Drug Side Effects

Proton Pump Inhibitor [EPC]

Proton Pump Inhibitor [EPC] was reported 578459 times

Drugs of the Proton Pump Inhibitor [EPC] class are most commonly taken among patients reporting these side effects:

# Drug class Count Frequency
0 RENAL HAEMANGIOMA 791 0.9925
1 CARDIOSPASM 424 0.7695
2 REBOUND ACID HYPERSECRETION 2064 0.6819
3 HYPERTENSIVE NEPHROPATHY 689 0.6469
4 CHRONIC KIDNEY DISEASE-MINERAL AND BONE DISORDER 672 0.6328
5 END STAGE RENAL DISEASE 10944 0.6020
6 PALMOPLANTAR KERATODERMA 421 0.5921
7 NEPHROGENIC ANAEMIA 2655 0.5755
8 CHRONIC KIDNEY DISEASE 37799 0.4997
9 HYPERPARATHYROIDISM SECONDARY 1165 0.4664
10 DEEP VEIN THROMBOSIS POSTOPERATIVE 783 0.4044
11 LUPUS VULGARIS 450 0.3830
12 HYPERCHLORHYDRIA 2241 0.3822
13 RENAL INJURY 10256 0.3462
14 DIABETIC NEPHROPATHY 717 0.3281
15 TUBULOINTERSTITIAL NEPHRITIS 6047 0.3271
16 SUBACUTE CUTANEOUS LUPUS ERYTHEMATOSUS 560 0.3217
17 ADJUSTMENT DISORDER WITH DEPRESSED MOOD 637 0.3203
18 X-RAY ABNORMAL 524 0.2974
19 HYPOMAGNESAEMIA 3869 0.2826
20 SWOLLEN JOINT COUNT INCREASED 833 0.2705
21 DISLOCATION OF VERTEBRA 581 0.2645
22 FACET JOINT SYNDROME 802 0.2577
23 ATRIAL TACHYCARDIA 530 0.2549
24 SEDATION COMPLICATION 594 0.2407
25 RHEUMATIC FEVER 956 0.2217
26 PRURITUS GENITAL 488 0.2124
27 PERIPHERAL VENOUS DISEASE 806 0.2045
28 GASTRIC POLYPS 448 0.2005
29 DUODENAL ULCER PERFORATION 1438 0.1985
30 RHEUMATOID FACTOR POSITIVE 1106 0.1942
31 NEPHROPATHY 1767 0.1908
32 ACUTE KIDNEY INJURY 28500 0.1896
33 C-REACTIVE PROTEIN ABNORMAL 1173 0.1855
34 CREATININE RENAL CLEARANCE DECREASED 705 0.1774
35 ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE 1224 0.1745
36 COLITIS MICROSCOPIC 782 0.1688
37 HELICOBACTER INFECTION 1691 0.1680
38 MUSCLE INJURY 1328 0.1639
39 PLEURITIC PAIN 437 0.1596
40 REBOUND EFFECT 1754 0.1567
41 DRUG TOLERANCE DECREASED 430 0.1556
42 CAROTID ARTERY OCCLUSION 555 0.1537
43 SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE 967 0.1522
44 RHEUMATOID NODULE 414 0.1506
45 HYPOCALCAEMIA 2750 0.1476
46 TENSION HEADACHE 626 0.1476
47 NEUTROPENIC SEPSIS 1033 0.1462
48 TENOSYNOVITIS 397 0.1455
49 RENAL FAILURE 19110 0.1448
50 FOLLICULITIS 1452 0.1424
51 RENAL CYST 1103 0.1404
52 BURSITIS 1589 0.1334
53 RHINITIS ALLERGIC 582 0.1327
54 PERICARDITIS 2121 0.1290
55 HYPONATRAEMIA 7057 0.1272
56 INFECTIVE PULMONARY EXACERBATION OF CYSTIC FIBROSIS 687 0.1269
57 GASTROOESOPHAGEAL REFLUX DISEASE 10003 0.1264
58 HIATUS HERNIA 1603 0.1252
59 LIP DRY 1094 0.1237
60 INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION 1220 0.1214
61 HYPOPHOSPHATAEMIA 880 0.1213
62 BONE EROSION 423 0.1210
63 BRONCHIECTASIS 790 0.1202
64 HAND DEFORMITY 1525 0.1181
65 SLEEP TERROR 474 0.1142
66 PEMPHIGUS 1399 0.1140
67 DIALYSIS 1596 0.1137
68 IRON DEFICIENCY 498 0.1135
69 ORTHOSTATIC HYPOTENSION 1954 0.1134
70 HYPERCHOLESTEROLAEMIA 1069 0.1131
71 BLOOD CALCIUM DECREASED 1258 0.1130
72 FIBROMYALGIA 2669 0.1114
73 VITAMIN B12 DEFICIENCY 441 0.1112
74 IRON DEFICIENCY ANAEMIA 1004 0.1108
75 LOWER RESPIRATORY TRACT INFECTION 4921 0.1100
76 RALES 624 0.1089
77 WOUND INFECTION 1163 0.1084
78 OESOPHAGITIS 1158 0.1073
79 SYNOVITIS 1910 0.1072
80 JOINT RANGE OF MOTION DECREASED 1407 0.1067
81 AUTOIMMUNE DISORDER 989 0.1047
82 BLOOD MAGNESIUM DECREASED 892 0.1047
83 EPIGASTRIC DISCOMFORT 400 0.1033
84 PULMONARY FIBROSIS 1915 0.1015
85 IRRITABLE BOWEL SYNDROME 2137 0.1014
86 GASTRITIS 2598 0.1001
87 AZOTAEMIA 394 0.0996
88 HYPOKALAEMIA 4453 0.0983
89 VITAMIN D DEFICIENCY 928 0.0965
90 SPINAL OSTEOARTHRITIS 837 0.0961
91 ABNORMAL LOSS OF WEIGHT 636 0.0953
92 OBESITY 1493 0.0948
93 RED BLOOD CELL SEDIMENTATION RATE INCREASED 1014 0.0926
94 GLOSSODYNIA 2042 0.0926
95 BREAST CANCER STAGE III 584 0.0920
96 RENAL TUBULAR NECROSIS 886 0.0913
97 URINARY TRACT DISORDER 404 0.0910
98 SCIATICA 1424 0.0910
99 BREATH SOUNDS ABNORMAL 441 0.0906
100 SUBARACHNOID HAEMORRHAGE 912 0.0904
101 FACIAL PAIN 794 0.0902
102 IMPAIRED GASTRIC EMPTYING 1134 0.0901
103 BLOOD URIC ACID INCREASED 510 0.0896
104 EXOSTOSIS 801 0.0889
105 SENSORY LOSS 706 0.0886
106 UPPER GASTROINTESTINAL HAEMORRHAGE 1473 0.0884
107 BLOOD PRESSURE DIASTOLIC DECREASED 647 0.0884
108 RHINITIS 699 0.0878
109 RASH VESICULAR 417 0.0877
110 TOXIC EPIDERMAL NECROLYSIS 1300 0.0873
111 OSTEOARTHRITIS 3660 0.0873
