Calcineurin Inhibitor Immunosuppressant [EPC]

Calcineurin Inhibitor Immunosuppressant [EPC] was reported 70516 times

Drugs of the Calcineurin Inhibitor Immunosuppressant [EPC] class are most commonly taken among patients reporting these side effects:

# Drug class Count Frequency
0 APPLICATION SITE BURNING 54 0.5143
1 CYTOMEGALOVIRUS ANTIGEN POSITIVE 86 0.4674
2 TRANSPLANT DYSFUNCTION 489 0.3903
3 GRAFT DYSFUNCTION 99 0.3449
4 SCLERAL HYPERAEMIA 168 0.2646
5 ACUTE GRAFT VERSUS HOST DISEASE IN SKIN 446 0.2634
6 CHRONIC ALLOGRAFT NEPHROPATHY 148 0.2629
7 ENGRAFT FAILURE 56 0.2593
8 CHRONIC GRAFT VERSUS HOST DISEASE 621 0.2583
9 PRODUCT DROPPER ISSUE 202 0.2563
10 ACUTE GRAFT VERSUS HOST DISEASE IN INTESTINE 227 0.2473
11 ACUTE GRAFT VERSUS HOST DISEASE IN LIVER 116 0.2432
12 LYMPHOCELE 137 0.2338
13 ACUTE GRAFT VERSUS HOST DISEASE 775 0.2284
14 EPSTEIN-BARR VIRUS ASSOCIATED LYMPHOPROLIFERATIVE DISORDER 257 0.2252
15 GRAFT VERSUS HOST DISEASE 1207 0.2208
16 KAPOSI'S SARCOMA 110 0.2187
17 FOREIGN BODY SENSATION IN EYES 885 0.2168
18 COMPLICATIONS OF BONE MARROW TRANSPLANT 63 0.2136
19 RED BLOOD CELL SCHISTOCYTES PRESENT 56 0.1965
20 TRANSPLANT REJECTION 1049 0.1897
21 SUPERFICIAL INJURY OF EYE 127 0.1841
22 HEART TRANSPLANT REJECTION 143 0.1763
23 ASPERGILLOSIS 229 0.1748
24 KIDNEY TRANSPLANT REJECTION 658 0.1737
25 COMPLICATIONS OF TRANSPLANTED KIDNEY 292 0.1731
26 EYE IRRITATION 5683 0.1725
27 GRAFT VERSUS HOST DISEASE IN SKIN 243 0.1717
28 MULTIPLE USE OF SINGLE-USE PRODUCT 445 0.1700
29 LUNG TRANSPLANT REJECTION 77 0.1681
30 GRAFT VERSUS HOST DISEASE IN LIVER 72 0.1644
31 PRODUCT CONTAINER ISSUE 856 0.1643
32 IMMUNOSUPPRESSANT DRUG LEVEL DECREASED 149 0.1641
33 REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME 125 0.1596
34 POLYOMAVIRUS VIRAEMIA 49 0.1561
35 IMMUNOSUPPRESSANT DRUG LEVEL INCREASED 304 0.1524
36 INSTILLATION SITE PAIN 317 0.1512
37 LIVER TRANSPLANT REJECTION 208 0.1466
38 VIRAL HAEMORRHAGIC CYSTITIS 51 0.1433
39 ENGRAFTMENT SYNDROME 51 0.1429
40 OBLITERATIVE BRONCHIOLITIS 144 0.1397
41 CHRONIC GRAFT VERSUS HOST DISEASE IN SKIN 66 0.1389
42 ADENOVIRUS INFECTION 245 0.1380
43 GRAFT VERSUS HOST DISEASE IN GASTROINTESTINAL TRACT 173 0.1354
44 CYTOMEGALOVIRUS INFECTION 1490 0.1301
45 PNEUMONIA CYTOMEGALOVIRAL 164 0.1291
46 CYTOMEGALOVIRUS INFECTION REACTIVATION 141 0.1281
47 EPSTEIN-BARR VIRUS INFECTION 530 0.1252
48 ZYGOMYCOSIS 58 0.1234
49 COMPLICATIONS OF TRANSPLANT SURGERY 54 0.1216
50 GRAFT LOSS 70 0.1173
51 RENAL TUBULAR ATROPHY 72 0.1156
52 GINGIVAL HYPERTROPHY 99 0.1143
53 SOFT TISSUE DISORDER 104 0.1134
54 TRANSPLANT FAILURE 196 0.1114
55 CYTOMEGALOVIRUS VIRAEMIA 260 0.1109
56 BK VIRUS INFECTION 207 0.1085
57 EPSTEIN-BARR VIRAEMIA 62 0.1084
58 GRAFT COMPLICATION 47 0.1044
59 GLOMERULOSCLEROSIS 50 0.1020
60 CYTOMEGALOVIRUS TEST POSITIVE 126 0.1012
61 VENOOCCLUSIVE DISEASE 175 0.1009
62 EYE DISCHARGE 618 0.1005
63 GINGIVAL HYPERPLASIA 60 0.0995
64 POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER 277 0.0988
65 LYMPHOPROLIFERATIVE DISORDER 189 0.0970
66 URETERIC STENOSIS 57 0.0969
67 ACUTE MYELOID LEUKAEMIA RECURRENT 99 0.0967
68 LYMPHADENECTOMY 65 0.0966
69 KIDNEY FIBROSIS 119 0.0965
70 ORAL ADMINISTRATION COMPLICATION 74 0.0932
71 FOCAL SEGMENTAL GLOMERULOSCLEROSIS 96 0.0922
72 STEM CELL TRANSPLANT 159 0.0897
73 APLASTIC ANAEMIA 321 0.0888
74 NEPHROPATHY TOXIC 615 0.0882
75 CYSTITIS HAEMORRHAGIC 242 0.0870
76 LEUKAEMIA RECURRENT 112 0.0851
77 ERYTHRODERMIC PSORIASIS 48 0.0833
78 THROMBOTIC MICROANGIOPATHY 484 0.0821
79 NEPHRECTOMY 79 0.0820
80 HUMAN HERPESVIRUS 6 INFECTION 117 0.0811
81 EYELID IRRITATION 112 0.0778
82 HISTIOCYTOSIS HAEMATOPHAGIC 235 0.0777
83 SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE 180 0.0776
84 TOXOPLASMOSIS 61 0.0770
85 MYCOSIS FUNGOIDES 62 0.0743
86 VIRAEMIA 58 0.0734
87 ANAEMIA HAEMOLYTIC AUTOIMMUNE 60 0.0725
88 PNEUMOCYSTIS JIROVECI PNEUMONIA 159 0.0712
89 SYSTEMIC MYCOSIS 49 0.0695
90 ERYTHEMA OF EYELID 240 0.0694
91 EYE PAIN 2331 0.0681
92 EYELID PAIN 60 0.0678
93 HODGKIN'S DISEASE 49 0.0674
94 ENCEPHALITIS VIRAL 59 0.0669
95 CORNEAL ABRASION 66 0.0665
96 POLYOMAVIRUS-ASSOCIATED NEPHROPATHY 84 0.0643
97 CYTOMEGALOVIRUS COLITIS 82 0.0642
98 ABNORMAL SENSATION IN EYE 213 0.0633
99 OCULAR HYPERAEMIA 1818 0.0632
