Drug Side Effects

Kinase Inhibitor [EPC]

Kinase Inhibitor [EPC] was reported 529992 times

Drugs of the Kinase Inhibitor [EPC] class are most commonly taken among patients reporting these side effects:

# Drug class Count Frequency
0 EGFR GENE MUTATION 311 0.8544
1 ACQUIRED GENE MUTATION 673 0.5213
2 NEOPLASM PROGRESSION 16239 0.4733
3 TRYPTASE INCREASED 263 0.4021
4 CARBOHYDRATE ANTIGEN 15-3 INCREASED 252 0.3424
5 MYELOFIBROSIS 941 0.3270
6 METASTASES TO MENINGES 668 0.3160
7 HAEMATOCRIT ABNORMAL 366 0.3139
8 TUMOUR MARKER INCREASED 1346 0.2899
9 MANTLE CELL LYMPHOMA 411 0.2892
10 HEPATOCELLULAR CARCINOMA 2011 0.2754
11 METASTASES TO PLEURA 264 0.2697
12 LYMPHANGIOSIS CARCINOMATOSA 265 0.2661
13 NON-SMALL CELL LUNG CANCER 1159 0.2596
14 METASTASES TO ADRENALS 225 0.2542
15 METASTATIC RENAL CELL CARCINOMA 454 0.2503
16 PARONYCHIA 1009 0.2483
17 WHITE BLOOD CELL COUNT ABNORMAL 1488 0.2446
18 METASTASES TO CENTRAL NERVOUS SYSTEM 2960 0.2438
19 POLYOMAVIRUS VIRAEMIA 228 0.2431
20 RED BLOOD CELL COUNT ABNORMAL 323 0.2322
21 MALIGNANT PLEURAL EFFUSION 376 0.2318
22 CHRONIC LYMPHOCYTIC LEUKAEMIA 1053 0.2289
23 ONYCHOCLASIS 1478 0.2265
24 POLYOMAVIRUS-ASSOCIATED NEPHROPATHY 483 0.2244
25 PLATELET COUNT ABNORMAL 1232 0.2153
26 MEDICAL PROCEDURE 314 0.2145
27 PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME 4809 0.2143
28 TUMOUR PAIN 269 0.2118
29 METASTASES TO SKIN 207 0.2117
30 SPLENOMEGALY 2327 0.2070
31 MALIGNANT NEOPLASM PROGRESSION 19699 0.2053
32 SECOND PRIMARY MALIGNANCY 1592 0.1985
33 METASTASES TO BONE 3010 0.1936
34 BLOOD COUNT ABNORMAL 2937 0.1933
35 CARCINOEMBRYONIC ANTIGEN INCREASED 356 0.1930
36 CANCER PAIN 471 0.1929
37 METASTASES TO LUNG 2096 0.1907
38 HEPATIC NEOPLASM MALIGNANT 398 0.1878
39 STOMATITIS 10842 0.1869
40 FULL BLOOD COUNT ABNORMAL 1861 0.1860
41 LYMPHOCYTOSIS 376 0.1827
42 METASTASES TO SPINE 576 0.1815
43 NEUROENDOCRINE TUMOUR 242 0.1779
44 CHRONIC GRAFT VERSUS HOST DISEASE 612 0.1755
45 HAEMATOCRIT INCREASED 382 0.1755
46 METASTASES TO LIVER 2900 0.1734
47 BREAST CANCER METASTATIC 1767 0.1726
48 GRAFT VERSUS HOST DISEASE IN GASTROINTESTINAL TRACT 350 0.1719
49 SPLEEN DISORDER 279 0.1697
50 SKIN TOXICITY 876 0.1686
51 GRAFT VERSUS HOST DISEASE IN SKIN 352 0.1665
52 BK VIRUS INFECTION 523 0.1639
53 GENE MUTATION 308 0.1624
54 DERMATITIS ACNEIFORM 914 0.1602
55 RENAL CELL CARCINOMA 751 0.1577
56 METASTASES TO PERITONEUM 373 0.1577
57 PLATELET COUNT INCREASED 1969 0.1571
58 HYPERKERATOSIS 828 0.1566
59 WHITE BLOOD CELL COUNT DECREASED 16259 0.1559
60 TUMOUR HAEMORRHAGE 412 0.1536
61 CYTOPENIA 1681 0.1528
62 FULL BLOOD COUNT DECREASED 2907 0.1502
63 METASTASES TO LYMPH NODES 957 0.1498
64 RED BLOOD CELL COUNT DECREASED 4098 0.1488
65 HAEMOGLOBIN ABNORMAL 890 0.1469
66 PNEUMONITIS 3678 0.1438
67 DRUG RESISTANCE 3496 0.1421
68 NAIL DISORDER 1165 0.1418
69 ASPERGILLUS INFECTION 840 0.1368
70 DISEASE PROGRESSION 15343 0.1365
71 INCREASED TENDENCY TO BRUISE 1216 0.1361
72 METASTASIS 930 0.1349
73 EARLY SATIETY 233 0.1327
74 ORAL PAIN 2826 0.1306
75 CYTOMEGALOVIRUS INFECTION REACTIVATION 491 0.1295
76 HEPATIC LESION 528 0.1292
77 NEOPLASM RECURRENCE 418 0.1279
78 WHITE BLOOD CELL DISORDER 328 0.1254
79 LYMPHOCYTE COUNT INCREASED 394 0.1252
80 LYMPHOEDEMA 812 0.1237
81 HEPATIC ENCEPHALOPATHY 1114 0.1234
82 GRAFT VERSUS HOST DISEASE 851 0.1217
83 SQUAMOUS CELL CARCINOMA OF SKIN 696 0.1211
84 BLOOD BLISTER 352 0.1165
85 HAEMORRHAGIC DIATHESIS 403 0.1164
86 ADENOVIRUS INFECTION 312 0.1160
87 RED BLOOD CELL COUNT INCREASED 306 0.1155
88 HOSPICE CARE 1064 0.1139
89 MEAN CELL VOLUME INCREASED 279 0.1137
90 SQUAMOUS CELL CARCINOMA 1007 0.1117
91 HAEMOGLOBIN INCREASED 472 0.1116
92 LUNG ADENOCARCINOMA 322 0.1111
93 GASTROINTESTINAL TOXICITY 482 0.1105
94 PLEURAL EFFUSION 6476 0.1105
95 PROTEINURIA 1949 0.1098
96 ACUTE MYELOID LEUKAEMIA RECURRENT 213 0.1082
97 INGROWING NAIL 244 0.1076
98 PLATELET COUNT DECREASED 10977 0.1075
99 POST TRANSPLANT LYMPHOPROLIFERATIVE DISORDER 494 0.1063
100 OESOPHAGEAL VARICES HAEMORRHAGE 222 0.1061
101 NEUTROPHIL COUNT DECREASED 3975 0.1033
102 ASCITES 2891 0.1024
103 WHITE BLOOD CELL COUNT INCREASED 3792 0.1020
104 HAEMATOTOXICITY 879 0.1018
105 TUMOUR LYSIS SYNDROME 836 0.1007
106 APHTHOUS ULCER 726 0.1001
