Central Nervous System Stimulant [EPC]

Central Nervous System Stimulant [EPC] was reported 189360 times

Drugs of the Central Nervous System Stimulant [EPC] class are most commonly taken among patients reporting these side effects:

# Drug class Count Frequency
0 SWOLLEN JOINT COUNT INCREASED 389 0.7613
1 ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE 1904 0.7371
2 DUODENAL ULCER PERFORATION 1543 0.6530
3 RHEUMATIC FEVER 483 0.6240
4 BLOOD PRESSURE DIASTOLIC ABNORMAL 897 0.6182
5 BLOOD PRESSURE SYSTOLIC ABNORMAL 699 0.5106
6 SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE 1212 0.4178
7 MUSCLE INJURY 1518 0.4097
8 RHEUMATOID FACTOR POSITIVE 1045 0.4068
9 MEDICATION OVERUSE HEADACHE 223 0.3933
10 FOLLICULITIS 1553 0.3700
11 ANION GAP 182 0.3597
12 HELICOBACTER INFECTION 1638 0.3553
13 EXPOSURE TO TOXIC AGENT 505 0.3492
14 HAND DEFORMITY 2175 0.3203
15 PEMPHIGUS 2068 0.3088
16 SEDATION COMPLICATION 401 0.2726
17 PERICARDITIS 2088 0.2466
18 SYNOVITIS 2590 0.2428
19 DISTURBANCE IN SOCIAL BEHAVIOUR 468 0.2335
20 ANALGESIC DRUG LEVEL INCREASED 175 0.1791
21 CHRONIC KIDNEY DISEASE-MINERAL AND BONE DISORDER 151 0.1659
22 BLOOD PRESSURE DIASTOLIC DECREASED 834 0.1625
23 INFUSION SITE BRUISING 161 0.1551
24 INFUSION RELATED REACTION 6285 0.1510
25 SOFT TISSUE DISORDER 141 0.1484
26 GLOSSODYNIA 2093 0.1473
27 INFUSION SITE PRURITUS 228 0.1433
28 BLOOD PRESSURE DIASTOLIC INCREASED 407 0.1414
29 BLOOD PRESSURE FLUCTUATION 2514 0.1413
30 CONTRAINDICATED PRODUCT ADMINISTERED 2517 0.1387
31 HEPATIC CYTOLYSIS 253 0.1378
32 ACUTE HEPATIC FAILURE 1334 0.1370
33 LYMPHOCYTE PERCENTAGE DECREASED 149 0.1348
34 SUSPECTED SUICIDE 263 0.1344
35 CREATININE RENAL CLEARANCE DECREASED 440 0.1338
36 IRRITABLE BOWEL SYNDROME 1823 0.1330
37 NEUTROPHIL PERCENTAGE INCREASED 139 0.1321
38 WOUND 2225 0.1312
39 WHITE BLOOD CELLS URINE POSITIVE 170 0.1256
40 HYPERPARATHYROIDISM SECONDARY 279 0.1253
41 EDUCATIONAL PROBLEM 183 0.1253
42 BLOOD PRESSURE SYSTOLIC INCREASED 1660 0.1251
43 INFUSION SITE SWELLING 395 0.1233
44 NEPHROGENIC ANAEMIA 499 0.1201
45 THERAPEUTIC PRODUCT EFFECT DECREASED 2719 0.1177
46 INFUSION SITE HAEMORRHAGE 194 0.1159
47 HEPATIC NECROSIS 362 0.1134
48 MULTIPLE DRUG OVERDOSE 563 0.1132
49 SYSTEMIC LUPUS ERYTHEMATOSUS 2239 0.1100
50 INFUSION SITE EXTRAVASATION 472 0.1081
51 COMPLETED SUICIDE 7331 0.1055
52 RED CELL DISTRIBUTION WIDTH INCREASED 272 0.1010
53 DRUG TOLERANCE DECREASED 141 0.0983
54 BODY TEMPERATURE DECREASED 746 0.0978
55 BODY TEMPERATURE FLUCTUATION 158 0.0977
56 MULTIPLE DRUG OVERDOSE INTENTIONAL 313 0.0972
57 INTENTIONAL MISUSE 184 0.0963
58 LOWER RESPIRATORY TRACT INFECTION 2802 0.0943
59 DRUG TOXICITY 1200 0.0880
60 IMPAIRED HEALING 1914 0.0825
61 INFUSION SITE ERYTHEMA 368 0.0817
62 POOR VENOUS ACCESS 500 0.0795
63 HEPATOTOXICITY 1202 0.0793
64 INFUSION SITE PAIN 574 0.0790
65 C-REACTIVE PROTEIN ABNORMAL 244 0.0788
66 RESPIRATORY RATE INCREASED 509 0.0776
67 TOXICITY TO VARIOUS AGENTS 8945 0.0764
68 HEART RATE DECREASED 1962 0.0760
69 EXPOSURE VIA INGESTION 186 0.0759
70 BODY TEMPERATURE INCREASED 1187 0.0747
71 DRUG ADMINISTRATION ERROR 2286 0.0744
72 MONOCYTE COUNT INCREASED 183 0.0741
73 SINUSITIS 5399 0.0738
74 BLOOD CALCIUM DECREASED 644 0.0736
75 APPLICATION SITE ERYTHEMA 1665 0.0733
76 EAR PRURITUS 140 0.0731
77 APPLICATION SITE URTICARIA 149 0.0730
78 ARTHROPATHY 2970 0.0725
79 END STAGE RENAL DISEASE 1143 0.0719
80 DRUG EFFECTIVE FOR UNAPPROVED INDICATION 767 0.0717
81 PNEUMONIA VIRAL 152 0.0714
82 BLOOD CREATININE DECREASED 156 0.0707
83 METABOLIC ACIDOSIS 1544 0.0699
84 CYTOLYTIC HEPATITIS 232 0.0697
85 SUBSTANCE ABUSE 463 0.0696
86 NO ADVERSE EVENT 7039 0.0688
87 MACULAR DEGENERATION 576 0.0686
88 LIVER INJURY 916 0.0685
89 HEPATIC ENZYME INCREASED 3255 0.0684
90 DRUG ADMINISTERED AT INAPPROPRIATE SITE 721 0.0683
91 OXYGEN SATURATION DECREASED 2476 0.0682
92 BURSITIS 510 0.0682
93 CYTOKINE RELEASE SYNDROME 390 0.0676
94 DRUG USE DISORDER 218 0.0671
95 DISCOMFORT 2452 0.0657
96 ILL-DEFINED DISORDER 1935 0.0648
97 URINE ABNORMALITY 201 0.0638
98 INCORRECT DRUG ADMINISTRATION RATE 160 0.0633
99 RED BLOOD CELL SEDIMENTATION RATE INCREASED 514 0.0633
100 CHRONIC SINUSITIS 155 0.0633
101 APPLICATION SITE IRRITATION 623 0.0629
102 JOINT SWELLING 5112 0.0626
