SEBELIPASE ALFA

SEBELIPASE ALFA was reported 397 times

These side effects are most commonly reported by patients taking SEBELIPASE ALFA:

# Side effect Count
0 PYREXIA 40
1 DIARRHOEA 29
2 VOMITING 29
3 DRUG INEFFECTIVE 21
4 HEADACHE 19
5 LOW DENSITY LIPOPROTEIN INCREASED 18
6 OFF LABEL USE 17
7 BLOOD CHOLESTEROL INCREASED 15
8 MALAISE 14
9 NAUSEA 13
10 WEIGHT INCREASED 13
11 ABDOMINAL DISTENSION 12
12 ABDOMINAL PAIN UPPER 12
13 HYPERSENSITIVITY 12
14 INCORRECT DOSE ADMINISTERED 12
15 INFUSION RELATED REACTION 12
16 POOR VENOUS ACCESS 12
17 URTICARIA 12
18 FATIGUE 11
19 BLOOD TRIGLYCERIDES INCREASED 10
20 COUGH 10
21 HEPATIC ENZYME INCREASED 10
22 ABDOMINAL PAIN 9
23 CONDITION AGGRAVATED 9
24 WEIGHT DECREASED 9
25 ANAPHYLACTIC REACTION 8
26 BLOOD BILIRUBIN INCREASED 8
27 HIGH DENSITY LIPOPROTEIN DECREASED 8
28 PNEUMONIA 8
29 ALANINE AMINOTRANSFERASE INCREASED 7
30 DEATH 7
31 DRUG SPECIFIC ANTIBODY PRESENT 7
32 HEPATOMEGALY 7
33 HYPOGLYCAEMIA 7
34 INFLUENZA 7
35 VIRAL INFECTION 7
36 ASPARTATE AMINOTRANSFERASE INCREASED 6
37 IRRITABILITY 6
38 LIPIDS INCREASED 6
39 LIVER FUNCTION TEST INCREASED 6
40 RESPIRATORY FAILURE 6
41 SEPSIS 6
42 TACHYCARDIA 6
43 ASCITES 5
44 ASTHENIA 5
45 ILL-DEFINED DISORDER 5
46 LABORATORY TEST ABNORMAL 5
47 MULTIPLE ORGAN DYSFUNCTION SYNDROME 5
48 PRURITUS 5
49 TACHYPNOEA 5
50 WEIGHT GAIN POOR 5
51 ABDOMINAL DISCOMFORT 4
52 ANXIETY 4
53 C-REACTIVE PROTEIN INCREASED 4
54 DARK CIRCLES UNDER EYES 4
55 DECREASED APPETITE 4
56 DEVICE RELATED INFECTION 4
57 DIZZINESS 4
58 DYSPNOEA 4
59 GASTROENTERITIS VIRAL 4
60 HEPATIC FAILURE 4
61 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 4
62 LIP SWELLING 4
63 LIVER DISORDER 4
64 PLATELET COUNT DECREASED 4
65 PRODUCT QUALITY ISSUE 4
66 ADRENAL INSUFFICIENCY 3
67 ANGIOEDEMA 3
68 ANTIBODY TEST POSITIVE 3
69 CARDIAC MURMUR 3
70 CENTRAL VENOUS CATHETERISATION 3
71 CHEST DISCOMFORT 3
72 CONSTIPATION 3
73 DEHYDRATION 3
74 DRUG HYPERSENSITIVITY 3
75 DYSLIPIDAEMIA 3
76 EAR PAIN 3
77 ERYTHEMA 3
78 FAILURE TO THRIVE 3
79 FALL 3
80 FLUSHING 3
81 HAEMOGLOBIN DECREASED 3
82 HEART RATE INCREASED 3
83 HOSPITALISATION 3
84 HYPOTENSION 3
85 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 3
86 INFECTIOUS MONONUCLEOSIS 3
87 INFUSION SITE PAIN 3
88 LETHARGY 3
89 MALNUTRITION 3
90 NASOPHARYNGITIS 3
91 PAIN 3
92 PALPITATIONS 3
93 PRODUCT DOSE OMISSION 3
94 RASH 3
95 RHINORRHOEA 3
96 RHINOVIRUS INFECTION 3
97 SINUSITIS 3
98 SPEECH DISORDER DEVELOPMENTAL 3
99 SPLENOMEGALY 3
100 TRANSAMINASES DECREASED 3
101 TRANSAMINASES INCREASED 3
102 UNDERDOSE 3
103 URINARY TRACT INFECTION 3
104 VEIN RUPTURE 3
