METHOTREXATE

METHOTREXATE was reported 396783 times

METHOTREXATE is most commonly taken among patients reporting these side effects:

# Side effect Count Frequency
0 ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE 3418 0.9193
1 SWOLLEN JOINT COUNT INCREASED 848 0.9031
2 HUMAN ANTICHIMERIC ANTIBODY POSITIVE 262 0.8763
3 RHEUMATOID FACTOR POSITIVE 2755 0.8199
4 PEMPHIGUS 5947 0.7675
5 RHEUMATIC FEVER 1010 0.7640
6 RED BLOOD CELL SEDIMENTATION RATE ABNORMAL 1510 0.7362
7 SYNOVITIS 8920 0.6910
8 C-REACTIVE PROTEIN ABNORMAL 2626 0.6909
9 HAND DEFORMITY 5640 0.6513
10 DUODENAL ULCER PERFORATION 2138 0.6407
11 GRANULOMA SKIN 438 0.6230
12 RHEUMATOID NODULE 1387 0.5666
13 BONE EROSION 1215 0.4965
14 BODY HEIGHT BELOW NORMAL 302 0.4943
15 CONTRAINDICATED PRODUCT ADMINISTERED 10770 0.4907
16 ENTHESOPATHY 579 0.4817
17 SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE 1547 0.4410
18 DACTYLITIS 303 0.4404
19 RHEUMATOID LUNG 329 0.4113
20 HELICOBACTER INFECTION 2374 0.4099
21 MUSCLE INJURY 1850 0.4068
22 BLOOD PARATHYROID HORMONE DECREASED 499 0.3948
23 DRUG TOLERANCE DECREASED 694 0.3936
24 X-RAY ABNORMAL 319 0.3881
25 JUVENILE IDIOPATHIC ARTHRITIS 704 0.3841
26 SERONEGATIVE ARTHRITIS 227 0.3802
27 BLOOD PRESSURE DIASTOLIC ABNORMAL 735 0.3795
28 FOLLICULITIS 2012 0.3783
29 BLOOD IRON ABNORMAL 295 0.3782
30 BLOOD PRESSURE SYSTOLIC ABNORMAL 650 0.3775
31 HYPOFIBRINOGENAEMIA 274 0.3748
32 RHEUMATOID ARTHRITIS 32618 0.3714
33 TENOSYNOVITIS 864 0.3700
34 PERICARDITIS 3671 0.3586
35 LYMPHOPROLIFERATIVE DISORDER 787 0.3563
36 DISLOCATION OF VERTEBRA 297 0.3445
37 DRUG CLEARANCE DECREASED 321 0.3441
38 ACUTE GRAFT VERSUS HOST DISEASE 1269 0.3417
39 ARTHRODESIS 281 0.3377
40 PANNICULITIS 629 0.3362
41 RED BLOOD CELL SEDIMENTATION RATE INCREASED 2901 0.3306
42 JOINT DESTRUCTION 415 0.3294
43 GLOSSODYNIA 5402 0.3276
44 CHRONIC GRAFT VERSUS HOST DISEASE 897 0.3234
45 EPSTEIN-BARR VIRUS ASSOCIATED LYMPHOPROLIFERATIVE DISORDER 410 0.3104
46 ADJUSTMENT DISORDER WITH DEPRESSED MOOD 223 0.3063
47 SYSTEMIC LUPUS ERYTHEMATOSUS 7194 0.3041
48 ACUTE GRAFT VERSUS HOST DISEASE IN SKIN 607 0.3015
49 ACUTE GRAFT VERSUS HOST DISEASE IN INTESTINE 311 0.2965
50 HISTOPLASMOSIS DISSEMINATED 266 0.2676
51 THERAPEUTIC PRODUCT EFFECT DECREASED 7882 0.2637
52 WOUND 4880 0.2463
53 DRUG SPECIFIC ANTIBODY 250 0.2449
54 FEBRILE BONE MARROW APLASIA 773 0.2436
55 CENTRAL NERVOUS SYSTEM LYMPHOMA 228 0.2373
56 ARTHROPATHY 10258 0.2305
57 GRIP STRENGTH DECREASED 1277 0.2275
58 PSORIATIC ARTHROPATHY 5979 0.2268
59 DRUG INTOLERANCE 16226 0.2243
60 FINGER DEFORMITY 802 0.2241
61 JOINT ARTHROPLASTY 325 0.2232
62 POLYARTHRITIS 842 0.2227
63 GRAFT VERSUS HOST DISEASE IN GASTROINTESTINAL TRACT 344 0.2190
64 MYELOPATHY 337 0.2181
65 GRAFT VERSUS HOST DISEASE IN SKIN 350 0.2120
66 LEUKOENCEPHALOPATHY 652 0.2087
67 FOOT DEFORMITY 1817 0.2078
68 SCLERITIS 239 0.2029
69 JOINT RANGE OF MOTION DECREASED 1851 0.2002
70 JOINT SWELLING 18395 0.1992
71 ACUTE LYMPHOCYTIC LEUKAEMIA RECURRENT 361 0.1991
72 VENOOCCLUSIVE LIVER DISEASE 732 0.1949
73 JOINT EFFUSION 1119 0.1940
74 SYNOVIAL CYST 748 0.1940
75 CYTOMEGALOVIRUS CHORIORETINITIS 277 0.1930
76 ALANINE AMINOTRANSFERASE ABNORMAL 295 0.1922
77 LIMB DEFORMITY 270 0.1915
78 TREATMENT FAILURE 11313 0.1914
79 PSEUDOMONAL SEPSIS 260 0.1903
80 C-REACTIVE PROTEIN INCREASED 5060 0.1833
81 SACROILIITIS 262 0.1819
82 TUBERCULIN TEST POSITIVE 434 0.1813
83 ANTIBODY TEST POSITIVE 268 0.1807
84 LATENT TUBERCULOSIS 277 0.1798
85 GRAFT VERSUS HOST DISEASE 1076 0.1794
86 ARTHRITIS BACTERIAL 586 0.1793
87 SHOULDER ARTHROPLASTY 320 0.1791
88 LEUKAEMIA RECURRENT 246 0.1714
89 EPSTEIN-BARR VIRUS INFECTION 814 0.1713
90 DISSEMINATED TUBERCULOSIS 329 0.1650
91 KNEE ARTHROPLASTY 2415 0.1649
92 ADENOVIRUS INFECTION 326 0.1619
93 VENOOCCLUSIVE DISEASE 316 0.1614
94 CYTOMEGALOVIRUS INFECTION REACTIVATION 286 0.1583
95 SPINAL STENOSIS 394 0.1580
96 FINE MOTOR SKILL DYSFUNCTION 334 0.1578
97 HISTOPLASMOSIS 224 0.1562
98 DIFFUSE LARGE B-CELL LYMPHOMA 765 0.1551
99 INFUSION RELATED REACTION 7343 0.1549
100 HIP ARTHROPLASTY 1667 0.1538
101 BLOOD PRESSURE DIASTOLIC DECREASED 912 0.1536
102 HUMAN HERPESVIRUS 6 INFECTION 243 0.1533
103 IRRITABLE BOWEL SYNDROME 2320 0.1522
104 PERIPHERAL VENOUS DISEASE 262 0.1521