103 DRUG LEVEL BELOW THERAPEUTIC 213 0.0625
104 INTENTIONAL PRODUCT USE ISSUE 3164 0.0624
105 RHEUMATOID ARTHRITIS 5001 0.0622
106 REBOUND ACID HYPERSECRETION 177 0.0612
107 URINE ANALYSIS ABNORMAL 148 0.0607
108 DRUG PRESCRIBING ERROR 1166 0.0605
109 COAGULOPATHY 802 0.0605
110 BLISTER 2437 0.0605
111 ANAL FISSURE 172 0.0599
112 APLASTIC ANAEMIA 236 0.0599
113 FIBROMYALGIA 962 0.0597
114 PRE-EXISTING CONDITION IMPROVED 330 0.0594
115 ORTHOSTATIC HYPOTENSION 777 0.0593
116 POISONING DELIBERATE 273 0.0592
117 RESPIRATORY DEPRESSION 566 0.0592
118 SWELLING 3780 0.0579
119 EAR PAIN 814 0.0578
120 POISONING 585 0.0578
121 JAUNDICE CHOLESTATIC 159 0.0577
122 RALES 250 0.0574
123 DRUG INTOLERANCE 3759 0.0564
124 WRONG TECHNIQUE IN DRUG USAGE PROCESS 2040 0.0561
125 TIC 242 0.0555
126 INCORRECT DRUG ADMINISTRATION DURATION 1564 0.0555
127 INTENTIONAL OVERDOSE 2427 0.0551
128 IMPULSIVE BEHAVIOUR 165 0.0551
129 PRODUCT ADMINISTRATION ERROR 553 0.0550
130 STOMATITIS 2321 0.0550
131 MUSCLE SPASTICITY 554 0.0548
132 ATELECTASIS 426 0.0547
133 PROTHROMBIN TIME PROLONGED 291 0.0544
134 CHRONIC KIDNEY DISEASE 3557 0.0543
135 BRAIN OEDEMA 517 0.0541
136 HIP ARTHROPLASTY 503 0.0535
137 IRON DEFICIENCY 153 0.0534
138 ACIDOSIS 315 0.0532
139 DEPRESSED LEVEL OF CONSCIOUSNESS 1563 0.0524
140 TOXIC EPIDERMAL NECROLYSIS 566 0.0519
141 DRUG LEVEL ABOVE THERAPEUTIC 147 0.0518
142 PRODUCT QUALITY ISSUE 5971 0.0513
143 SKIN LACERATION 326 0.0512
144 PSYCHOMOTOR HYPERACTIVITY 694 0.0508
145 JOINT RANGE OF MOTION DECREASED 403 0.0507
146 LYMPHOCYTE COUNT DECREASED 649 0.0503
147 WOUND INFECTION 322 0.0496
148 DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS 161 0.0494
149 CARDIO-RESPIRATORY ARREST 1702 0.0490
150 SLEEP APNOEA SYNDROME 741 0.0487
151 SEDATION 868 0.0484
152 LIVE BIRTH 228 0.0484
153 HEPATIC ENCEPHALOPATHY 348 0.0479
154 RESPIRATORY ARREST 1144 0.0476
155 LOGORRHOEA 139 0.0473
156 ESCHERICHIA URINARY TRACT INFECTION 152 0.0473
157 JOINT EFFUSION 250 0.0472
158 C-REACTIVE PROTEIN INCREASED 1155 0.0469
159 ARTERIOSCLEROSIS CORONARY ARTERY 235 0.0466
160 COVID-19 PNEUMONIA 266 0.0461
161 SEROTONIN SYNDROME 608 0.0460
162 HEART RATE IRREGULAR 835 0.0455
163 THERAPEUTIC RESPONSE SHORTENED 460 0.0453
164 APPLICATION SITE PRURITUS 828 0.0453
165 FOOD ALLERGY 183 0.0451
166 GASTROINTESTINAL DISORDER 2451 0.0448
167 APHTHOUS ULCER 195 0.0446
168 SKIN INFECTION 344 0.0445
169 HEPATIC FAILURE 1055 0.0445
170 GRIP STRENGTH DECREASED 206 0.0443
171 BLOOD PRESSURE SYSTOLIC DECREASED 142 0.0442
172 HAEMATOCRIT DECREASED 718 0.0440
173 POST-TRAUMATIC STRESS DISORDER 204 0.0439
174 SPINAL OSTEOARTHRITIS 301 0.0437
175 EAR INFECTION 747 0.0436
176 SCIATICA 435 0.0434
177 KNEE ARTHROPLASTY 545 0.0434
178 BLOOD LACTIC ACID INCREASED 154 0.0433
179 RENAL TUBULAR NECROSIS 307 0.0422
180 SCOLIOSIS 196 0.0417
181 MULTIPLE ALLERGIES 211 0.0417
182 VASCULITIS 339 0.0417
183 NIGHT SWEATS 928 0.0416
184 ACCIDENTAL EXPOSURE 173 0.0415
185 UNRESPONSIVE TO STIMULI 804 0.0414
186 ALANINE AMINOTRANSFERASE INCREASED 1968 0.0411
187 CHOLECYSTITIS CHRONIC 265 0.0408
188 BLOOD ALBUMIN DECREASED 250 0.0408
189 ENCEPHALOPATHY 714 0.0407
190 BLOOD PRESSURE INCREASED 4569 0.0407
191 SINUS TACHYCARDIA 442 0.0406
192 DRUG-INDUCED LIVER INJURY 691 0.0406
193 PERIPHERAL SWELLING 4129 0.0405
194 NASOPHARYNGITIS 5035 0.0404
195 NEUTROPHIL COUNT INCREASED 314 0.0404
196 DRUG ABUSE 2470 0.0401
197 ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED 170 0.0400
198 HEPATITIS CHOLESTATIC 177 0.0399
199 INTERNATIONAL NORMALISED RATIO INCREASED 1044 0.0398
200 SEASONAL ALLERGY 343 0.0397
201 CONCUSSION 217 0.0397
202 APPLICATION SITE SWELLING 170 0.0396
203 IMMUNODEFICIENCY 335 0.0392
204 UPPER RESPIRATORY TRACT INFECTION 1305 0.0390
205 ACUTE KIDNEY INJURY 4022 0.0389
206 PULMONARY CONGESTION 380 0.0389
207 WALKING AID USER 174 0.0388
208 ASPARTATE AMINOTRANSFERASE INCREASED 1603 0.0386
209 DRUG LEVEL INCREASED 463 0.0385
210 FEBRILE NEUTROPENIA 1715 0.0384
211 TACHYPNOEA 363 0.0384
212 OSTEOPENIA 440 0.0383
213 BRONCHIECTASIS 161 0.0382
214 HEPATITIS ACUTE 189 0.0379
215 MIGRAINE 2508 0.0376
216 ABDOMINAL TENDERNESS 146 0.0376
217 MATERNAL EXPOSURE DURING PREGNANCY 1962 0.0376
218 PRESCRIBED OVERDOSE 524 0.0373
219 OSTEOARTHRITIS 1154 0.0373