112 ULCER 1370 0.0871
113 HAEMATEMESIS 2176 0.0867
114 GASTRITIS EROSIVE 399 0.0866
115 SLEEP APNOEA SYNDROME 1633 0.0865
116 HYPERLIPIDAEMIA 1022 0.0864
117 SPUTUM DISCOLOURED 803 0.0861
118 CLOSTRIDIUM DIFFICILE COLITIS 900 0.0859
119 CHOLESTASIS 1614 0.0857
120 CHOLECYSTITIS CHRONIC 572 0.0854
121 ATELECTASIS 816 0.0852
122 GRIP STRENGTH DECREASED 732 0.0848
123 HEPATITIS CHOLESTATIC 501 0.0847
124 DIVERTICULUM 594 0.0836
125 DRUG INTERACTION 12934 0.0826
126 HYPERKALAEMIA 2842 0.0825
127 HEPATIC CYTOLYSIS 993 0.0823
128 INTERVERTEBRAL DISC DEGENERATION 755 0.0822
129 WALKING AID USER 534 0.0817
130 POLYP 528 0.0817
131 INTESTINAL ISCHAEMIA 441 0.0815
132 ABDOMINAL TENDERNESS 397 0.0810
133 MAJOR DEPRESSION 585 0.0809
134 CYSTIC FIBROSIS 444 0.0808
135 DYSLIPIDAEMIA 404 0.0806
136 ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED 404 0.0805
137 PANCREATITIS ACUTE 1771 0.0804
138 NOCTURIA 961 0.0804
139 TYPE 2 DIABETES MELLITUS 2665 0.0800
140 WOUND 2190 0.0798
141 FAECALOMA 427 0.0796
142 CARPAL TUNNEL SYNDROME 1101 0.0794
143 ODYNOPHAGIA 463 0.0794
144 WHEEZING 4619 0.0791
145 CHOLECYSTITIS ACUTE 440 0.0788
146 MELAENA 1710 0.0785
147 RENAL FAILURE ACUTE 3333 0.0785
148 NEUTROPHIL COUNT INCREASED 795 0.0784
149 LIVER INJURY 1871 0.0784
150 FOOT DEFORMITY 853 0.0779
151 LOWER LIMB FRACTURE 1467 0.0778
152 VASCULITIS 895 0.0778
153 MYOSITIS 686 0.0775
154 ASPIRATION 824 0.0771
155 HYDRONEPHROSIS 567 0.0770
156 GASTROINTESTINAL MOTILITY DISORDER 402 0.0768
157 HEMIPLEGIA 630 0.0764
158 BLOOD PRESSURE SYSTOLIC INCREASED 1471 0.0761
159 PRE-EXISTING CONDITION IMPROVED 473 0.0759
160 LIVER FUNCTION TEST ABNORMAL 2188 0.0758
161 MALNUTRITION 830 0.0757
162 HEPATIC ENCEPHALOPATHY 697 0.0756
163 AGRANULOCYTOSIS 1378 0.0755
164 BLOOD ALBUMIN DECREASED 588 0.0753
165 LABELLED DRUG-DRUG INTERACTION MEDICATION ERROR 663 0.0753
166 ELECTROLYTE IMBALANCE 854 0.0752
167 VENTRICULAR TACHYCARDIA 1228 0.0751
168 EOSINOPHILIA 1291 0.0749
169 HEPATIC STEATOSIS 1375 0.0749
170 GINGIVAL PAIN 588 0.0748
171 SWOLLEN TONGUE 2307 0.0748
172 RECTAL HAEMORRHAGE 3181 0.0748
173 COORDINATION ABNORMAL 1035 0.0747
174 HAEMORRHAGIC STROKE 578 0.0745
175 C-REACTIVE PROTEIN INCREASED 2672 0.0744
176 INTERNATIONAL NORMALISED RATIO INCREASED 2114 0.0744
177 BLOOD TEST ABNORMAL 1024 0.0739
178 HAEMATURIA 2501 0.0739
179 BLOOD UREA INCREASED 1224 0.0737
180 IMPAIRED HEALING 2380 0.0734
181 OSTEOPENIA 1103 0.0733
182 POLYURIA 592 0.0732
183 PROTEINURIA 1360 0.0731
184 OBSTRUCTIVE AIRWAYS DISORDER 805 0.0731
185 URINE OUTPUT DECREASED 632 0.0731
186 VENTRICULAR FIBRILLATION 801 0.0729
187 BLOOD CHOLESTEROL INCREASED 3352 0.0728
188 DYSPEPSIA 7011 0.0724
189 TROPONIN INCREASED 536 0.0720
190 RENAL IMPAIRMENT 5934 0.0719
191 SEROTONIN SYNDROME 1355 0.0718
192 DUODENAL ULCER 499 0.0717
193 ORAL CANDIDIASIS 920 0.0716
194 HAEMODIALYSIS 599 0.0715
195 FULL BLOOD COUNT ABNORMAL 742 0.0713
196 ULCER HAEMORRHAGE 476 0.0713
197 PYELONEPHRITIS 605 0.0712
198 LUPUS-LIKE SYNDROME 633 0.0711
199 APPENDICITIS 652 0.0711
200 GASTRIC ULCER 1333 0.0709
201 CARDIAC MURMUR 609 0.0709
202 BLOOD SODIUM DECREASED 1312 0.0707
203 GASTROENTERITIS 1012 0.0703
204 DELIRIUM 2394 0.0702
205 OSTEOPOROSIS 2850 0.0701
206 INCORRECT PRODUCT ADMINISTRATION DURATION 1397 0.0698
207 MITRAL VALVE INCOMPETENCE 775 0.0694
208 CARDIOMEGALY 847 0.0692
209 CHOLECYSTITIS 811 0.0692
210 TONGUE DISORDER 496 0.0690
211 BLOOD ALKALINE PHOSPHATASE INCREASED 1694 0.0690
212 ATRIOVENTRICULAR BLOCK COMPLETE 454 0.0689
213 LEFT VENTRICULAR DYSFUNCTION 452 0.0687
214 CONFUSIONAL STATE 10976 0.0687
215 ASCITES 1990 0.0686
216 LIP SWELLING 2247 0.0685
217 LIVE BIRTH 563 0.0685
218 SYSTEMIC LUPUS ERYTHEMATOSUS 2388 0.0684
219 TOXIC SKIN ERUPTION 682 0.0684
220 PAROSMIA 507 0.0682
221 ACUTE RESPIRATORY FAILURE 1285 0.0680
222 MOUTH ULCERATION 1411 0.0680
223 SEASONAL ALLERGY 947 0.0680
224 MUSCULOSKELETAL CHEST PAIN 1038 0.0679
225 CHOLANGITIS 413 0.0679
226 HEPATOCELLULAR INJURY 950 0.0677
227 HYPOALBUMINAEMIA 511 0.0677
228 NIGHT SWEATS 2151 0.0677
229 UROSEPSIS 615 0.0676
230 ARTERIOSCLEROSIS CORONARY ARTERY 441 0.0676
231 COLITIS ISCHAEMIC 448 0.0675
232 HYPERCALCAEMIA 820 0.0674
233 GENERALISED OEDEMA 816 0.0671
234 RENAL FAILURE CHRONIC 516 0.0671