105 ANKYLOSING SPONDYLITIS 1290 0.1520
106 PNEUMOCYSTIS JIROVECI PNEUMONIA 338 0.1514
107 OSTEOARTHRITIS 5016 0.1511
108 CYTOMEGALOVIRUS VIRAEMIA 440 0.1509
109 LOWER RESPIRATORY TRACT INFECTION 4844 0.1502
110 ASPERGILLUS INFECTION 698 0.1502
111 PULMONARY TUBERCULOSIS 530 0.1489
112 HEPATIC ENZYME INCREASED 7626 0.1483
113 FIBROMYALGIA 2652 0.1469
114 MUCOSAL INFLAMMATION 2993 0.1460
115 SENSITIVITY TO WEATHER CHANGE 541 0.1449
116 NODULE 1480 0.1443
117 PULMONARY FIBROSIS 2025 0.1437
118 MUSCULOSKELETAL STIFFNESS 10063 0.1435
119 FAECAL CALPROTECTIN INCREASED 283 0.1430
120 HISTIOCYTOSIS HAEMATOPHAGIC 429 0.1424
121 CYSTITIS HAEMORRHAGIC 445 0.1421
122 IMPAIRED HEALING 3560 0.1407
123 BASAL CELL CARCINOMA 1730 0.1397
124 PNEUMOCYSTIS JIROVECII PNEUMONIA 982 0.1395
125 SKIN NECROSIS 613 0.1394
126 INFLAMMATORY MARKER INCREASED 476 0.1393
127 JOINT STIFFNESS 2940 0.1390
128 BLOOD PRESSURE DIASTOLIC INCREASED 469 0.1375
129 CHONDROPATHY 331 0.1371
130 PUSTULAR PSORIASIS 365 0.1371
131 DEMYELINATION 458 0.1370
132 PULMONARY TOXICITY 644 0.1335
133 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 4205 0.1328
134 MYCOBACTERIUM TUBERCULOSIS COMPLEX TEST POSITIVE 253 0.1321
135 ONYCHOMYCOSIS 396 0.1310
136 B-CELL LYMPHOMA 375 0.1298
137 FOOT OPERATION 465 0.1288
138 PNEUMONIA VIRAL 303 0.1281
139 SWELLING 9321 0.1276
140 ARTHRITIS INFECTIVE 453 0.1261
141 APLASIA 245 0.1260
142 INJECTION SITE IRRITATION 1281 0.1258
143 INFLAMMATION 4731 0.1258
144 BURSITIS 1022 0.1256
145 MOUTH ULCERATION 2015 0.1250
146 UVEITIS 1173 0.1243
147 POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME 874 0.1239
148 HEPATIC FIBROSIS 327 0.1233
149 CUSHINGOID 296 0.1225
150 SARCOIDOSIS 457 0.1217
151 EXOSTOSIS 862 0.1209
152 LIVER FUNCTION TEST INCREASED 1749 0.1209
153 MUCORMYCOSIS 231 0.1201
154 TUBERCULOSIS 1210 0.1192
155 INJECTION SITE HAEMATOMA 1658 0.1188
156 JOINT LOCK 276 0.1171
157 BRONCHITIS CHRONIC 245 0.1155
158 BLOOD PRESSURE SYSTOLIC INCREASED 1763 0.1149
159 BLOOD PRESSURE FLUCTUATION 2286 0.1138
160 BLOOD CULTURE POSITIVE 314 0.1131
161 HAEMATOTOXICITY 711 0.1118
162 ARTHRITIS 6917 0.1112
163 ACUTE LYMPHOCYTIC LEUKAEMIA 257 0.1105
164 STOMATITIS 5171 0.1103
165 DISCOMFORT 4743 0.1096
166 IMMUNOSUPPRESSION 650 0.1088
167 ANTINUCLEAR ANTIBODY POSITIVE 304 0.1078
168 BODY TEMPERATURE DECREASED 905 0.1073
169 LIVER INJURY 1587 0.1062
170 PULMONARY MASS 1195 0.1056
171 IMMUNODEFICIENCY 1041 0.1052
172 HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS 379 0.1045
173 STAPHYLOCOCCAL SEPSIS 441 0.1042
174 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 4850 0.1041
175 GRANULOMA 287 0.1039
176 LUPUS-LIKE SYNDROME 699 0.1039
177 FEAR OF INJECTION 469 0.1039
178 BK VIRUS INFECTION 229 0.1039
179 JOINT DISLOCATION 843 0.1029
180 SKIN ULCER 2147 0.1020
181 HEPATOTOXICITY 1732 0.1019
182 BRONCHIECTASIS 487 0.1018
183 PHARYNGITIS 1040 0.1016
184 CYTOPENIA 740 0.1013
185 SINUSITIS 8221 0.1011
186 CREPITATIONS 267 0.1009
187 APHTHOUS ULCER 519 0.1006
188 RHINOVIRUS INFECTION 221 0.0999
189 PANCYTOPENIA 4288 0.0990
190 GASTROINTESTINAL TOXICITY 315 0.0989
191 BRONCHOPULMONARY ASPERGILLOSIS 572 0.0989
192 FEBRILE NEUTROPENIA 4893 0.0986
193 APPARENT DEATH 352 0.0982
194 IRITIS 243 0.0981
195 PLEURISY 501 0.0970
196 THYROID NEOPLASM 252 0.0969
197 HEPATIC ENZYME ABNORMAL 375 0.0965
198 INFECTION 10413 0.0961
199 HEPATITIS B REACTIVATION 231 0.0956
200 TENDERNESS 826 0.0956
201 ARTHRALGIA 30120 0.0955
202 MOBILITY DECREASED 5299 0.0948
203 LUNG ADENOCARCINOMA 224 0.0947
204 WOUND INFECTION 668 0.0938
205 PLEURITIC PAIN 220 0.0937
206 IMMOBILE 330 0.0933
207 BACTERIAL SEPSIS 240 0.0931
208 SCIATICA 1037 0.0924
209 TONSILLITIS 370 0.0915
210 DIVERTICULITIS 1993 0.0913
211 ANAL FISSURE 329 0.0911
212 MUSCULOSKELETAL PAIN 4270 0.0898
213 VIRAL UPPER RESPIRATORY TRACT INFECTION 376 0.0888
214 WHEELCHAIR USER 317 0.0886
215 RED CELL DISTRIBUTION WIDTH INCREASED 269 0.0886
216 DEAFNESS NEUROSENSORY 222 0.0882
217 PERIPHERAL SWELLING 10190 0.0881
218 HYPERCHOLESTEROLAEMIA 575 0.0877
219 CYTOMEGALOVIRUS INFECTION 1131 0.0870
220 HERPES ZOSTER 4008 0.0866
221 POSTOPERATIVE WOUND INFECTION 450 0.0862
222 HERPES SIMPLEX 433 0.0861
223 POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER 294 0.0859
224 ABSCESS LIMB 281 0.0856
