Drug Side Effects

Tumor Necrosis Factor Blocker [EPC]

Tumor Necrosis Factor Blocker [EPC] was reported 871675 times

Drugs of the Tumor Necrosis Factor Blocker [EPC] class are most commonly taken among patients reporting these side effects:

# Drug class Count Frequency
0 INJECTION SITE RECALL REACTION 484 0.9719
1 ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE 3691 0.9234
2 SWOLLEN JOINT COUNT INCREASED 1011 0.8884
3 RHEUMATOID FACTOR POSITIVE 3103 0.8692
4 RED BLOOD CELL SEDIMENTATION RATE ABNORMAL 1741 0.8354
5 RHEUMATIC FEVER 1253 0.8174
6 PEMPHIGUS 6482 0.7952
7 C-REACTIVE PROTEIN ABNORMAL 3118 0.7752
8 HAND DEFORMITY 6581 0.7241
9 SYNOVITIS 9703 0.7206
10 INJECTION SITE MACULE 469 0.7010
11 GRANULOMA SKIN 490 0.6815
12 DUODENAL ULCER PERFORATION 2438 0.6625
13 DEEP VEIN THROMBOSIS POSTOPERATIVE 333 0.6392
14 DRUG SPECIFIC ANTIBODY 680 0.6239
15 FAECAL CALPROTECTIN INCREASED 1287 0.6017
16 JOINT DESTRUCTION 782 0.5979
17 INJECTION SITE WARMTH 10491 0.5791
18 JUVENILE IDIOPATHIC ARTHRITIS 1109 0.5746
19 SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE 2159 0.5686
20 BONE EROSION 1411 0.5593
21 RHEUMATOID ARTHRITIS 51110 0.5579
22 RHEUMATOID NODULE 1356 0.5407
23 ANKYLOSING SPONDYLITIS 4886 0.5310
24 COVID-19 IMMUNISATION 382 0.5226
25 ENTHESOPATHY 657 0.5153
26 CONTRAINDICATED PRODUCT ADMINISTERED 11885 0.5091
27 BODY HEIGHT BELOW NORMAL 305 0.4967
28 LUPUS-LIKE SYNDROME 3334 0.4800
29 DRUG LEVEL BELOW THERAPEUTIC 2126 0.4793
30 BLOOD IRON ABNORMAL 378 0.4632
31 HELICOBACTER INFECTION 2851 0.4595
32 MUSCLE INJURY 2190 0.4482
33 SINUSITIS BACTERIAL 375 0.4459
34 FOLLICULITIS 2619 0.4455
35 INJECTION SITE HAEMATOMA 6223 0.4436
36 BLOOD PARATHYROID HORMONE DECREASED 560 0.4318
37 JOINT ARTHROPLASTY 632 0.4183
38 RHEUMATOID LUNG 346 0.4154
39 DISSEMINATED TUBERCULOSIS 851 0.4147
40 FINGER DEFORMITY 1542 0.4142
41 INJECTION SITE PRURITUS 22401 0.4125
42 INJECTION SITE ERYTHEMA 41800 0.4110
43 DRUG TOLERANCE DECREASED 783 0.4104
44 PSORIATIC ARTHROPATHY 11631 0.4085
45 INJECTION SITE SWELLING 23975 0.4062
46 X-RAY ABNORMAL 353 0.4007
47 ARTHRODESIS 344 0.4005
48 DRUG SPECIFIC ANTIBODY PRESENT 1981 0.3960
49 SYSTEMIC LUPUS ERYTHEMATOSUS 9544 0.3845
50 INTESTINAL RESECTION 1631 0.3835
51 PERICARDITIS 4267 0.3823
52 DISLOCATION OF VERTEBRA 356 0.3787
53 ANAL FISSURE 1487 0.3787
54 ADJUSTMENT DISORDER WITH DEPRESSED MOOD 305 0.3765
55 INJECTION SITE REACTION 21239 0.3746
56 RED BLOOD CELL SEDIMENTATION RATE INCREASED 3360 0.3677
57 PANNICULITIS 698 0.3594
58 INJECTION SITE INDURATION 4000 0.3543
