0320
648 OESOPHAGITIS 288 0.0319
649 HEMIPLEGIA 230 0.0319
650 MALNUTRITION 280 0.0318
651 CARDIAC MURMUR 247 0.0318
652 NEOPLASM 294 0.0317
653 CHOLESTASIS 487 0.0317
654 SCAR 462 0.0316
655 PETECHIAE 275 0.0314
656 PRURITUS 8777 0.0314
657 EXPOSURE DURING PREGNANCY 1540 0.0314
658 MOVEMENT DISORDER 859 0.0314
659 NAUSEA 20365 0.0313
660 SURGERY 1330 0.0313
661 EAR DISCOMFORT 257 0.0312
662 VOMITING 11903 0.0311
663 HAEMATOCRIT DECREASED 548 0.0311
664 ANAEMIA 4972 0.0309
665 PANCREATITIS 1374 0.0309
666 ILLNESS 1634 0.0308
667 ABDOMINAL PAIN UPPER 5134 0.0306
668 MIGRAINE 2314 0.0306
669 ACUTE RESPIRATORY FAILURE 461 0.0306
670 METASTASES TO LUNG 277 0.0304
671 HYPERTENSIVE CRISIS 289 0.0304
672 GALLBLADDER DISORDER 472 0.0302
673 INFLAMMATORY BOWEL DISEASE 255 0.0302
674 RENAL IMPAIRMENT 2041 0.0302
675 APHONIA 334 0.0302
676 GAMMA-GLUTAMYLTRANSFERASE INCREASED 588 0.0301
677 DYSPEPSIA 2398 0.0300
678 HYPOKINESIA 373 0.0299
679 NEUTROPHIL COUNT DECREASED 938 0.0298
680 ILEUS 293 0.0297
681 GENERALISED OEDEMA 294 0.0296
682 OSTEONECROSIS 884 0.0294
683 HEPATIC FAILURE 754 0.0293
684 ASTHMA 2385 0.0292
685 BLOOD CREATININE INCREASED 1628 0.0292
686 CARDIOMEGALY 327 0.0291
687 ERYTHEMA 4964 0.0291
688 DEEP VEIN THROMBOSIS 1699 0.0291
689 CHILLS 2866 0.0291
690 SKIN DISCOLOURATION 1120 0.0291
691 AGRANULOCYTOSIS 416 0.0290
692 WHITE BLOOD CELL COUNT DECREASED 2592 0.0290
693 POOR QUALITY SLEEP 494 0.0290
694 HYPOXIA 819 0.0289
695 DIARRHOEA 14846 0.0288
696 FALL 7929 0.0288
697 COVID-19 3716 0.0287
698 RASH PAPULAR 561 0.0287
699 NO THERAPEUTIC RESPONSE 350 0.0287
700 CONFUSIONAL STATE 3894 0.0285
701 DEVICE MALFUNCTION 1396 0.0285
702 TACHYPNOEA 309 0.0285
703 INFLUENZA LIKE ILLNESS 2056 0.0285
704 MITRAL VALVE INCOMPETENCE 273 0.0285
705 ORAL DISCOMFORT 333 0.0284
706 ATRIAL FIBRILLATION 2307 0.0284
707 OBSTRUCTIVE AIRWAYS DISORDER 260 0.0284
708 ADVERSE EVENT 2156 0.0282
709 THROAT IRRITATION 1014 0.0282
710 DRY THROAT 237 0.0282
711 HAEMOGLOBIN DECREASED 2456 0.0281
712 PANCREATITIS ACUTE 506 0.0280
713 RECTAL HAEMORRHAGE 1026 0.0280
714 DISEASE PROGRESSION 2596 0.0280
715 DRUG TOXICITY 381 0.0279
716 HYPOTHYROIDISM 698 0.0278
717 PULMONARY EMBOLISM 2300 0.0276
718 INTESTINAL OBSTRUCTION 803 0.0276
719 DYSPHONIA 1312 0.0275