107 ORAL MUCOSAL BLISTERING 612 0.0995
108 BONE MARROW DISORDER 285 0.0988
109 MUCOSAL INFLAMMATION 2462 0.0988
110 NEOPLASM 1081 0.0980
111 SKIN PAPILLOMA 374 0.0967
112 ACUTE GRAFT VERSUS HOST DISEASE 428 0.0966
113 PLATELET DISORDER 233 0.0963
114 PRODUCT AVAILABILITY ISSUE 1990 0.0957
115 BONE LESION 328 0.0953
116 RED CELL DISTRIBUTION WIDTH INCREASED 379 0.0951
117 HAEMOTHORAX 265 0.0945
118 PERIORBITAL SWELLING 467 0.0934
119 AMYLASE INCREASED 326 0.0932
120 NEUTROPHIL COUNT ABNORMAL 248 0.0926
121 THROMBOTIC MICROANGIOPATHY 840 0.0922
122 TASTE DISORDER 1696 0.0917
123 BONE MARROW FAILURE 1801 0.0905
124 NAIL DISCOLOURATION 337 0.0900
125 NEUTROPENIA 11596 0.0897
126 DECREASED ACTIVITY 907 0.0887
127 AMMONIA INCREASED 435 0.0885
128 DECREASED IMMUNE RESPONSIVENESS 816 0.0883
129 TRANSPLANT REJECTION 683 0.0882
130 MOUTH ULCERATION 1766 0.0881
131 LUNG OPACITY 205 0.0881
132 BREAST CANCER RECURRENT 262 0.0874
133 HAEMOGLOBIN DECREASED 8661 0.0873
134 INTERSTITIAL LUNG DISEASE 4007 0.0871
135 BLOOD TEST ABNORMAL 1156 0.0864
136 PNEUMATOSIS INTESTINALIS 234 0.0863
137 PETECHIAE 841 0.0854
138 HEPATIC FUNCTION ABNORMAL 2983 0.0848
139 PERICARDIAL EFFUSION 1831 0.0834
140 HYPERTRIGLYCERIDAEMIA 460 0.0825
141 ACUTE GRAFT VERSUS HOST DISEASE IN SKIN 215 0.0822
142 BRONCHOPULMONARY ASPERGILLOSIS 604 0.0816
143 HEPATIC NEOPLASM 257 0.0815
144 DECREASED APPETITE 17965 0.0815
145 PNEUMONIA FUNGAL 294 0.0805
146 RECURRENT CANCER 309 0.0805
147 THERAPY PARTIAL RESPONDER 1077 0.0801
148 PULMONARY TOXICITY 533 0.0800
149 HYPERURICAEMIA 313 0.0796
150 PORTAL VEIN THROMBOSIS 242 0.0787
151 TONGUE ULCERATION 253 0.0776
152 RENAL FUNCTION TEST ABNORMAL 339 0.0776
153 EPSTEIN-BARR VIRUS INFECTION 457 0.0772
154 BLOOD URIC ACID INCREASED 424 0.0772
155 EPISTAXIS 5538 0.0770
156 GASTROINTESTINAL PERFORATION 307 0.0769
157 MYELOSUPPRESSION 2239 0.0766
158 BLOOD IRON DECREASED 843 0.0757
159 MELANOCYTIC NAEVUS 318 0.0753
160 PNEUMOCYSTIS JIROVECII PNEUMONIA 712 0.0752
161 METASTATIC NEOPLASM 307 0.0748
162 CACHEXIA 366 0.0743
163 THYROIDITIS 208 0.0736
164 BLOOD BILIRUBIN INCREASED 1917 0.0734
165 BRAIN FOG 880 0.0732
166 ONYCHOMADESIS 282 0.0731
167 HYPOALBUMINAEMIA 527 0.0730
168 SUNBURN 525 0.0728
169 HAEMORRHAGE SUBCUTANEOUS 252 0.0727
170 HAEMATOCRIT DECREASED 1410 0.0727
171 DEATH 59442 0.0721
172 POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME 646 0.0719
173 BLOOD LACTATE DEHYDROGENASE INCREASED 1111 0.0717
174 DIARRHOEA 43739 0.0716
175 CHOLANGITIS 414 0.0716
176 PROTEIN TOTAL DECREASED 257 0.0713
177 LYMPHADENOPATHY 2409 0.0710
178 URINARY TRACT DISORDER 304 0.0705
179 PNEUMOTHORAX 1068 0.0704
180 HYPOGAMMAGLOBULINAEMIA 408 0.0703
181 APPETITE DISORDER 427 0.0702
182 FEEDING DISORDER 1290 0.0702
183 THROMBOCYTOPENIA 7456 0.0700
184 CYTOMEGALOVIRUS VIRAEMIA 285 0.0700
185 CARDIAC DYSFUNCTION 239 0.0698
186 MASS 933 0.0691
187 HEPATOTOXICITY 1457 0.0691
188 BLOOD CREATININE ABNORMAL 224 0.0691
189 ANAEMIA 12658 0.0690
190 AUTOIMMUNE HAEMOLYTIC ANAEMIA 219 0.0687
191 LABORATORY TEST ABNORMAL 1933 0.0685
192 HYPOPHOSPHATAEMIA 476 0.0682
193 HYPOTHYROIDISM 2061 0.0679
194 PULMONARY MASS 965 0.0679
195 ADRENAL INSUFFICIENCY 759 0.0677
196 BONE PAIN 3756 0.0669
197 BONE CANCER 282 0.0668
198 IMMUNOSUPPRESSANT DRUG LEVEL INCREASED 212 0.0668
199 CONTUSION 6138 0.0667
200 HEPATIC PAIN 273 0.0667
201 DYSPHONIA 3715 0.0664
202 WOUND HAEMORRHAGE 239 0.0664
203 THERAPY CHANGE 593 0.0664
204 LIVER ABSCESS 203 0.0658
205 BLOOD ALBUMIN DECREASED 496 0.0654
206 ATRIAL FIBRILLATION 6109 0.0653
207 PRODUCT DOSE OMISSION IN ERROR 1538 0.0652
208 SKIN MASS 403 0.0644
209 ENTEROCOLITIS 344 0.0642
210 LIPASE INCREASED 470 0.0642
211 THROMBOCYTOSIS 220 0.0641
212 FATIGUE 47549 0.0641
213 GINGIVAL PAIN 487 0.0640
214 NEPHROTIC SYNDROME 419 0.0639
215 BLOOD MAGNESIUM DECREASED 526 0.0638
216 BRAIN NEOPLASM 560 0.0637
217 CYTOMEGALOVIRUS INFECTION 1014 0.0637
218 BLOOD DISORDER 493 0.0636
219 TRANSFUSION 644 0.0635
220 EATING DISORDER 1309 0.0635
221 HYPERTRANSAMINASAEMIA 391 0.0635
222 BLOOD SODIUM DECREASED 1143 0.0634
223 GLOSSITIS 214 0.0630
224 LUNG INFILTRATION 542 0.0623
225 DEHYDRATION 7910 0.0618
226 SKIN ATROPHY 338 0.0617
227 DIFFUSE LARGE B-CELL LYMPHOMA 436 0.0616