220 ASPHYXIA 214 0.0372
221 INFLAMMATION 1246 0.0369
222 HYPOTHERMIA 288 0.0369
223 BLOOD CHOLESTEROL INCREASED 1265 0.0367
224 MUSCULOSKELETAL STIFFNESS 2347 0.0366
225 INTENTIONAL DRUG MISUSE 765 0.0365
226 APPENDICITIS 231 0.0364
227 SPUTUM DISCOLOURED 240 0.0363
228 INFECTION 3529 0.0362
229 WEIGHT FLUCTUATION 233 0.0361
230 RESPIRATORY DISORDER 800 0.0360
231 PHARYNGITIS 342 0.0359
232 HYPOXIA 920 0.0359
233 BACTERAEMIA 284 0.0358
234 TRANSAMINASES INCREASED 613 0.0358
235 TUBULOINTERSTITIAL NEPHRITIS 484 0.0358
236 LEUKOCYTOSIS 481 0.0358
237 TOOTH INFECTION 331 0.0357
238 TROPONIN INCREASED 171 0.0356
239 ADRENAL INSUFFICIENCY 253 0.0355
240 CONTUSION 2470 0.0355
241 TENDERNESS 282 0.0354
242 ORAL CANDIDIASIS 321 0.0354
243 RESPIRATORY TRACT INFECTION 613 0.0354
244 HYPERCHOLESTEROLAEMIA 215 0.0353
245 MENTAL STATUS CHANGES 768 0.0352
246 MOBILITY DECREASED 1814 0.0350
247 MALNUTRITION 274 0.0350
248 AUTOIMMUNE DISORDER 176 0.0349
249 ULCER 414 0.0349
250 DRUG SCREEN POSITIVE 227 0.0349
251 PHARYNGITIS STREPTOCOCCAL 247 0.0348
252 ECCHYMOSIS 193 0.0348
253 DISTURBANCE IN ATTENTION 1481 0.0348
254 HYPOTENSION 5144 0.0347
255 COGNITIVE DISORDER 1176 0.0347
256 INTERVERTEBRAL DISC DEGENERATION 264 0.0347
257 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 912 0.0346
258 MYDRIASIS 335 0.0344
259 HEART RATE INCREASED 2483 0.0343
260 DELIRIUM 835 0.0343
261 TOOTH ABSCESS 278 0.0343
262 BLOOD ALKALINE PHOSPHATASE INCREASED 700 0.0342
263 HYPOALBUMINAEMIA 186 0.0341
264 TRICUSPID VALVE INCOMPETENCE 201 0.0341
265 CONFUSIONAL STATE 4209 0.0341
266 TACHYCARDIA 2230 0.0339
267 HYPERSENSITIVITY 4602 0.0339
268 SUICIDE ATTEMPT 1583 0.0339
269 NEUTROPENIC SEPSIS 189 0.0338
270 WEIGHT INCREASED 5455 0.0338
271 COMA 1253 0.0338
272 BRONCHITIS 1937 0.0337
273 ABDOMINAL DISCOMFORT 3915 0.0337
274 DRUG EFFECT DELAYED 153 0.0337
275 TREATMENT FAILURE 1785 0.0336
276 ECONOMIC PROBLEM 482 0.0334
277 CYSTITIS 824 0.0334
278 RHINITIS 192 0.0332
279 CARDIAC MURMUR 242 0.0332
280 EYE INFECTION 248 0.0331
281 HAEMOLYSIS 196 0.0330
282 LOCALISED INFECTION 572 0.0329
283 CARDIOMEGALY 347 0.0329
284 GASTRIC ULCER 494 0.0328
285 FAILURE TO THRIVE 139 0.0328
286 PYREXIA 8332 0.0327
287 RENAL CYST 205 0.0326
288 TYPE 2 DIABETES MELLITUS 823 0.0325
289 EOSINOPHIL COUNT INCREASED 190 0.0325
290 PULMONARY OEDEMA 1124 0.0324
291 ARTHRALGIA 9040 0.0324
292 OFF LABEL USE 15321 0.0324
293 HYPOPHOSPHATAEMIA 161 0.0323
294 UPPER-AIRWAY COUGH SYNDROME 174 0.0323
295 MAJOR DEPRESSION 171 0.0322
296 DRUG LEVEL DECREASED 211 0.0321
297 PYELONEPHRITIS 200 0.0320
298 LYMPHOEDEMA 152 0.0320
299 FOOT DEFORMITY 256 0.0320
300 MEDICATION ERROR 1376 0.0320
301 SARS-COV-2 TEST POSITIVE 188 0.0320
302 LIGAMENT SPRAIN 222 0.0320
303 BLOOD BILIRUBIN INCREASED 688 0.0320
304 LIVER FUNCTION TEST INCREASED 409 0.0320
305 HEPATIC STEATOSIS 438 0.0320
306 POST PROCEDURAL INFECTION 172 0.0319
307 RENAL INJURY 864 0.0319
308 NEURALGIA 538 0.0319
309 PULMONARY FIBROSIS 410 0.0318
310 FACIAL PARALYSIS 182 0.0318
311 GENERAL PHYSICAL HEALTH DETERIORATION 2360 0.0318
312 PHOTOPHOBIA 407 0.0316
313 BLOOD UREA INCREASED 442 0.0316
314 HYPERBILIRUBINAEMIA 233 0.0315
315 POSTOPERATIVE WOUND INFECTION 147 0.0315
316 POOR QUALITY SLEEP 468 0.0315
317 ULCER HAEMORRHAGE 162 0.0315
318 CLOSTRIDIUM DIFFICILE COLITIS 245 0.0314
319 ACUTE RESPIRATORY DISTRESS SYNDROME 415 0.0314
320 NODULE 289 0.0313
321 MYOCARDITIS 203 0.0313
322 ACCIDENTAL OVERDOSE 801 0.0313
323 THROAT IRRITATION 974 0.0313
324 FLANK PAIN 218 0.0312
325 CELLULITIS 1199 0.0311
326 CARDIAC ARREST 2045 0.0310
327 HYPOVOLAEMIA 140 0.0310
328 CHOLESTASIS 426 0.0310
329 EMPHYSEMA 249 0.0310
330 SMALL INTESTINAL OBSTRUCTION 277 0.0308
331 ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS 179 0.0307
332 TUMOUR LYSIS SYNDROME 175 0.0307
333 ACUTE RESPIRATORY FAILURE 399 0.0306
334 ARTHROPOD BITE 161 0.0306
335 RIB FRACTURE 464 0.0306
336 PSEUDOMONAS INFECTION 176 0.0306
337 HEPATOMEGALY 245 0.0306
338 RESPIRATORY DISTRESS 655 0.0306
339 PRODUCT ADHESION ISSUE 729 0.0305
340 ANAL INCONTINENCE 157 0.0305
341 DENTAL CARIES 263 0.0305
342 UROSEPSIS 203 0.0305
343 HYPOKALAEMIA 1012 0.0304
344 OLIGURIA 147 0.0303
345 HYPERTHERMIA 179 0.0303
346 HYPERTENSION 4651 0.0303