720 TOXIC EPIDERMAL NECROLYSIS 337 0.0274
721 NEUTROPHIL COUNT INCREASED 237 0.0273
722 PROCEDURAL PAIN 593 0.0272
723 GINGIVAL BLEEDING 288 0.0272
724 DYSPNOEA EXERTIONAL 801 0.0271
725 RASH MACULO-PAPULAR 481 0.0271
726 QUALITY OF LIFE DECREASED 303 0.0271
727 CARDIOMYOPATHY 342 0.0271
728 CHEST PAIN 4273 0.0269
729 RENAL PAIN 236 0.0269
730 CYTOKINE RELEASE SYNDROME 233 0.0266
731 FEELING HOT 1385 0.0266
732 RED BLOOD CELL COUNT DECREASED 630 0.0265
733 MACULAR DEGENERATION 254 0.0265
734 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 1155 0.0264
735 APHASIA 675 0.0262
736 TOXICITY TO VARIOUS AGENTS 3489 0.0262
737 EATING DISORDER 473 0.0261
738 GOUT 386 0.0261
739 ASTHENIA 8093 0.0260
740 BLOOD URINE PRESENT 424 0.0259
741 METASTASES TO LIVER 366 0.0259
742 HYPERLIPIDAEMIA 271 0.0258
743 BODY HEIGHT DECREASED 255 0.0258
744 NEUROPATHY PERIPHERAL 1899 0.0257
745 SARS-COV-2 TEST POSITIVE 282 0.0256
746 HEART RATE INCREASED 2088 0.0254
747 ANGINA PECTORIS 646 0.0254
748 PERIPHERAL COLDNESS 292 0.0252
749 EPISTAXIS 1579 0.0251
750 BONE DENSITY DECREASED 716 0.0251
751 DYSPNOEA 11728 0.0250
752 DRUG INTERACTION 3331 0.0250
753 NERVOUS SYSTEM DISORDER 692 0.0250
754 GASTROOESOPHAGEAL REFLUX DISEASE 1616 0.0249
755 PAIN OF SKIN 575 0.0248
756 NEOPLASM MALIGNANT 1326 0.0248
757 PARAESTHESIA 3357 0.0248
758 ANOREXIA 319 0.0247
759 RASH MACULAR 681 0.0247
760 PHARYNGEAL OEDEMA 374 0.0246
761 EJECTION FRACTION DECREASED 319 0.0246
762 HYPOKALAEMIA 921 0.0246
763 ECZEMA 628 0.0246
764 PULMONARY OEDEMA 925 0.0245
765 ATAXIA 250 0.0244
766 LUNG NEOPLASM MALIGNANT 895 0.0244
767 ABASIA 602 0.0243
768 BLOOD PRESSURE ABNORMAL 374 0.0243
769 LABORATORY TEST ABNORMAL 585 0.0242
770 THROMBOSIS 1658 0.0242
771 MEDICATION ERROR 1121 0.0242
772 ACUTE HEPATIC FAILURE 258 0.0241
773 BURNING SENSATION 1435 0.0241
774 DYSURIA 754 0.0240
775 WRONG TECHNIQUE IN DRUG USAGE PROCESS 874 0.0240
776 FEELING COLD 564 0.0240
777 BLINDNESS UNILATERAL 278 0.0239
778 LEUKOCYTOSIS 355 0.0239
779 TACHYCARDIA 1757 0.0238
780 PALLOR 553 0.0236
781 DRY MOUTH 1549 0.0236
782 DEVICE ISSUE 1487 0.0235
783 HIP FRACTURE 613 0.0233
784 MYOCARDIAL ISCHAEMIA 244 0.0233
785 BLOOD ALKALINE PHOSPHATASE INCREASED 510 0.0233
786 RENAL FAILURE 2766 0.0232
787 PRODUCT PRESCRIBING ERROR 386 0.0231