105 ABDOMINAL LYMPHADENOPATHY 2
106 ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED 2
107 ADVERSE DRUG REACTION 2
108 ADVERSE REACTION 2
109 ANAEMIA 2
110 ANAPHYLACTIC SHOCK 2
111 ARRHYTHMIA 2
112 BACK PAIN 2
113 BILIRUBIN CONJUGATED INCREASED 2
114 BLOOD ALKALINE PHOSPHATASE INCREASED 2
115 BLOOD CHOLESTEROL DECREASED 2
116 BLOOD CREATININE DECREASED 2
117 BLOOD POTASSIUM DECREASED 2
118 BLOOD SODIUM DECREASED 2
119 BODY TEMPERATURE INCREASED 2
120 CHOLESTASIS 2
121 CLOSTRIDIUM DIFFICILE INFECTION 2
122 CONJUNCTIVITIS 2
123 CYTOMEGALOVIRUS TEST POSITIVE 2
124 DISEASE PROGRESSION 2
125 DRUG ADMINISTRATION ERROR 2
126 DRUG DOSE OMISSION 2
127 DRUG EFFECT INCOMPLETE 2
128 EAR INFECTION 2
129 EOSINOPHILIA 2
130 EXTRASYSTOLES 2
131 FEEDING DISORDER 2
132 FEELING ABNORMAL 2
133 FLATULENCE 2
134 FUNCTIONAL GASTROINTESTINAL DISORDER 2
135 GAMMA-GLUTAMYLTRANSFERASE INCREASED 2
136 GASTROINTESTINAL DISORDER 2
137 GASTROINTESTINAL INFECTION 2
138 GASTROOESOPHAGEAL REFLUX DISEASE 2
139 GENERAL PHYSICAL HEALTH DETERIORATION 2
140 HAEMOLYSIS 2
141 HEAD INJURY 2
142 HEART RATE DECREASED 2
143 HEPATIC ENZYME ABNORMAL 2
144 HEPATIC FIBROSIS 2
145 HEPATOSPLENOMEGALY 2
146 HYPERHIDROSIS 2
147 HYPOAESTHESIA 2
148 HYPOALBUMINAEMIA 2
149 INFECTION 2
150 INFLAMMATION 2
151 INFUSION SITE EXTRAVASATION 2
152 INFUSION SITE REACTION 2
153 LEUKOPENIA 2
154 LIPIDS DECREASED 2
155 LOW DENSITY LIPOPROTEIN DECREASED 2
156 LYMPHOCYTE COUNT DECREASED 2
157 LYSOSOMAL ACID LIPASE DEFICIENCY 2
158 MALABSORPTION 2
159 MIGRAINE 2
160 MUSCLE SPASMS 2
161 MUSCLE STRAIN 2
162 NASAL CONGESTION 2
163 NON-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL INCREASED 2
164 OROPHARYNGEAL PAIN 2
165 PANIC ATTACK 2
166 PERIPHERAL SWELLING 2
167 PHARYNGITIS STREPTOCOCCAL 2
168 PROTEIN TOTAL DECREASED 2
169 PRURITUS GENERALISED 2
170 RASH PRURITIC 2
171 RED BLOOD CELL COUNT DECREASED 2
172 RENAL FAILURE 2
173 RESPIRATORY DISTRESS 2
174 RESPIRATORY TRACT INFECTION 2
175 STRIDOR 2
176 THERAPEUTIC RESPONSE DECREASED 2
177 THERAPEUTIC RESPONSE UNEXPECTED 2
178 THROAT IRRITATION 2
179 THROMBOCYTOPENIA 2
180 TOTAL CHOLESTEROL/HDL RATIO INCREASED 2
181 TOXICITY TO VARIOUS AGENTS 2
182 WHITE BLOOD CELL COUNT DECREASED 2
183 ABNORMAL BEHAVIOUR 1
184 ACNE 1
185 ACUTE ABDOMEN 1
186 ACUTE KIDNEY INJURY 1
187 ADENOVIRUS INFECTION 1
188 ADMINISTRATION SITE ERYTHEMA 1
189 ADRENAL CALCIFICATION 1
190 ADRENOMEGALY 1
191 ADVERSE EVENT 1
192 AGITATION 1
193 ALOPECIA 1
194 ANAEMIA OF CHRONIC DISEASE 1
195 ANGINA PECTORIS 1
196 ANTI-TRANSGLUTAMINASE ANTIBODY INCREASED 1
197 ANTITHROMBIN III DECREASED 1
198 AORTIC STENOSIS 1
199 APNOEA 1