235 ATRIAL FLUTTER 529 0.0669
236 TENDERNESS 689 0.0669
237 ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS 510 0.0668
238 HAEMOPTYSIS 1841 0.0667
239 DYSPNOEA EXERTIONAL 2470 0.0667
240 ARTHROPATHY 3657 0.0664
241 ARTERIAL OCCLUSIVE DISEASE 518 0.0664
242 FAECES DISCOLOURED 1419 0.0663
243 TRANSIENT ISCHAEMIC ATTACK 2207 0.0660
244 HEPATIC CIRRHOSIS 1214 0.0658
245 SUPRAVENTRICULAR TACHYCARDIA 621 0.0658
246 LARGE INTESTINE POLYP 450 0.0658
247 HEPATITIS ACUTE 420 0.0657
248 MUSCULOSKELETAL PAIN 3425 0.0657
249 RASH MACULO-PAPULAR 1435 0.0656
250 PURPURA 572 0.0655
251 DRY MOUTH 5230 0.0654
252 PSORIATIC ARTHROPATHY 2587 0.0652
253 LUNG DISORDER 3143 0.0650
254 DYSURIA 2360 0.0649
255 NAIL DISORDER 556 0.0648
256 HEMIPARESIS 1089 0.0647
257 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 3329 0.0647
258 OEDEMA 3451 0.0646
259 BLOOD IRON DECREASED 751 0.0645
260 LARYNGITIS 689 0.0643
261 CIRCULATORY COLLAPSE 1085 0.0643
262 ELECTROCARDIOGRAM QT PROLONGED 2283 0.0643
263 MOTOR DYSFUNCTION 641 0.0642
264 CONTRAINDICATED PRODUCT ADMINISTERED 1910 0.0642
265 DIPLOPIA 1642 0.0641
266 LOWER GASTROINTESTINAL HAEMORRHAGE 469 0.0640
267 CHOLELITHIASIS 2071 0.0640
268 BLOOD CREATININE INCREASED 4128 0.0639
269 JOINT DISLOCATION 664 0.0639
270 TENDONITIS 980 0.0638
271 BODY HEIGHT DECREASED 679 0.0636
272 ARTHRITIS 4946 0.0636
273 CHROMATURIA 1417 0.0636
274 POST-TRAUMATIC STRESS DISORDER 421 0.0635
275 TRICUSPID VALVE INCOMPETENCE 495 0.0635
276 ADRENAL INSUFFICIENCY 750 0.0635
277 RHABDOMYOLYSIS 2606 0.0634
278 MYASTHENIA GRAVIS 493 0.0634
279 METABOLIC ACIDOSIS 1981 0.0634
280 JOINT EFFUSION 432 0.0633
281 SLEEP DISORDER DUE TO A GENERAL MEDICAL CONDITION 1009 0.0632
282 ACUTE CORONARY SYNDROME 520 0.0632
283 MOUTH HAEMORRHAGE 457 0.0631
284 SINUS CONGESTION 842 0.0631
285 RESTLESS LEGS SYNDROME 1132 0.0630
286 MYOCARDIAL ISCHAEMIA 713 0.0630
287 CLOSTRIDIUM DIFFICILE INFECTION 1344 0.0628
288 NEPHROLITHIASIS 2831 0.0627
289 SEDATION 1613 0.0627
290 PRODUCTIVE COUGH 2928 0.0627
291 KIDNEY INFECTION 1212 0.0626
292 ABDOMINAL PAIN UPPER 12675 0.0625
293 ABDOMINAL PAIN 14323 0.0624
294 HYPERTRANSAMINASAEMIA 419 0.0623
295 PRESCRIBED OVERDOSE 1188 0.0622
296 SKIN ULCER 1583 0.0621
297 ELECTROCARDIOGRAM ABNORMAL 482 0.0620
298 SMALL INTESTINAL OBSTRUCTION 749 0.0619
299 TINNITUS 2808 0.0618
300 DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS 1556 0.0617
301 HAEMORRHOIDS 1190 0.0617
302 GAMMA-GLUTAMYLTRANSFERASE INCREASED 1350 0.0617
303 BLISTER 3409 0.0617
304 INTERSTITIAL LUNG DISEASE 2937 0.0616
305 JAUNDICE 1640 0.0616
306 MICTURITION URGENCY 689 0.0616
307 ANGIOEDEMA 2682 0.0616
308 LIVER DISORDER 2687 0.0615
309 PNEUMONIA ASPIRATION 1510 0.0614
310 ANAL INCONTINENCE 539 0.0614
311 ANGINA PECTORIS 1746 0.0613
312 PULMONARY MASS 899 0.0613
313 ROTATOR CUFF SYNDROME 779 0.0612
314 CHEST PAIN 11212 0.0612
315 OEDEMA PERIPHERAL 7385 0.0612
316 HAEMATOCRIT DECREASED 1203 0.0610
317 FLANK PAIN 563 0.0610
318 BASAL CELL CARCINOMA 937 0.0608
319 MUSCLE TWITCHING 1386 0.0608
320 INFLAMMATION 3074 0.0607
321 STOMATITIS 3625 0.0606
322 MOBILITY DECREASED 4268 0.0604
323 PRESYNCOPE 1440 0.0603
324 WHITE BLOOD CELL COUNT INCREASED 2290 0.0603
325 PRODUCT ADMINISTRATION INTERRUPTED 456 0.0602
326 RESPIRATORY TRACT INFECTION 1536 0.0599
327 BODY TEMPERATURE DECREASED 586 0.0598
328 URINARY INCONTINENCE 1748 0.0598
329 RESPIRATORY RATE INCREASED 525 0.0597
330 SPINAL COMPRESSION FRACTURE 495 0.0597
331 SUBDURAL HAEMATOMA 846 0.0597
332 ARTERIOSCLEROSIS 554 0.0596
333 DEHYDRATION 7840 0.0596
334 ACUTE MYOCARDIAL INFARCTION 1739 0.0595
335 COVID-19 PNEUMONIA 698 0.0595
336 PSEUDOMONAS INFECTION 497 0.0595
337 ANAEMIA 11199 0.0595
338 ORAL PAIN 1318 0.0594
339 MYOPATHY 508 0.0594
340 RENAL PAIN 619 0.0594
341 BLOOD PRESSURE FLUCTUATION 1409 0.0593
342 DERMATITIS BULLOUS 421 0.0593
343 DIVERTICULITIS 1615 0.0592
344 URINARY RETENTION 1943 0.0592
345 PNEUMONIA BACTERIAL 533 0.0591
346 EMPHYSEMA 590 0.0590
347 FEBRILE NEUTROPENIA 3858 0.0590
348 HYPOXIA 2041 0.0590
349 SPLENOMEGALY 681 0.0590
350 CONTUSION 5592 0.0589
351 SINUSITIS 5976 0.0589
352 ATRIAL FIBRILLATION 5668 0.0589
353 UPPER-AIRWAY COUGH SYNDROME 476 0.0589
354 RIB FRACTURE 1192 0.0588
355 OXYGEN SATURATION DECREASED 3234 0.0587
356 PANCYTOPENIA 3224 0.0586