788 DELIRIUM 636 0.0230
789 PLATELET COUNT DECREASED 2008 0.0229
790 HAEMOPTYSIS 541 0.0229
791 CHEST DISCOMFORT 1872 0.0227
792 SINUS TACHYCARDIA 271 0.0226
793 ACUTE KIDNEY INJURY 2699 0.0225
794 ACTIVITIES OF DAILY LIVING IMPAIRED 446 0.0225
795 RENAL DISORDER 876 0.0224
796 HYPOCALCAEMIA 343 0.0224
797 DIPLOPIA 474 0.0224
798 ABDOMINAL DISTENSION 1878 0.0223
799 VERTIGO 1151 0.0223
800 BONE PAIN 1095 0.0222
801 TRANSIENT ISCHAEMIC ATTACK 657 0.0222
802 DECREASED APPETITE 4109 0.0222
803 INCORRECT DOSE ADMINISTERED 3493 0.0222
804 INSOMNIA 5016 0.0222
805 RENAL FAILURE ACUTE 937 0.0220
806 ABDOMINAL PAIN LOWER 473 0.0220
807 INTRAOCULAR PRESSURE INCREASED 242 0.0220
808 PRURITUS GENERALISED 476 0.0220
809 PARALYSIS 267 0.0219
810 HYPOTENSION 3661 0.0219
811 CEREBRAL INFARCTION 457 0.0219
812 PROTEINURIA 320 0.0218
813 PREGNANCY 398 0.0217
814 SWELLING FACE 1173 0.0217
815 EYE HAEMORRHAGE 249 0.0216
816 HAEMATOMA 491 0.0216
817 BLOOD TRIGLYCERIDES INCREASED 328 0.0215
818 LACRIMATION INCREASED 492 0.0215
819 SHOCK 394 0.0215
820 THYROID CANCER 234 0.0214
821 VISUAL IMPAIRMENT 2073 0.0214
822 DYSARTHRIA 678 0.0212
823 BLOOD PRESSURE DECREASED 1165 0.0211
824 DEPRESSION 4181 0.0211
825 INJURY 1325 0.0211
826 LYMPHOCYTE COUNT DECREASED 311 0.0210
827 EYE PAIN 883 0.0210
828 HAEMATURIA 623 0.0209
829 MENTAL STATUS CHANGES 492 0.0209
830 HAEMORRHAGE 1759 0.0208
831 AMNESIA 1175 0.0208
832 PERITONITIS 367 0.0206
833 INJECTION SITE MASS 599 0.0206
834 CARDIAC FAILURE 1372 0.0205
835 URINARY INCONTINENCE 511 0.0205
836 HEAD DISCOMFORT 283 0.0204
837 DYSPHAGIA 1553 0.0204
838 MYALGIA 2881 0.0203
839 SENSORY DISTURBANCE 291 0.0203
840 CORONARY ARTERY DISEASE 568 0.0201
841 MULTIPLE FRACTURES 300 0.0200
842 INTENTIONAL DOSE OMISSION 254 0.0200
843 SKIN EXFOLIATION 1289 0.0200
844 ANAPHYLACTIC SHOCK 400 0.0199
845 DIZZINESS 8211 0.0198
846 LOSS OF CONSCIOUSNESS 2134 0.0197
847 HYPERGLYCAEMIA 606 0.0197
848 NEEDLE ISSUE 381 0.0197
849 INCORRECT PRODUCT STORAGE 257 0.0195
850 MUSCLE SPASMS 2995 0.0195
851 ACUTE MYOCARDIAL INFARCTION 503 0.0194
852 EPILEPSY 466 0.0193
853 BLINDNESS 634 0.0193
854 HAEMATEMESIS 420 0.0192
855 BLOOD POTASSIUM DECREASED 485 0.0192
856 EOSINOPHILIA 268 0.0191
857 BLOOD UREA INCREASED 284 0.0190
858 SUBDURAL HAEMATOMA 236 0.0189