347 LIP DRY 144 0.0302
348 CARDIOGENIC SHOCK 286 0.0301
349 BREAST MASS 152 0.0301
350 PALLOR 571 0.0301
351 URINARY TRACT INFECTION 3573 0.0300
352 CHOLELITHIASIS 771 0.0300
353 PNEUMONIA ASPIRATION 543 0.0299
354 CONDITION AGGRAVATED 5612 0.0299
355 MITRAL VALVE INCOMPETENCE 265 0.0299
356 JOINT INJURY 457 0.0299
357 LIVER FUNCTION TEST ABNORMAL 760 0.0299
358 EXOSTOSIS 200 0.0299
359 GENERALISED OEDEMA 262 0.0299
360 BLOOD CREATININE INCREASED 1493 0.0297
361 RENAL FAILURE ACUTE 1261 0.0297
362 HEPATITIS 560 0.0295
363 OVERDOSE 4810 0.0295
364 RENAL FAILURE 3268 0.0295
365 ARTERIOSCLEROSIS 221 0.0294
366 COELIAC DISEASE 208 0.0294
367 SOMNAMBULISM 158 0.0294
368 GASTROENTERITIS 320 0.0294
369 PRODUCTIVE COUGH 936 0.0294
370 OSTEOPOROSIS 919 0.0293
371 SINUS CONGESTION 289 0.0292
372 PULMONARY MASS 301 0.0292
373 ABSCESS 329 0.0292
374 DECUBITUS ULCER 185 0.0292
375 HIATUS HERNIA 305 0.0292
376 KIDNEY INFECTION 407 0.0292
377 HYDRONEPHROSIS 161 0.0291
378 ESCHERICHIA INFECTION 162 0.0291
379 ATRIOVENTRICULAR BLOCK COMPLETE 148 0.0291
380 OBESITY 317 0.0291
381 CYST 263 0.0290
382 APPLICATION SITE RASH 343 0.0290
383 BLOOD MAGNESIUM DECREASED 173 0.0290
384 OESOPHAGITIS 241 0.0289
385 RED BLOOD CELL COUNT DECREASED 586 0.0288
386 HEAD DISCOMFORT 340 0.0287
387 NERVE COMPRESSION 190 0.0285
388 TOOTHACHE 381 0.0285
389 VITAMIN D DEFICIENCY 201 0.0285
390 DIVERTICULUM 182 0.0284
391 HAEMOGLOBIN DECREASED 2216 0.0284
392 STEVENS-JOHNSON SYNDROME 509 0.0283
393 FOOT FRACTURE 408 0.0283
394 COLITIS ISCHAEMIC 143 0.0283
395 CLOSTRIDIUM DIFFICILE INFECTION 411 0.0283
396 JOINT DISLOCATION 213 0.0282
397 GAMMA-GLUTAMYLTRANSFERASE INCREASED 514 0.0282
398 MUSCULOSKELETAL CHEST PAIN 321 0.0282
399 ATRIAL FLUTTER 179 0.0282
400 APNOEA 179 0.0282
401 LARYNGITIS 211 0.0282
402 HERPES ZOSTER 1211 0.0281
403 PERIPHERAL COLDNESS 296 0.0280
404 GASTROENTERITIS VIRAL 344 0.0280
405 ANHEDONIA 615 0.0279
406 WRIST FRACTURE 255 0.0279
407 PLATELET COUNT INCREASED 258 0.0279
408 DIVERTICULITIS 558 0.0279
409 NEPHROLITHIASIS 904 0.0279
410 HAEMATEMESIS 555 0.0278
411 SINUS BRADYCARDIA 208 0.0278
412 MULTI-ORGAN FAILURE 482 0.0278
413 ORAL HERPES 354 0.0278
414 ILLNESS 730 0.0278
415 NEPHROPATHY 212 0.0276
416 ARTHRITIS 1536 0.0275
417 INITIAL INSOMNIA 194 0.0275
418 HYPONATRAEMIA 1174 0.0275
419 AGITATION 1654 0.0275
420 GLOMERULAR FILTRATION RATE DECREASED 202 0.0275
421 BLOOD URINE PRESENT 405 0.0275
422 HALLUCINATION, VISUAL 392 0.0275
423 APPLICATION SITE PAIN 486 0.0275
424 CHILLS 2373 0.0275
425 ERYTHEMA MULTIFORME 197 0.0274
426 HAEMODYNAMIC INSTABILITY 139 0.0273
427 GASTROOESOPHAGEAL REFLUX DISEASE 1591 0.0272
428 SEPSIS 2261 0.0272
429 TEMPERATURE INTOLERANCE 188 0.0271
430 ABNORMAL BEHAVIOUR 920 0.0270
431 BRADYCARDIA 1127 0.0270
432 ASPIRATION 210 0.0270
433 ABDOMINAL PAIN 4583 0.0269
434 INTERVERTEBRAL DISC PROTRUSION 462 0.0269
435 TOOTH DISORDER 466 0.0269
436 HERNIA 358 0.0269
437 AGGRESSION 1097 0.0269
438 MUSCLE RIGIDITY 243 0.0269
439 VIRAL INFECTION 611 0.0268
440 NECK PAIN 1120 0.0268
441 PAIN 12212 0.0268
442 CHOLECYSTITIS 239 0.0268
443 PNEUMONIA BACTERIAL 145 0.0267
444 TOOTH FRACTURE 230 0.0267
445 HYPERAESTHESIA 177 0.0267
446 PETECHIAE 210 0.0267
447 LIMB INJURY 484 0.0266
448 MOUTH HAEMORRHAGE 142 0.0264
449 PLEURAL EFFUSION 1233 0.0264
450 SOMNOLENCE 3957 0.0263
451 MOUTH ULCERATION 388 0.0263
452 MYOSITIS 160 0.0263
453 GASTROINTESTINAL INFECTION 161 0.0262
454 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 945 0.0262
455 BLOOD IRON DECREASED 200 0.0262
456 GASTRITIS 524 0.0261
457 SPINAL DISORDER 184 0.0259
458 HAEMORRHOIDS 387 0.0259
459 BACK PAIN 4462 0.0259
460 MUSCULOSKELETAL PAIN 1200 0.0258
461 DISSEMINATED INTRAVASCULAR COAGULATION 294 0.0258
462 INFLUENZA 1905 0.0258
463 ABDOMINAL PAIN UPPER 3799 0.0257
464 CONJUNCTIVITIS 291 0.0257
465 UVEITIS 205 0.0257
466 CYANOSIS 315 0.0256
467 OEDEMA 1005 0.0256
468 SLEEP DISORDER 1229 0.0256
469 MYOCLONUS 235 0.0256
470 AFFECT LABILITY 207 0.0255
471 BACTERIAL INFECTION 321 0.0255
472 ASCITES 564 0.0255
473 BLOOD SODIUM DECREASED 356 0.0255
474 BLOOD LACTATE DEHYDROGENASE INCREASED 332 0.0255
475 WHITE BLOOD CELL COUNT INCREASED 765 0.0255
476 IRON DEFICIENCY ANAEMIA 175 0.0255
477 BLOOD PRESSURE DECREASED 1252 0.0255