225 DEFORMITY 706 0.0855
226 TOOTH INFECTION 888 0.0854
227 ORAL HERPES 1223 0.0850
228 LOCALISED INFECTION 1631 0.0846
229 ENCEPHALITIS 438 0.0845
230 HEPATIC STEATOSIS 1239 0.0843
231 CHRONIC SINUSITIS 233 0.0843
232 PNEUMONIA FUNGAL 221 0.0842
233 DRUG ERUPTION 1125 0.0841
234 ILL-DEFINED DISORDER 2833 0.0837
235 TOOTH ABSCESS 723 0.0837
236 EAR PAIN 1286 0.0833
237 SKIN PLAQUE 543 0.0832
238 BLISTER 3581 0.0832
239 STAPHYLOCOCCAL BACTERAEMIA 266 0.0830
240 LYMPHOMA 1056 0.0830
241 ABDOMINAL DISCOMFORT 10705 0.0826
242 POOR VENOUS ACCESS 587 0.0818
243 THROMBOTIC MICROANGIOPATHY 562 0.0815
244 OESOPHAGEAL CANDIDIASIS 243 0.0812
245 ANAL ABSCESS 320 0.0809
246 MENISCUS INJURY 399 0.0808
247 NEUROTOXICITY 1018 0.0806
248 HYPOGAMMAGLOBULINAEMIA 314 0.0803
249 SQUAMOUS CELL CARCINOMA 608 0.0803
250 ULCER 1036 0.0802
251 JOINT INJURY 1358 0.0799
252 LUNG NEOPLASM 306 0.0799
253 MUSCULOSKELETAL DISORDER 1290 0.0797
254 BACTERIAL INFECTION 1105 0.0794
255 INJECTION SITE WARMTH 1407 0.0792
256 ORGANISING PNEUMONIA 273 0.0789
257 HYPERCALCAEMIA 771 0.0787
258 POST PROCEDURAL INFECTION 477 0.0787
259 BRONCHOPNEUMONIA 270 0.0787
260 HEPATIC CIRRHOSIS 1112 0.0786
261 GASTROINTESTINAL DISORDER 4629 0.0783
262 BONE MARROW FAILURE 1452 0.0782
263 SKIN PAPILLOMA 249 0.0779
264 CARPAL TUNNEL SYNDROME 878 0.0779
265 SPINAL OSTEOARTHRITIS 570 0.0777
266 INJECTION SITE PAPULE 292 0.0777
267 HYPERTRIGLYCERIDAEMIA 349 0.0776
268 VASCULITIS 682 0.0770
269 SPINAL PAIN 700 0.0764
270 WALKING AID USER 378 0.0763
271 PARANASAL SINUS HYPERSECRETION 253 0.0762
272 EAR INFECTION 1483 0.0762
273 RESPIRATORY TRACT CONGESTION 934 0.0761
274 LIMB OPERATION 250 0.0761
275 DRUG SPECIFIC ANTIBODY PRESENT 353 0.0760
276 NASOPHARYNGITIS 10627 0.0758
277 SINUS CONGESTION 823 0.0757
278 DRUG LEVEL BELOW THERAPEUTIC 314 0.0757
279 INTERSTITIAL LUNG DISEASE 2774 0.0752
280 TRIGGER FINGER 232 0.0752
281 THERAPY NON-RESPONDER 2196 0.0752
282 THERAPY PARTIAL RESPONDER 473 0.0751
283 CYST 739 0.0743
284 INTERVERTEBRAL DISC DEGENERATION 600 0.0741
285 LARYNGITIS 609 0.0738
286 NAIL DISORDER 450 0.0737
287 PSORIASIS 7731 0.0737
288 SKIN INFECTION 618 0.0736
289 SUBCUTANEOUS ABSCESS 289 0.0734
290 INTENTIONAL PRODUCT USE ISSUE 4566 0.0732
291 ADRENAL INSUFFICIENCY 572 0.0729
292 SEPTIC SHOCK 2391 0.0725
293 BODY TEMPERATURE INCREASED 1230 0.0718
294 ALOPECIA 11585 0.0716
295 BLOOD CHOLESTEROL INCREASED 2623 0.0713
296 COLITIS MICROSCOPIC 234 0.0713
297 ANAL FISTULA 289 0.0713
298 MYELODYSPLASTIC SYNDROME 840 0.0712
299 NEUTROPENIC SEPSIS 427 0.0708
300 ENTEROCOCCAL INFECTION 259 0.0707
301 DRUG EFFECT INCOMPLETE 2576 0.0707
302 HERPES VIRUS INFECTION 325 0.0704
303 MALIGNANT MELANOMA 767 0.0702
304 GAIT INABILITY 1479 0.0700
305 SKIN LESION 1466 0.0700
306 INJECTION SITE PRURITUS 3678 0.0699
307 ESCHERICHIA URINARY TRACT INFECTION 242 0.0699
308 VAGINAL INFECTION 262 0.0690
309 OSTEOPOROSIS 2336 0.0686
310 HYPERBILIRUBINAEMIA 549 0.0685
311 ABSCESS 857 0.0682
312 BRONCHITIS 4220 0.0682
313 EPIGASTRIC DISCOMFORT 219 0.0681
314 MATERNAL EXPOSURE DURING PREGNANCY 4133 0.0677
315 PHARYNGITIS STREPTOCOCCAL 539 0.0676
316 ROTATOR CUFF SYNDROME 718 0.0672
317 INJECTION SITE REACTION 3699 0.0672
318 CONDITION AGGRAVATED 14481 0.0666
319 SKIN LACERATION 501 0.0666
320 THERAPEUTIC RESPONSE DECREASED 3057 0.0664
321 PURULENT DISCHARGE 238 0.0663
322 PYELONEPHRITIS 448 0.0662
323 AUTOIMMUNE DISORDER 381 0.0658
324 TENDON DISORDER 355 0.0658
325 HEART RATE DECREASED 1893 0.0656
326 OBESITY 777 0.0656
327 LIVE BIRTH 364 0.0655
328 UPPER RESPIRATORY TRACT INFECTION 2353 0.0653
329 DERMATITIS ALLERGIC 592 0.0651
330 PSEUDOMONAS INFECTION 411 0.0649
331 TIBIA FRACTURE 247 0.0649
332 BACTERAEMIA 570 0.0649
333 LIGAMENT RUPTURE 233 0.0648
334 OSTEOMYELITIS 996 0.0646
335 HYPERKERATOSIS 285 0.0645
336 STREPTOCOCCAL INFECTION 262 0.0642
337 ERYSIPELAS 260 0.0640
338 RESPIRATORY TRACT INFECTION 1222 0.0640
339 CLOSTRIDIUM DIFFICILE COLITIS 537 0.0638
340 ARTHROPOD BITE 369 0.0634
341 CELLULITIS 2630 0.0632
342 INTERVERTEBRAL DISC PROTRUSION 1160 0.0631
343 DISABILITY 985 0.0628
344 PHARYNGOLARYNGEAL PAIN 334 0.0628
345 PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY 420 0.0627
346 ORAL DISORDER 372 0.0623
347 ACUTE MYELOID LEUKAEMIA 757 0.0623