100 LACRIMATION INCREASED 1154 0.0626
101 BONE MARROW TRANSPLANT 77 0.0615
102 VENOOCCLUSIVE LIVER DISEASE 198 0.0611
103 BRONCHOPULMONARY ASPERGILLOSIS 298 0.0610
104 PNEUMONIA VIRAL 123 0.0609
105 GLOMERULONEPHRITIS MEMBRANOUS 48 0.0608
106 DRY EYE 1478 0.0590
107 OCULAR DISCOMFORT 319 0.0588
108 NON-HODGKIN'S LYMPHOMA 77 0.0586
109 CONCOMITANT DISEASE PROGRESSION 102 0.0583
110 OVARIAN CYST 466 0.0582
111 INSTILLATION SITE REACTION 61 0.0575
112 APLASIA PURE RED CELL 143 0.0570
113 MUCORMYCOSIS 88 0.0563
114 EYE PRURITUS 1007 0.0561
115 HAEMOLYTIC URAEMIC SYNDROME 110 0.0559
116 PNEUMOMEDIASTINUM 58 0.0548
117 JC VIRUS INFECTION 53 0.0544
118 CHORIORETINOPATHY 71 0.0541
119 EYELID MARGIN CRUSTING 74 0.0541
120 NOCARDIOSIS 85 0.0530
121 GASTROENTERITIS NOROVIRUS 56 0.0520
122 HIRSUTISM 52 0.0510
123 CYTOMEGALOVIRUS CHORIORETINITIS 63 0.0497
124 MECHANICAL VENTILATION 72 0.0497
125 PSEUDOMONAL SEPSIS 60 0.0496
126 NEPHROTIC SYNDROME 235 0.0489
127 ACUTE LYMPHOCYTIC LEUKAEMIA RECURRENT 71 0.0485
128 APLASIA 82 0.0477
129 ENTEROCOCCAL INFECTION 153 0.0475
130 HYPOGAMMAGLOBULINAEMIA 148 0.0460
131 POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME 279 0.0460
132 LEUKOENCEPHALOPATHY 130 0.0459
133 BLOOD PARATHYROID HORMONE DECREASED 49 0.0451
134 PSEUDOMONAS INFECTION 240 0.0441
135 EYELIDS PRURITUS 81 0.0440
136 PNEUMONIA FUNGAL 82 0.0440
137 ASTHENOPIA 161 0.0435
138 BACTERIAL SEPSIS 100 0.0429
139 RENAL TRANSPLANT 105 0.0423
140 HYPERTRICHOSIS 63 0.0414
141 PANNICULITIS 65 0.0413
142 BRAIN ABSCESS 67 0.0413
143 ENTEROBACTER INFECTION 46 0.0401
144 PUSTULAR PSORIASIS 93 0.0384
145 THROMBOTIC THROMBOCYTOPENIC PURPURA 111 0.0379
146 C-REACTIVE PROTEIN ABNORMAL 108 0.0375
147 ESCHERICHIA SEPSIS 79 0.0373
148 PRODUCT PACKAGING QUANTITY ISSUE 184 0.0373
149 BLEPHARITIS 85 0.0373
150 HAEMODIALYSIS 294 0.0370
151 B-CELL LYMPHOMA 97 0.0367
152 HERPES SIMPLEX 163 0.0355
153 STAPHYLOCOCCAL BACTERAEMIA 97 0.0351
154 CANDIDIASIS 141 0.0351
155 SQUAMOUS CELL CARCINOMA 237 0.0350
156 STAPHYLOCOCCAL SEPSIS 135 0.0350
157 MULTI-ORGAN FAILURE 605 0.0349
158 KLEBSIELLA INFECTION 111 0.0347
159 RENAL TUBULAR NECROSIS 245 0.0346
160 GLOMERULONEPHRITIS 56 0.0342
161 SERUM SICKNESS 71 0.0341
162 HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS 81 0.0340
163 ACTINIC KERATOSIS 65 0.0339
164 ASPERGILLUS INFECTION 118 0.0333
165 BLOOD CREATININE INCREASED 1609 0.0333
166 DIFFUSE LARGE B-CELL LYMPHOMA 131 0.0330
167 PNEUMATOSIS INTESTINALIS 56 0.0323
168 CUSHINGOID 70 0.0322
169 PROTEINURIA 387 0.0321
170 BLOOD LACTATE DEHYDROGENASE INCREASED 404 0.0318
171 SERUM FERRITIN INCREASED 119 0.0318
172 PHOTOPHOBIA 386 0.0314
173 EYELID OEDEMA 304 0.0307
174 LUNG INFILTRATION 231 0.0305
175 ACUTE LYMPHOCYTIC LEUKAEMIA 62 0.0304
176 DISSEMINATED TUBERCULOSIS 54 0.0299
177 OLIGURIA 140 0.0297
178 BASAL CELL CARCINOMA 319 0.0293
179 DRUG ERUPTION 343 0.0292
180 EYE INFLAMMATION 155 0.0292
181 EYELID DISORDER 48 0.0292
182 PNEUMONIA BACTERIAL 141 0.0289
183 RENAL TUBULAR DISORDER 66 0.0286
184 BRONCHIECTASIS 112 0.0285
185 SQUAMOUS CELL CARCINOMA OF SKIN 109 0.0284
186 KERATITIS 54 0.0281
187 RENAL FAILURE CHRONIC 216 0.0281
188 HEPATIC FUNCTION ABNORMAL 671 0.0277
189 ESCHERICHIA URINARY TRACT INFECTION 86 0.0277
190 LIVER TRANSPLANT 75 0.0275
191 BLOOD AMYLASE INCREASED 47 0.0274
192 SKIN PLAQUE 143 0.0272
193 HEPATOSPLENOMEGALY 54 0.0272
194 SKIN HYPERTROPHY 53 0.0271
195 PYODERMA GANGRENOSUM 52 0.0269
196 HYPERURICAEMIA 78 0.0267
197 PULMONARY ALVEOLAR HAEMORRHAGE 94 0.0264
198 SKIN PAPILLOMA 75 0.0263
199 PRODUCT USE COMPLAINT 150 0.0262
200 GRANULOMA 64 0.0261
201 ENDOTRACHEAL INTUBATION 47 0.0260
202 HAEMOLYSIS 148 0.0257
203 ESCHERICHIA INFECTION 135 0.0254
204 FIBROSIS 58 0.0254
205 ENCEPHALITIS 116 0.0253
206 BLOOD CREATINE INCREASED 78 0.0253
207 DRUG LEVEL INCREASED 288 0.0253
208 WOUND DEHISCENCE 66 0.0252
209 RENAL IMPAIRMENT 1394 0.0252
210 BLOOD UREA INCREASED 343 0.0250
211 OESOPHAGEAL CANDIDIASIS 67 0.0248
212 PYELONEPHRITIS 148 0.0248
213 BLOOD URIC ACID INCREASED 95 0.0248
214 DERMATITIS ATOPIC 189 0.0247
215 EYE INFECTION 171 0.0246
216 NEPHROGENIC SYSTEMIC FIBROSIS 73 0.0244
217 BACTERAEMIA 183 0.0244
218 SWELLING OF EYELID 53 0.0243
219 BLOOD BILIRUBIN INCREASED 502 0.0240