478 NAIL DISORDER 144 0.0254
479 HAEMODIALYSIS 203 0.0254
480 COORDINATION ABNORMAL 302 0.0254
481 URINE OUTPUT DECREASED 179 0.0254
482 PNEUMONIA 5822 0.0254
483 HEADACHE 11750 0.0254
484 OROPHARYNGEAL PAIN 1635 0.0253
485 WHEEZING 1012 0.0253
486 LUNG INFILTRATION 196 0.0253
487 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 1912 0.0252
488 MULTIPLE ORGAN DYSFUNCTION SYNDROME 407 0.0251
489 SINUS DISORDER 356 0.0251
490 PURPURA 175 0.0251
491 RASH 7514 0.0251
492 PNEUMONITIS 443 0.0250
493 FEELING JITTERY 385 0.0250
494 FISTULA 188 0.0249
495 VENTRICULAR FIBRILLATION 218 0.0249
496 NASAL CONGESTION 978 0.0248
497 SPINAL COMPRESSION FRACTURE 169 0.0248
498 SPLENOMEGALY 219 0.0248
499 SUPRAVENTRICULAR TACHYCARDIA 185 0.0247
500 GALLBLADDER DISORDER 357 0.0247
501 WEIGHT DECREASED 4989 0.0246
502 DRUG INTERACTION 2966 0.0246
503 STRESS 1262 0.0246
504 BALANCE DISORDER 1631 0.0246
505 DRUG ABUSER 148 0.0246
506 EXPOSURE DURING PREGNANCY 1039 0.0245
507 RESPIRATORY FAILURE 1379 0.0245
508 PULMONARY HYPERTENSION 405 0.0245
509 FATIGUE 13337 0.0245
510 URINARY INCONTINENCE 550 0.0244
511 INTENTIONAL PRODUCT MISUSE 1522 0.0243
512 LYMPHOPENIA 243 0.0243
513 ALOPECIA 3624 0.0243
514 COLITIS 593 0.0243
515 THERAPEUTIC RESPONSE UNEXPECTED 848 0.0243
516 NEUTROPHIL COUNT DECREASED 638 0.0242
517 PSYCHOTIC DISORDER 550 0.0242
518 DEVICE ADHESION ISSUE 199 0.0242
519 PROTEINURIA 306 0.0242
520 CANDIDA INFECTION 262 0.0241
521 PRESYNCOPE 425 0.0241
522 RECTAL HAEMORRHAGE 814 0.0240
523 CHEST DISCOMFORT 1754 0.0240
524 COUGH 4562 0.0239
525 CATARACT 991 0.0239
526 BLADDER DISORDER 187 0.0239
527 VOMITING 8124 0.0239
528 EAR DISCOMFORT 171 0.0239
529 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 213 0.0238
530 HYPOTHYROIDISM 512 0.0238
531 CONSTIPATION 3519 0.0238
532 URTICARIA 2789 0.0237
533 ANAPHYLACTIC REACTION 875 0.0237
534 HAEMORRHAGIC STROKE 152 0.0237
535 RASH MACULO-PAPULAR 372 0.0237
536 JAUNDICE 527 0.0237
537 GAIT INABILITY 439 0.0237
538 HYPERKALAEMIA 626 0.0237
539 PRURITUS 5684 0.0237
540 BLOOD POTASSIUM INCREASED 292 0.0236
541 PULMONARY HAEMORRHAGE 152 0.0236
542 LETHARGY 1069 0.0236
543 SCRATCH 141 0.0236
544 ELECTROCARDIOGRAM ABNORMAL 145 0.0236
545 RESTLESSNESS 661 0.0235
546 HAEMATOMA 492 0.0235
547 ATRIAL FIBRILLATION 1693 0.0235
548 LIPASE INCREASED 139 0.0235
549 RENAL FAILURE CHRONIC 181 0.0235
550 SEPTIC SHOCK 726 0.0235
551 EOSINOPHILIA 290 0.0235
552 FALL 5766 0.0235
553 TONGUE DISORDER 141 0.0234
554 THERAPY NON-RESPONDER 563 0.0234
555 MELAENA 404 0.0233
556 GLAUCOMA 335 0.0232
557 FACIAL PAIN 146 0.0232
558 INJURY 1362 0.0232
559 FEELING COLD 485 0.0232
560 MUSCULOSKELETAL DISCOMFORT 286 0.0232
561 ELECTROLYTE IMBALANCE 185 0.0231
562 SKIN ULCER 447 0.0231
563 DEFORMITY 167 0.0231
564 LIVER DISORDER 743 0.0230
565 SCHIZOPHRENIA 189 0.0230
566 RESTLESS LEGS SYNDROME 320 0.0230
567 DECREASED APPETITE 3683 0.0229
568 DERMATITIS CONTACT 181 0.0229
569 SHOCK 378 0.0229
570 JOINT STIFFNESS 436 0.0229
571 RENAL PAIN 176 0.0229
572 PRODUCT USE ISSUE 2894 0.0229
573 PRODUCT USE IN UNAPPROVED INDICATION 3042 0.0228
574 BACK INJURY 168 0.0228
575 LUNG DISORDER 786 0.0228
576 BLOOD TEST ABNORMAL 215 0.0228
577 ILEUS 204 0.0227
578 ALTERED STATE OF CONSCIOUSNESS 336 0.0227
579 INCREASED APPETITE 277 0.0227
580 DISEASE RECURRENCE 396 0.0227
581 BLOOD CREATINE PHOSPHOKINASE INCREASED 542 0.0226
582 DECREASED ACTIVITY 158 0.0226
583 ROTATOR CUFF SYNDROME 226 0.0226
584 THROMBOCYTOPENIA 1807 0.0226
585 CHEST PAIN 3256 0.0226
586 RASH ERYTHEMATOUS 680 0.0226
587 BRAIN INJURY 164 0.0224
588 RHABDOMYOLYSIS 708 0.0224
589 COVID-19 1530 0.0224
590 PSORIATIC ARTHROPATHY 494 0.0224
591 PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY 140 0.0224
592 DYSKINESIA 695 0.0224
593 FUNGAL INFECTION 536 0.0224
594 STAPHYLOCOCCAL INFECTION 587 0.0223
595 BASAL CELL CARCINOMA 254 0.0223
596 ANKLE FRACTURE 260 0.0223
597 INSOMNIA 4548 0.0223
598 MASS 240 0.0223
599 URINARY RETENTION 546 0.0222
600 DYSPNOEA EXERTIONAL 568 0.0222
601 PANCYTOPENIA 907 0.0222
602 THROAT TIGHTNESS 447 0.0222
603 HAEMOPTYSIS 478 0.0220
604 HYPOMAGNESAEMIA 206 0.0220
605 UPPER GASTROINTESTINAL HAEMORRHAGE 296 0.0220
606 DEHYDRATION 2245 0.0220
607 OSTEOMYELITIS 320 0.0220
608 GOUT 288 0.0220