348 NECK PAIN 2785 0.0622
349 LUNG DISORDER 2324 0.0618
350 HYPERSENSITIVITY 9131 0.0617
351 HYPOALBUMINAEMIA 357 0.0617
352 INJECTION SITE ERYTHEMA 6068 0.0615
353 INJECTION SITE PAIN 13467 0.0615
354 GASTROINTESTINAL INFLAMMATION 357 0.0615
355 ESCHERICHIA INFECTION 378 0.0615
356 SPINAL DISORDER 473 0.0612
357 SPINAL COLUMN STENOSIS 290 0.0612
358 ORAL CANDIDIASIS 601 0.0611
359 TRANSAMINASES INCREASED 1112 0.0611
360 UMBILICAL HERNIA 230 0.0610
361 HEPATITIS 1248 0.0610
362 LOCAL SWELLING 1065 0.0610
363 CANDIDA INFECTION 742 0.0609
364 LIVER FUNCTION TEST ABNORMAL 1587 0.0608
365 MENINGITIS 321 0.0607
366 DRUG HYPERSENSITIVITY 9739 0.0607
367 GASTROINTESTINAL INFECTION 414 0.0607
368 STAPHYLOCOCCAL INFECTION 1685 0.0606
369 NEPHROPATHY TOXIC 488 0.0604
370 PAIN IN EXTREMITY 14760 0.0604
371 INJECTION SITE INFLAMMATION 226 0.0603
372 DRUG INEFFECTIVE 62472 0.0602
373 INJECTION SITE SWELLING 3408 0.0602
374 KLEBSIELLA INFECTION 225 0.0601
375 PNEUMONITIS 1181 0.0601
376 ACUTE RESPIRATORY DISTRESS SYNDROME 857 0.0600
377 LIVER DISORDER 2071 0.0599
378 NIGHT SWEATS 1460 0.0598
379 SKIN MASS 294 0.0597
380 MYELOSUPPRESSION 630 0.0594
381 NERVE COMPRESSION 434 0.0594
382 LEUKOPENIA 2329 0.0593
383 CYSTITIS 1574 0.0590
384 KIDNEY INFECTION 903 0.0586
385 TENDONITIS 765 0.0585
386 ENTERITIS 268 0.0584
387 PAIN 29508 0.0584
388 VIRAL INFECTION 1445 0.0581
389 RHINITIS 366 0.0581
390 FOOT FRACTURE 909 0.0579
391 FURUNCLE 378 0.0579
392 SQUAMOUS CELL CARCINOMA OF SKIN 260 0.0578
393 SEPSIS 5184 0.0578
394 PNEUMONIA BACTERIAL 363 0.0577
395 APLASTIC ANAEMIA 241 0.0576
396 IMMUNE SYSTEM DISORDER 583 0.0571
397 DRUG USE DISORDER 228 0.0571
398 TYPE 2 DIABETES MELLITUS 1531 0.0570
399 THERAPEUTIC RESPONSE SHORTENED 848 0.0569
400 TONGUE DISORDER 361 0.0567
401 SPUTUM DISCOLOURED 413 0.0566
402 MUSCULOSKELETAL DISCOMFORT 769 0.0563
403 FUNGAL INFECTION 1482 0.0562
404 GASTROENTERITIS 655 0.0562
405 MATERNAL EXPOSURE BEFORE PREGNANCY 258 0.0562
406 CATARACT 2494 0.0558
407 ADVERSE REACTION 588 0.0557
408 SECRETION DISCHARGE 487 0.0556
409 LUNG INFILTRATION 446 0.0556
410 INJECTION SITE BRUISING 3322 0.0555
411 DRUG EFFECT DECREASED 2995 0.0555
412 TUMOUR LYSIS SYNDROME 358 0.0555
413 DRUG-INDUCED LIVER INJURY 1076 0.0551
414 LYMPHADENOPATHY 1556 0.0550
415 RESPIRATORY DISORDER 1316 0.0550
416 OSTEOPENIA 703 0.0548
417 TENDON RUPTURE 571 0.0546
418 TOOTH FRACTURE 497 0.0546
419 EYE INFECTION 448 0.0546
420 MASS 629 0.0544
421 INJECTION SITE INDURATION 599 0.0544
422 MUSCLE SPASTICITY 585 0.0543
423 OROPHARYNGEAL PAIN 3932 0.0542
424 INJECTION SITE RASH 1201 0.0540
425 ALANINE AMINOTRANSFERASE INCREASED 2739 0.0539
426 SKIN ATROPHY 237 0.0532
427 INJECTION SITE VESICLES 221 0.0529
428 LUNG INFECTION 825 0.0529
429 ATELECTASIS 433 0.0528
430 CARDIOTOXICITY 334 0.0528
431 GASTROINTESTINAL PAIN 438 0.0527
432 SPINAL COMPRESSION FRACTURE 388 0.0527
433 ODYNOPHAGIA 237 0.0525
434 KNEE OPERATION 345 0.0524
435 VITAMIN D DECREASED 370 0.0524
436 DECREASED IMMUNE RESPONSIVENESS 345 0.0519
437 INJECTION SITE URTICARIA 915 0.0519
438 HEPATOMEGALY 439 0.0518
439 CONTUSION 3949 0.0518
440 FISTULA 445 0.0517
441 GENERAL PHYSICAL HEALTH DETERIORATION 4307 0.0517
442 PRODUCTIVE COUGH 1791 0.0517
443 LIGAMENT SPRAIN 389 0.0513
444 INFLUENZA 4196 0.0513
445 INCREASED TENDENCY TO BRUISE 404 0.0513
446 STRESS FRACTURE 244 0.0513
447 SINUS HEADACHE 265 0.0512
448 BREAST CANCER STAGE III 228 0.0512
449 BREAST MASS 279 0.0511
450 PRODUCT USE ISSUE 7154 0.0511
451 IMPAIRED WORK ABILITY 931 0.0509
452 PELVIC FRACTURE 314 0.0509
453 DIVERTICULUM 339 0.0508
454 MULTIPLE ORGAN DYSFUNCTION SYNDROME 945 0.0507
455 NEPHROLITHIASIS 1755 0.0502
456 INJECTION SITE DISCOLOURATION 486 0.0501
457 RESPIRATORY RATE INCREASED 354 0.0499
458 GINGIVITIS 223 0.0498
459 PNEUMONIA 12412 0.0497
460 LYMPHOPENIA 531 0.0493
461 COLITIS 1339 0.0492
462 RHINORRHOEA 2402 0.0492
463 LIP DRY 259 0.0485
464 BLOOD TEST ABNORMAL 511 0.0485
465 DIARRHOEA HAEMORRHAGIC 365 0.0483
466 PULMONARY THROMBOSIS 408 0.0482
467 NECROSIS 225 0.0481
468 UROSEPSIS 350 0.0480
469 OXYGEN SATURATION DECREASED 1960 0.0478
470 BONE DISORDER 770 0.0478
471 FACIAL PARALYSIS 303 0.0478
472 RASH PUSTULAR 310 0.0478
473 TOOTH DISORDER 892 0.0478
474 HEPATOCELLULAR INJURY 605 0.0477