200 ARNOLD-CHIARI MALFORMATION 1
201 ARTHRITIS 1
202 ASTHMA 1
203 ATRIAL THROMBOSIS 1
204 AUTISM SPECTRUM DISORDER 1
205 BACTERAEMIA 1
206 BASOPHIL COUNT DECREASED 1
207 BEDRIDDEN 1
208 BLISTER 1
209 BLOOD ALBUMIN DECREASED 1
210 BLOOD CREATININE INCREASED 1
211 BLOOD FIBRINOGEN DECREASED 1
212 BLOOD GLUCOSE DECREASED 1
213 BLOOD GLUCOSE INCREASED 1
214 BLOOD IMMUNOGLOBULIN E INCREASED 1
215 BLOOD IMMUNOGLOBULIN G DECREASED 1
216 BLOOD LACTATE DEHYDROGENASE INCREASED 1
217 BLOOD LACTIC ACID INCREASED 1
218 BLOOD PH DECREASED 1
219 BLOOD PRESSURE INCREASED 1
220 BLOOD SODIUM INCREASED 1
221 BLOOD TEST ABNORMAL 1
222 BLOOD TRIGLYCERIDES DECREASED 1
223 BLOOD UREA INCREASED 1
224 BODY FAT DISORDER 1
225 BRONCHIOLITIS 1
226 BRONCHITIS 1
227 CARDIAC ANEURYSM 1
228 CARDIAC DISORDER 1
229 CARDIAC FAILURE CONGESTIVE 1
230 CARDIO-RESPIRATORY ARREST 1
231 CATHETER SITE ERYTHEMA 1
232 CATHETER SITE INFECTION 1
233 CATHETER SITE SWELLING 1
234 CD4 LYMPHOCYTE PERCENTAGE DECREASED 1
235 CD8 LYMPHOCYTES DECREASED 1
236 CENTRAL VENOUS CATHETER REMOVAL 1
237 CHEST PAIN 1
238 CHITOTRIOSIDASE INCREASED 1
239 CHOLELITHIASIS 1
240 CLOSTRIDIUM DIFFICILE COLITIS 1
241 CLOSTRIDIUM TEST POSITIVE 1
242 COAGULOPATHY 1
243 CONFUSIONAL STATE 1
244 CONJUNCTIVAL HYPERAEMIA 1
245 CONTUSION 1
246 CRYING 1
247 CYTOMEGALOVIRUS INFECTION 1
248 CYTOPENIA 1
249 DACRYOSTENOSIS ACQUIRED 1
250 DECREASED ACTIVITY 1
251 DECUBITUS ULCER 1
252 DEPENDENCE 1
253 DEPRESSED MOOD 1
254 DEPRESSION 1
255 DERMATITIS ATOPIC 1
256 DEVELOPMENTAL DELAY 1
257 DEVICE BREAKAGE 1
258 DEVICE INFUSION ISSUE 1
259 DEVICE ISSUE 1
260 DIARRHOEA HAEMORRHAGIC 1
261 DISCOMFORT 1
262 DISORIENTATION 1
263 DRUG ABUSE 1
264 DRUG EFFECT DECREASED 1
265 DRUG INTOLERANCE 1
266 DRY MOUTH 1
267 EAR DISCOMFORT 1
268 ENTEROVIRUS INFECTION 1
269 ENZYME LEVEL DECREASED 1
270 EOSINOPHIL COUNT DECREASED 1
271 ERYTHEMA OF EYELID 1
272 EXPOSURE DURING PREGNANCY 1
273 EXPOSURE TO SARS-COV-2 1
274 EYE IRRITATION 1
275 EYE PAIN 1
276 EYE PRURITUS 1
277 EYE SWELLING 1
278 FATTY ACID DEFICIENCY 1
279 FEEDING INTOLERANCE 1
280 FEMUR FRACTURE 1
281 FLUID RETENTION 1
282 FOETAL EXPOSURE DURING PREGNANCY 1
283 FOOD ALLERGY 1
284 FREE FATTY ACIDS INCREASED 1
285 GAIT DISTURBANCE 1
286 GALLBLADDER DISORDER 1
287 GASTRIC INFECTION 1
288 GASTROENTERITIS ESCHERICHIA COLI 1
289 GASTROENTERITIS NOROVIRUS 1
290 GASTROINTESTINAL INFLAMMATION 1
291 GENERAL PHYSICAL CONDITION ABNORMAL 1
292 GILBERT^S SYNDROME 1
293 GLOMERULONEPHRITIS MEMBRANOUS 1
294 GRANULOCYTE COUNT INCREASED 1
295 GROWTH RETARDATION 1
296 GRUNTING 1
297 HAEMATOCHEZIA 1
298 HAEMATOCRIT DECREASED 1