228 TONGUE DISCOMFORT 246 0.0615
229 KIDNEY TRANSPLANT REJECTION 287 0.0613
230 CYSTITIS HAEMORRHAGIC 236 0.0611
231 LEUKOPENIA 2907 0.0610
232 ORGANISING PNEUMONIA 282 0.0608
233 ALOPECIA 11492 0.0607
234 HEPATIC FAILURE 1761 0.0607
235 MOUTH HAEMORRHAGE 426 0.0606
236 BLOOD CREATININE INCREASED 3824 0.0606
237 NASAL DRYNESS 362 0.0605
238 PERFORMANCE STATUS DECREASED 272 0.0602
239 HEPATIC ENZYME ABNORMAL 283 0.0597
240 SKIN LESION 1540 0.0596
241 FLUID INTAKE REDUCED 275 0.0595
242 GENERALISED OEDEMA 698 0.0595
243 PROSTATOMEGALY 221 0.0587
244 ORAL DISORDER 414 0.0587
245 LEUKAEMIA 532 0.0587
246 PHOTOSENSITIVITY REACTION 929 0.0586
247 PERIORBITAL OEDEMA 289 0.0583
248 BASAL CELL CARCINOMA 874 0.0582
249 ECCHYMOSIS 385 0.0581
250 CARDIAC TAMPONADE 265 0.0580
251 HAEMOPTYSIS 1557 0.0580
252 TRANSAMINASES INCREASED 1232 0.0579
253 CHRONIC MYELOID LEUKAEMIA 256 0.0575
254 LIVER FUNCTION TEST INCREASED 1151 0.0574
255 HYPERBILIRUBINAEMIA 562 0.0574
256 CHEILITIS 297 0.0572
257 NIGHT SWEATS 1754 0.0571
258 PROTEIN URINE PRESENT 271 0.0570
259 HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS 376 0.0569
260 GINGIVAL BLEEDING 746 0.0568
261 SKIN CANCER 1162 0.0565
262 MUSCULOSKELETAL CHEST PAIN 833 0.0562
263 SKIN DISORDER 1772 0.0560
264 BLOOD CALCIUM DECREASED 610 0.0559
265 SKIN ULCER 1384 0.0558
266 BLOOD CREATINE INCREASED 237 0.0557
267 IMMUNE SYSTEM DISORDER 701 0.0557
268 PNEUMONIA BACTERIAL 480 0.0557
269 ODYNOPHAGIA 311 0.0556
270 LYMPHOCYTE COUNT DECREASED 939 0.0550
271 CHOLECYSTITIS 621 0.0550
272 IMMUNODEFICIENCY 754 0.0547
273 FAECES SOFT 371 0.0547
274 HEPATOMEGALY 519 0.0543
275 ACUTE MYELOID LEUKAEMIA 806 0.0543
276 ASPARTATE AMINOTRANSFERASE INCREASED 2761 0.0541
277 EYE OPERATION 225 0.0538
278 FEBRILE NEUTROPENIA 3395 0.0538
279 PIGMENTATION DISORDER 316 0.0536
280 OSTEONECROSIS OF JAW 1298 0.0536
281 INTESTINAL PERFORATION 574 0.0535
282 OESOPHAGITIS 559 0.0535
283 PULMONARY OEDEMA 2305 0.0535
284 HYPERTENSION 10844 0.0534
285 LUNG NEOPLASM 223 0.0532
286 LUNG DISORDER 2493 0.0532
287 RENAL IMPAIRMENT 4233 0.0530
288 IMMUNE THROMBOCYTOPENIA 216 0.0527
289 CARDIOTOXICITY 440 0.0527
290 DYSLIPIDAEMIA 256 0.0525
291 LIVER DISORDER 2214 0.0522
292 ASTHENIA 18820 0.0522
293 ESCHERICHIA URINARY TRACT INFECTION 213 0.0521
294 HYPOPHAGIA 1249 0.0520
295 HYPERCALCAEMIA 613 0.0520
296 CONSTIPATION 10606 0.0519
297 HAIR COLOUR CHANGES 634 0.0518
298 ONYCHOMYCOSIS 214 0.0517
299 PRODUCT DISTRIBUTION ISSUE 388 0.0517
300 PANCYTOPENIA 2743 0.0516
301 GOUT 885 0.0514
302 LYMPHOPENIA 683 0.0511
303 GLOMERULAR FILTRATION RATE DECREASED 581 0.0511
304 CHAPPED LIPS 213 0.0510
305 IMMUNOSUPPRESSION 411 0.0510
306 ELECTROLYTE IMBALANCE 554 0.0510
307 PULMONARY HAEMORRHAGE 385 0.0509
308 BLISTER 2717 0.0508
309 BLOOD POTASSIUM INCREASED 791 0.0508
310 COVID-19 PNEUMONIA 580 0.0507
311 SKIN FISSURES 867 0.0507
312 PULMONARY THROMBOSIS 530 0.0505
313 PATHOLOGICAL FRACTURE 246 0.0505
314 BLOOD POTASSIUM DECREASED 1454 0.0502
315 BLOOD THYROID STIMULATING HORMONE INCREASED 446 0.0502
316 BLOOD ALKALINE PHOSPHATASE INCREASED 1196 0.0496
317 GAMMA-GLUTAMYLTRANSFERASE INCREASED 1063 0.0496
318 HYPERCHOLESTEROLAEMIA 447 0.0496
319 ATRIAL FLUTTER 381 0.0496
320 AGEUSIA 1183 0.0493
321 BRAIN OEDEMA 595 0.0492
322 EMBOLISM 397 0.0491
323 HAEMORRHAGIC STROKE 373 0.0490
324 NEPHROPATHY TOXIC 515 0.0490
325 IRON DEFICIENCY 205 0.0490
326 YELLOW SKIN 221 0.0489
327 ALANINE AMINOTRANSFERASE INCREASED 2879 0.0488
328 APHONIA 649 0.0487
329 ENTEROCOCCAL INFECTION 225 0.0486
330 GLOSSODYNIA 1035 0.0486
331 ENERGY INCREASED 279 0.0486
332 EJECTION FRACTION DECREASED 726 0.0485
333 GASTROINTESTINAL MOTILITY DISORDER 242 0.0485
334 PSEUDOMONAS INFECTION 387 0.0484
335 NEUROPATHY PERIPHERAL 4320 0.0483
336 PERIPHERAL SWELLING 7037 0.0482
337 HAIR GROWTH ABNORMAL 318 0.0480
338 LARGE INTESTINE PERFORATION 319 0.0479
339 LACRIMATION INCREASED 1341 0.0476
340 MULTIPLE ORGAN DYSFUNCTION SYNDROME 1227 0.0476
341 COLITIS 1689 0.0475
342 CHOLECYSTITIS ACUTE 258 0.0474
343 LEUKOCYTOSIS 813 0.0471
344 HYDRONEPHROSIS 336 0.0470
345 CEREBRAL DISORDER 332 0.0470
346 BLOOD CALCIUM INCREASED 394 0.0469
347 SKIN INFECTION 498 0.0469
348 BLOOD PRESSURE ABNORMAL 883 0.0468