475 GLAUCOMA 743 0.0476
476 EMPHYSEMA 405 0.0476
477 BLOOD IRON DECREASED 404 0.0476
478 PYREXIA 13150 0.0474
479 DISSEMINATED INTRAVASCULAR COAGULATION 566 0.0473
480 INCREASED UPPER AIRWAY SECRETION 220 0.0473
481 BACK INJURY 371 0.0472
482 PHOTOSENSITIVITY REACTION 623 0.0470
483 GASTROENTERITIS VIRAL 639 0.0470
484 PULMONARY HAEMORRHAGE 314 0.0469
485 HEPATITIS B 238 0.0469
486 RASH 15407 0.0467
487 LIMB DISCOMFORT 1144 0.0466
488 SLEEP DISORDER 2406 0.0465
489 ENCEPHALOPATHY 869 0.0462
490 GROIN PAIN 336 0.0461
491 RENAL CYST 307 0.0459
492 LIMB INJURY 939 0.0457
493 IMPAIRED GASTRIC EMPTYING 273 0.0456
494 ORAL PAIN 840 0.0454
495 CLOSTRIDIUM DIFFICILE INFECTION 734 0.0453
496 APPENDICITIS 317 0.0453
497 SKIN CANCER 767 0.0452
498 NASAL CONGESTION 1968 0.0451
499 COVID-19 PNEUMONIA 381 0.0451
500 EYE INFLAMMATION 294 0.0450
501 INGUINAL HERNIA 225 0.0450
502 NEUTROPENIA 4516 0.0450
503 MOUTH HAEMORRHAGE 259 0.0449
504 ASPARTATE AMINOTRANSFERASE INCREASED 1976 0.0449
505 HAND FRACTURE 254 0.0448
506 LOWER LIMB FRACTURE 627 0.0448
507 SCAB 392 0.0444
508 MULTI-ORGAN FAILURE 770 0.0444
509 POLYP 234 0.0442
510 DENTAL CARIES 406 0.0441
511 ANKLE FRACTURE 557 0.0441
512 HEMIPARESIS 635 0.0438
513 INJECTION SITE HAEMORRHAGE 2620 0.0438
514 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 457 0.0438
515 SKIN REACTION 481 0.0437
516 HYPERTENSION 7326 0.0435
517 WEIGHT INCREASED 7645 0.0434
518 SCRATCH 295 0.0432
519 GASTRIC DISORDER 1452 0.0428
520 GAIT DISTURBANCE 6706 0.0428
521 TOOTHACHE 618 0.0426
522 GASTRIC ULCER 679 0.0426
523 POLYNEUROPATHY 374 0.0426
524 DRUG LEVEL DECREASED 324 0.0426
525 URINARY TRACT INFECTION 5567 0.0424
526 MYOSITIS 278 0.0422
527 COELIAC DISEASE 316 0.0421
528 ONYCHOCLASIS 225 0.0421
529 DEVICE RELATED INFECTION 552 0.0421
530 IRON DEFICIENCY ANAEMIA 306 0.0420
531 INTESTINAL PERFORATION 375 0.0420
532 BEDRIDDEN 448 0.0418
533 RASH PRURITIC 1720 0.0417
534 HIATUS HERNIA 458 0.0417
535 COUGH 8891 0.0416
536 DYSSTASIA 1003 0.0415
537 MUSCULOSKELETAL CHEST PAIN 513 0.0415
538 HEPATIC FUNCTION ABNORMAL 1164 0.0414
539 DRY EYE 1282 0.0413
540 BACK PAIN 7757 0.0412
541 OVARIAN CYST 356 0.0410
542 PNEUMOTHORAX 510 0.0410
543 ADVERSE DRUG REACTION 2581 0.0410
544 UTERINE LEIOMYOMA 247 0.0409
545 THROMBOCYTOPENIA 3554 0.0408
546 LARGE INTESTINE PERFORATION 229 0.0408
547 SPLENOMEGALY 389 0.0407
548 CONJUNCTIVITIS 521 0.0405
549 SKIN HAEMORRHAGE 374 0.0405
550 OFF LABEL USE 22763 0.0405
551 HERNIA 596 0.0403
552 ANAPHYLACTIC REACTION 1630 0.0403
553 PLEURAL EFFUSION 2003 0.0402
554 UPPER LIMB FRACTURE 690 0.0402
555 BLOOD ALBUMIN DECREASED 262 0.0402
556 CROHN'S DISEASE 276 0.0402
557 POST PROCEDURAL COMPLICATION 641 0.0402
558 VITAMIN D DEFICIENCY 308 0.0400
559 MUSCLE STRAIN 282 0.0400
560 PULMONARY CONGESTION 417 0.0400
561 FREQUENT BOWEL MOVEMENTS 745 0.0396
562 INJECTION SITE EXTRAVASATION 461 0.0395
563 SPINAL OPERATION 298 0.0395
564 FEMUR FRACTURE 1051 0.0392
565 EYE DISORDER 1006 0.0392
566 WEIGHT FLUCTUATION 299 0.0391
567 WRIST FRACTURE 379 0.0390
568 FATIGUE 23573 0.0390
569 NERVE INJURY 362 0.0389
570 COAGULOPATHY 543 0.0387
571 UPPER-AIRWAY COUGH SYNDROME 236 0.0387
572 STRESS 2153 0.0387
573 HYPOPHAGIA 758 0.0386
574 DISEASE RECURRENCE 1225 0.0386
575 DRUG LEVEL INCREASED 512 0.0385
576 PRODUCT USE IN UNAPPROVED INDICATION 5994 0.0384
577 SKIN DISORDER 980 0.0384
578 SENSORY LOSS 255 0.0383
579 RESPIRATORY FAILURE 2278 0.0382
580 BLOOD PRESSURE INCREASED 4686 0.0381
581 COLITIS ULCERATIVE 1107 0.0379
582 MOTOR DYSFUNCTION 305 0.0379
583 NEURALGIA 708 0.0379
584 GASTRITIS 811 0.0376
585 DRUG RESISTANCE 729 0.0376
586 PLATELET COUNT INCREASED 386 0.0376
587 SEASONAL ALLERGY 358 0.0372
588 PAIN IN JAW 881 0.0370
589 CHOLECYSTITIS 351 0.0370
590 LACERATION 347 0.0368
591 INJECTION SITE DISCOMFORT 259 0.0361
592 BLOOD LACTATE DEHYDROGENASE INCREASED 495 0.0361
593 THYROID DISORDER 435 0.0359
594 RIB FRACTURE 591 0.0359
595 ACCIDENT 328 0.0359
596 PERICARDIAL EFFUSION 641 0.0357
597 PHOTOPHOBIA 507 0.0357
598 PRESCRIBED OVERDOSE 543 0.0357
599 HAEMATOCHEZIA 1488 0.0356
600 CHOLELITHIASIS 953 0.0355
601 WEIGHT DECREASED 7863 0.0353
602 OEDEMA PERIPHERAL 3712 0.0353
603 DIABETES MELLITUS 2262 0.0351
604 FRACTURE 546 0.0351
605 FACIAL PAIN 239 0.0351