859 FEELING ABNORMAL 3949 0.0188
860 HEAD INJURY 480 0.0186
861 METASTASES TO BONE 233 0.0185
862 LETHARGY 906 0.0185
863 BREAST CANCER 1620 0.0185
864 UNEVALUABLE EVENT 1224 0.0185
865 PULMONARY HYPERTENSION 331 0.0184
866 OCULAR HYPERAEMIA 644 0.0182
867 MEMORY IMPAIRMENT 2107 0.0182
868 THROAT TIGHTNESS 411 0.0182
869 HYPERHIDROSIS 1988 0.0180
870 PRESYNCOPE 353 0.0179
871 SYNCOPE 1512 0.0178
872 HOT FLUSH 1030 0.0178
873 DEHYDRATION 2005 0.0178
874 JAUNDICE 420 0.0177
875 TINNITUS 681 0.0177
876 OSTEONECROSIS OF JAW 395 0.0177
877 COLD SWEAT 263 0.0177
878 RESTLESS LEGS SYNDROME 268 0.0173
879 ARRHYTHMIA 708 0.0172
880 POLLAKIURIA 594 0.0172
881 SWOLLEN TONGUE 459 0.0171
882 HAEMORRHAGE INTRACRANIAL 229 0.0171
883 DEPRESSED MOOD 723 0.0170
884 BLOOD SODIUM DECREASED 265 0.0169
885 HYPERSOMNIA 398 0.0169
886 PALPITATIONS 1650 0.0169
887 RASH GENERALISED 436 0.0168
888 CEREBRAL HAEMORRHAGE 506 0.0167
889 MIDDLE INSOMNIA 248 0.0167
890 BLOOD POTASSIUM INCREASED 229 0.0167
891 FAECES DISCOLOURED 306 0.0166
892 ISCHAEMIC STROKE 253 0.0166
893 EYE SWELLING 497 0.0165
894 FACE OEDEMA 234 0.0162
895 MELAENA 308 0.0162
896 THERAPY INTERRUPTED 568 0.0161
897 MYOCARDIAL INFARCTION 2585 0.0161
898 EYE PRURITUS 374 0.0160
899 SPEECH DISORDER 709 0.0159
900 GASTROINTESTINAL HAEMORRHAGE 1182 0.0157
901 HYPOACUSIS 531 0.0157
902 THERAPY CESSATION 628 0.0156
903 PNEUMONIA ASPIRATION 316 0.0156
904 CRYING 501 0.0155
905 LIP SWELLING 431 0.0155
906 DRUG DOSE OMISSION 2562 0.0155
907 ACCIDENTAL OVERDOSE 437 0.0154
908 INJURY ASSOCIATED WITH DEVICE 232 0.0154
909 TOOTH LOSS 280 0.0154
910 SEIZURE 1338 0.0153
911 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 1084 0.0152
912 TUBULOINTERSTITIAL NEPHRITIS 232 0.0152
913 FLUID RETENTION 653 0.0152
914 HYPONATRAEMIA 718 0.0151
915 NERVOUSNESS 707 0.0151
916 VISUAL ACUITY REDUCED 465 0.0150
917 URINARY RETENTION 410 0.0150
918 VISION BLURRED 1669 0.0149
919 CARDIAC DISORDER 1195 0.0148
920 ANXIETY 3609 0.0148
921 TREATMENT NONCOMPLIANCE 604 0.0147
922 BALANCE DISORDER 1081 0.0147
923 FLATULENCE 678 0.0147
924 CONVULSION 821 0.0143
925 CARDIAC FAILURE CONGESTIVE 1070 0.0143
926 ALTERED STATE OF CONSCIOUSNESS 240 0.0142
927 PRODUCT DOSE OMISSION ISSUE 2151 0.0142
928 CEREBROVASCULAR ACCIDENT 2078 0.0140