349 FAILURE TO THRIVE 237 0.0468
350 ERYTHEMA MULTIFORME 418 0.0467
351 HEPATIC CYTOLYSIS 500 0.0463
352 RASH PUSTULAR 328 0.0462
353 DISEASE COMPLICATION 204 0.0459
354 HAIR TEXTURE ABNORMAL 602 0.0458
355 ENCEPHALITIS 301 0.0458
356 ESCHERICHIA INFECTION 353 0.0455
357 ERYSIPELAS 221 0.0455
358 ATELECTASIS 426 0.0454
359 OEDEMA 2354 0.0454
360 OFF LABEL USE 36877 0.0452
361 IMPAIRED HEALING 1421 0.0452
362 WEIGHT DECREASED 12069 0.0451
363 BLOOD URINE PRESENT 827 0.0450
364 RENAL CYST 344 0.0449
365 KLEBSIELLA INFECTION 214 0.0448
366 HAEMATEMESIS 1092 0.0446
367 MALNUTRITION 466 0.0443
368 BLOOD PRESSURE INCREASED 6504 0.0442
369 PNEUMONIA 13608 0.0442
370 RENAL DISORDER 1985 0.0442
371 PULMONARY ALVEOLAR HAEMORRHAGE 236 0.0441
372 HYPOACUSIS 1802 0.0440
373 DRY SKIN 5405 0.0439
374 NEOPLASM MALIGNANT 2791 0.0437
375 PURPURA 368 0.0432
376 DYSPHAGIA 3895 0.0432
377 INTERNAL HAEMORRHAGE 475 0.0431
378 LEFT VENTRICULAR DYSFUNCTION 272 0.0430
379 CANDIDA INFECTION 674 0.0429
380 RASH 17630 0.0428
381 HAEMATURIA 1414 0.0427
382 SKIN LACERATION 434 0.0426
383 CEREBRAL HAEMORRHAGE 1461 0.0425
384 DYSPNOEA EXERTIONAL 1517 0.0425
385 HAEMORRHOIDAL HAEMORRHAGE 202 0.0424
386 ILLNESS 3843 0.0424
387 SEPSIS 4533 0.0424
388 HAEMORRHAGE 4242 0.0423
389 HEPATITIS 1039 0.0423
390 PLEURISY 245 0.0423
391 LUNG INFECTION 657 0.0423
392 HYPERLIPIDAEMIA 488 0.0422
393 MALIGNANT MELANOMA 544 0.0421
394 BLOOD UREA INCREASED 688 0.0421
395 ARTHROPOD BITE 298 0.0420
396 GINGIVITIS 218 0.0419
397 PYREXIA 13942 0.0419
398 HYPOCALCAEMIA 751 0.0418
399 SKIN HAEMORRHAGE 553 0.0415
400 LUNG NEOPLASM MALIGNANT 1659 0.0414
401 ACUTE RESPIRATORY FAILURE 749 0.0412
402 HAEMATOMA 1032 0.0410
403 SPINAL PAIN 461 0.0410
404 GENERAL PHYSICAL HEALTH DETERIORATION 4428 0.0408
405 OEDEMA PERIPHERAL 4823 0.0408
406 CARDIAC FAILURE ACUTE 258 0.0408
407 SUBDURAL HAEMATOMA 563 0.0407
408 RESPIRATORY FAILURE 2849 0.0407
409 SEPTIC SHOCK 1670 0.0406
410 UROSEPSIS 354 0.0404
411 CARDIAC FAILURE 3110 0.0404
412 POST PROCEDURAL HAEMORRHAGE 451 0.0402
413 INFECTION 5516 0.0402
414 FLATULENCE 2157 0.0402
415 THROMBOSIS 3110 0.0400
416 NAUSEA 30061 0.0399
417 SKIN DISCOLOURATION 1755 0.0399
418 HERPES SIMPLEX 245 0.0399
419 MYOCARDITIS 421 0.0398
420 ORAL DISCOMFORT 532 0.0398
421 CARDIOMYOPATHY 566 0.0396
422 ULCER 605 0.0395
423 BACTERAEMIA 440 0.0394
424 URINARY TRACT INFECTION 6399 0.0394
425 TONGUE DISORDER 279 0.0394
426 RETINAL DETACHMENT 346 0.0394
427 HYPERAESTHESIA 316 0.0393
428 BACTERIAL INFECTION 692 0.0392
429 TERMINAL STATE 253 0.0391
430 DRY MOUTH 3018 0.0391
431 HYPERSOMNIA 1070 0.0391
432 HYPERGLYCAEMIA 1361 0.0390
433 GENERAL PHYSICAL CONDITION ABNORMAL 255 0.0389
434 HIP FRACTURE 1190 0.0388
435 SUDDEN DEATH 401 0.0387
436 BOWEL MOVEMENT IRREGULARITY 278 0.0386
437 JAUNDICE 1004 0.0385
438 DRUG INTOLERANCE 3520 0.0384
439 NECROSIS 206 0.0384
440 EYE HAEMORRHAGE 495 0.0384
441 CATARACT 2166 0.0384
442 HYPOKALAEMIA 1669 0.0381
443 HOT FLUSH 2766 0.0381
444 SCAB 410 0.0380
445 PULMONARY EMBOLISM 3488 0.0379
446 THYROID DISORDER 557 0.0378
447 ENTERITIS 227 0.0378
448 CEREBRAL INFARCTION 889 0.0377
449 COUGH 10039 0.0377
450 CELLULITIS 1828 0.0376
451 LOCALISED INFECTION 873 0.0376
452 PHOTOPSIA 226 0.0375
453 NODULE 472 0.0375
454 VOMITING 16749 0.0375
455 INCREASED APPETITE 648 0.0375
456 GAIT INABILITY 1162 0.0374
457 COVID-19 6417 0.0374
458 SENSITIVE SKIN 247 0.0373
459 HEPATIC ENZYME INCREASED 2411 0.0372
460 HYPOXIA 1243 0.0371
461 C-REACTIVE PROTEIN INCREASED 1290 0.0370
462 RASH MACULO-PAPULAR 781 0.0370
463 ILEUS 434 0.0370
464 BLOOD TRIGLYCERIDES INCREASED 631 0.0369
465 HERPES VIRUS INFECTION 204 0.0369
466 MUSCLE STRAIN 305 0.0367
467 BLOOD PRESSURE SYSTOLIC INCREASED 692 0.0367
468 DUODENAL ULCER 247 0.0365
469 CYSTITIS 1127 0.0364
470 HEPATOCELLULAR INJURY 499 0.0363
471 RASH MACULAR 1199 0.0362
472 DIZZINESS POSTURAL 327 0.0362
473 HYPERTHYROIDISM 496 0.0362
474 LYMPHOMA 540 0.0362
475 CONCOMITANT DISEASE AGGRAVATED 214 0.0361
476 ORAL HERPES 666 0.0360
477 PRODUCT DOSE OMISSION 2379 0.0359
478 CLOSTRIDIUM DIFFICILE COLITIS 364 0.0359
479 DYSGEUSIA 2592 0.0358
480 SURGERY 1932 0.0358
481 BREAST PAIN 367 0.0356
482 MEMORY IMPAIRMENT 4705 0.0356
483 ACUTE CORONARY SYNDROME 288 0.0355