609 VITAMIN D DECREASED 146 0.0220
610 BLOOD POTASSIUM DECREASED 504 0.0220
611 INCONTINENCE 176 0.0219
612 ELECTROCARDIOGRAM QT PROLONGED 580 0.0219
613 ROAD TRAFFIC ACCIDENT 683 0.0218
614 HYPOGLYCAEMIA 829 0.0217
615 PNEUMOTHORAX 246 0.0217
616 HYPERHIDROSIS 2130 0.0217
617 ANAEMIA 3128 0.0217
618 DIPLOPIA 408 0.0216
619 HYPERCALCAEMIA 197 0.0216
620 OVARIAN CYST 180 0.0215
621 VENTRICULAR EXTRASYSTOLES 177 0.0215
622 VENTRICULAR TACHYCARDIA 267 0.0215
623 DYSPEPSIA 1514 0.0214
624 PARANOIA 293 0.0214
625 INJECTION SITE EXTRAVASATION 238 0.0214
626 ANURIA 151 0.0214
627 ANXIETY 4684 0.0214
628 MUSCLE TWITCHING 379 0.0213
629 DYSPNOEA 8914 0.0213
630 INCREASED TENDENCY TO BRUISE 154 0.0213
631 PERICARDIAL EFFUSION 350 0.0213
632 HYPOAESTHESIA 2394 0.0213
633 OBSTRUCTIVE AIRWAYS DISORDER 173 0.0213
634 OEDEMA PERIPHERAL 2126 0.0213
635 DIABETES MELLITUS INADEQUATE CONTROL 287 0.0212
636 POST PROCEDURAL COMPLICATION 317 0.0212
637 ASTHENIA 5843 0.0212
638 BEDRIDDEN 208 0.0212
639 DYSPHAGIA 1448 0.0211
640 DEPRESSED MOOD 798 0.0211
641 LYMPHADENOPATHY 547 0.0211
642 PULMONARY EMBOLISM 1627 0.0211
643 LEUKOPENIA 783 0.0210
644 DEVICE RELATED INFECTION 261 0.0210
645 ATAXIA 197 0.0210
646 HAEMOLYTIC ANAEMIA 148 0.0210
647 DEPENDENCE 158 0.0210
648 MUSCULAR WEAKNESS 1774 0.0210
649 SCAR 278 0.0210
650 PAIN IN EXTREMITY 4689 0.0209
651 SUBARACHNOID HAEMORRHAGE 160 0.0209
652 BIPOLAR DISORDER 186 0.0208
653 LOWER LIMB FRACTURE 264 0.0208
654 PREGNANCY 362 0.0208
655 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 824 0.0208
656 DYSARTHRIA 607 0.0208
657 HYPOPHAGIA 374 0.0207
658 GROIN PAIN 141 0.0207
659 NAUSEA 11917 0.0207
660 HEAD INJURY 476 0.0207
661 PLATELET COUNT DECREASED 1570 0.0207
662 PAIN IN JAW 462 0.0207
663 HAEMATOCHEZIA 757 0.0207
664 PARAESTHESIA ORAL 212 0.0207
665 EJECTION FRACTION DECREASED 232 0.0206
666 HYPERLIPIDAEMIA 204 0.0206
667 DEEP VEIN THROMBOSIS 1129 0.0206
668 GRAND MAL CONVULSION 190 0.0205
669 RHINORRHOEA 917 0.0205
670 SYNCOPE 1570 0.0205
671 PANCREATITIS ACUTE 333 0.0204
672 HYPOKINESIA 229 0.0204
673 FEEDING DISORDER 242 0.0204
674 FACE OEDEMA 265 0.0202
675 MYOCARDIAL ISCHAEMIA 200 0.0202
676 DRY THROAT 149 0.0202
677 DRUG ERUPTION 247 0.0202
678 HALLUCINATION, AUDITORY 235 0.0201
679 CARPAL TUNNEL SYNDROME 208 0.0201
680 HYPERGLYCAEMIA 562 0.0201
681 AGRANULOCYTOSIS 245 0.0201
682 DEPRESSION 3675 0.0201
683 EUPHORIC MOOD 167 0.0201
684 SKIN LESION 382 0.0200
685 FEELING HOT 908 0.0200
686 SUDDEN DEATH 181 0.0200
687 WHITE BLOOD CELL COUNT DECREASED 1527 0.0200
688 DRUG HYPERSENSITIVITY 2985 0.0199
689 DRY EYE 535 0.0199
690 HAEMATURIA 554 0.0199
691 HEPATOCELLULAR INJURY 245 0.0199
692 THYROID DISORDER 217 0.0198
693 MICTURITION URGENCY 167 0.0198
694 BLOOD PRESSURE ABNORMAL 256 0.0198
695 GASTRIC DISORDER 617 0.0197
696 ORAL PAIN 333 0.0196
697 DISABILITY 272 0.0196
698 CRYING 589 0.0196
699 GENERALISED TONIC-CLONIC SEIZURE 213 0.0196
700 NEUTROPENIA 1741 0.0195
701 MUSCLE TIGHTNESS 244 0.0195
702 PALPITATIONS 1693 0.0194
703 CIRCULATORY COLLAPSE 270 0.0194
704 INCORRECT PRODUCT ADMINISTRATION DURATION 226 0.0194
705 TOXIC SKIN ERUPTION 146 0.0194
706 ASTHMA 1358 0.0193
707 NEPHROPATHY TOXIC 142 0.0193
708 DRY MOUTH 1127 0.0192
709 DELUSION 216 0.0192
710 APHONIA 187 0.0192
711 TOOTH LOSS 316 0.0192
712 HEMIPARESIS 263 0.0191
713 EYE DISORDER 445 0.0191
714 HEPATIC FUNCTION ABNORMAL 490 0.0191
715 HALLUCINATION 1023 0.0191
716 DYSURIA 538 0.0190
717 FAECES DISCOLOURED 313 0.0188
718 SKIN REACTION 193 0.0188
719 RENAL IMPAIRMENT 1102 0.0187
720 METASTASES TO BONE 198 0.0187
721 DRUG INEFFECTIVE 17587 0.0187
722 SKIN DISORDER 413 0.0187
723 FLUID OVERLOAD 274 0.0187
724 LOSS OF CONSCIOUSNESS 1836 0.0187
725 HYPERSOMNIA 390 0.0187
726 ACCIDENT 154 0.0186
727 PRESCRIBED UNDERDOSE 242 0.0186
728 GAIT DISTURBANCE 2687 0.0186
729 IRRITABILITY 914 0.0186
730 SPINAL FRACTURE 259 0.0185
731 ACUTE MYOCARDIAL INFARCTION 453 0.0185
732 MOTOR DYSFUNCTION 139 0.0185
733 ABDOMINAL DISTENSION 1381 0.0185
734 NERVE INJURY 162 0.0185
735 STATUS EPILEPTICUS 155 0.0184
736 LIMB DISCOMFORT 405 0.0184
737 TINNITUS 629 0.0184
738 TRANSFUSION 145 0.0183
739 HIP FRACTURE 428 0.0183
740 INTESTINAL PERFORATION 152 0.0183
741 EATING DISORDER 289 0.0182