929 RETCHING 242 0.0139
930 DISORIENTATION 483 0.0139
931 SOMNOLENCE 2326 0.0139
932 THERAPEUTIC RESPONSE UNEXPECTED 529 0.0137
933 COMA 550 0.0137
934 ACNE 903 0.0135
935 PRODUCT DOSE OMISSION 896 0.0135
936 STEVENS-JOHNSON SYNDROME 260 0.0135
937 CARDIOVASCULAR DISORDER 313 0.0134
938 METABOLIC ACIDOSIS 338 0.0133
939 CONSTIPATION 2244 0.0132
940 UNRESPONSIVE TO STIMULI 278 0.0131
941 TREMOR 1843 0.0130
942 CARDIAC ARREST 907 0.0128
943 CHROMATURIA 245 0.0127
944 EMOTIONAL DISORDER 331 0.0125
945 BLOOD CREATINE PHOSPHOKINASE INCREASED 323 0.0125
946 UNDERDOSE 744 0.0125
947 DEMENTIA 267 0.0124
948 DEPRESSED LEVEL OF CONSCIOUSNESS 415 0.0124
949 PANIC ATTACK 376 0.0123
950 MENTAL DISORDER 440 0.0121
951 ABORTION SPONTANEOUS 418 0.0121
952 FLUSHING 1080 0.0121
953 ANGIOEDEMA 437 0.0120
954 MALIGNANT NEOPLASM PROGRESSION 953 0.0120
955 CARDIO-RESPIRATORY ARREST 435 0.0118
956 INTENTIONAL PRODUCT MISUSE 843 0.0118
957 DRY SKIN 1156 0.0117
958 HYPOGLYCAEMIA 481 0.0116
959 VAGINAL HAEMORRHAGE 437 0.0115
960 ACCIDENTAL EXPOSURE TO PRODUCT 710 0.0114
961 COGNITIVE DISORDER 431 0.0112
962 CHRONIC KIDNEY DISEASE 759 0.0109
963 FEAR 263 0.0107
964 BREAST CANCER FEMALE 264 0.0107
965 EYE IRRITATION 426 0.0105
966 NEOPLASM PROGRESSION 310 0.0104
967 MOOD SWINGS 289 0.0104
968 BRADYCARDIA 472 0.0103
969 DYSGEUSIA 646 0.0099
970 DISTURBANCE IN ATTENTION 441 0.0095
971 MULTIPLE SCLEROSIS 386 0.0094
972 SUICIDAL IDEATION 722 0.0093
973 HOSPITALISATION 1036 0.0091
974 IRRITABILITY 476 0.0091
975 INTERNATIONAL NORMALISED RATIO INCREASED 243 0.0090
976 PRODUCT STORAGE ERROR 456 0.0088
977 DYSKINESIA 300 0.0088
978 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 1332 0.0086
979 FOETAL EXPOSURE DURING PREGNANCY 551 0.0085
980 PROSTATE CANCER 648 0.0084
981 BLOOD GLUCOSE INCREASED 1382 0.0084
982 DRUG EXPOSURE DURING PREGNANCY 270 0.0079
983 AGITATION 488 0.0076
984 BLOOD GLUCOSE DECREASED 299 0.0071
985 HALLUCINATION 407 0.0068
986 SKIN BURNING SENSATION 402 0.0067
987 SKIN IRRITATION 262 0.0066
988 NO ADVERSE EVENT 736 0.0060
989 OVERDOSE 1045 0.0056
990 SUICIDE ATTEMPT 284 0.0056
991 DEATH 3891 0.0055
992 BLADDER CANCER 300 0.0052
993 EMOTIONAL DISTRESS 507 0.0045
994 PRODUCT QUALITY ISSUE 439 0.0036
995 DRUG DEPENDENCE 495 0.0032