357 PULMONARY HYPERTENSION 1209 0.0586
358 NEURALGIA 1399 0.0585
359 COGNITIVE DISORDER 2680 0.0584
360 VITAMIN D DECREASED 493 0.0583
361 IMPAIRED QUALITY OF LIFE 828 0.0583
362 HYPOTHYROIDISM 1832 0.0583
363 SEPTIC SHOCK 2484 0.0582
364 ALANINE AMINOTRANSFERASE INCREASED 3526 0.0582
365 MUCOSAL INFLAMMATION 1494 0.0581
366 SEPSIS 6394 0.0581
367 INFUSION RELATED REACTION 3785 0.0581
368 ASTHMA 6408 0.0579
369 WEIGHT FLUCTUATION 595 0.0579
370 DRUG LEVEL INCREASED 943 0.0577
371 HYPOPHAGIA 1443 0.0576
372 BLOOD POTASSIUM INCREASED 923 0.0576
373 GOUT 1021 0.0576
374 BALANCE DISORDER 4919 0.0576
375 GAIT INABILITY 1871 0.0573
376 DRUG ERUPTION 996 0.0573
377 PLATELET COUNT INCREASED 738 0.0572
378 ESCHERICHIA INFECTION 461 0.0572
379 SHOCK HAEMORRHAGIC 458 0.0571
380 CARDIOGENIC SHOCK 803 0.0570
381 BLOOD CALCIUM INCREASED 494 0.0570
382 ORAL DISORDER 413 0.0569
383 CORONARY ARTERY DISEASE 1713 0.0569
384 EAR PAIN 1091 0.0568
385 ABNORMAL FAECES 460 0.0568
386 HIP ARTHROPLASTY 852 0.0568
387 EATING DISORDER 1199 0.0568
388 PEMPHIGOID 415 0.0567
389 PULMONARY CONGESTION 740 0.0567
390 MUSCULOSKELETAL STIFFNESS 4900 0.0566
391 MUSCULAR WEAKNESS 6351 0.0566
392 UPPER RESPIRATORY TRACT INFECTION 2578 0.0566
393 MULTIPLE ORGAN DYSFUNCTION SYNDROME 1556 0.0565
394 HEPATOMEGALY 550 0.0564
395 PERIPHERAL SWELLING 8543 0.0564
396 SINUS BRADYCARDIA 539 0.0564
397 PHARYNGITIS 693 0.0564
398 INCONTINENCE 589 0.0563
399 DIZZINESS POSTURAL 533 0.0562
400 INTERVERTEBRAL DISC PROTRUSION 1216 0.0562
401 PHOTOPHOBIA 1035 0.0562
402 APHASIA 1677 0.0561
403 SINUS DISORDER 1097 0.0560
404 LUNG INFILTRATION 492 0.0560
405 INFUSION SITE ERYTHEMA 458 0.0560
406 PLEURAL EFFUSION 3361 0.0559
407 URINARY TRACT INFECTION 9362 0.0558
408 GASTROINTESTINAL HAEMORRHAGE 4629 0.0558
409 BRONCHITIS 4092 0.0557
410 FACIAL PARALYSIS 466 0.0557
411 GLOMERULAR FILTRATION RATE DECREASED 665 0.0556
412 NECK PAIN 3066 0.0555
413 HAEMOGLOBIN DECREASED 5635 0.0555
414 ACIDOSIS 419 0.0555
415 CELLULITIS 2760 0.0554
416 HEPATITIS 1399 0.0554
417 CONSTIPATION 11825 0.0554
418 RENAL DISORDER 2543 0.0552
419 JOINT SWELLING 6561 0.0552
420 BONE DISORDER 996 0.0549
421 ALTERED STATE OF CONSCIOUSNESS 1168 0.0549
422 GALLBLADDER DISORDER 969 0.0548
423 CANDIDA INFECTION 903 0.0548
424 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 2573 0.0548
425 DYSPHAGIA 5117 0.0548
426 CORONARY ARTERY OCCLUSION 745 0.0548
427 SYNCOPE 5407 0.0547
428 MUSCLE STRAIN 466 0.0547
429 BACK DISORDER 880 0.0546
430 LETHARGY 3092 0.0545
431 SPINAL DISORDER 510 0.0544
432 FLATULENCE 3037 0.0544
433 HEAD DISCOMFORT 945 0.0544
434 NERVE COMPRESSION 494 0.0543
435 ERYTHEMA MULTIFORME 499 0.0542
436 AFFECT LABILITY 517 0.0542
437 LEUKOCYTOSIS 966 0.0541
438 PNEUMONIA 17259 0.0541
439 INFUSION SITE PAIN 681 0.0540
440 TORSADE DE POINTES 419 0.0540
441 NIGHTMARE 1852 0.0540
442 FOOT FRACTURE 1013 0.0540
443 HYPOGLYCAEMIA 2585 0.0540
444 DECREASED APPETITE 12320 0.0539
445 PHARYNGEAL SWELLING 509 0.0539
446 DYSARTHRIA 1994 0.0537
447 KNEE ARTHROPLASTY 1103 0.0536
448 SLEEP DISORDER 3701 0.0536
449 GROIN PAIN 466 0.0536
450 PNEUMONITIS 1429 0.0536
451 GASTROINTESTINAL DISORDER 4665 0.0535
452 ABDOMINAL DISTENSION 5486 0.0535
453 ABDOMINAL DISCOMFORT 8818 0.0535
454 DIARRHOEA 33923 0.0534
455 ANURIA 456 0.0534
456 ASPARTATE AMINOTRANSFERASE INCREASED 2795 0.0533
457 RED BLOOD CELL COUNT DECREASED 1506 0.0533
458 EOSINOPHIL COUNT INCREASED 437 0.0533
459 AMNESIA 3434 0.0533
460 LIPASE INCREASED 401 0.0533
461 BRADYCARDIA 2790 0.0532
462 PERICARDIAL EFFUSION 1206 0.0531
463 GASTROINTESTINAL PAIN 574 0.0531
464 HYPERTENSION 11100 0.0531
465 HAEMATOMA 1360 0.0530
466 HALLUCINATION 3919 0.0530
467 LIGAMENT SPRAIN 515 0.0529
468 INCREASED TENDENCY TO BRUISE 481 0.0529
469 SWELLING 4870 0.0528
470 ERUCTATION 990 0.0527
471 BACTERIAL INFECTION 965 0.0526
472 DISCOMFORT 3147 0.0526
473 COUGH 14520 0.0526
474 TACHYCARDIA 4601 0.0525
475 PELVIC FRACTURE 402 0.0524
476 LYMPHOCYTE COUNT DECREASED 915 0.0524
477 FALL 17186 0.0524
478 FREQUENT BOWEL MOVEMENTS 1387 0.0522
479 RESPIRATORY TRACT CONGESTION 819 0.0522
480 HYPERBILIRUBINAEMIA 530 0.0521
481 BLADDER DISORDER 511 0.0520
482 MYOCLONUS 612 0.0520
483 COLITIS 1928 0.0519
484 SUDDEN DEATH 546 0.0518
485 TASTE DISORDER 1023 0.0517