220 PNEUMOCYSTIS JIROVECII PNEUMONIA 139 0.0239
221 ANURIA 164 0.0238
222 NEUROTOXICITY 247 0.0234
223 URINE OUTPUT DECREASED 160 0.0233
224 GROWTH RETARDATION 51 0.0233
225 PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY 140 0.0233
226 SKIN NECROSIS 93 0.0232
227 AZOTAEMIA 66 0.0231
228 VISION BLURRED 2193 0.0231
229 THERAPEUTIC AGENT TOXICITY 76 0.0227
230 HEPATIC FIBROSIS 53 0.0223
231 MUCOSAL INFLAMMATION 405 0.0223
232 HERPES VIRUS INFECTION 91 0.0221
233 C-REACTIVE PROTEIN INCREASED 516 0.0221
234 HYDRONEPHROSIS 117 0.0220
235 ACUTE RESPIRATORY DISTRESS SYNDROME 276 0.0219
236 SCLERODERMA 60 0.0218
237 CYTOLYTIC HEPATITIS 72 0.0216
238 TOXIC ENCEPHALOPATHY 66 0.0216
239 IMMOBILE 68 0.0215
240 SYSTEMIC INFLAMMATORY RESPONSE SYNDROME 63 0.0215
241 HEPATITIS B 101 0.0214
242 LUNG NEOPLASM 76 0.0213
243 DEMYELINATION 65 0.0213
244 HYPERBILIRUBINAEMIA 151 0.0212
245 IMMUNOSUPPRESSION 107 0.0212
246 HYPOALBUMINAEMIA 108 0.0211
247 HAEMOLYTIC ANAEMIA 144 0.0210
248 ORGANISING PNEUMONIA 62 0.0210
249 BACTERIAL INFECTION 250 0.0209
250 MYOPATHY 131 0.0207
251 DISEASE RECURRENCE 341 0.0207
252 NECROSIS 89 0.0207
253 SYNOVITIS 195 0.0206
254 LIVER FUNCTION TEST ABNORMAL 511 0.0206
255 EYE SWELLING 533 0.0206
256 BLOOD PRESSURE DIASTOLIC INCREASED 54 0.0204
257 ELECTROENCEPHALOGRAM ABNORMAL 53 0.0204
258 CHOLANGITIS 79 0.0203
259 BLOOD CULTURE POSITIVE 54 0.0203
260 PANCYTOPENIA 774 0.0201
261 PROTEIN URINE PRESENT 69 0.0200
262 GUILLAIN-BARRE SYNDROME 63 0.0198
263 VITREOUS FLOATERS 122 0.0197
264 DRUG LEVEL DECREASED 113 0.0194
265 DISSEMINATED INTRAVASCULAR COAGULATION 215 0.0193
266 PULMONARY TUBERCULOSIS 64 0.0193
267 RENAL FAILURE ACUTE 818 0.0192
268 PULMONARY HAEMORRHAGE 117 0.0190
269 RED BLOOD CELL SEDIMENTATION RATE INCREASED 142 0.0190
270 AUTOIMMUNE HEPATITIS 84 0.0183
271 ACUTE MYELOID LEUKAEMIA 196 0.0183
272 INCORRECT PRODUCT STORAGE 240 0.0182
273 LEUKOPENIA 632 0.0180
274 PAPILLOEDEMA 59 0.0180
275 HAEMORRHAGIC DIATHESIS 49 0.0180
276 PRE-EXISTING CONDITION IMPROVED 98 0.0179
277 FUNGAL SKIN INFECTION 48 0.0177
278 MYASTHENIA GRAVIS 58 0.0177
279 BONE MARROW FAILURE 318 0.0177
280 NEUROLOGICAL SYMPTOM 70 0.0177
281 SEPTIC SHOCK 507 0.0175
282 HYPERCALCAEMIA 152 0.0175
283 HEPATITIS CHOLESTATIC 75 0.0174
284 GENERALISED OEDEMA 146 0.0172
285 MALIGNANT MELANOMA 167 0.0172
286 SEPSIS 1368 0.0171
287 ACUTE PULMONARY OEDEMA 74 0.0171
288 CONCOMITANT DISEASE AGGRAVATED 78 0.0170
289 CHOLESTASIS 224 0.0170
290 HERPES ZOSTER 681 0.0169
291 RHABDOMYOLYSIS 518 0.0169
292 AGRANULOCYTOSIS 194 0.0166
293 SKIN LESION 301 0.0165
294 STOMATITIS 649 0.0164
295 INTRACRANIAL PRESSURE INCREASED 65 0.0163
296 MULTIPLE ORGAN DYSFUNCTION SYNDROME 245 0.0163
297 NORMAL NEWBORN 64 0.0162
298 HAEMODYNAMIC INSTABILITY 78 0.0161
299 CREATININE RENAL CLEARANCE DECREASED 49 0.0160
300 STAPHYLOCOCCAL INFECTION 407 0.0160
301 RESPIRATORY SYNCYTIAL VIRUS INFECTION 56 0.0160
302 EYELID PTOSIS 111 0.0160
303 CHRONIC MYELOID LEUKAEMIA 53 0.0159
304 DERMATITIS EXFOLIATIVE 72 0.0158
305 PRODUCT USE IN UNAPPROVED INDICATION 1881 0.0158
306 TENDERNESS 120 0.0157
307 SPLENOMEGALY 134 0.0157
308 HYPERKERATOSIS 61 0.0157
309 POLYDIPSIA 47 0.0156
310 LYMPHOMA 168 0.0155
311 TUBULOINTERSTITIAL NEPHRITIS 200 0.0154
312 HEPATIC NECROSIS 48 0.0153
313 ORAL CANDIDIASIS 134 0.0153
314 PURULENT DISCHARGE 50 0.0153
315 PRODUCT STORAGE ERROR 420 0.0152
316 LYMPHADENOPATHY 378 0.0152
317 BLOOD ALKALINE PHOSPHATASE INCREASED 304 0.0152
318 PERIORBITAL OEDEMA 57 0.0151
319 HEPATITIS C 162 0.0151
320 LEFT VENTRICULAR HYPERTROPHY 49 0.0151
321 NEPHROGENIC ANAEMIA 60 0.0151
322 GRAND MAL CONVULSION 139 0.0150
323 CONJUNCTIVITIS 159 0.0150
324 BLOOD ALBUMIN DECREASED 89 0.0150
325 STREPTOCOCCAL INFECTION 54 0.0149
326 METASTASES TO LYMPH NODES 63 0.0149
327 SKIN TIGHTNESS 53 0.0149
328 ENCEPHALOPATHY 250 0.0149
329 DIALYSIS 166 0.0149
330 CATARACT 569 0.0148
331 SKIN ATROPHY 58 0.0148
332 HEPATOTOXICITY 212 0.0147
333 ASCITES 312 0.0147
334 RASH PUSTULAR 90 0.0146
335 MYELODYSPLASTIC SYNDROME 157 0.0146
336 UROSEPSIS 93 0.0146
337 GLOMERULAR FILTRATION RATE DECREASED 101 0.0146
338 FEBRILE NEUTROPENIA 610 0.0145
339 CONTRAINDICATED PRODUCT ADMINISTERED 233 0.0143
340 INTERSTITIAL LUNG DISEASE 460 0.0143