484 OCULAR DISCOMFORT 355 0.0355
485 ELECTROCARDIOGRAM QT PROLONGED 1217 0.0355
486 HERPES ZOSTER 1963 0.0354
487 SPINAL COMPRESSION FRACTURE 294 0.0354
488 HERNIA 646 0.0352
489 HAEMOLYTIC ANAEMIA 303 0.0352
490 TOOTHACHE 611 0.0352
491 TOOTH EXTRACTION 423 0.0352
492 MENINGITIS 224 0.0351
493 FACIAL PARALYSIS 280 0.0351
494 HEPATITIS B 205 0.0350
495 FLUID RETENTION 1709 0.0349
496 CLOSTRIDIUM DIFFICILE INFECTION 714 0.0348
497 DYSPEPSIA 3236 0.0347
498 FLANK PAIN 310 0.0346
499 GASTRIC HAEMORRHAGE 390 0.0346
500 HEAD DISCOMFORT 578 0.0345
501 FEELING COLD 925 0.0345
502 GASTRIC ULCER 632 0.0344
503 GASTROENTERITIS 479 0.0344
504 LIVER FUNCTION TEST ABNORMAL 976 0.0344
505 RESPIRATORY SYNCYTIAL VIRUS INFECTION 267 0.0342
506 BREAST MASS 221 0.0342
507 FAECES DISCOLOURED 712 0.0342
508 THERAPY CESSATION 1659 0.0342
509 GASTRITIS 856 0.0339
510 HAEMORRHOIDS 637 0.0339
511 MYOSITIS 287 0.0338
512 ABDOMINAL PAIN 7499 0.0338
513 PYELONEPHRITIS 277 0.0336
514 RETINAL HAEMORRHAGE 229 0.0336
515 SMALL INTESTINAL OBSTRUCTION 392 0.0336
516 ABDOMINAL DISTENSION 3316 0.0336
517 POOR QUALITY SLEEP 683 0.0335
518 FURUNCLE 256 0.0335
519 URINE OUTPUT DECREASED 283 0.0335
520 NEUTROPHIL COUNT INCREASED 333 0.0335
521 ABDOMINAL DISCOMFORT 5327 0.0334
522 PRODUCTIVE COUGH 1488 0.0334
523 PAROSMIA 240 0.0333
524 VITAMIN D DECREASED 274 0.0333
525 FACE OEDEMA 544 0.0333
526 DISSEMINATED INTRAVASCULAR COAGULATION 454 0.0333
527 HYPONATRAEMIA 1795 0.0332
528 HAEMOLYSIS 246 0.0332
529 BLOOD CREATINE PHOSPHOKINASE INCREASED 950 0.0331
530 SEASONAL ALLERGY 441 0.0331
531 MYELODYSPLASTIC SYNDROME 458 0.0329
532 TOOTH DISORDER 710 0.0328
533 SKIN REACTION 439 0.0328
534 BLOOD CHOLESTEROL INCREASED 1463 0.0327
535 MUSCLE SPASMS 5737 0.0326
536 RASH PRURITIC 1671 0.0326
537 HICCUPS 252 0.0326
538 ABDOMINAL PAIN UPPER 6372 0.0326
539 ABNORMAL FAECES 254 0.0325
540 MYALGIA 5292 0.0325
541 IRON DEFICIENCY ANAEMIA 284 0.0325
542 LIP DRY 271 0.0325
543 VIRAL INFECTION 1023 0.0324
544 ANAL INCONTINENCE 269 0.0324
545 DEMENTIA 853 0.0324
546 DRUG ERUPTION 542 0.0324
547 GASTROENTERITIS VIRAL 556 0.0323
548 DRY THROAT 310 0.0320
549 PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY 254 0.0320
550 CORONAVIRUS INFECTION 206 0.0320
551 DECUBITUS ULCER 250 0.0320
552 SCIATICA 479 0.0318
553 HYPOMAGNESAEMIA 420 0.0318
554 CENTRAL NERVOUS SYSTEM LESION 428 0.0318
555 RIB FRACTURE 625 0.0318
556 APHASIA 920 0.0316
557 ORAL CANDIDIASIS 391 0.0316
558 LIMB INJURY 816 0.0315
559 DEAFNESS 789 0.0315
560 DYSURIA 1118 0.0315
561 SKIN EXFOLIATION 2462 0.0315
562 TENDERNESS 318 0.0315
563 PRODUCT DOSE OMISSION ISSUE 7899 0.0314
564 MALAISE 13269 0.0313
565 HAEMORRHAGE INTRACRANIAL 454 0.0312
566 DRUG-INDUCED LIVER INJURY 893 0.0312
567 OROPHARYNGEAL PAIN 2763 0.0311
568 POLYNEUROPATHY 350 0.0311
569 ACUTE RESPIRATORY DISTRESS SYNDROME 525 0.0310
570 RENAL TUBULAR NECROSIS 291 0.0310
571 TOOTH INFECTION 392 0.0310
572 ARTHRALGIA 12168 0.0308
573 BACK PAIN 6863 0.0307
574 PULMONARY FIBROSIS 557 0.0307
575 DIVERTICULITIS 808 0.0307
576 SINUS DISORDER 581 0.0306
577 DERMATITIS 588 0.0304
578 PAIN IN EXTREMITY 8595 0.0302
579 BONE DISORDER 539 0.0302
580 ENCEPHALOPATHY 702 0.0302
581 TOOTH FRACTURE 322 0.0302
582 CYTOKINE RELEASE SYNDROME 504 0.0301
583 DRY EYE 1340 0.0301
584 BODY TEMPERATURE DECREASED 290 0.0301
585 ACUTE KIDNEY INJURY 4338 0.0300
586 HYPERTENSIVE CRISIS 321 0.0300
587 PELVIC FRACTURE 222 0.0300
588 CHOLESTASIS 544 0.0299
589 BODY HEIGHT DECREASED 315 0.0298
590 RENAL PAIN 302 0.0297
591 SPINAL FRACTURE 563 0.0297
592 DRUG LEVEL DECREASED 293 0.0296
593 WOUND 782 0.0296
594 LARYNGITIS 307 0.0296
595 MUSCULOSKELETAL DISCOMFORT 487 0.0296
596 SPINAL OPERATION 332 0.0295
597 DYSPNOEA 16003 0.0295
598 KIDNEY INFECTION 555 0.0295
599 RESPIRATORY TRACT INFECTION 725 0.0295
600 DIARRHOEA HAEMORRHAGIC 265 0.0294
601 ALTERED STATE OF CONSCIOUSNESS 602 0.0294
602 SUPRAVENTRICULAR TACHYCARDIA 270 0.0293
603 RENAL FAILURE 3797 0.0292
604 MELAENA 622 0.0292
605 DEVICE RELATED INFECTION 436 0.0292
606 WEIGHT FLUCTUATION 289 0.0292
607 LIMB DISCOMFORT 866 0.0292
608 LIVER INJURY 654 0.0291
609 TOXIC SKIN ERUPTION 282 0.0291
610 LIGAMENT SPRAIN 273 0.0289
611 NERVE COMPRESSION 255 0.0289