486 HALLUCINATION, VISUAL 1071 0.0517
487 RESPIRATORY FAILURE 3723 0.0517
488 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 857 0.0517
489 HYPOTENSION 10208 0.0516
490 CYSTITIS 1629 0.0516
491 EAR INFECTION 1351 0.0516
492 GENERAL PHYSICAL HEALTH DETERIORATION 5843 0.0515
493 DYSPNOEA 28752 0.0515
494 DEPRESSED LEVEL OF CONSCIOUSNESS 2002 0.0514
495 HYPERGLYCAEMIA 1842 0.0514
496 SKIN LACERATION 547 0.0513
497 HEPATIC ENZYME INCREASED 3440 0.0513
498 ISCHAEMIC STROKE 903 0.0512
499 ECONOMIC PROBLEM 777 0.0511
500 DYSPHONIA 2946 0.0511
501 THROMBOCYTOPENIA 5622 0.0511
502 VOMITING 23617 0.0510
503 PSYCHOLOGICAL TRAUMA 439 0.0509
504 DECUBITUS ULCER 409 0.0509
505 COAGULOPATHY 833 0.0508
506 DISORIENTATION 1991 0.0508
507 SPINAL PAIN 587 0.0508
508 RESPIRATORY DISORDER 1502 0.0507
509 BLOOD BILIRUBIN INCREASED 1354 0.0506
510 HICCUPS 407 0.0506
511 SWELLING FACE 3234 0.0504
512 JOINT INJURY 1063 0.0504
513 POLLAKIURIA 2066 0.0503
514 PARAESTHESIA ORAL 713 0.0503
515 HAIR DISORDER 413 0.0502
516 PETECHIAE 515 0.0502
517 ASTHENIA 18604 0.0501
518 BACK PAIN 11488 0.0501
519 PANCREATITIS 2614 0.0501
520 PULMONARY EMBOLISM 4703 0.0499
521 DIARRHOEA HAEMORRHAGIC 461 0.0499
522 WEIGHT DECREASED 13682 0.0497
523 PYREXIA 16970 0.0497
524 MUSCULOSKELETAL DISCOMFORT 842 0.0496
525 CHOLECYSTECTOMY 556 0.0496
526 TOOTH INFECTION 645 0.0495
527 BACTERAEMIA 575 0.0495
528 MUSCLE RIGIDITY 583 0.0494
529 PALPITATIONS 5704 0.0494
530 RHEUMATOID ARTHRITIS 5509 0.0494
531 PRESCRIBED UNDERDOSE 971 0.0493
532 JOINT STIFFNESS 1271 0.0491
533 OROPHARYNGEAL PAIN 4484 0.0491
534 PULMONARY OEDEMA 2170 0.0491
535 PARKINSONISM 472 0.0490
536 SQUAMOUS CELL CARCINOMA 456 0.0490
537 ANOSMIA 701 0.0490
538 HEART RATE IRREGULAR 1098 0.0490
539 BLOOD CREATINE PHOSPHOKINASE INCREASED 1413 0.0489
540 SINUS TACHYCARDIA 684 0.0489
541 NODULE 630 0.0489
542 ACUTE RESPIRATORY DISTRESS SYNDROME 854 0.0489
543 SALIVARY HYPERSECRETION 482 0.0489
544 ILEUS 593 0.0488
545 DRUG-INDUCED LIVER INJURY 1484 0.0488
546 WRIST FRACTURE 576 0.0487
547 LUNG INFECTION 755 0.0486
548 ANKLE FRACTURE 743 0.0486
549 ATAXIA 571 0.0486
550 DRY THROAT 486 0.0485
551 CARDIAC FAILURE 3840 0.0484
552 MIGRAINE 4532 0.0484
553 VENTRICULAR EXTRASYSTOLES 497 0.0484
554 CHEST DISCOMFORT 4862 0.0483
555 MASS 668 0.0483
556 BODY TEMPERATURE INCREASED 975 0.0483
557 OCULAR DISCOMFORT 517 0.0482
558 LIMB INJURY 1289 0.0482
559 THYROID DISORDER 733 0.0482
560 DEEP VEIN THROMBOSIS 3104 0.0482
561 MULTI-ORGAN FAILURE 833 0.0481
562 PHOTOSENSITIVITY REACTION 781 0.0481
563 IMMUNODEFICIENCY 699 0.0481
564 TENDON RUPTURE 587 0.0481
565 THROAT IRRITATION 2119 0.0480
566 CATARACT 2811 0.0480
567 SKIN INFECTION 529 0.0480
568 GASTROENTERITIS VIRAL 857 0.0480
569 ARTHRALGIA 19593 0.0479
570 NERVE INJURY 527 0.0479
571 FEEDING DISORDER 941 0.0478
572 MUSCLE SPASMS 8656 0.0478
573 NEUROPATHY PERIPHERAL 4456 0.0478
574 OROPHARYNGEAL DISCOMFORT 421 0.0477
575 HERNIA 907 0.0477
576 HYPERHIDROSIS 6070 0.0477
577 DENTAL CARIES 520 0.0477
578 GASTROINTESTINAL INFECTION 420 0.0477
579 APHONIA 656 0.0477
580 RESPIRATORY DISTRESS 1298 0.0476
581 STAPHYLOCOCCAL INFECTION 1555 0.0476
582 CYST 583 0.0475
583 LACTIC ACIDOSIS 1503 0.0475
584 ROAD TRAFFIC ACCIDENT 1957 0.0474
585 PNEUMOTHORAX 740 0.0473
586 IMMUNOSUPPRESSION 405 0.0473
587 MYALGIA 7920 0.0472
588 RASH PRURITIC 2513 0.0472
589 PERIPHERAL COLDNESS 640 0.0471
590 HEAD INJURY 1466 0.0470
591 ENCEPHALOPATHY 1135 0.0470
592 HEART RATE DECREASED 1634 0.0469
593 DIABETES MELLITUS INADEQUATE CONTROL 819 0.0469
594 EPISTAXIS 3466 0.0469
595 TOOTH FRACTURE 509 0.0468
596 PAIN IN JAW 1308 0.0467
597 VERTIGO 2812 0.0467
598 TOOTH ABSCESS 471 0.0467
599 MUSCLE SPASTICITY 571 0.0467
600 RETCHING 979 0.0466
601 SKIN LESION 1253 0.0466
602 GASTRIC DISORDER 1600 0.0466
603 INTESTINAL OBSTRUCTION 1712 0.0463
604 HEART RATE INCREASED 4524 0.0463
605 SPINAL FRACTURE 909 0.0462
606 PARAESTHESIA 7175 0.0461
607 PALLOR 1239 0.0460
608 BLOOD TRIGLYCERIDES INCREASED 804 0.0460
609 DEPRESSION 10358 0.0459
610 POOR VENOUS ACCESS 468 0.0459
611 PAIN IN EXTREMITY 13373 0.0459
612 ORAL DISCOMFORT 630 0.0459
613 FLUID RETENTION 2301 0.0459
614 RHINORRHOEA 2915 0.0458
615 NEUTROPHIL COUNT DECREASED 1831 0.0458
616 LYMPHOPENIA 635 0.0457