341 SKIN INFECTION 103 0.0143
342 BRONCHOPNEUMONIA 49 0.0143
343 EYE DISORDER 316 0.0142
344 FUNGAL INFECTION 328 0.0142
345 GASTROENTERITIS 150 0.0142
346 HYPERCHOLESTEROLAEMIA 84 0.0142
347 GAMMA-GLUTAMYLTRANSFERASE INCREASED 251 0.0142
348 ACCIDENTAL EXPOSURE TO PRODUCT 601 0.0142
349 LARGE INTESTINE PERFORATION 72 0.0141
350 ASPARTATE AMINOTRANSFERASE INCREASED 569 0.0141
351 PSORIATIC ARTHROPATHY 292 0.0141
352 BRAIN OEDEMA 129 0.0140
353 PHOTOPSIA 65 0.0140
354 SKIN MASS 59 0.0140
355 VISUAL ACUITY REDUCED 407 0.0139
356 FOLLICULITIS 47 0.0139
357 PAPULE 55 0.0139
358 HEPATOMEGALY 108 0.0139
359 TRANSAMINASES INCREASED 225 0.0138
360 PATHOGEN RESISTANCE 76 0.0137
361 ALANINE AMINOTRANSFERASE INCREASED 634 0.0136
362 RESPIRATORY FAILURE 738 0.0136
363 WOUND INFECTION 84 0.0135
364 RALES 56 0.0134
365 RENAL CELL CARCINOMA 50 0.0134
366 CLOSTRIDIUM DIFFICILE COLITIS 100 0.0134
367 LYMPHOPENIA 123 0.0134
368 NEPHROPATHY 96 0.0133
369 ENDOCARDITIS 48 0.0133
370 SHOCK HAEMORRHAGIC 73 0.0132
371 ORAL DISORDER 70 0.0132
372 GLUCOSE TOLERANCE IMPAIRED 52 0.0132
373 LOW BIRTH WEIGHT BABY 69 0.0131
374 MALABSORPTION 48 0.0129
375 UVEITIS 95 0.0129
376 INFLAMMATION 395 0.0129
377 PLATELET COUNT INCREASED 113 0.0128
378 HEPATIC FAILURE 294 0.0128
379 DRUG RESISTANCE 209 0.0128
380 UPPER-AIRWAY COUGH SYNDROME 65 0.0128
381 ECZEMA 227 0.0127
382 PRODUCT PACKAGING ISSUE 73 0.0127
383 PERICARDIAL EFFUSION 199 0.0127
384 FIBROMYALGIA 195 0.0126
385 HYPERLIPIDAEMIA 121 0.0126
386 OEDEMA 475 0.0126
387 MADAROSIS 130 0.0125
388 INFECTION 1153 0.0125
389 INTRAOCULAR PRESSURE INCREASED 122 0.0125
390 ANGIOPATHY 55 0.0125
391 RENAL FAILURE 1330 0.0124
392 LUNG INFECTION 194 0.0124
393 SKIN HAEMORRHAGE 96 0.0124
394 ACIDOSIS 71 0.0123
395 RENAL DISORDER 403 0.0123
396 ANOREXIA 158 0.0123
397 SKIN FISSURES 113 0.0122
398 DRUG TOXICITY 167 0.0122
399 LEUKOCYTOSIS 158 0.0122
400 HYDROCEPHALUS 49 0.0122
401 PYREXIA 2979 0.0122
402 AUTOIMMUNE DISORDER 54 0.0121
403 MALNUTRITION 91 0.0121
404 PEMPHIGOID 54 0.0121
405 PSORIASIS 1055 0.0120
406 HYPERTRIGLYCERIDAEMIA 48 0.0120
407 HYPOXIA 287 0.0120
408 VIRAL INFECTION 264 0.0119
409 EXPIRED PRODUCT ADMINISTERED 276 0.0119
410 HAEMATOCRIT DECREASED 189 0.0119
411 IMPAIRED GASTRIC EMPTYING 62 0.0119
412 SKIN CANCER 157 0.0119
413 PLATELET COUNT DECREASED 854 0.0119
414 VASCULITIS 93 0.0119
415 EYE MOVEMENT DISORDER 60 0.0118
416 THERAPEUTIC RESPONSE DECREASED 482 0.0118
417 BLOOD MAGNESIUM DECREASED 67 0.0118
418 RENAL CYST 71 0.0117
419 SECRETION DISCHARGE 85 0.0116
420 DRUG INTOLERANCE 697 0.0116
421 TOE AMPUTATION 49 0.0115
422 ACUTE RESPIRATORY FAILURE 140 0.0115
423 PLEURAL EFFUSION 515 0.0115
424 CANDIDA INFECTION 117 0.0115
425 SCRATCH 65 0.0114
426 TREATMENT FAILURE 580 0.0114
427 SCAB 89 0.0114
428 DERMATITIS 149 0.0114
429 PHOTOSENSITIVITY REACTION 134 0.0113
430 MOUTH ULCERATION 159 0.0113
431 BLOOD CREATINE PHOSPHOKINASE INCREASED 263 0.0113
432 ATELECTASIS 85 0.0112
433 HAEMOGLOBIN DECREASED 844 0.0112
434 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 801 0.0112
435 TUBERCULOSIS 100 0.0112
436 TRICUSPID VALVE INCOMPETENCE 64 0.0112
437 GOUT 140 0.0111
438 PRODUCT DOSE OMISSION 744 0.0111
439 GLAUCOMA 153 0.0110
440 SKIN ULCER 205 0.0110
441 LIVER DISORDER 331 0.0110
442 ILEUS 95 0.0109
443 HAEMATOTOXICITY 58 0.0109
444 CATARACT OPERATION 46 0.0108
445 THROMBOCYTOPENIA 825 0.0108
446 HYPERTHERMIA 61 0.0108
447 PREMATURE LABOUR 52 0.0107
448 DRUG INTERACTION 1242 0.0107
449 HAEMATURIA 283 0.0106
450 IMMUNE SYSTEM DISORDER 93 0.0106
451 HEPATIC ENCEPHALOPATHY 74 0.0106
452 NODULE 92 0.0105
453 CHOLECYSTITIS 91 0.0105
454 ABSCESS 113 0.0105
455 HYPERKALAEMIA 262 0.0104
456 JAUNDICE 226 0.0104
457 FACIAL PAIN 63 0.0104
458 HAIR GROWTH ABNORMAL 53 0.0104
459 RETINAL DETACHMENT 66 0.0103
460 HEPATIC CIRRHOSIS 129 0.0103
461 NO THERAPEUTIC RESPONSE 126 0.0103
462 ULCER 117 0.0103
463 HAEMORRHAGE INTRACRANIAL 126 0.0103
464 PNEUMOTHORAX 111 0.0102
465 PHARYNGITIS 93 0.0101
466 CAESAREAN SECTION 98 0.0101
467 PETECHIAE 77 0.0101
468 METASTASIS 47 0.0100
469 RESPIRATORY DISTRESS 208 0.0100
470 ORAL PAIN 162 0.0100
471 SKIN DISORDER 209 0.0100
472 SKIN HYPERPIGMENTATION 65 0.0100
473 RHEUMATOID ARTHRITIS 725 0.0099
474 PULMONARY CONGESTION 93 0.0099