612 RASH GENERALISED 748 0.0288
613 LOW DENSITY LIPOPROTEIN INCREASED 211 0.0288
614 INTESTINAL OBSTRUCTION 1021 0.0288
615 COGNITIVE DISORDER 1278 0.0287
616 HOSPITALISATION 4123 0.0287
617 NEPHROLITHIASIS 1249 0.0287
618 UPPER-AIRWAY COUGH SYNDROME 222 0.0286
619 PRODUCT USE IN UNAPPROVED INDICATION 6511 0.0285
620 GASTROINTESTINAL DISORDER 2355 0.0285
621 MACULAR DEGENERATION 324 0.0285
622 CHILLS 3217 0.0285
623 PRODUCT USE COMPLAINT 405 0.0284
624 HEPATIC CIRRHOSIS 501 0.0282
625 PERIPHERAL COLDNESS 372 0.0282
626 WOUND INFECTION 288 0.0282
627 SUBARACHNOID HAEMORRHAGE 276 0.0281
628 GASTROINTESTINAL INFECTION 238 0.0280
629 FRUSTRATION TOLERANCE DECREASED 212 0.0279
630 EYE INFECTION 299 0.0279
631 BACK DISORDER 439 0.0279
632 BLOOD PRESSURE FLUCTUATION 646 0.0278
633 THYROID CANCER 326 0.0278
634 OROPHARYNGEAL DISCOMFORT 232 0.0278
635 GROIN PAIN 236 0.0278
636 CARDIAC DISORDER 2513 0.0277
637 DRUG LEVEL INCREASED 442 0.0277
638 GASTROINTESTINAL PAIN 288 0.0277
639 INCONTINENCE 282 0.0277
640 POLLAKIURIA 1099 0.0276
641 APPENDICITIS 242 0.0275
642 STAPHYLOCOCCAL INFECTION 878 0.0275
643 FALL 8741 0.0275
644 FUNGAL INFECTION 875 0.0274
645 RHINORRHOEA 1677 0.0274
646 MUSCULOSKELETAL PAIN 1407 0.0273
647 SCRATCH 263 0.0272
648 UVEITIS 350 0.0272
649 RETCHING 552 0.0272
650 ACNE 2002 0.0272
651 TEMPERATURE INTOLERANCE 263 0.0270
652 VITREOUS FLOATERS 249 0.0270
653 PULMONARY CONGESTION 343 0.0269
654 UPPER RESPIRATORY TRACT INFECTION 1180 0.0267
655 FOLLICULITIS 256 0.0267
656 INTENTIONAL DOSE OMISSION 647 0.0266
657 NOCTURIA 307 0.0265
658 DEPRESSED MOOD 1329 0.0265
659 MENTAL STATUS CHANGES 709 0.0265
660 DEEP VEIN THROMBOSIS 1672 0.0264
661 SWELLING FACE 1644 0.0264
662 HEAD INJURY 797 0.0264
663 NASOPHARYNGITIS 4633 0.0263
664 NEURALGIA 607 0.0263
665 GASTROOESOPHAGEAL REFLUX DISEASE 2004 0.0263
666 CHOLELITHIASIS 823 0.0263
667 PANCREATITIS ACUTE 557 0.0263
668 HAEMATOCHEZIA 1373 0.0262
669 PRODUCT USE ISSUE 4617 0.0262
670 SARS-COV-2 TEST POSITIVE 341 0.0261
671 CARDIOMEGALY 315 0.0261
672 CONFUSIONAL STATE 4058 0.0261
673 DRUG INTERACTION 3970 0.0261
674 UPPER GASTROINTESTINAL HAEMORRHAGE 424 0.0260
675 ERUCTATION 448 0.0260
676 GASTROINTESTINAL HAEMORRHAGE 2111 0.0259
677 INFLAMMATION 1259 0.0259
678 FRACTURE 471 0.0258
679 DIPLOPIA 640 0.0258
680 INFLUENZA 2703 0.0257
681 EAR PAIN 481 0.0257
682 EYE DISORDER 805 0.0257
683 RESPIRATORY DISORDER 738 0.0257
684 CYST 307 0.0256
685 PHOTOPHOBIA 457 0.0256
686 PRODUCT DISPENSING ERROR 518 0.0255
687 SPEECH DISORDER 1284 0.0255
688 PERICARDITIS 398 0.0255
689 HYPERKALAEMIA 849 0.0254
690 DIZZINESS 12120 0.0254
691 PNEUMONIA ASPIRATION 605 0.0254
692 MYOPATHY 211 0.0253
693 ISCHAEMIC STROKE 435 0.0253
694 TRANSIENT ISCHAEMIC ATTACK 828 0.0253
695 PAIN OF SKIN 656 0.0253
696 MUSCULAR WEAKNESS 2754 0.0253
697 PANCREATITIS 1279 0.0252
698 THERAPY NON-RESPONDER 1049 0.0251
699 WEIGHT INCREASED 5316 0.0251
700 GASTRIC DISORDER 859 0.0250
701 GALLBLADDER DISORDER 428 0.0249
702 RASH PAPULAR 537 0.0248
703 DENTAL CARIES 265 0.0248
704 CHROMATURIA 536 0.0247
705 HEMIPARESIS 406 0.0247
706 BALANCE DISORDER 2058 0.0247
707 ACUTE MYOCARDIAL INFARCTION 705 0.0246
708 PRURITUS 8680 0.0246
709 BLADDER DISORDER 236 0.0246
710 EAR DISCOMFORT 241 0.0246
711 SLUGGISHNESS 239 0.0245
712 BODY TEMPERATURE INCREASED 484 0.0244
713 DIABETES MELLITUS 1800 0.0243
714 SEIZURE 2614 0.0242
715 TOOTH ABSCESS 240 0.0242
716 SWELLING 2158 0.0242
717 BLINDNESS 940 0.0242
718 ARRHYTHMIA 1108 0.0242
719 SINUS CONGESTION 313 0.0241
720 CONJUNCTIVITIS 416 0.0240
721 UPPER LIMB FRACTURE 463 0.0240
722 EMOTIONAL DISORDER 713 0.0239
723 SPINAL DISORDER 218 0.0238
724 PRODUCT PRESCRIBING ERROR 525 0.0238
725 HEPATIC STEATOSIS 420 0.0237
726 SECRETION DISCHARGE 273 0.0237
727 LOWER LIMB FRACTURE 427 0.0236
728 GAIT DISTURBANCE 4374 0.0236
729 KNEE OPERATION 215 0.0236
730 HEART RATE IRREGULAR 519 0.0236
731 HYPOAESTHESIA 3386 0.0235
732 DYSSTASIA 663 0.0235
733 THERAPY INTERRUPTED 1450 0.0234
734 VISUAL IMPAIRMENT 2721 0.0233
735 HEADACHE 13994 0.0233
736 PRODUCT PRESCRIBING ISSUE 393 0.0233
737 HUNGER 279 0.0233
738 RASH ERYTHEMATOUS 1010 0.0232
739 OSTEOMYELITIS 405 0.0232
740 ARTHRITIS 1746 0.0231
741 LETHARGY 1276 0.0231
742 AMNESIA 1447 0.0230