617 MALAISE 19833 0.0457
618 INTENTIONAL PRODUCT USE ISSUE 3962 0.0456
619 BLOOD LACTATE DEHYDROGENASE INCREASED 718 0.0456
620 EYE PAIN 2483 0.0456
621 CHOKING 872 0.0455
622 LOCALISED INFECTION 1085 0.0454
623 DIABETES MELLITUS 3422 0.0453
624 FACE OEDEMA 757 0.0453
625 HAEMATOCHEZIA 2458 0.0452
626 LIVER FUNCTION TEST INCREASED 951 0.0452
627 DISTURBANCE IN ATTENTION 2405 0.0451
628 CARDIO-RESPIRATORY ARREST 1871 0.0451
629 DRUG INTOLERANCE 4276 0.0450
630 TOOTH DISORDER 993 0.0450
631 BLOOD PRESSURE INCREASED 6803 0.0450
632 PULMONARY THROMBOSIS 485 0.0450
633 BLOOD PRESSURE DECREASED 2942 0.0450
634 BACK INJURY 480 0.0449
635 MUSCLE ATROPHY 557 0.0449
636 DIZZINESS 22050 0.0449
637 RASH PAPULAR 993 0.0448
638 HYPOAESTHESIA 6623 0.0448
639 INFECTION 6364 0.0447
640 EYE INFECTION 495 0.0447
641 UNRESPONSIVE TO STIMULI 1135 0.0447
642 HEPATIC FAILURE 1333 0.0447
643 PLATELET COUNT DECREASED 4695 0.0447
644 NAUSEA 34733 0.0446
645 OSTEOMYELITIS 796 0.0446
646 TRANSFUSION 462 0.0445
647 HAIR COLOUR CHANGES 552 0.0445
648 VIRAL INFECTION 1457 0.0444
649 GASTRIC HAEMORRHAGE 507 0.0443
650 DISSEMINATED INTRAVASCULAR COAGULATION 616 0.0442
651 GINGIVAL BLEEDING 596 0.0442
652 TRANSAMINASES INCREASED 968 0.0442
653 MEDICATION ERROR 2407 0.0439
654 COLD SWEAT 763 0.0438
655 EYE HAEMORRHAGE 577 0.0437
656 STEVENS-JOHNSON SYNDROME 961 0.0437
657 BLOOD COUNT ABNORMAL 662 0.0436
658 POOR QUALITY SLEEP 921 0.0436
659 CYTOKINE RELEASE SYNDROME 819 0.0436
660 NASAL CONGESTION 2509 0.0434
661 HYPOAESTHESIA ORAL 645 0.0434
662 CARDIAC FAILURE CONGESTIVE 3459 0.0432
663 THERAPY NON-RESPONDER 1899 0.0432
664 INSOMNIA 11350 0.0431
665 ANAPHYLACTIC REACTION 2333 0.0430
666 FEELING COLD 1183 0.0430
667 TREMOR 7046 0.0429
668 ANXIETY 12089 0.0429
669 HEPATIC FUNCTION ABNORMAL 1570 0.0429
670 FATIGUE 32889 0.0429
671 PHARYNGEAL OEDEMA 660 0.0429
672 CYANOSIS 667 0.0429
673 SKIN HAEMORRHAGE 610 0.0428
674 MENTAL STATUS CHANGES 1173 0.0428
675 EAR DISCOMFORT 432 0.0428
676 BLOOD URINE PRESENT 804 0.0428
677 TOOTHACHE 759 0.0425
678 DEPRESSED MOOD 2206 0.0425
679 MEMORY IMPAIRMENT 5758 0.0424
680 DEVICE RELATED INFECTION 646 0.0424
681 HEADACHE 26203 0.0424
682 BONE PAIN 2452 0.0424
683 LEUKOPENIA 2086 0.0424
684 FEELING HOT 2565 0.0423
685 CONDITION AGGRAVATED 12619 0.0423
686 ANOREXIA 546 0.0423
687 STRESS 2999 0.0423
688 BURNING SENSATION 2923 0.0422
689 SOMNOLENCE 8376 0.0422
690 INFLUENZA 4651 0.0421
691 SNEEZING 930 0.0421
692 NASOPHARYNGITIS 7673 0.0421
693 HOSPICE CARE 409 0.0421
694 HYPOTHERMIA 421 0.0421
695 BLOOD PRESSURE ABNORMAL 822 0.0420
696 THERAPEUTIC PRODUCT EFFECT DECREASED 1841 0.0420
697 TEMPERATURE INTOLERANCE 423 0.0420
698 INITIAL INSOMNIA 422 0.0419
699 GAIT DISTURBANCE 7938 0.0419
700 EJECTION FRACTION DECREASED 643 0.0419
701 CEREBRAL INFARCTION 1010 0.0418
702 INTESTINAL PERFORATION 464 0.0418
703 DERMATITIS CONTACT 468 0.0418
704 CEREBRAL HAEMORRHAGE 1472 0.0417
705 PNEUMOCYSTIS JIROVECII PNEUMONIA 411 0.0417
706 BRONCHOSPASM 588 0.0416
707 DYSSTASIA 1193 0.0413
708 MIDDLE INSOMNIA 757 0.0412
709 LOCAL SWELLING 719 0.0412
710 SECRETION DISCHARGE 501 0.0411
711 ARRHYTHMIA 1923 0.0410
712 CHILLS 4735 0.0409
713 PRURITUS GENERALISED 884 0.0408
714 LIMB DISCOMFORT 1244 0.0407
715 HAIR TEXTURE ABNORMAL 542 0.0407
716 DRY EYE 1946 0.0407
717 POST PROCEDURAL COMPLICATION 773 0.0407
718 HYPERSOMNIA 1149 0.0407
719 CARDIOMYOPATHY 594 0.0407
720 THIRST 715 0.0406
721 THROAT TIGHTNESS 1083 0.0406
722 ANHEDONIA 1062 0.0406
723 NEUTROPENIA 5426 0.0406
724 LYMPHADENOPATHY 1415 0.0405
725 INJURY 2811 0.0403
726 DYSGEUSIA 2967 0.0403
727 LOSS OF CONSCIOUSNESS 5093 0.0402
728 RASH MACULAR 1383 0.0402
729 FLUID OVERLOAD 586 0.0402
730 CONJUNCTIVITIS 728 0.0402
731 DYSKINESIA 1599 0.0399
732 HYPERTHYROIDISM 569 0.0399
733 UPPER LIMB FRACTURE 786 0.0398
734 SENSORY DISTURBANCE 633 0.0398
735 PAIN 24067 0.0396
736 AGEUSIA 976 0.0395
737 EPILEPSY 1189 0.0395
738 BONE MARROW FAILURE 797 0.0395
739 WHITE BLOOD CELL COUNT DECREASED 4226 0.0395
740 ORAL HERPES 757 0.0394
741 FULL BLOOD COUNT DECREASED 784 0.0394
742 HYPERTENSIVE CRISIS 434 0.0394
743 AGITATION 2859 0.0393
744 RASH ERYTHEMATOUS 1810 0.0392
745 FEMUR FRACTURE 1198 0.0391
746 SPEECH DISORDER 2009 0.0389
747 URTICARIA 6377 0.0388
748 HIP FRACTURE 1227 0.0387