59 FACET JOINT SYNDROME 328 0.3542
60 INJECTION SITE DISCOLOURATION 3533 0.3531
61 PYODERMA GANGRENOSUM 894 0.3525
62 GLOSSODYNIA 6011 0.3518
63 PUSTULAR PSORIASIS 955 0.3446
64 TENOSYNOVITIS 812 0.3371
65 HISTOPLASMOSIS DISSEMINATED 346 0.3305
66 INFUSION RELATED REACTION 16375 0.3295
67 PULMONARY TUBERCULOSIS 1202 0.3285
68 INJECTION SITE IRRITATION 3435 0.3278
69 SACROILIITIS 500 0.3266
70 TUBERCULIN TEST POSITIVE 786 0.3240
71 TUBERCULOSIS 3465 0.3230
72 TRANSPLANT DYSFUNCTION 461 0.3224
73 RHEUMATOID FACTOR INCREASED 319 0.3219
74 THERAPEUTIC PRODUCT EFFECT DECREASED 10317 0.3210
75 INJECTION SITE RASH 7428 0.3197
76 HISTOPLASMOSIS 474 0.3196
77 SHOULDER ARTHROPLASTY 610 0.3192
78 LATENT TUBERCULOSIS 512 0.3159
79 GRIP STRENGTH DECREASED 1845 0.3119
80 IRITIS 795 0.3103
81 COLECTOMY 1319 0.3054
82 JOINT WARMTH 323 0.3016
83 KNEE ARTHROPLASTY 4666 0.3010
84 CROHN'S DISEASE 2065 0.3010
85 DEMYELINATION 1041 0.3008
86 EXPOSURE TO SARS-COV-2 444 0.3002
87 MYCOBACTERIUM TUBERCULOSIS COMPLEX TEST POSITIVE 593 0.2962
88 UVEITIS 2956 0.2959
89 ARTHROPATHY 13602 0.2946
90 SCLERITIS 365 0.2941
91 WOUND 6087 0.2940
92 INJECTION SITE URTICARIA 5415 0.2931
93 DRUG LEVEL ABOVE THERAPEUTIC 1014 0.2921
94 PNEUMONIA LEGIONELLA 383 0.2884
95 ANTIBODY TEST POSITIVE 425 0.2833
96 FISTULA 2550 0.2814
97 FOOT DEFORMITY 2543 0.2813
98 FOOT OPERATION 1046 0.2757
99 ANAL FISTULA 1181 0.2745
100 JOINT SWELLING 26409 0.2725
101 ANAL ABSCESS 1133 0.2722
102 PSORIASIS 29907 0.2711
103 INJECTION SITE HYPERSENSITIVITY 532 0.2680
104 HIP ARTHROPLASTY 3070 0.2667
105 LOWER RESPIRATORY TRACT INFECTION 8884 0.2662
106 ILEOSTOMY 454 0.2655
107 ERYTHEMA NODOSUM 733 0.2623
108 SKIN PLAQUE 1853 0.2622
109 POLYARTHRITIS 1044 0.2617
110 ILEAL STENOSIS 338 0.2582
111 FEAR OF INJECTION 1245 0.2579
112 JOINT EFFUSION 1526 0.2561
113 INJECTION SITE PAIN 58710 0.2559
114 BODY TEMPERATURE FLUCTUATION 462 0.2558
115 JOINT STIFFNESS 5575 0.2549
116 DERMATITIS PSORIASIFORM 402 0.2536
117 DRUG LEVEL DECREASED 2058 0.2520
118 LIMB DEFORMITY 364 0.2517
119 PARANASAL SINUS HYPERSECRETION 846 0.2474
120 INJECTION SITE DISCOMFORT 1854 0.2452
121 RECTAL ABSCESS 338 0.2382
122 DRUG EFFECT INCOMPLETE 8646 0.2375
123 INTESTINAL STENOSIS 811 0.2349
124 INJECTION SITE BRUISING 14484 0.2331
125 JOINT RANGE OF MOTION DECREASED 2230 0.2311
126 BLOOD PRESSURE FLUCTUATION 4776 0.2290
127 JOINT LOCK 560 0.2288
128 MATERNAL EXPOSURE DURING BREAST FEEDING 521 0.2270
129 INTENTIONAL PRODUCT USE ISSUE 15380 0.2262
130 DRUG INTOLERANCE 17282 0.2261
131 NODULE 2421 0.2250