743 MITRAL VALVE INCOMPETENCE 248 0.0229
744 PULMONARY HYPERTENSION 461 0.0229
745 MADAROSIS 260 0.0227
746 CARDIAC FAILURE CONGESTIVE 1800 0.0227
747 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 1017 0.0226
748 THERAPEUTIC RESPONSE UNEXPECTED 984 0.0226
749 PAIN 13391 0.0226
750 EAR INFECTION 572 0.0226
751 NECK PAIN 1214 0.0226
752 MYOCARDIAL ISCHAEMIA 251 0.0225
753 INSOMNIA 5778 0.0225
754 NERVE INJURY 242 0.0225
755 ADVERSE DRUG REACTION 1897 0.0225
756 HIP ARTHROPLASTY 321 0.0224
757 RESPIRATORY DISTRESS 593 0.0224
758 EYE SWELLING 792 0.0224
759 COAGULOPATHY 356 0.0222
760 HEART RATE DECREASED 756 0.0222
761 WRIST FRACTURE 254 0.0221
762 CHEST PAIN 3932 0.0220
763 AGRANULOCYTOSIS 384 0.0220
764 EYE DISCHARGE 210 0.0219
765 CEREBROVASCULAR ACCIDENT 3572 0.0218
766 BRONCHITIS 1562 0.0217
767 JOINT INJURY 445 0.0217
768 TUBERCULOSIS 267 0.0216
769 JOINT SWELLING 2473 0.0215
770 HEPATIC CANCER 510 0.0214
771 MUSCLE ATROPHY 255 0.0214
772 FISTULA 232 0.0214
773 SYNCOPE 2056 0.0214
774 ANOREXIA 275 0.0213
775 URINARY RETENTION 678 0.0213
776 THIRST 361 0.0213
777 FREQUENT BOWEL MOVEMENTS 539 0.0212
778 CHOLECYSTECTOMY 229 0.0211
779 HYPOTENSION 4057 0.0211
780 PHARYNGITIS 253 0.0211
781 FEELING ABNORMAL 4900 0.0211
782 BACK INJURY 216 0.0210
783 HIATUS HERNIA 263 0.0210
784 ILL-DEFINED DISORDER 1223 0.0209
785 INTENTIONAL PRODUCT USE ISSUE 1754 0.0209
786 RECTAL HAEMORRHAGE 867 0.0209
787 MICTURITION URGENCY 225 0.0208
788 PARALYSIS 288 0.0208
789 VENTRICULAR FIBRILLATION 222 0.0208
790 MUSCULOSKELETAL DISORDER 384 0.0207
791 GLAUCOMA 384 0.0207
792 ASPIRATION 212 0.0207
793 PAIN IN JAW 567 0.0207
794 EYELID OEDEMA 236 0.0207
795 SLEEP DISORDER 1370 0.0206
796 NERVOUS SYSTEM DISORDER 625 0.0206
797 TINNITUS 906 0.0205
798 EPILEPSY 594 0.0205
799 SINUSITIS 2017 0.0204
800 SINUS TACHYCARDIA 279 0.0204
801 DISORIENTATION 782 0.0204
802 ACUTE HEPATIC FAILURE 262 0.0203
803 VASCULITIS 226 0.0203
804 BLOOD PRESSURE DECREASED 1285 0.0202
805 PRESYNCOPE 465 0.0202
806 VERTIGO 1179 0.0201
807 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 1080 0.0200
808 SOMNOLENCE 3853 0.0200
809 BURNING SENSATION 1342 0.0199
810 HEART RATE INCREASED 1887 0.0199
811 VISION BLURRED 2585 0.0199
812 JOINT STIFFNESS 500 0.0198
813 ACCIDENT 226 0.0198
814 CHOKING 366 0.0197
815 HYPOAESTHESIA ORAL 285 0.0197
816 ANGINA PECTORIS 550 0.0197
817 NASAL CONGESTION 1088 0.0196
818 ABSCESS 299 0.0195
819 INCORRECT DOSE ADMINISTERED 4102 0.0195
820 MULTI-ORGAN FAILURE 336 0.0194
821 BLOOD GLUCOSE ABNORMAL 341 0.0192
822 NEUROTOXICITY 312 0.0191
823 BEDRIDDEN 240 0.0190
824 PERITONITIS 377 0.0190
825 FEMUR FRACTURE 569 0.0190
826 KNEE ARTHROPLASTY 370 0.0188
827 ERYTHEMA 3683 0.0187
828 POST PROCEDURAL COMPLICATION 346 0.0186
829 OXYGEN SATURATION DECREASED 982 0.0186
830 VENTRICULAR TACHYCARDIA 295 0.0186
831 URINARY INCONTINENCE 527 0.0185
832 RESPIRATORY TRACT CONGESTION 279 0.0184
833 LOSS OF CONSCIOUSNESS 2240 0.0182
834 MOVEMENT DISORDER 563 0.0181
835 PARAESTHESIA 2710 0.0178
836 DERMATITIS ALLERGIC 208 0.0178
837 DISEASE RECURRENCE 820 0.0178
838 MOBILITY DECREASED 1211 0.0177
839 OSTEOPENIA 261 0.0177
840 EXTRA DOSE ADMINISTERED 650 0.0177
841 BREAST CANCER 1618 0.0176
842 SWOLLEN TONGUE 529 0.0176
843 STRESS 1206 0.0176
844 ATAXIA 201 0.0176
845 SNEEZING 374 0.0175
846 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 865 0.0173
847 CARPAL TUNNEL SYNDROME 233 0.0173
848 THINKING ABNORMAL 313 0.0172
849 STEVENS-JOHNSON SYNDROME 371 0.0172
850 TREATMENT FAILURE 1339 0.0172
851 MENTAL IMPAIRMENT 401 0.0172
852 ANKLE FRACTURE 256 0.0172
853 PALLOR 450 0.0171
854 COMA 780 0.0170
855 FOOT FRACTURE 311 0.0170
856 TACHYCARDIA 1440 0.0169
857 DELIRIUM 554 0.0168
858 QUALITY OF LIFE DECREASED 217 0.0168
859 NERVOUSNESS 848 0.0166
860 CARDIO-RESPIRATORY ARREST 673 0.0166
861 CHEST DISCOMFORT 1603 0.0165
862 COLON CANCER 236 0.0165
863 RHABDOMYOLYSIS 648 0.0163
864 BLINDNESS UNILATERAL 219 0.0162
865 MYOCARDIAL INFARCTION 2762 0.0161
866 DISCOMFORT 920 0.0161
867 UNEVALUABLE EVENT 1174 0.0160
868 TUBULOINTERSTITIAL NEPHRITIS 287 0.0160
869 LIP SWELLING 506 0.0159
870 LOWER RESPIRATORY TRACT INFECTION 677 0.0159
871 BLOOD GLUCOSE DECREASED 735 0.0158