606 OEDEMA 1482 0.0351
607 BRAIN OEDEMA 357 0.0350
608 HYPERAESTHESIA 248 0.0349
609 ABDOMINAL PAIN 6447 0.0348
610 BACK DISORDER 458 0.0347
611 PROCEDURAL COMPLICATION 235 0.0346
612 SINUS DISORDER 544 0.0345
613 FEEDING DISORDER 454 0.0345
614 MYOPATHY 240 0.0343
615 HYPOAESTHESIA 4170 0.0343
616 SECOND PRIMARY MALIGNANCY 228 0.0342
617 BLOOD BILIRUBIN INCREASED 775 0.0342
618 TOOTH EXTRACTION 353 0.0342
619 COLON CANCER 414 0.0341
620 URTICARIA 4349 0.0341
621 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 3377 0.0338
622 HEART RATE IRREGULAR 660 0.0337
623 AORTIC ANEURYSM 220 0.0335
624 SMALL INTESTINAL OBSTRUCTION 320 0.0334
625 CORONARY ARTERY OCCLUSION 402 0.0332
626 HEADACHE 16679 0.0330
627 FLANK PAIN 250 0.0329
628 PRESCRIBED UNDERDOSE 498 0.0329
629 INJECTION SITE NODULE 304 0.0328
630 DERMATITIS 485 0.0327
631 OPTIC NEURITIS 249 0.0327
632 CHOLECYSTECTOMY 293 0.0327
633 SPINAL FRACTURE 499 0.0326
634 MALAISE 11813 0.0325
635 RESPIRATORY DISTRESS 738 0.0325
636 SNEEZING 539 0.0323
637 RASH ERYTHEMATOUS 1060 0.0323
638 SLEEP APNOEA SYNDROME 521 0.0322
639 ASCITES 767 0.0321
640 WHITE BLOOD CELL COUNT INCREASED 1027 0.0320
641 PETECHIAE 270 0.0319
642 DEAFNESS 651 0.0319
643 MUSCULAR WEAKNESS 2904 0.0319
644 SKIN FISSURES 358 0.0318
645 MALNUTRITION 269 0.0318
646 SCAR 450 0.0318
647 CHOLESTASIS 466 0.0315
648 SURGERY 1277 0.0315
649 EAR DISCOMFORT 249 0.0314
650 NAUSEA 19708 0.0314
651 OESOPHAGITIS 275 0.0313
652 METASTASES TO LUNG 272 0.0312
653 NEOPLASM 276 0.0312
654 IMPAIRED QUALITY OF LIFE 288 0.0310
655 VOMITING 11429 0.0310
656 ILLNESS 1386 0.0310
657 HAEMATOCRIT DECREASED 530 0.0309
658 HAEMORRHOIDS 493 0.0308
659 PRURITUS 8195 0.0307
660 ANAEMIA 4783 0.0307
661 ACUTE RESPIRATORY FAILURE 442 0.0306
662 RENAL IMPAIRMENT 1980 0.0305
663 EXPOSURE DURING PREGNANCY 1437 0.0304
664 APHONIA 322 0.0304
665 ABDOMINAL PAIN UPPER 4889 0.0303
666 PANCREATITIS 1308 0.0302
667 WHEEZING 1300 0.0302
668 GENERALISED OEDEMA 288 0.0301
669 NEUTROPHIL COUNT DECREASED 895 0.0300
670 ILEUS 286 0.0299
671 HYPERTENSIVE CRISIS 276 0.0298
672 HYPOXIA 812 0.0298
673 HEPATIC FAILURE 741 0.0296
674 GALLBLADDER DISORDER 450 0.0295
675 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 1137 0.0295
676 MOVEMENT DISORDER 777 0.0294
677 WHITE BLOOD CELL COUNT DECREASED 2518 0.0294
678 RASH PAPULAR 553 0.0294
679 DEVICE MALFUNCTION 1368 0.0294
680 BLOOD CREATININE INCREASED 1582 0.0293
681 INFLAMMATORY BOWEL DISEASE 242 0.0293
682 MIGRAINE 2113 0.0293
683 CHILLS 2778 0.0293
684 TACHYPNOEA 304 0.0292
685 HYPOKINESIA 352 0.0291
686 AGRANULOCYTOSIS 395 0.0290
687 GAMMA-GLUTAMYLTRANSFERASE INCREASED 555 0.0290
688 MITRAL VALVE INCOMPETENCE 271 0.0290
689 DYSPEPSIA 2236 0.0290
690 SKIN DISCOLOURATION 1077 0.0289
691 ROAD TRAFFIC ACCIDENT 967 0.0289
692 OBSTRUCTIVE AIRWAYS DISORDER 258 0.0289
693 ORAL DISCOMFORT 328 0.0288
694 DIARRHOEA 14240 0.0288
695 CARDIOMEGALY 318 0.0288
696 FALL 7659 0.0288
697 NO THERAPEUTIC RESPONSE 351 0.0287
698 ERYTHEMA 4719 0.0287
699 ATRIAL FIBRILLATION 2229 0.0284
700 OSTEONECROSIS 837 0.0284
701 DEEP VEIN THROMBOSIS 1620 0.0283
702 DRY THROAT 229 0.0282
703 INFLUENZA LIKE ILLNESS 1978 0.0282
704 HYPOTHYROIDISM 675 0.0281
705 ASTHMA 2193 0.0281
706 PANCREATITIS ACUTE 489 0.0281
707 HAEMOGLOBIN DECREASED 2362 0.0280
708 POOR QUALITY SLEEP 457 0.0280
709 DRUG TOXICITY 381 0.0279
710 THROAT IRRITATION 962 0.0279
711 PROCEDURAL PAIN 579 0.0276
712 GINGIVAL BLEEDING 283 0.0276
713 DYSPHONIA 1267 0.0275
714 TOXIC EPIDERMAL NECROLYSIS 322 0.0275
715 ADVERSE EVENT 2037 0.0275
716 INTESTINAL OBSTRUCTION 762 0.0272
717 DYSPNOEA EXERTIONAL 772 0.0272
718 NEUTROPHIL COUNT INCREASED 227 0.0272
719 CARDIOMYOPATHY 334 0.0272
720 CONFUSIONAL STATE 3587 0.0271
721 PULMONARY EMBOLISM 2202 0.0271
722 RASH MACULO-PAPULAR 462 0.0271
723 RENAL PAIN 229 0.0270
724 MACULAR DEGENERATION 248 0.0268
725 METASTASES TO LIVER 362 0.0267
726 RED BLOOD CELL COUNT DECREASED 605 0.0267
727 FEELING HOT 1336 0.0264
728 CHEST PAIN 4061 0.0264
729 COVID-19 3039 0.0264
730 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 1116 0.0263
731 RECTAL HAEMORRHAGE 937 0.0263
732 APHASIA 654 0.0262
733 DISEASE PROGRESSION 2261 0.0259
734 NEUROPATHY PERIPHERAL 1833 0.0259
735 ASTHENIA 7746 0.0258