132 TREATMENT FAILURE 13993 0.2225
133 PNEUMOCYSTIS JIROVECI PNEUMONIA 493 0.2209
134 ANTINUCLEAR ANTIBODY POSITIVE 634 0.2195
135 SINUSITIS 18519 0.2194
136 BASAL CELL CARCINOMA 2782 0.2167
137 PHARYNGITIS STREPTOCOCCAL 1836 0.2165
138 MATERNAL EXPOSURE BEFORE PREGNANCY 1067 0.2159
139 CHONDROPATHY 528 0.2144
140 MUSCULOSKELETAL STIFFNESS 15592 0.2138
141 INJECTION SITE INFLAMMATION 833 0.2124
142 INCORRECT PRODUCT STORAGE 2776 0.2110
143 APHTHOUS ULCER 1159 0.2071
144 TOOTH INFECTION 2248 0.2070
145 RESPIRATORY TRACT CONGESTION 2626 0.2069
146 POOR VENOUS ACCESS 1584 0.2059
147 ARTHRITIS BACTERIAL 694 0.2045
148 IRIDOCYCLITIS 463 0.2044
149 MUCOUS STOOLS 721 0.2041
150 INJECTION SITE VESICLES 898 0.2034
151 IMPAIRED HEALING 5306 0.2029
152 RHEUMATIC DISORDER 330 0.2023
153 LOCAL SWELLING 3519 0.2015
154 ONYCHOMYCOSIS 636 0.2008
155 ARTHRITIS INFECTIVE 749 0.1990
156 TONSILLITIS 842 0.1986
157 SYNOVIAL CYST 798 0.1983
158 FIBROMYALGIA 3719 0.1978
159 PERIPHERAL VENOUS DISEASE 377 0.1976
160 ABSCESS 2599 0.1976
161 DECREASED IMMUNE RESPONSIVENESS 1412 0.1975
162 COLITIS ULCERATIVE 6166 0.1970
163 SARCOIDOSIS 756 0.1942
164 ALANINE AMINOTRANSFERASE ABNORMAL 308 0.1925
165 THERAPEUTIC RESPONSE DECREASED 9142 0.1908
166 SPINAL FUSION SURGERY 583 0.1894
167 C-REACTIVE PROTEIN INCREASED 5431 0.1881
168 IRRITABLE BOWEL SYNDROME 2964 0.1864
169 ARTHROPOD BITE 1139 0.1861
170 SINUS CONGESTION 2077 0.1845
171 JOINT CREPITATION 366 0.1844
172 LIMB OPERATION 638 0.1836
173 LYMPHOPROLIFERATIVE DISORDER 431 0.1829
174 POST PROCEDURAL INFECTION 1150 0.1817
175 ANIMAL BITE 386 0.1816
176 THERAPEUTIC RESPONSE SHORTENED 3071 0.1814
177 INFECTIOUS MONONUCLEOSIS 341 0.1805
178 PHARYNGITIS 1904 0.1792
179 INFLAMMATION 7076 0.1788
180 EAR INFECTION 3647 0.1785
181 FINE MOTOR SKILL DYSFUNCTION 397 0.1778
182 BURSITIS 1510 0.1773
183 ARTHRALGIA 58580 0.1771
184 MOBILITY DECREASED 10274 0.1766
185 SENSITIVITY TO WEATHER CHANGE 691 0.1754
186 TOOTH ABSCESS 1556 0.1751
187 DRUG EFFECT DECREASED 9415 0.1744
188 BRONCHITIS CHRONIC 375 0.1739
189 ARTHRITIS 11272 0.1735
190 PROCTITIS 364 0.1700
191 LYMPHOMA 2243 0.1696
192 HERPES ZOSTER 8156 0.1696
193 ENDODONTIC PROCEDURE 363 0.1695
194 SWELLING 12814 0.1688
195 MUSCULOSKELETAL PAIN 8099 0.1683
196 WOUND INFECTION 1262 0.1682
197 FURUNCLE 1134 0.1680
198 NASOPHARYNGITIS 24334 0.1670
199 LOCALISED INFECTION 3344 0.1667
200 IMMUNOSUPPRESSION 1057 0.1667
201 STREPTOCOCCAL INFECTION 718 0.1660
202 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 5600 0.1655
203 SERUM SICKNESS 386 0.1643