872 ARTHROPATHY 847 0.0158
873 DYSARTHRIA 569 0.0157
874 THROAT IRRITATION 666 0.0157
875 HYPOGLYCAEMIA 729 0.0157
876 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 2538 0.0155
877 TOXICITY TO VARIOUS AGENTS 2470 0.0155
878 CARDIAC ARREST 1234 0.0155
879 ORTHOSTATIC HYPOTENSION 259 0.0154
880 PALPITATIONS 1719 0.0154
881 HYPOKINESIA 214 0.0153
882 OSTEOPOROSIS 606 0.0153
883 DRUG DOSE OMISSION 2525 0.0152
884 MOOD ALTERED 396 0.0152
885 ABASIA 371 0.0150
886 CORONARY ARTERY OCCLUSION 200 0.0149
887 PRODUCT PHYSICAL ISSUE 280 0.0149
888 CARDIOGENIC SHOCK 201 0.0149
889 FEELING HOT 872 0.0147
890 ABDOMINAL PAIN LOWER 356 0.0147
891 DRUG EFFECTIVE FOR UNAPPROVED INDICATION 407 0.0146
892 DEPRESSION 3227 0.0146
893 DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS 354 0.0146
894 RENAL CANCER 691 0.0146
895 INTERVERTEBRAL DISC PROTRUSION 309 0.0146
896 ADVERSE EVENT 1288 0.0145
897 CIRCULATORY COLLAPSE 239 0.0145
898 ECZEMA 641 0.0145
899 SHOCK 310 0.0143
900 MENTAL DISORDER 599 0.0143
901 OSTEONECROSIS 461 0.0142
902 EYE PAIN 740 0.0142
903 PROCEDURAL PAIN 367 0.0142
904 LOCAL SWELLING 247 0.0141
905 MUSCLE TIGHTNESS 219 0.0141
906 RENAL FAILURE ACUTE 595 0.0140
907 CONDITION AGGRAVATED 3998 0.0140
908 RESTLESS LEGS SYNDROME 242 0.0138
909 BLOOD GLUCOSE INCREASED 2493 0.0137
910 ROAD TRAFFIC ACCIDENT 547 0.0136
911 ANXIETY 3700 0.0135
912 TREMOR 2144 0.0134
913 EOSINOPHILIA 223 0.0134
914 OSTEOARTHRITIS 545 0.0134
915 HALLUCINATION 948 0.0133
916 PRURITUS GENERALISED 287 0.0132
917 CARDIOVASCULAR DISORDER 330 0.0132
918 MUSCULOSKELETAL STIFFNESS 1106 0.0131
919 COLD SWEAT 222 0.0131
920 INTERNATIONAL NORMALISED RATIO INCREASED 367 0.0130
921 CORONARY ARTERY DISEASE 385 0.0129
922 PELVIC PAIN 220 0.0129
923 HYPERSENSITIVITY 2279 0.0128
924 HYPERHIDROSIS 1597 0.0128
925 DISTURBANCE IN ATTENTION 666 0.0127
926 EYE PRURITUS 388 0.0127
927 METABOLIC ACIDOSIS 380 0.0127
928 OCULAR HYPERAEMIA 542 0.0124
929 CHRONIC KIDNEY DISEASE 916 0.0123
930 SCAR 201 0.0122
931 TOOTH LOSS 242 0.0119
932 GLYCOSYLATED HAEMOGLOBIN INCREASED 286 0.0119
933 MIGRAINE 1058 0.0117
934 DEPRESSED LEVEL OF CONSCIOUSNESS 440 0.0117
935 BRADYCARDIA 594 0.0116
936 MIDDLE INSOMNIA 205 0.0115
937 SLEEP APNOEA SYNDROME 210 0.0114
938 INFLUENZA LIKE ILLNESS 904 0.0113
939 INTENTIONAL PRODUCT MISUSE 942 0.0113
940 TYPE 2 DIABETES MELLITUS 359 0.0110
941 IRRITABLE BOWEL SYNDROME 223 0.0110
942 PRESCRIBED UNDERDOSE 207 0.0109
943 ANGIOEDEMA 459 0.0109
944 URTICARIA 1706 0.0108
945 UNRESPONSIVE TO STIMULI 264 0.0108
946 TREATMENT NONCOMPLIANCE 546 0.0106
947 DRUG INEFFECTIVE 13255 0.0105
948 CRYING 371 0.0105
949 WHEEZING 588 0.0105
950 THERAPEUTIC RESPONSE DECREASED 600 0.0104
951 BREAST CANCER FEMALE 271 0.0104
952 SKIN IRRITATION 451 0.0102
953 VISUAL ACUITY REDUCED 333 0.0102
954 RESTLESSNESS 359 0.0102
955 IRRITABILITY 577 0.0099
956 RESPIRATORY ARREST 263 0.0097
957 THERAPEUTIC PRODUCT EFFECT DECREASED 375 0.0090
958 MOOD SWINGS 275 0.0089
959 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 628 0.0088
960 UNDERDOSE 614 0.0088
961 VAGINAL HAEMORRHAGE 364 0.0088
962 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 580 0.0086
963 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 1662 0.0086
964 RENAL INJURY 244 0.0083
965 FLUSHING 818 0.0083
966 DRUG HYPERSENSITIVITY 1522 0.0081
967 ABNORMAL BEHAVIOUR 310 0.0080
968 FEAR 211 0.0080
969 ANGER 257 0.0078
970 AGITATION 543 0.0076
971 PSYCHOTIC DISORDER 207 0.0073
972 NO ADVERSE EVENT 1221 0.0073
973 ANAPHYLACTIC REACTION 371 0.0071
974 PANCREATIC CARCINOMA 201 0.0071
975 EYE IRRITATION 359 0.0071
976 ACCIDENTAL OVERDOSE 237 0.0068
977 LACTIC ACIDOSIS 203 0.0067
978 MEDICATION ERROR 332 0.0063
979 CONVULSION 351 0.0061
980 PANIC ATTACK 215 0.0061
981 PROSTATE CANCER 487 0.0061
982 INFUSION RELATED REACTION 384 0.0061
983 SKIN BURNING SENSATION 413 0.0061
984 DYSKINESIA 234 0.0060
985 ASTHMA 612 0.0058
986 AGGRESSION 279 0.0058
987 INJURY 367 0.0053
988 COLITIS ULCERATIVE 212 0.0051
989 PRODUCT STORAGE ERROR 354 0.0044
990 BLADDER CANCER 214 0.0037
991 SUICIDAL IDEATION 274 0.0031
992 OVERDOSE 536 0.0026
993 PSORIASIS 317 0.0025
994 RHEUMATOID ARTHRITIS 255 0.0024
995 EMOTIONAL DISTRESS 237 0.0020
996 INJECTION SITE PAIN 501 0.0018