299 HAEMATOCRIT INCREASED 1
300 HAEMOGLOBIN INCREASED 1
301 HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS 1
302 HAEMOPTYSIS 1
303 HAEMORRHAGE 1
304 HAEMORRHOIDS 1
305 HEART RATE ABNORMAL 1
306 HEAT EXHAUSTION 1
307 HEPATIC ATROPHY 1
308 HEPATIC ENCEPHALOPATHY 1
309 HEPATIC ENZYME DECREASED 1
310 HEPATIC FUNCTION ABNORMAL 1
311 HEPATIC STEATO-FIBROSIS 1
312 HEPATITIS VIRAL 1
313 HIGH DENSITY LIPOPROTEIN INCREASED 1
314 HISTIOCYTOSIS HAEMATOPHAGIC 1
315 HYPERAEMIA 1
316 HYPERTENSION 1
317 HYPERTHERMIA 1
318 HYPERVENTILATION 1
319 HYPOAESTHESIA ORAL 1
320 HYPOKALAEMIA 1
321 HYPOPERFUSION 1
322 HYPOTHERMIA NEONATAL 1
323 HYPOTHYROIDISM 1
324 HYPOTONIA 1
325 HYPOXIA 1
326 INABILITY TO AFFORD MEDICATION 1
327 INCORRECT DRUG ADMINISTRATION DURATION 1
328 INCORRECT DRUG ADMINISTRATION RATE 1
329 INCORRECT PRODUCT STORAGE 1
330 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 1
331 INFANTILE VOMITING 1
332 INFLAMMATORY MARKER INCREASED 1
333 INFLUENZA LIKE ILLNESS 1
334 INFUSION SITE RASH 1
335 INFUSION SITE SWELLING 1
336 INFUSION SITE URTICARIA 1
337 INJECTION RELATED REACTION 1
338 INJECTION SITE ERYTHEMA 1
339 INJECTION SITE MASS 1
340 INJECTION SITE PAIN 1
341 INJECTION SITE REACTION 1
342 INJECTION SITE SCAR 1
343 INTERNATIONAL NORMALISED RATIO DECREASED 1
344 INTERNATIONAL NORMALISED RATIO INCREASED 1
345 INTESTINAL STEATOSIS 1
346 IRON DEFICIENCY ANAEMIA 1
347 IRRITABLE BOWEL SYNDROME 1
348 KLEBSIELLA BACTERAEMIA 1
349 KLEBSIELLA INFECTION 1
350 KLEBSIELLA SEPSIS 1
351 LDL/HDL RATIO INCREASED 1
352 LICE INFESTATION 1
353 LIMB MALFORMATION 1
354 LIP DISCOLOURATION 1
355 LIPIDOSIS 1
356 LIVER INJURY 1
357 LOSS OF CONSCIOUSNESS 1
358 LOWER RESPIRATORY TRACT INFECTION 1
359 LUNG DISORDER 1
360 MASS 1
361 MATERNAL EXPOSURE DURING PREGNANCY 1
362 MEDICAL DEVICE SITE DISCOMFORT 1
363 MEDICATION ERROR 1
364 METABOLIC ACIDOSIS 1
365 MOBILITY DECREASED 1
366 MOTOR DEVELOPMENTAL DELAY 1
367 MUSCULOSKELETAL CHEST PAIN 1
368 MUSCULOSKELETAL STIFFNESS 1
369 MYDRIASIS 1
370 NECK PAIN 1
371 NEPHROTIC SYNDROME 1
372 NERVOUSNESS 1
373 NEURODEVELOPMENTAL DISORDER 1
374 NEUROLOGICAL SYMPTOM 1
375 NEUTRALISING ANTIBODIES POSITIVE 1
376 NEUTROPENIA 1
377 NEUTROPHIL COUNT DECREASED 1
378 NUCLEAR MAGNETIC RESONANCE IMAGING ABNORMAL 1
379 NUTRITIONAL CONDITION ABNORMAL 1
380 OCULAR HYPERAEMIA 1
381 OCULAR ICTERUS 1
382 ODYNOPHAGIA 1
383 OEDEMA 1
384 OEDEMA PERIPHERAL 1
385 OLIGURIA 1
386 OROPHARYNGEAL BLISTERING 1
387 OSTEOPENIA 1
388 OVERDOSE 1
389 OXYGEN SATURATION DECREASED 1
390 PAIN IN EXTREMITY 1
391 PAINFUL RESPIRATION 1
392 PALLIATIVE CARE 1
393 PANCYTOPENIA 1