736 SARS-COV-2 TEST POSITIVE 265 0.0257
737 HYPERLIPIDAEMIA 264 0.0257
738 TOXICITY TO VARIOUS AGENTS 3293 0.0256
739 EATING DISORDER 445 0.0256
740 HEART RATE INCREASED 2004 0.0254
741 BLOOD URINE PRESENT 401 0.0253
742 EPISTAXIS 1535 0.0251
743 GOUT 359 0.0251
744 PERIPHERAL COLDNESS 280 0.0251
745 RASH MACULAR 663 0.0251
746 BODY HEIGHT DECREASED 243 0.0250
747 DRUG INTERACTION 3228 0.0250
748 DYSPNOEA 11264 0.0249
749 EJECTION FRACTION DECREASED 310 0.0249
750 BONE DENSITY DECREASED 701 0.0249
751 NERVOUS SYSTEM DISORDER 675 0.0248
752 ANGINA PECTORIS 617 0.0248
753 ANOREXIA 319 0.0247
754 PULMONARY OEDEMA 903 0.0247
755 PHARYNGEAL OEDEMA 374 0.0247
756 ATAXIA 246 0.0246
757 BLOOD PRESSURE ABNORMAL 361 0.0246
758 NEOPLASM MALIGNANT 1263 0.0246
759 LABORATORY TEST ABNORMAL 571 0.0245
760 HYPOKALAEMIA 881 0.0245
761 THROMBOSIS 1623 0.0245
762 ABASIA 602 0.0243
763 FEELING COLD 551 0.0243
764 ACUTE HEPATIC FAILURE 249 0.0242
765 DEVICE ISSUE 1444 0.0242
766 LUNG NEOPLASM MALIGNANT 868 0.0242
767 PARAESTHESIA 3177 0.0241
768 BURNING SENSATION 1396 0.0241
769 LEUKOCYTOSIS 347 0.0241
770 DYSURIA 734 0.0241
771 WRONG TECHNIQUE IN DRUG USAGE PROCESS 874 0.0240
772 TACHYCARDIA 1703 0.0240
773 PALLOR 545 0.0239
774 GASTROOESOPHAGEAL REFLUX DISEASE 1501 0.0238
775 ECZEMA 550 0.0238
776 PRODUCT PRESCRIBING ERROR 366 0.0237
777 PAIN OF SKIN 523 0.0236
778 HIP FRACTURE 599 0.0236
779 MYOCARDIAL ISCHAEMIA 242 0.0235
780 QUALITY OF LIFE DECREASED 251 0.0233
781 RENAL FAILURE 2690 0.0231
782 PLATELET COUNT DECREASED 1934 0.0230
783 INCORRECT DOSE ADMINISTERED 3379 0.0230
784 SINUS TACHYCARDIA 267 0.0230
785 CHEST DISCOMFORT 1805 0.0227
786 BLOOD ALKALINE PHOSPHATASE INCREASED 484 0.0226
787 HAEMOPTYSIS 521 0.0226
788 DIPLOPIA 457 0.0226
789 BLINDNESS UNILATERAL 253 0.0225
790 MEDICATION ERROR 1013 0.0225
791 ACTIVITIES OF DAILY LIVING IMPAIRED 446 0.0225
792 TRANSIENT ISCHAEMIC ATTACK 642 0.0225
793 RENAL DISORDER 842 0.0224
794 BONE PAIN 1062 0.0223
795 INTRAOCULAR PRESSURE INCREASED 238 0.0223
796 CEREBRAL INFARCTION 451 0.0222
797 ABDOMINAL DISTENSION 1794 0.0221
798 RENAL FAILURE ACUTE 938 0.0221
799 PARALYSIS 259 0.0220
800 HYPOTENSION 3546 0.0220
801 ACUTE KIDNEY INJURY 2524 0.0220
802 PRURITUS GENERALISED 476 0.0220
803 EYE HAEMORRHAGE 245 0.0219
804 DELIRIUM 579 0.0219
805 PROTEINURIA 305 0.0218
806 HYPOCALCAEMIA 321 0.0218
807 DECREASED APPETITE 3871 0.0218
808 VISUAL IMPAIRMENT 2015 0.0217
809 DRY MOUTH 1377 0.0217
810 INSOMNIA 4745 0.0217
811 SWELLING FACE 1133 0.0216
812 VERTIGO 1079 0.0215
813 BLOOD TRIGLYCERIDES INCREASED 321 0.0215
814 THYROID CANCER 231 0.0215
815 LACRIMATION INCREASED 463 0.0214
816 SHOCK 379 0.0214
817 HAEMATOMA 472 0.0213
818 ABDOMINAL PAIN LOWER 445 0.0213
819 BLOOD PRESSURE DECREASED 1131 0.0212
820 DYSARTHRIA 654 0.0211
821 MENTAL STATUS CHANGES 486 0.0211
822 INJECTION SITE MASS 585 0.0210
823 EYE PAIN 831 0.0210
824 HAEMATURIA 610 0.0209
825 HAEMORRHAGE 1697 0.0207
826 URINARY INCONTINENCE 498 0.0207
827 PERITONITIS 359 0.0206
828 ANAPHYLACTIC SHOCK 396 0.0205
829 SENSORY DISTURBANCE 286 0.0205
830 DEPRESSION 3943 0.0204
831 HEAD DISCOMFORT 269 0.0204
832 CARDIAC FAILURE 1308 0.0203
833 AMNESIA 1103 0.0201
834 MYALGIA 2759 0.0201
835 CORONARY ARTERY DISEASE 559 0.0201
836 DYSPHAGIA 1477 0.0201
837 NEEDLE ISSUE 350 0.0197
838 LYMPHOCYTE COUNT DECREASED 278 0.0197
839 MULTIPLE FRACTURES 285 0.0196
840 LOSS OF CONSCIOUSNESS 2058 0.0196
841 EOSINOPHILIA 264 0.0196
842 DIZZINESS 7828 0.0195
843 INCORRECT PRODUCT STORAGE 257 0.0195
844 PREGNANCY 353 0.0195
845 METASTASES TO BONE 231 0.0195
846 HAEMATEMESIS 412 0.0195
847 BLINDNESS 608 0.0194
848 BLOOD POTASSIUM DECREASED 473 0.0194
849 ACUTE MYOCARDIAL INFARCTION 492 0.0194
850 HYPERGLYCAEMIA 574 0.0192
851 INJURY 1184 0.0191
852 MUSCLE SPASMS 2844 0.0191
853 SUBDURAL HAEMATOMA 230 0.0189
854 FEELING ABNORMAL 3842 0.0188
855 BLOOD UREA INCREASED 274 0.0188
856 LETHARGY 887 0.0187
857 HEAD INJURY 466 0.0187
858 GENERALISED TONIC-CLONIC SEIZURE 222 0.0186
859 OCULAR HYPERAEMIA 610 0.0182
860 BREAST CANCER 1571 0.0181
861 HYPERHIDROSIS 1929 0.0180
862 UNEVALUABLE EVENT 1165 0.0180
863 PRESYNCOPE 343 0.0180
864 SKIN EXFOLIATION 1106 0.0180
865 MEMORY IMPAIRMENT 1992 0.0179
866 PULMONARY HYPERTENSION 313 0.0179