204 B-CELL LYMPHOMA 483 0.1635
205 KNEE OPERATION 1143 0.1633
206 SINUS HEADACHE 863 0.1633
207 BLOOD PRESSURE DIASTOLIC INCREASED 597 0.1632
208 VARICELLA 326 0.1630
209 VIRAL UPPER RESPIRATORY TRACT INFECTION 698 0.1624
210 FREQUENT BOWEL MOVEMENTS 3230 0.1619
211 HIP SURGERY 621 0.1611
212 CONDITION AGGRAVATED 36787 0.1605
213 OSTEOARTHRITIS 5518 0.1603
214 HEPATIC ENZYME INCREASED 8436 0.1575
215 EXOSTOSIS 1149 0.1562
216 MALIGNANT MELANOMA 1755 0.1555
217 SHOULDER OPERATION 458 0.1554
218 LYME DISEASE 421 0.1547
219 SUBCUTANEOUS ABSCESS 631 0.1547
220 MUSCULOSKELETAL DISORDER 2568 0.1547
221 VULVOVAGINAL MYCOTIC INFECTION 529 0.1542
222 PULMONARY FIBROSIS 2222 0.1516
223 THERAPEUTIC RESPONSE DELAYED 358 0.1514
224 UPPER RESPIRATORY TRACT INFECTION 5617 0.1504
225 INFLAMMATORY MARKER INCREASED 546 0.1501
226 INJECTION SITE HAEMORRHAGE 9401 0.1494
227 SURGERY 6339 0.1491
228 BLOOD PRESSURE DIASTOLIC DECREASED 932 0.1487
229 INFECTION 16687 0.1469
230 ONYCHOMADESIS 387 0.1465
231 INJECTION SITE EXTRAVASATION 1719 0.1461
232 WALKING AID USER 737 0.1443
233 INCREASED TENDENCY TO BRUISE 1158 0.1434
234 SKIN PAPILLOMA 483 0.1434
235 SQUAMOUS CELL CARCINOMA 1112 0.1428
236 ABSCESS LIMB 484 0.1414
237 WHEELCHAIR USER 523 0.1411
238 DIVERTICULITIS 3186 0.1408
239 SKIN INFECTION 1234 0.1401
240 BRONCHITIS 8890 0.1397
241 THYROID NEOPLASM 366 0.1390
242 THERAPY NON-RESPONDER 4340 0.1387
243 POSTOPERATIVE WOUND INFECTION 756 0.1385
244 NECK MASS 322 0.1379
245 UPPER RESPIRATORY TRACT CONGESTION 347 0.1372
246 EAR PAIN 2191 0.1368
247 BODY TEMPERATURE DECREASED 1188 0.1364
248 CYST 1410 0.1362
249 SPONDYLITIS 370 0.1349
250 DISCOMFORT 6145 0.1344
251 TENDERNESS 1201 0.1339
252 SPINAL PAIN 1282 0.1332
253 CLOSTRIDIUM DIFFICILE INFECTION 2241 0.1323
254 LARYNGITIS 1128 0.1321
255 SCIATICA 1561 0.1320
256 INFLUENZA 11162 0.1320
257 LUNG ADENOCARCINOMA 322 0.1311
258 JOINT DISLOCATION 1106 0.1307
259 ABDOMINAL ABSCESS 462 0.1305
260 SKIN CANCER 2298 0.1304
261 LACERATION 1228 0.1303
262 PNEUMONIA VIRAL 321 0.1301
263 EYE INFECTION 1128 0.1300
264 ADVERSE REACTION 1409 0.1295
265 HAEMATOCHEZIA 5667 0.1293
266 INJECTION SITE MASS 3761 0.1291
267 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 6653 0.1289
268 SKIN NECROSIS 581 0.1283
269 THERAPY INTERRUPTED 4501 0.1279
270 SUSPECTED COVID-19 376 0.1278
271 JOINT INJURY 2247 0.1274
272 PERIPHERAL SWELLING 15496 0.1273
273 MATERNAL EXPOSURE DURING PREGNANCY 8228 0.1268
274 INFUSION SITE EXTRAVASATION 682 0.1266
275 KIDNEY INFECTION 2040 0.1266
276 INTENTIONAL DOSE OMISSION 1599 0.1260