742 INTENTIONAL SELF-INJURY 279 0.0182
743 GASTRIC HAEMORRHAGE 177 0.0182
744 PANIC ATTACK 504 0.0181
745 FLUSHING 1503 0.0181
746 TENDONITIS 223 0.0181
747 PULMONARY THROMBOSIS 139 0.0181
748 BONE DISORDER 275 0.0181
749 CHOLECYSTECTOMY 151 0.0181
750 BONE DENSITY DECREASED 477 0.0181
751 HUNGER 139 0.0180
752 DIARRHOEA 8044 0.0180
753 DISORIENTATION 587 0.0180
754 CARDIOMYOPATHY 208 0.0180
755 TREMOR 2314 0.0180
756 ECZEMA 347 0.0179
757 APATHY 195 0.0179
758 SPINAL PAIN 149 0.0179
759 APHASIA 416 0.0178
760 VERTIGO 845 0.0178
761 SCAB 143 0.0177
762 DIZZINESS 6508 0.0177
763 MALAISE 5949 0.0177
764 HYPOCALCAEMIA 242 0.0176
765 DYSSTASIA 387 0.0176
766 NEUROPATHY PERIPHERAL 1116 0.0175
767 ARRHYTHMIA 653 0.0175
768 ANGER 485 0.0175
769 DYSTONIA 284 0.0174
770 COLD SWEAT 236 0.0174
771 UPPER LIMB FRACTURE 274 0.0174
772 FLUID RETENTION 668 0.0173
773 GINGIVAL BLEEDING 166 0.0173
774 ANGINA PECTORIS 407 0.0173
775 CHROMATURIA 304 0.0173
776 THIRST 207 0.0172
777 RETCHING 267 0.0172
778 TREATMENT NONCOMPLIANCE 609 0.0172
779 SUBDURAL HAEMATOMA 199 0.0172
780 CHOKING 239 0.0171
781 DERMATITIS ALLERGIC 142 0.0171
782 EPISTAXIS 974 0.0171
783 NEUROLEPTIC MALIGNANT SYNDROME 157 0.0171
784 LACRIMATION INCREASED 330 0.0171
785 LUNG INFECTION 267 0.0171
786 AMNESIA 895 0.0170
787 SUICIDAL IDEATION 1222 0.0170
788 DEVICE DIFFICULT TO USE 328 0.0168
789 BRONCHOSPASM 188 0.0168
790 LACTIC ACIDOSIS 358 0.0168
791 DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS 280 0.0167
792 EYE PAIN 595 0.0167
793 LACERATION 157 0.0167
794 GASTROINTESTINAL HAEMORRHAGE 1184 0.0166
795 MUCOSAL INFLAMMATION 315 0.0166
796 SWELLING FACE 807 0.0165
797 INTESTINAL OBSTRUCTION 424 0.0165
798 MUSCULOSKELETAL DISORDER 244 0.0165
799 SPEECH DISORDER 676 0.0165
800 COLITIS ULCERATIVE 400 0.0165
801 PARAESTHESIA 1944 0.0164
802 IMMUNE SYSTEM DISORDER 155 0.0164
803 MUSCLE ATROPHY 144 0.0164
804 SEIZURE 1208 0.0163
805 HOT FLUSH 838 0.0163
806 INTERSTITIAL LUNG DISEASE 546 0.0162
807 INFLUENZA LIKE ILLNESS 1084 0.0162
808 ERYTHEMA 2480 0.0162
809 PREMATURE BABY 375 0.0162
810 SKIN DISCOLOURATION 567 0.0162
811 MENTAL DISORDER 534 0.0161
812 ADVERSE DRUG REACTION 924 0.0161
813 HYPERTHYROIDISM 166 0.0161
814 POST PROCEDURAL HAEMORRHAGE 150 0.0161
815 DEMENTIA 297 0.0160
816 TRANSIENT ISCHAEMIC ATTACK 435 0.0160
817 MYALGIA 2044 0.0160
818 LIP SWELLING 396 0.0160
819 BONE PAIN 718 0.0160
820 IMPAIRED DRIVING ABILITY 146 0.0159
821 MANIA 206 0.0159
822 MOOD ALTERED 328 0.0159
823 RENAL DISORDER 545 0.0158
824 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 525 0.0158
825 MIDDLE INSOMNIA 209 0.0158
826 PHOTOSENSITIVITY REACTION 197 0.0157
827 THERAPEUTIC RESPONSE DECREASED 667 0.0157
828 DEVICE BREAKAGE 282 0.0156
829 PANCREATITIS 646 0.0156
830 CORONARY ARTERY DISEASE 424 0.0155
831 RESPIRATORY TRACT CONGESTION 173 0.0155
832 CONVULSION 889 0.0155
833 FEAR 360 0.0155
834 BACK DISORDER 187 0.0155
835 ABDOMINAL PAIN LOWER 301 0.0154
836 HYPOAESTHESIA ORAL 176 0.0154
837 POLLAKIURIA 486 0.0154
838 TENDON RUPTURE 153 0.0154
839 PARALYSIS 172 0.0154
840 BONE LOSS 188 0.0153
841 NERVOUSNESS 671 0.0153
842 SNEEZING 225 0.0152
843 THROMBOSIS 954 0.0152
844 PRODUCT DOSE OMISSION ISSUE 1270 0.0152
845 MUSCLE SPASMS 2094 0.0152
846 MOVEMENT DISORDER 369 0.0152
847 EMOTIONAL DISORDER 374 0.0151
848 METASTASES TO LIVER 186 0.0151
849 VISION BLURRED 1490 0.0151
850 UNDERDOSE 811 0.0151
851 ANOREXIA 193 0.0150
852 SENSORY DISTURBANCE 197 0.0150
853 WITHDRAWAL SYNDROME 447 0.0150
854 SWOLLEN TONGUE 365 0.0149
855 QUALITY OF LIFE DECREASED 149 0.0149
856 CEREBRAL HAEMORRHAGE 409 0.0148
857 RASH PRURITIC 565 0.0146
858 EXPIRED PRODUCT ADMINISTERED 354 0.0146
859 PRODUCT SUBSTITUTION ISSUE 648 0.0146
860 CENTRAL NERVOUS SYSTEM LESION 170 0.0146
861 ACUTE MYELOID LEUKAEMIA 166 0.0145
862 FEELING ABNORMAL 2730 0.0145
863 HEPATIC CIRRHOSIS 189 0.0145
864 DYSPHONIA 619 0.0145
865 ISCHAEMIC STROKE 201 0.0144
866 FEMUR FRACTURE 366 0.0144
867 CARDIAC FAILURE 860 0.0142
868 CYTOMEGALOVIRUS INFECTION 175 0.0142
869 CORONARY ARTERY OCCLUSION 166 0.0142
870 ANGIOEDEMA 457 0.0141
871 RASH MACULAR 339 0.0141
872 SKIN FISSURES 139 0.0141
873 HAEMORRHAGE INTRACRANIAL 177 0.0141
874 FREQUENT BOWEL MOVEMENTS 227 0.0141
875 UNEVALUABLE EVENT 852 0.0140