749 THROMBOSIS 3082 0.0387
750 WEIGHT INCREASED 8498 0.0387
751 HAEMORRHAGE INTRACRANIAL 571 0.0386
752 HERPES ZOSTER 2188 0.0385
753 FUNGAL INFECTION 1264 0.0385
754 HEPATOTOXICITY 840 0.0384
755 GLAUCOMA 728 0.0383
756 BLINDNESS 1537 0.0382
757 ACUTE HEPATIC FAILURE 512 0.0382
758 ALOPECIA 7408 0.0382
759 DERMATITIS ALLERGIC 468 0.0380
760 PARANOIA 650 0.0380
761 VISION BLURRED 5125 0.0380
762 HYPOKINESIA 545 0.0380
763 BRAIN FOG 547 0.0380
764 GENERALISED TONIC-CLONIC SEIZURE 613 0.0380
765 SKIN DISCOLOURATION 1719 0.0379
766 PRURITUS 14124 0.0379
767 MYOCARDITIS 421 0.0377
768 HOT FLUSH 2795 0.0376
769 TACHYPNOEA 502 0.0376
770 RASH GENERALISED 966 0.0373
771 DELUSION 569 0.0372
772 MADAROSIS 428 0.0370
773 HYPERSENSITIVITY 6762 0.0370
774 INTERNAL HAEMORRHAGE 417 0.0369
775 BEDRIDDEN 478 0.0369
776 MOVEMENT DISORDER 1170 0.0367
777 BIPOLAR DISORDER 396 0.0366
778 DEMENTIA 1005 0.0366
779 INCORRECT DRUG ADMINISTRATION DURATION 1021 0.0363
780 ABSCESS 569 0.0362
781 RASH 15442 0.0361
782 NEUROLEPTIC MALIGNANT SYNDROME 423 0.0360
783 EYE PRURITUS 1169 0.0359
784 ABDOMINAL PAIN LOWER 899 0.0359
785 MULTIPLE FRACTURES 586 0.0358
786 PULMONARY ARTERIAL HYPERTENSION 515 0.0358
787 CARDIAC ARREST 2919 0.0357
788 ILL-DEFINED DISORDER 2137 0.0356
789 MUSCLE TIGHTNESS 567 0.0355
790 HUNGER 471 0.0355
791 HALLUCINATION, AUDITORY 557 0.0355
792 RESTLESSNESS 1281 0.0354
793 COLITIS ULCERATIVE 1559 0.0354
794 SOPOR 467 0.0354
795 SCHIZOPHRENIA 424 0.0353
796 PANIC ATTACK 1271 0.0353
797 FEELING JITTERY 665 0.0353
798 COVID-19 6159 0.0353
799 DEAFNESS 912 0.0353
800 FLUSHING 3531 0.0350
801 INSURANCE ISSUE 513 0.0350
802 SPINAL OPERATION 415 0.0347
803 NERVOUSNESS 1796 0.0347
804 ABASIA 857 0.0346
805 IMPAIRED WORK ABILITY 732 0.0346
806 THINKING ABNORMAL 639 0.0346
807 METASTASES TO LIVER 598 0.0346
808 VISUAL IMPAIRMENT 4194 0.0345
809 APATHY 494 0.0344
810 IMMUNE SYSTEM DISORDER 447 0.0344
811 EYELID OEDEMA 397 0.0344
812 QUALITY OF LIFE DECREASED 455 0.0343
813 FEELING ABNORMAL 8143 0.0343
814 ACTIVITIES OF DAILY LIVING IMPAIRED 679 0.0343
815 LACRIMATION INCREASED 1010 0.0343
816 COMA 1611 0.0342
817 MANIA 554 0.0342
818 ERECTILE DYSFUNCTION 864 0.0340
819 DRUG HYPERSENSITIVITY 6515 0.0340
820 OSTEONECROSIS OF JAW 831 0.0338
821 SCAR 568 0.0336
822 MUSCULOSKELETAL DISORDER 633 0.0335
823 INFLUENZA LIKE ILLNESS 2732 0.0335
824 MENTAL IMPAIRMENT 796 0.0332
825 PAIN OF SKIN 885 0.0332
826 SEIZURE 3749 0.0331
827 TOOTH EXTRACTION 406 0.0330
828 INTENTIONAL PRODUCT MISUSE 2832 0.0330
829 PLASMA CELL MYELOMA 1268 0.0329
830 ILLNESS 3250 0.0328
831 LABORATORY TEST ABNORMAL 953 0.0328
832 BRAIN OEDEMA 407 0.0327
833 DERMATITIS 668 0.0327
834 ABNORMAL DREAMS 896 0.0327
835 SHOCK 735 0.0326
836 CYTOMEGALOVIRUS INFECTION 535 0.0326
837 PARALYSIS 462 0.0326
838 SKIN DISORDER 1069 0.0326
839 MALIGNANT MELANOMA 429 0.0324
840 METASTASES TO BONE 523 0.0324
841 ERYTHEMA 6560 0.0324
842 PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME 742 0.0321
843 SKIN FISSURES 595 0.0319
844 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 2206 0.0316
845 CARDIAC DISORDER 2917 0.0315
846 DIABETIC KETOACIDOSIS 743 0.0314
847 CEREBROVASCULAR ACCIDENT 5254 0.0313
848 ANAPHYLACTIC SHOCK 790 0.0312
849 MYELODYSPLASTIC SYNDROME 446 0.0312
850 PSYCHOTIC DISORDER 908 0.0311
851 EYE SWELLING 1136 0.0311
852 ECZEMA 1545 0.0311
853 COLON CANCER 457 0.0310
854 PERITONITIS 633 0.0310
855 DISABILITY 600 0.0307
856 SUICIDAL IDEATION 2769 0.0306
857 MYOCARDIAL INFARCTION 5276 0.0304
858 FEAR 808 0.0302
859 PRODUCT SUBSTITUTION ISSUE 1691 0.0298
860 DISEASE RECURRENCE 1399 0.0297
861 BLINDNESS UNILATERAL 411 0.0296
862 INCREASED APPETITE 548 0.0295
863 FRACTURE 551 0.0295
864 INTENTIONAL DOSE OMISSION 795 0.0295
865 PRODUCT USE ISSUE 5429 0.0294
866 SKIN EXFOLIATION 2407 0.0294
867 PRODUCT USE IN UNAPPROVED INDICATION 7053 0.0293
868 OFF LABEL USE 24760 0.0289
869 ACUTE MYELOID LEUKAEMIA 444 0.0289
870 TREATMENT NONCOMPLIANCE 1548 0.0289
871 PSYCHOMOTOR HYPERACTIVITY 472 0.0287
872 PSORIASIS 3693 0.0286
873 HAEMORRHAGE 2942 0.0285
874 SURGERY 1626 0.0284
875 SKIN CANCER 604 0.0284
876 MENTAL DISORDER 1221 0.0284
877 LYMPHOMA 434 0.0284
878 DISEASE PROGRESSION 3293 0.0283
879 MOOD ALTERED 756 0.0282
880 MOOD SWINGS 880 0.0280