475 EYE HAEMORRHAGE 98 0.0098
476 MYOCLONUS 87 0.0098
477 MYOSITIS 57 0.0098
478 PURPURA 66 0.0098
479 OESOPHAGITIS 78 0.0097
480 BLOOD PRESSURE DIASTOLIC DECREASED 46 0.0097
481 ELECTROLYTE IMBALANCE 75 0.0097
482 PNEUMONIA 2113 0.0096
483 CELLULITIS 357 0.0096
484 ALTERED STATE OF CONSCIOUSNESS 135 0.0096
485 DEVICE RELATED INFECTION 115 0.0095
486 DIPLOPIA 173 0.0095
487 BLINDNESS TRANSIENT 50 0.0095
488 ADRENAL INSUFFICIENCY 61 0.0095
489 PULMONARY FIBROSIS 116 0.0095
490 ANAEMIA 1311 0.0094
491 JOINT RANGE OF MOTION DECREASED 71 0.0094
492 SHOCK 149 0.0094
493 LUNG DISORDER 309 0.0093
494 BLOOD POTASSIUM INCREASED 111 0.0093
495 ACNE 556 0.0093
496 ARTHRITIS 492 0.0093
497 PULMONARY MASS 90 0.0092
498 TACHYPNOEA 82 0.0092
499 RED BLOOD CELL COUNT DECREASED 177 0.0092
500 RESPIRATORY TRACT INFECTION 152 0.0091
501 BLOOD PRESSURE SYSTOLIC INCREASED 113 0.0091
502 PNEUMONITIS 152 0.0091
503 POST PROCEDURAL COMPLICATION 132 0.0091
504 TONGUE DISORDER 53 0.0091
505 HYPERTENSION 1330 0.0091
506 MACULAR DEGENERATION 71 0.0090
507 INCORRECT DOSE ADMINISTERED 1026 0.0089
508 WHITE BLOOD CELL COUNT INCREASED 260 0.0089
509 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 213 0.0089
510 STATUS EPILEPTICUS 72 0.0089
511 DIARRHOEA HAEMORRHAGIC 59 0.0089
512 THERAPY NON-RESPONDER 196 0.0089
513 SPINAL OSTEOARTHRITIS 59 0.0088
514 IMPAIRED HEALING 193 0.0088
515 HYPOTHYROIDISM 180 0.0088
516 DIABETES MELLITUS 509 0.0088
517 VISUAL IMPAIRMENT 696 0.0088
518 NEUTROPENIA 705 0.0088
519 VISUAL FIELD DEFECT 50 0.0087
520 VITAMIN D DEFICIENCY 59 0.0087
521 METASTASES TO LUNG 65 0.0087
522 MITRAL VALVE INCOMPETENCE 75 0.0087
523 FOOT DEFORMITY 66 0.0087
524 PANCREATITIS ACUTE 136 0.0087
525 HEPATITIS 159 0.0087
526 END STAGE RENAL DISEASE 132 0.0087
527 SLEEP APNOEA SYNDROME 125 0.0086
528 POLYNEUROPATHY 64 0.0086
529 MASS 89 0.0086
530 CEREBRAL HAEMORRHAGE 230 0.0086
531 EAR PAIN 115 0.0086
532 DERMATITIS CONTACT 65 0.0085
533 LIPASE INCREASED 49 0.0085
534 CONVULSION 488 0.0085
535 ORAL HERPES 103 0.0085
536 OSTEOPENIA 90 0.0085
537 ECCHYMOSIS 46 0.0085
538 RHINORRHOEA 349 0.0085
539 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 271 0.0085
540 HEPATIC ENZYME INCREASED 369 0.0085
541 CONDITION AGGRAVATED 1484 0.0084
542 EPISTAXIS 464 0.0084
543 CARDIAC MURMUR 60 0.0084
544 UPPER LIMB FRACTURE 126 0.0083
545 SCAR 107 0.0083
546 PERITONITIS 133 0.0083
547 MYOCARDITIS 49 0.0082
548 FLUID OVERLOAD 121 0.0082
549 DEPRESSED LEVEL OF CONSCIOUSNESS 233 0.0082
550 HEARING IMPAIRED 49 0.0082
551 ATRIAL FLUTTER 50 0.0082
552 CARDIOMEGALY 84 0.0082
553 SPINAL COMPRESSION FRACTURE 53 0.0081
554 GINGIVAL BLEEDING 75 0.0081
555 RESPIRATORY DISORDER 173 0.0081
556 BLOOD CHOLESTEROL INCREASED 262 0.0081
557 CHOLECYSTECTOMY 65 0.0081
558 DYSURIA 219 0.0080
559 BURNING SENSATION 411 0.0080
560 UPPER RESPIRATORY TRACT INFECTION 255 0.0080
561 WHITE BLOOD CELL COUNT DECREASED 577 0.0080
562 CLOSTRIDIUM DIFFICILE INFECTION 110 0.0080
563 CEREBRAL INFARCTION 146 0.0079
564 MELAENA 131 0.0078
565 PERICARDITIS 56 0.0078
566 URINARY TRACT INFECTION 879 0.0078
567 IRON DEFICIENCY ANAEMIA 51 0.0077
568 OSTEOARTHRITIS 223 0.0077
569 SINUSITIS 529 0.0076
570 EJECTION FRACTION DECREASED 81 0.0076
571 HEPATOCELLULAR INJURY 93 0.0076
572 ERYTHEMA 1115 0.0075
573 BLOOD TRIGLYCERIDES INCREASED 104 0.0075
574 URTICARIA 843 0.0075
575 LIVER FUNCTION TEST INCREASED 90 0.0075
576 TOXIC EPIDERMAL NECROLYSIS 79 0.0075
577 DRY THROAT 53 0.0074
578 HEMIPARESIS 99 0.0074
579 IMMUNODEFICIENCY 59 0.0074
580 COLITIS 171 0.0074
581 CARPAL TUNNEL SYNDROME 73 0.0074
582 NEUTROPHIL COUNT DECREASED 182 0.0074
583 EAR DISCOMFORT 51 0.0074
584 BLISTER 273 0.0074
585 THERAPEUTIC PRODUCT EFFECT DECREASED 146 0.0074
586 HYPOMAGNESAEMIA 65 0.0073
587 DRUG EXPOSURE DURING PREGNANCY 250 0.0073
588 COAGULOPATHY 94 0.0073
589 LYMPHOCYTE COUNT DECREASED 89 0.0073
590 ARTERIOSCLEROSIS 52 0.0073
591 INFUSION RELATED REACTION 272 0.0073
592 SURGERY 248 0.0073
593 GASTRITIS 140 0.0072
594 DYSPNOEA EXERTIONAL 176 0.0072
595 OSTEOPOROSIS 213 0.0072
596 METABOLIC ACIDOSIS 150 0.0071
597 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 467 0.0071
598 GASTROENTERITIS VIRAL 84 0.0071
599 RASH PAPULAR 123 0.0071
600 APPLICATION SITE PAIN 122 0.0071