876 MENTAL IMPAIRMENT 258 0.0139
877 EYELID OEDEMA 140 0.0139
878 MEMORY IMPAIRMENT 1401 0.0138
879 ANAPHYLACTIC SHOCK 244 0.0138
880 BURNING SENSATION 735 0.0138
881 IMPAIRED WORK ABILITY 238 0.0137
882 DIABETES MELLITUS 826 0.0137
883 PHARYNGEAL OEDEMA 206 0.0137
884 NIGHTMARE 373 0.0137
885 LYMPHOMA 157 0.0136
886 INCORRECT DOSE ADMINISTERED 1764 0.0136
887 DIALYSIS 155 0.0136
888 MOOD SWINGS 353 0.0136
889 MULTIPLE FRACTURES 182 0.0136
890 PREMATURE DELIVERY 154 0.0133
891 PRURITUS GENERALISED 289 0.0133
892 PELVIC PAIN 188 0.0133
893 THERAPY CESSATION 459 0.0133
894 VISUAL IMPAIRMENT 1113 0.0133
895 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 1647 0.0132
896 BLOOD TRIGLYCERIDES INCREASED 187 0.0132
897 PERITONITIS 214 0.0130
898 LABORATORY TEST ABNORMAL 276 0.0130
899 DRUG DOSE OMISSION 2142 0.0129
900 FOETAL EXPOSURE DURING PREGNANCY 752 0.0129
901 HAEMORRHAGE 971 0.0129
902 PULMONARY ARTERIAL HYPERTENSION 150 0.0129
903 EYE SWELLING 346 0.0128
904 DISEASE PROGRESSION 1001 0.0128
905 FULL BLOOD COUNT DECREASED 168 0.0128
906 DEAFNESS 239 0.0128
907 DRUG EXPOSURE DURING PREGNANCY 432 0.0127
908 CARDIAC FAILURE CONGESTIVE 905 0.0126
909 SURGERY 453 0.0126
910 MYELODYSPLASTIC SYNDROME 139 0.0125
911 FLATULENCE 523 0.0125
912 ACTIVITIES OF DAILY LIVING IMPAIRED 247 0.0125
913 NEUROTOXICITY 143 0.0124
914 RASH GENERALISED 322 0.0124
915 DRUG EFFECT DECREASED 666 0.0123
916 MULTIPLE SCLEROSIS 449 0.0123
917 EPILEPSY 259 0.0123
918 EXTRA DOSE ADMINISTERED 238 0.0122
919 SKIN CANCER 180 0.0122
920 EMOTIONAL DISTRESS 1295 0.0122
921 BLINDNESS 350 0.0121
922 CEREBRAL INFARCTION 228 0.0120
923 MULTIPLE SCLEROSIS RELAPSE 673 0.0118
924 NERVOUS SYSTEM DISORDER 307 0.0118
925 PLASMA CELL MYELOMA 316 0.0117
926 PRODUCT PRESCRIBING ERROR 148 0.0116
927 MALIGNANT NEOPLASM PROGRESSION 783 0.0116
928 DYSGEUSIA 639 0.0116
929 NO THERAPEUTIC RESPONSE 141 0.0115
930 DERMATITIS 156 0.0114
931 ADVERSE EVENT 801 0.0114
932 PROCEDURAL PAIN 223 0.0113
933 RASH PAPULAR 201 0.0113
934 CARDIAC DISORDER 829 0.0112
935 FRACTURE 162 0.0112
936 THERAPY INTERRUPTED 219 0.0111
937 CEREBROVASCULAR ACCIDENT 1510 0.0111
938 PRODUCT PHYSICAL ISSUE 145 0.0111
939 BLOOD COUNT ABNORMAL 179 0.0110
940 OSTEONECROSIS 309 0.0109
941 THINKING ABNORMAL 165 0.0108
942 NEOPLASM PROGRESSION 256 0.0107
943 BONE MARROW FAILURE 190 0.0105
944 DEATH 6403 0.0105
945 ABASIA 247 0.0100
946 OCULAR HYPERAEMIA 302 0.0100
947 DRUG DEPENDENCE 1379 0.0099
948 EYE PRURITUS 189 0.0099
949 HYPOACUSIS 272 0.0097
950 ABORTION SPONTANEOUS 305 0.0096
951 DRUG EFFECT INCOMPLETE 350 0.0096
952 NEEDLE ISSUE 139 0.0096
953 HOSPITALISATION 887 0.0095
954 LOCAL SWELLING 165 0.0094
955 MYOCARDIAL INFARCTION 1431 0.0094
956 NEOPLASM MALIGNANT 436 0.0093
957 ABNORMAL DREAMS 209 0.0089
958 BLOOD GLUCOSE DECREASED 343 0.0089
959 CARDIOVASCULAR DISORDER 193 0.0086
960 SKIN EXFOLIATION 476 0.0084
961 OSTEONECROSIS OF JAW 175 0.0084
962 ACCIDENTAL EXPOSURE TO PRODUCT 380 0.0082
963 DIABETIC KETOACIDOSIS 146 0.0080
964 VISUAL ACUITY REDUCED 234 0.0079
965 BLOOD GLUCOSE INCREASED 1166 0.0078
966 VAGINAL HAEMORRHAGE 276 0.0077
967 ERECTILE DYSFUNCTION 144 0.0077
968 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 548 0.0077
969 EYE IRRITATION 265 0.0077
970 PHARMACEUTICAL PRODUCT COMPLAINT 198 0.0076
971 AGEUSIA 138 0.0075
972 PAIN OF SKIN 155 0.0074
973 MENORRHAGIA 142 0.0072
974 ACNE 440 0.0072
975 EXTRAPYRAMIDAL DISORDER 156 0.0070
976 PRODUCT DOSE OMISSION 455 0.0068
977 TARDIVE DYSKINESIA 173 0.0068
978 DRUG WITHDRAWAL SYNDROME 545 0.0068
979 DRY SKIN 609 0.0068
980 INJECTION SITE REACTION 332 0.0065
981 INJECTION SITE ERYTHEMA 597 0.0064
982 INJECTION SITE SWELLING 317 0.0061
983 LUNG NEOPLASM MALIGNANT 194 0.0059
984 PSORIASIS 551 0.0059
985 INJECTION SITE PRURITUS 281 0.0058
986 DEVICE ISSUE 299 0.0057
987 INJECTION SITE MASS 140 0.0056
988 INJECTION SITE PAIN 1078 0.0054
989 INJECTION SITE BRUISING 292 0.0053
990 SKIN IRRITATION 193 0.0053
991 DEVICE DISLOCATION 166 0.0051
992 INJECTION SITE HAEMORRHAGE 265 0.0049
993 BREAST CANCER 384 0.0046
994 PRODUCT STORAGE ERROR 142 0.0045
995 INCORRECT ROUTE OF DRUG ADMINISTRATION 143 0.0040
996 DEVICE MALFUNCTION 150 0.0037
997 SKIN BURNING SENSATION 170 0.0030
998 PROSTATE CANCER 152 0.0024