867 EPILEPSY 412 0.0179
868 HOT FLUSH 992 0.0179
869 SYNCOPE 1466 0.0178
870 JAUNDICE 412 0.0178
871 COLD SWEAT 257 0.0178
872 DEHYDRATION 1928 0.0177
873 THROAT TIGHTNESS 386 0.0176
874 OSTEONECROSIS OF JAW 382 0.0175
875 POLLAKIURIA 576 0.0172
876 BLOOD SODIUM DECREASED 260 0.0172
877 ARRHYTHMIA 682 0.0171
878 DEPRESSED MOOD 698 0.0170
879 RESTLESS LEGS SYNDROME 254 0.0169
880 BLOOD POTASSIUM INCREASED 224 0.0169
881 ISCHAEMIC STROKE 249 0.0169
882 HYPERSOMNIA 383 0.0169
883 RASH GENERALISED 436 0.0168
884 CEREBRAL HAEMORRHAGE 495 0.0168
885 THERAPY INTERRUPTED 487 0.0168
886 EYE PRURITUS 362 0.0167
887 PALPITATIONS 1563 0.0166
888 FAECES DISCOLOURED 296 0.0166
889 TINNITUS 608 0.0165
890 FACE OEDEMA 230 0.0164
891 EYE SWELLING 475 0.0163
892 MELAENA 301 0.0162
893 INJURY ASSOCIATED WITH DEVICE 224 0.0161
894 MYOCARDIAL INFARCTION 2528 0.0160
895 HYPOACUSIS 507 0.0159
896 THERAPY CESSATION 607 0.0158
897 MIDDLE INSOMNIA 225 0.0157
898 SEIZURE 1307 0.0157
899 SPEECH DISORDER 676 0.0156
900 CRYING 492 0.0156
901 GASTROINTESTINAL HAEMORRHAGE 1152 0.0156
902 SWOLLEN TONGUE 405 0.0155
903 LIP SWELLING 414 0.0155
904 TOOTH LOSS 275 0.0155
905 DRUG DOSE OMISSION 2563 0.0155
906 PNEUMONIA ASPIRATION 301 0.0154
907 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 1084 0.0152
908 FLUID RETENTION 628 0.0151
909 URINARY RETENTION 399 0.0151
910 DIABETES MELLITUS INADEQUATE CONTROL 219 0.0150
911 VISUAL ACUITY REDUCED 461 0.0150
912 HYPONATRAEMIA 688 0.0150
913 VISION BLURRED 1611 0.0149
914 NERVOUSNESS 682 0.0149
915 CARDIAC DISORDER 1147 0.0147
916 PRODUCT DOSE OMISSION ISSUE 1925 0.0146
917 BALANCE DISORDER 1031 0.0144
918 ALTERED STATE OF CONSCIOUSNESS 233 0.0144
919 FLATULENCE 640 0.0144
920 CONVULSION 821 0.0143
921 TREATMENT NONCOMPLIANCE 561 0.0143
922 ANXIETY 3377 0.0143
923 RETCHING 237 0.0141
924 CARDIAC FAILURE CONGESTIVE 1038 0.0140
925 SOMNOLENCE 2241 0.0139
926 COMA 542 0.0138
927 THERAPEUTIC RESPONSE UNEXPECTED 519 0.0138
928 CEREBROVASCULAR ACCIDENT 1977 0.0137
929 STEVENS-JOHNSON SYNDROME 256 0.0136
930 ACCIDENTAL OVERDOSE 370 0.0135
931 PRODUCT DOSE OMISSION 896 0.0135
932 UNRESPONSIVE TO STIMULI 276 0.0134
933 CARDIOVASCULAR DISORDER 307 0.0133
934 DISORIENTATION 450 0.0133
935 CONSTIPATION 2148 0.0132
936 ACNE 853 0.0131
937 METABOLIC ACIDOSIS 318 0.0130
938 TREMOR 1777 0.0129
939 CARDIAC ARREST 888 0.0129
940 CHROMATURIA 237 0.0126
941 BLOOD CREATINE PHOSPHOKINASE INCREASED 312 0.0123
942 EMOTIONAL DISORDER 319 0.0123
943 DEMENTIA 251 0.0122
944 PANIC ATTACK 363 0.0122
945 DEPRESSED LEVEL OF CONSCIOUSNESS 397 0.0122
946 ACCIDENTAL EXPOSURE TO PRODUCT 682 0.0122
947 ANGIOEDEMA 422 0.0121
948 UNDERDOSE 697 0.0121
949 FLUSHING 1055 0.0121
950 ABORTION SPONTANEOUS 401 0.0119
951 MENTAL DISORDER 416 0.0119
952 CARDIO-RESPIRATORY ARREST 430 0.0119
953 MALIGNANT NEOPLASM PROGRESSION 884 0.0117
954 MENORRHAGIA 226 0.0115
955 VAGINAL HAEMORRHAGE 425 0.0114
956 INTENTIONAL PRODUCT MISUSE 781 0.0114
957 HYPOGLYCAEMIA 456 0.0113
958 DRY SKIN 1076 0.0113
959 COGNITIVE DISORDER 414 0.0112
960 BREAST CANCER FEMALE 260 0.0106
961 CHRONIC KIDNEY DISEASE 732 0.0106
962 FEAR 252 0.0104
963 MOOD SWINGS 284 0.0104
964 EYE IRRITATION 396 0.0104
965 BRADYCARDIA 459 0.0103
966 NEOPLASM PROGRESSION 285 0.0102
967 PRODUCT STORAGE ERROR 423 0.0097
968 DISTURBANCE IN ATTENTION 427 0.0095
969 SUICIDAL IDEATION 703 0.0094
970 DYSGEUSIA 590 0.0093
971 MULTIPLE SCLEROSIS 365 0.0092
972 HOSPITALISATION 983 0.0092
973 IRRITABILITY 456 0.0089
974 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 1290 0.0089
975 INTERNATIONAL NORMALISED RATIO INCREASED 237 0.0088
976 DYSKINESIA 294 0.0088
977 BLOOD GLUCOSE INCREASED 1324 0.0083
978 PROSTATE CANCER 627 0.0083
979 DRUG EXPOSURE DURING PREGNANCY 270 0.0079
980 FOETAL EXPOSURE DURING PREGNANCY 494 0.0079
981 AGITATION 478 0.0077
982 DRUG ADMINISTRATION ERROR 227 0.0074
983 RESTLESSNESS 221 0.0073
984 BLOOD GLUCOSE DECREASED 289 0.0071
985 HALLUCINATION 399 0.0070
986 SKIN IRRITATION 251 0.0065
987 SKIN BURNING SENSATION 373 0.0064
988 NO ADVERSE EVENT 698 0.0060
989 OVERDOSE 988 0.0057
990 SUICIDE ATTEMPT 275 0.0056
991 BLADDER CANCER 294 0.0053
992 DEATH 3525 0.0052
993 EMOTIONAL DISTRESS 488 0.0044
994 PRODUCT QUALITY ISSUE 398 0.0033
995 DRUG DEPENDENCE 491 0.0032