601 CYSTITIS 168 0.0071
602 ACUTE KIDNEY INJURY 688 0.0070
603 PULMONARY OEDEMA 230 0.0070
604 PRODUCT PRESCRIBING ERROR 74 0.0070
605 COLON CANCER 73 0.0070
606 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 52 0.0070
607 SUBARACHNOID HAEMORRHAGE 52 0.0070
608 ALOPECIA 1000 0.0070
609 SKIN DISCOLOURATION 231 0.0070
610 OEDEMA PERIPHERAL 679 0.0070
611 HYPERSENSITIVITY 900 0.0069
612 OSTEOMYELITIS 98 0.0069
613 BURSITIS 50 0.0069
614 DRUG INEFFECTIVE 6205 0.0069
615 NEOPLASM 51 0.0069
616 FACE OEDEMA 88 0.0069
617 CARDIAC FAILURE 389 0.0069
618 ACUTE HEPATIC FAILURE 62 0.0069
619 BLOOD SODIUM DECREASED 92 0.0069
620 THERAPY INTERRUPTED 79 0.0069
621 SINUS DISORDER 93 0.0069
622 BRONCHITIS 383 0.0069
623 INTESTINAL PERFORATION 55 0.0068
624 TRANSFUSION 52 0.0068
625 BLOOD PRESSURE INCREASED 732 0.0068
626 LARYNGITIS 49 0.0068
627 ROTATOR CUFF SYNDROME 66 0.0068
628 BODY TEMPERATURE INCREASED 103 0.0068
629 NEUTROPHIL COUNT INCREASED 51 0.0068
630 GASTRIC ULCER 98 0.0067
631 SKIN EXFOLIATION 367 0.0067
632 SWELLING FACE 316 0.0067
633 DISEASE PROGRESSION 473 0.0067
634 PRODUCTIVE COUGH 198 0.0067
635 NEURALGIA 107 0.0067
636 INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION 47 0.0067
637 PRURITUS 1510 0.0066
638 CIRCULATORY COLLAPSE 90 0.0066
639 TENDONITIS 79 0.0066
640 BLOOD CALCIUM DECREASED 55 0.0066
641 OSTEONECROSIS 179 0.0066
642 APHASIA 148 0.0066
643 PULMONARY HYPERTENSION 105 0.0066
644 OROPHARYNGEAL PAIN 406 0.0066
645 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 203 0.0066
646 SENSORY DISTURBANCE 84 0.0065
647 JOINT SWELLING 498 0.0065
648 JOINT DISLOCATION 47 0.0065
649 EAR INFECTION 104 0.0064
650 SINUS CONGESTION 61 0.0064
651 BLINDNESS 175 0.0063
652 GENERAL PHYSICAL HEALTH DETERIORATION 446 0.0063
653 OXYGEN SATURATION DECREASED 215 0.0063
654 NASAL CONGESTION 229 0.0063
655 INTENTIONAL PRODUCT USE ISSUE 294 0.0063
656 PNEUMONIA ASPIRATION 110 0.0063
657 HAEMATOMA 126 0.0062
658 WOUND 95 0.0062
659 CHOLELITHIASIS 153 0.0062
660 ATAXIA 56 0.0062
661 SYSTEMIC LUPUS ERYTHEMATOSUS 113 0.0061
662 OFF LABEL USE 2668 0.0061
663 NERVOUS SYSTEM DISORDER 156 0.0061
664 PREMATURE BABY 136 0.0061
665 MUSCULAR WEAKNESS 501 0.0061
666 HIP ARTHROPLASTY 54 0.0061
667 MENTAL STATUS CHANGES 129 0.0061
668 CHILLS 504 0.0061
669 POST PROCEDURAL HAEMORRHAGE 55 0.0061
670 HEPATIC STEATOSIS 80 0.0061
671 JOINT INJURY 88 0.0060
672 RASH ERYTHEMATOUS 175 0.0060
673 CENTRAL NERVOUS SYSTEM LESION 68 0.0060
674 PAIN IN EXTREMITY 1298 0.0060
675 CARDIOMYOPATHY 67 0.0060
676 HAEMOPTYSIS 125 0.0060
677 NECK PAIN 234 0.0059
678 RASH PRURITIC 213 0.0059
679 OBESITY 62 0.0059
680 DYSPHAGIA 388 0.0059
681 CYST 51 0.0059
682 ABDOMINAL PAIN 956 0.0059
683 HYPERTENSIVE CRISIS 48 0.0058
684 SCIATICA 56 0.0058
685 ANKLE FRACTURE 65 0.0058
686 METASTASES TO LIVER 68 0.0058
687 INFLUENZA 407 0.0058
688 MUSCULOSKELETAL STIFFNESS 340 0.0057
689 HYPERGLYCAEMIA 154 0.0057
690 DIVERTICULITIS 110 0.0057
691 RASH MACULO-PAPULAR 86 0.0057
692 SNEEZING 80 0.0057
693 GASTROINTESTINAL DISORDER 283 0.0057
694 PERIPHERAL SWELLING 541 0.0057
695 THERAPEUTIC RESPONSE UNEXPECTED 191 0.0057
696 COLITIS ULCERATIVE 126 0.0057
697 MYOCARDIAL ISCHAEMIA 55 0.0057
698 COUGH 1020 0.0056
699 LOCALISED INFECTION 94 0.0056
700 APPLICATION SITE ERYTHEMA 126 0.0056
701 PAIN OF SKIN 112 0.0055
702 JOINT STIFFNESS 101 0.0055
703 WRIST FRACTURE 47 0.0055
704 KIDNEY INFECTION 73 0.0055
705 DIARRHOEA 2315 0.0055
706 COVID-19 182 0.0054
707 MYALGIA 671 0.0054
708 THROAT IRRITATION 162 0.0054
709 DYSGEUSIA 292 0.0054
710 RASH 1543 0.0054
711 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 617 0.0054
712 LIMB INJURY 93 0.0054
713 HYPONATRAEMIA 222 0.0054
714 DRY MOUTH 305 0.0054
715 SLEEP DISORDER 237 0.0054
716 SWELLING 330 0.0054
717 DEHYDRATION 531 0.0054
718 CHROMATURIA 92 0.0054
719 DYSPHONIA 214 0.0054
720 PRODUCT USE ISSUE 632 0.0054
721 MIGRAINE 332 0.0053
722 BLOOD PRESSURE DECREASED 252 0.0053
723 HAEMORRHOIDS 77 0.0053
724 EPILEPSY 107 0.0053
725 GASTROINTESTINAL HAEMORRHAGE 372 0.0053
726 DYSARTHRIA 150 0.0053
727 PARALYSIS 56 0.0053
728 RASH MACULAR 122 0.0053
729 ATRIAL FIBRILLATION 362 0.0053
730 ARTHROPATHY 194 0.0053
731 EOSINOPHILIA 62 0.0053
732 NEUROPATHY PERIPHERAL 314 0.0052