881 CONVULSION 1596 0.0279
882 PRODUCT ADMINISTRATION ERROR 547 0.0278
883 PROCEDURAL PAIN 756 0.0277
884 ABNORMAL BEHAVIOUR 1081 0.0275
885 TOXICITY TO VARIOUS AGENTS 4544 0.0274
886 PRODUCT DOSE OMISSION IN ERROR 726 0.0274
887 INTENTIONAL SELF-INJURY 543 0.0273
888 ACCIDENTAL OVERDOSE 982 0.0272
889 PRODUCT PRESCRIBING ERROR 636 0.0272
890 THERAPEUTIC RESPONSE UNEXPECTED 1205 0.0271
891 EYE DISORDER 877 0.0271
892 CRYING 975 0.0271
893 PELVIC PAIN 485 0.0270
894 EMOTIONAL DISORDER 820 0.0268
895 PREGNANCY 534 0.0267
896 ADVERSE DRUG REACTION 2360 0.0267
897 IRRITABILITY 1586 0.0267
898 BONE DENSITY DECREASED 829 0.0265
899 GLYCOSYLATED HAEMOGLOBIN INCREASED 657 0.0264
900 VISUAL ACUITY REDUCED 871 0.0264
901 THERAPEUTIC RESPONSE DECREASED 1555 0.0261
902 AGGRESSION 1293 0.0261
903 TREATMENT FAILURE 2115 0.0261
904 MATERNAL EXPOSURE DURING PREGNANCY 2263 0.0260
905 EYE IRRITATION 1429 0.0260
906 DRUG PRESCRIBING ERROR 499 0.0259
907 MALIGNANT NEOPLASM PROGRESSION 2601 0.0259
908 DYSTONIA 495 0.0258
909 HYPOACUSIS 1092 0.0258
910 BLOOD GLUCOSE DECREASED 1222 0.0257
911 OCULAR HYPERAEMIA 1183 0.0257
912 NEUROTOXICITY 440 0.0257
913 RESPIRATORY ARREST 703 0.0256
914 THERAPY CESSATION 1282 0.0254
915 ANGER 846 0.0252
916 INTENTIONAL DRUG MISUSE 525 0.0251
917 INTENTIONAL OVERDOSE 1575 0.0250
918 PRODUCT DOSE OMISSION 1630 0.0249
919 DRY SKIN 3228 0.0249
920 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 4318 0.0247
921 BLOOD GLUCOSE ABNORMAL 452 0.0247
922 BLOOD GLUCOSE INCREASED 4603 0.0247
923 CARDIOVASCULAR DISORDER 622 0.0246
924 UNEVALUABLE EVENT 1837 0.0246
925 GASTRIC CANCER 618 0.0244
926 WRONG TECHNIQUE IN DRUG USAGE PROCESS 887 0.0244
927 WITHDRAWAL SYNDROME 1010 0.0242
928 TOOTH LOSS 497 0.0241
929 SUICIDE ATTEMPT 1427 0.0238
930 PRODUCT DOSE OMISSION ISSUE 6638 0.0236
931 NEOPLASM PROGRESSION 810 0.0234
932 NERVOUS SYSTEM DISORDER 713 0.0231
933 THERAPY INTERRUPTED 1570 0.0231
934 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 1628 0.0229
935 ADVERSE EVENT 2075 0.0228
936 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 1253 0.0228
937 DRUG DOSE OMISSION 3744 0.0226
938 PRODUCT AVAILABILITY ISSUE 498 0.0225
939 HOSPITALISATION 3339 0.0222
940 OSTEONECROSIS 720 0.0220
941 LUNG NEOPLASM MALIGNANT 886 0.0217
942 DRUG EFFECT DECREASED 1161 0.0215
943 PRODUCT PHYSICAL ISSUE 423 0.0215
944 DRUG INEFFECTIVE 27903 0.0215
945 PHARMACEUTICAL PRODUCT COMPLAINT 556 0.0214
946 THERAPEUTIC RESPONSE SHORTENED 662 0.0211
947 EXPOSURE DURING PREGNANCY 1281 0.0209
948 INJECTION SITE MASS 741 0.0204
949 EMOTIONAL DISTRESS 2434 0.0203
950 INJECTION SITE PRURITUS 1332 0.0203
951 MULTIPLE SCLEROSIS 962 0.0203
952 EXTRAPYRAMIDAL DISORDER 501 0.0202
953 INJECTION SITE RASH 595 0.0199
954 DRUG EFFECT INCOMPLETE 710 0.0195
955 INJECTION SITE BRUISING 1511 0.0194
956 TARDIVE DYSKINESIA 545 0.0194
957 NEOPLASM MALIGNANT 1269 0.0193
958 PREMATURE BABY 566 0.0190
959 DRUG ADMINISTRATION ERROR 579 0.0188
960 PRODUCT QUALITY ISSUE 2492 0.0187
961 UNDERDOSE 1350 0.0187
962 INJECTION SITE URTICARIA 444 0.0185
963 PRODUCT DISPENSING ERROR 398 0.0185
964 INJECTION SITE ERYTHEMA 2258 0.0185
965 INJECTION SITE REACTION 1248 0.0184
966 INCORRECT DOSE ADMINISTERED 4041 0.0182
967 DEATH 15381 0.0181
968 INJECTION SITE PAIN 5382 0.0180
969 MULTIPLE SCLEROSIS RELAPSE 1211 0.0178
970 OVERDOSE 3771 0.0176
971 COMPLETED SUICIDE 1458 0.0176
972 NEEDLE ISSUE 491 0.0174
973 INJECTION SITE SWELLING 1277 0.0171
974 INJECTION SITE HAEMORRHAGE 1336 0.0171
975 EXPIRED PRODUCT ADMINISTERED 550 0.0168
976 VAGINAL HAEMORRHAGE 670 0.0159
977 EXTRA DOSE ADMINISTERED 624 0.0158
978 DEVICE MALFUNCTION 1009 0.0152
979 PANCREATIC CARCINOMA 433 0.0151
980 DEVICE ISSUE 1289 0.0150
981 FOETAL EXPOSURE DURING PREGNANCY 1140 0.0142
982 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 2779 0.0139
983 DERMATITIS ATOPIC 678 0.0138
984 DRUG ABUSE 1063 0.0129
985 DEVICE DISLOCATION 538 0.0126
986 DRUG WITHDRAWAL SYNDROME 1080 0.0123
987 SKIN IRRITATION 549 0.0121
988 SKIN BURNING SENSATION 837 0.0119
989 NO ADVERSE EVENT 2072 0.0118
990 ACNE 889 0.0118
991 BREAST CANCER 990 0.0107
992 DRUG DEPENDENCE 1608 0.0100
993 PROSTATE CANCER 663 0.0083
994 PRODUCT STORAGE ERROR 621 0.0073
995 ACCIDENTAL EXPOSURE TO PRODUCT 690 0.0070