394 PARACENTESIS 1
395 PARAESTHESIA 1
396 PARAINFLUENZAE VIRUS INFECTION 1
397 PERIPHERAL COLDNESS 1
398 PHARYNGEAL ERYTHEMA 1
399 PHARYNGEAL OEDEMA 1
400 PIGMENTATION DISORDER 1
401 PLATELET COUNT INCREASED 1
402 PNEUMOPERITONEUM 1
403 POLYMERASE CHAIN REACTION 1
404 POOR QUALITY SLEEP 1
405 POOR WEIGHT GAIN NEONATAL 1
406 PORTAL FIBROSIS 1
407 PORTAL TRACT INFLAMMATION 1
408 POST PROCEDURAL COMPLICATION 1
409 POST PROCEDURAL INFECTION 1
410 POST PROCEDURAL SWELLING 1
411 PRE-EXISTING CONDITION IMPROVED 1
412 PREGNANCY 1
413 PROCALCITONIN ABNORMAL 1
414 PROCEDURAL PAIN 1
415 PRODUCT ADMINISTRATION ERROR 1
416 PRODUCT PACKAGING ISSUE 1
417 PRODUCT PACKAGING QUANTITY ISSUE 1
418 PRODUCT PREPARATION ERROR 1
419 PRODUCT STORAGE ERROR 1
420 PRODUCT USE IN UNAPPROVED INDICATION 1
421 PRODUCT USE ISSUE 1
422 PROTHROMBIN TIME PROLONGED 1
423 PSYCHOMOTOR SKILLS IMPAIRED 1
424 RASH ERYTHEMATOUS 1
425 RASH MACULAR 1
426 RASH PAPULAR 1
427 RED BLOOD CELL COUNT INCREASED 1
428 REFRACTORY CYTOPENIA WITH UNILINEAGE DYSPLASIA 1
429 RESPIRATORY DISORDER 1
430 RESPIRATORY SYMPTOM 1
431 RESPIRATORY SYNCYTIAL VIRUS TEST POSITIVE 1
432 RESPIRATORY TRACT INFECTION BACTERIAL 1
433 RESPIRATORY TRACT INFECTION VIRAL 1
434 RESTLESSNESS 1
435 RETINAL TEAR 1
436 RHESUS ANTIGEN NEGATIVE 1
437 RHINITIS ALLERGIC 1
438 ROTATOR CUFF SYNDROME 1
439 ROTAVIRUS INFECTION 1
440 SALMONELLA BACTERAEMIA 1
441 SARCOIDOSIS 1
442 SEIZURE 1
443 SELECTIVE EATING DISORDER 1
444 SENSITIVE SKIN 1
445 SERUM FERRITIN INCREASED 1
446 SINUS CONGESTION 1
447 SINUS DISORDER 1
448 SKIN DISCOLOURATION 1
449 SKIN LACERATION 1
450 SKIN TEST POSITIVE 1
451 SKULL FRACTURE 1
452 SLEEP APNOEA SYNDROME 1
453 SLUGGISHNESS 1
454 SOMNOLENCE 1
455 SPERM CONCENTRATION DECREASED 1
456 SPLEEN ATROPHY 1
457 STAPHYLOCOCCAL INFECTION 1
458 STAPHYLOCOCCAL SEPSIS 1
459 STRESS 1
460 SUPRAVALVULAR AORTIC STENOSIS 1
461 SWELLING FACE 1
462 SWOLLEN TONGUE 1
463 SYNCOPE 1
464 SYSTEMIC INFECTION 1
465 SYSTEMIC INFLAMMATORY RESPONSE SYNDROME 1
466 TENDERNESS 1
467 THERAPY NON-RESPONDER 1
468 THROAT CLEARING 1
469 THROMBOSIS 1
470 THROMBOSIS IN DEVICE 1
471 THYROID DISORDER 1
472 TONGUE DISCOLOURATION 1
473 TONGUE ERYTHEMA 1
474 TRANSAMINASES ABNORMAL 1
475 TRANSPLANT 1
476 TREATMENT NONCOMPLIANCE 1
477 TREMOR 1
478 UPPER GASTROINTESTINAL HAEMORRHAGE 1
479 UPPER RESPIRATORY TRACT INFECTION 1
480 VASCULAR DEVICE INFECTION 1
481 VENTRICULAR EXTRASYSTOLES 1
482 VIRAL DIARRHOEA 1
483 VIRAL UPPER RESPIRATORY TRACT INFECTION 1
484 WEIGHT ABNORMAL 1
485 WEIGHT DECREASE NEONATAL 1
486 WEIGHT FLUCTUATION 1
487 WHITE BLOOD CELL COUNT INCREASED 1