733 HYPOKALAEMIA 166 0.0052
734 LIMB DISCOMFORT 108 0.0052
735 MUSCLE SPASMS 687 0.0052
736 STRESS 246 0.0052
737 TENDON RUPTURE 50 0.0052
738 CARDIOGENIC SHOCK 47 0.0052
739 FLUID RETENTION 192 0.0052
740 HEADACHE 2290 0.0051
741 DEAFNESS 92 0.0051
742 LIVER INJURY 61 0.0051
743 ARTHRALGIA 1347 0.0051
744 CHRONIC KIDNEY DISEASE 317 0.0051
745 INTERVERTEBRAL DISC PROTRUSION 84 0.0051
746 FEEDING DISORDER 54 0.0051
747 BLOOD PRESSURE FLUCTUATION 84 0.0050
748 LOWER RESPIRATORY TRACT INFECTION 140 0.0050
749 ANAPHYLACTIC REACTION 175 0.0050
750 NASOPHARYNGITIS 591 0.0050
751 LIP SWELLING 118 0.0050
752 METASTASES TO BONE 49 0.0050
753 WEIGHT DECREASED 955 0.0049
754 LOCAL SWELLING 85 0.0049
755 BLINDNESS UNILATERAL 49 0.0049
756 EMOTIONAL DISORDER 117 0.0048
757 MOBILITY DECREASED 232 0.0048
758 MUSCULOSKELETAL PAIN 221 0.0048
759 BLOOD PRESSURE ABNORMAL 59 0.0048
760 MUSCULOSKELETAL CHEST PAIN 53 0.0048
761 DEEP VEIN THROMBOSIS 259 0.0048
762 CONTUSION 321 0.0048
763 TOOTH DISORDER 80 0.0048
764 RIB FRACTURE 70 0.0048
765 APPLICATION SITE IRRITATION 47 0.0048
766 NIGHT SWEATS 103 0.0048
767 ORAL DISCOMFORT 49 0.0048
768 GASTROOESOPHAGEAL REFLUX DISEASE 271 0.0048
769 SUBDURAL HAEMATOMA 54 0.0048
770 TREMOR 596 0.0048
771 TACHYCARDIA 302 0.0048
772 VOMITING 1569 0.0048
773 DISCOMFORT 164 0.0048
774 INTESTINAL OBSTRUCTION 117 0.0048
775 CORONARY ARTERY DISEASE 126 0.0047
776 LABORATORY TEST ABNORMAL 95 0.0047
777 IRRITABLE BOWEL SYNDROME 59 0.0047
778 PANCREATITIS 186 0.0047
779 PAIN 1867 0.0047
780 HYPOKINESIA 50 0.0047
781 DELIRIUM 108 0.0046
782 ASTHENIA 1223 0.0046
783 DYSPNOEA 1848 0.0046
784 CONFUSIONAL STATE 548 0.0046
785 ARRHYTHMIA 166 0.0046
786 COMA 162 0.0046
787 DISORIENTATION 143 0.0046
788 FOOT FRACTURE 63 0.0046
789 RESPIRATORY TRACT CONGESTION 49 0.0045
790 ANGIOEDEMA 141 0.0045
791 HALLUCINATION, VISUAL 61 0.0045
792 NEOPLASM MALIGNANT 196 0.0045
793 HEART RATE DECREASED 108 0.0045
794 WRONG TECHNIQUE IN DRUG USAGE PROCESS 162 0.0045
795 URINARY INCONTINENCE 97 0.0045
796 HYPOAESTHESIA 481 0.0044
797 BACK PAIN 730 0.0044
798 DRUG DOSE OMISSION 729 0.0044
799 TINNITUS 145 0.0044
800 HYPOPHAGIA 76 0.0044
801 PRODUCT DOSE OMISSION ISSUE 260 0.0044
802 LOWER LIMB FRACTURE 53 0.0044
803 CORONARY ARTERY OCCLUSION 50 0.0044
804 GAIT DISTURBANCE 607 0.0044
805 URINARY RETENTION 103 0.0044
806 ILLNESS 82 0.0043
807 HERNIA 55 0.0043
808 DRY SKIN 366 0.0043
809 HYPOTENSION 611 0.0043
810 BLOOD POTASSIUM DECREASED 93 0.0043
811 PRURITUS GENERALISED 93 0.0043
812 ORTHOSTATIC HYPOTENSION 53 0.0043
813 ANGINA PECTORIS 97 0.0043
814 PULMONARY ARTERIAL HYPERTENSION 48 0.0042
815 EATING DISORDER 64 0.0042
816 WHEEZING 156 0.0042
817 FEELING HOT 181 0.0042
818 PHARYNGEAL OEDEMA 63 0.0042
819 HOT FLUSH 200 0.0042
820 HAEMATEMESIS 81 0.0042
821 APPLICATION SITE PRURITUS 75 0.0042
822 HYPOCALCAEMIA 55 0.0042
823 SWOLLEN TONGUE 99 0.0042
824 HEART RATE INCREASED 289 0.0042
825 FALL 980 0.0042
826 NAUSEA 2300 0.0042
827 RASH GENERALISED 108 0.0042
828 CARDIOVASCULAR DISORDER 91 0.0041
829 COORDINATION ABNORMAL 48 0.0041
830 DECREASED APPETITE 629 0.0041
831 SPEECH DISORDER 160 0.0041
832 HAEMORRHAGE 295 0.0041
833 ABDOMINAL DISTENSION 295 0.0041
834 POOR QUALITY SLEEP 58 0.0041
835 MALAISE 1326 0.0041
836 MUSCLE TWITCHING 70 0.0041
837 MUSCULOSKELETAL DISCOMFORT 48 0.0041
838 GAIT INABILITY 64 0.0040
839 NEPHROLITHIASIS 122 0.0040
840 DRUG HYPERSENSITIVITY 583 0.0040
841 CARDIAC ARREST 252 0.0040
842 FATIGUE 2064 0.0040
843 FAECES DISCOLOURED 64 0.0040
844 GALLBLADDER DISORDER 56 0.0040
845 BONE PAIN 168 0.0040
846 HALLUCINATION 199 0.0039
847 INSOMNIA 775 0.0039
848 CHEST PAIN 547 0.0039
849 HYPOACUSIS 103 0.0039
850 VERTIGO 177 0.0039
851 CHEST DISCOMFORT 272 0.0039
852 PARAESTHESIA 447 0.0039
853 FRACTURE 54 0.0039
854 FULL BLOOD COUNT DECREASED 48 0.0039
855 MATERNAL EXPOSURE DURING PREGNANCY 184 0.0039
856 TOOTHACHE 50 0.0039
857 PULMONARY EMBOLISM 288 0.0038
858 ABDOMINAL DISCOMFORT 422 0.0038
859 HAEMATOCHEZIA 132 0.0038
860 DEMENTIA 67 0.0038
861 ABDOMINAL PAIN LOWER 72 0.0038
862 ASTHMA 251 0.0038
863 MUSCULOSKELETAL DISORDER 54 0.0038
864 HEART RATE IRREGULAR 67 0.0038
865 LUNG NEOPLASM MALIGNANT 111 0.0038
866 INJURY 215 0.0037
867 POLLAKIURIA 111 0.0037
868 PALLOR 68 0.0037
869 AMNESIA 186 0.0037
870 DYSSTASIA 78 0.0037
871 WEIGHT INCREASED 570 0.0037
872 HEAD INJURY 82 0.0037
873 DRUG EFFECT INCOMPLETE 135 0.0037
874 RETCHING 55 0.0037
875 BALANCE DISORDER 234 0.0037
876 DRUG-INDUCED LIVER INJURY 58 0.0037
877 RESTLESS LEGS SYNDROME 49 0.0037
878 BLOOD URINE PRESENT 52 0.0036
879 RENAL INJURY 97 0.0036
880 HIP FRACTURE 81 0.0036
881 ABDOMINAL PAIN UPPER 514 0.0036
882 SKIN IRRITATION 129 0.0036
883 GLYCOSYLATED HAEMOGLOBIN INCREASED 60 0.0036
884 ABASIA 89 0.0036
885 AGEUSIA 63 0.0036
886 LETHARGY 155 0.0036
887 LOSS OF CONSCIOUSNESS 339 0.0036
888 SOMNOLENCE 514 0.0036
889 PAIN IN JAW 77 0.0036
890 CONSTIPATION 496 0.0035
891 INTERNATIONAL NORMALISED RATIO INCREASED 91 0.0035
892 TREATMENT NONCOMPLIANCE 118 0.0035
893 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 134 0.0035
894 MENTAL DISORDER 106 0.0035
895 BONE DISORDER 51 0.0035
896 ILL-DEFINED DISORDER 96 0.0035
897 BRADYCARDIA 136 0.0034
898 COGNITIVE DISORDER 111 0.0034
899 PSYCHOTIC DISORDER 75 0.0034
900 NERVOUSNESS 143 0.0034
901 CARDIAC FAILURE CONGESTIVE 239 0.0034
902 ACUTE MYOCARDIAL INFARCTION 80 0.0034
903 THINKING ABNORMAL 50 0.0034
904 FEELING ABNORMAL 607 0.0034
905 MEMORY IMPAIRMENT 326 0.0034
906 THROMBOSIS 196 0.0034
907 DIZZINESS 1178 0.0033
908 UNEVALUABLE EVENT 189 0.0033
909 FREQUENT BOWEL MOVEMENTS 50 0.0033
910 DEPRESSION 582 0.0033
911 DYSPEPSIA 223 0.0033
912 PALPITATIONS 275 0.0033
913 PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME 52 0.0033
914 ANAPHYLACTIC SHOCK 55 0.0032
915 TRANSIENT ISCHAEMIC ATTACK 86 0.0032
916 FEELING COLD 65 0.0032
917 MOVEMENT DISORDER 75 0.0032
918 CRYING 93 0.0032
919 GASTRIC DISORDER 95 0.0031
920 ACTIVITIES OF DAILY LIVING IMPAIRED 62 0.0031
921 CARDIO-RESPIRATORY ARREST 103 0.0031
922 STEVENS-JOHNSON SYNDROME 54 0.0031
923 THERAPY CESSATION 101 0.0031
924 HYPOGLYCAEMIA 113 0.0031
925 TOXICITY TO VARIOUS AGENTS 338 0.0030
926 FLATULENCE 120 0.0030
927 DISTURBANCE IN ATTENTION 122 0.0030
928 BLOOD COUNT ABNORMAL 51 0.0030
929 THROAT TIGHTNESS 58 0.0030
930 DRUG ADMINISTRATION ERROR 92 0.0030
931 ACCIDENTAL OVERDOSE 74 0.0030
932 ADVERSE DRUG REACTION 153 0.0029
933 ROAD TRAFFIC ACCIDENT 89 0.0029
934 DRUG EFFECT DECREASED 158 0.0029
935 ANXIETY 606 0.0029
936 HYPERSOMNIA 58 0.0029
937 PREGNANCY 49 0.0029
938 UNRESPONSIVE TO STIMULI 53 0.0028
939 RESPIRATORY ARREST 66 0.0028
940 RESTLESSNESS 76 0.0028
941 DYSKINESIA 84 0.0028
942 MEDICATION ERROR 114 0.0028
943 SKIN BURNING SENSATION 153 0.0028
944 INFLUENZA LIKE ILLNESS 179 0.0028
945 SEIZURE 193 0.0028
946 DRUG PRESCRIBING ERROR 53 0.0028
947 FEMUR FRACTURE 68 0.0027
948 TYPE 2 DIABETES MELLITUS 67 0.0027
949 ANHEDONIA 56 0.0027
950 INTENTIONAL PRODUCT MISUSE 162 0.0027
951 ABORTION SPONTANEOUS 83 0.0027
952 DEATH 1536 0.0027
953 RECTAL HAEMORRHAGE 86 0.0027
954 SYNCOPE 195 0.0026
955 MYOCARDIAL INFARCTION 392 0.0026
956 INJECTION SITE SWELLING 131 0.0026
957 HYPERHIDROSIS 248 0.0026
958 AGITATION 150 0.0026
959 INJECTION SITE BRUISING 135 0.0025
960 MALIGNANT NEOPLASM PROGRESSION 155 0.0024
961 IRRITABILITY 115 0.0024
962 DEPRESSED MOOD 87 0.0024
963 CARDIAC DISORDER 167 0.0024
964 INJECTION SITE HAEMORRHAGE 121 0.0024
965 EXPOSURE DURING PREGNANCY 93 0.0023
966 CEREBROVASCULAR ACCIDENT 308 0.0023
967 FOETAL EXPOSURE DURING PREGNANCY 128 0.0023
968 NEOPLASM PROGRESSION 51 0.0023
969 PANIC ATTACK 61 0.0023
970 ADVERSE EVENT 147 0.0022
971 NIGHTMARE 59 0.0022
972 FLUSHING 178 0.0022
973 EMOTIONAL DISTRESS 144 0.0022
974 MULTIPLE SCLEROSIS 75 0.0022
975 ABNORMAL BEHAVIOUR 72 0.0022
976 PRODUCT QUALITY ISSUE 246 0.0021
977 INJECTION SITE REACTION 107 0.0021
978 OVERDOSE 301 0.0021
979 FEAR 47 0.0021
980 INJECTION SITE ERYTHEMA 179 0.0020
981 INJECTION SITE PRURITUS 93 0.0020
982 BLOOD GLUCOSE INCREASED 286 0.0020
983 MOOD SWINGS 50 0.0020
984 HOSPITALISATION 168 0.0019
985 SUICIDAL IDEATION 131 0.0019
986 INJECTION SITE PAIN 364 0.0019
987 BLOOD GLUCOSE DECREASED 70 0.0019
988 PRODUCT SUBSTITUTION ISSUE 74 0.0017
989 NO ADVERSE EVENT 162 0.0017
990 DEVICE MALFUNCTION 63 0.0017
991 BREAST CANCER 122 0.0017
992 DEVICE ISSUE 71 0.0015
993 AGGRESSION 56 0.0014
994 UNDERDOSE 67 0.0013
995 MULTIPLE SCLEROSIS RELAPSE 56 0.0010
996 PROSTATE CANCER 51 0.0010
997 DRUG DEPENDENCE 53 0.0006