277 NAIL DISORDER 800 0.1260
278 HERPES VIRUS INFECTION 598 0.1258
279 IMMUNE SYSTEM DISORDER 1336 0.1252
280 CHRONIC SINUSITIS 364 0.1250
281 GALLBLADDER OPERATION 395 0.1243
282 BRONCHIECTASIS 626 0.1242
283 OROPHARYNGEAL PAIN 9401 0.1241
284 SPINAL OPERATION 1011 0.1241
285 IMMOBILE 450 0.1237
286 SKIN ULCER 2677 0.1234
287 APPARENT DEATH 440 0.1226
288 ORAL INFECTION 401 0.1226
289 HEPATIC ENZYME ABNORMAL 495 0.1224
290 LUNG NEOPLASM 477 0.1223
291 GRANULOMA 349 0.1218
292 DIARRHOEA HAEMORRHAGIC 956 0.1217
293 INSURANCE ISSUE 805 0.1214
294 COLITIS MICROSCOPIC 414 0.1214
295 STAPHYLOCOCCAL INFECTION 3456 0.1212
296 HIDRADENITIS 647 0.1209
297 GASTROINTESTINAL INFECTION 860 0.1208
298 RECTAL CANCER 310 0.1205
299 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 13376 0.1199
300 PHARYNGOLARYNGEAL PAIN 635 0.1194
301 VAGINAL INFECTION 467 0.1194
302 SECRETION DISCHARGE 1103 0.1193
303 FUNGAL SKIN INFECTION 378 0.1172
304 PAIN IN EXTREMITY 29469 0.1168
305 CARPAL TUNNEL SYNDROME 1363 0.1162
306 AUTOIMMUNE DISORDER 726 0.1161
307 LIVER FUNCTION TEST INCREASED 1763 0.1158
308 INCORRECT DRUG ADMINISTRATION RATE 357 0.1157
309 HYSTERECTOMY 790 0.1156
310 DEFAECATION URGENCY 556 0.1146
311 ACCIDENTAL EXPOSURE TO PRODUCT 7080 0.1142
312 HEART RATE DECREASED 3436 0.1142
313 PULMONARY MASS 1344 0.1133
314 CELLULITIS 4857 0.1128
315 NECK PAIN 5223 0.1127
316 GASTROINTESTINAL INFLAMMATION 680 0.1120
317 ORAL HERPES 1691 0.1118
318 PLEURISY 586 0.1114
319 MELANOCYTIC NAEVUS 408 0.1109
320 MOUTH ULCERATION 1877 0.1109
321 EYE OPERATION 348 0.1108
322 RESPIRATORY TRACT INFECTION 2208 0.1108
323 GASTROENTERITIS VIRAL 1568 0.1104
324 INTERCEPTED PRODUCT ADMINISTRATION ERROR 473 0.1100
325 ULCER 1466 0.1098
326 ERYSIPELAS 462 0.1097
327 NEPHROLITHIASIS 4002 0.1097
328 RHINORRHOEA 5592 0.1096
329 INCREASED UPPER AIRWAY SECRETION 514 0.1090
330 NASAL CONGESTION 4969 0.1088
331 PRODUCT USE ISSUE 15900 0.1087
332 BLISTER 4851 0.1085
333 MENISCUS INJURY 558 0.1083
334 SKIN MASS 557 0.1076
335 OVARIAN CYST 948 0.1070
336 GAIT INABILITY 2417 0.1064
337 MASS 1256 0.1052
338 DRUG DELIVERY SYSTEM MALFUNCTION 394 0.1049
339 WEIGHT FLUCTUATION 854 0.1048
340 CYSTITIS 2866 0.1040
341 SPINAL COLUMN STENOSIS 492 0.1039
342 RASH PUSTULAR 688 0.1038
343 HYPERSENSITIVITY 15844 0.1033
344 DRUG EFFECT DELAYED 468 0.1031
345 RHINITIS 672 0.1026
346 SPINAL DISORDER 818 0.1025
347 IMMUNODEFICIENCY 1071 0.1020
348 CONTUSION 8023 0.1015
349 PAIN 52943 0.1013
350 GASTRIC INFECTION 312 0.1011
351 VIRAL INFECTION 2624 0.1011
352 BODY TEMPERATURE INCREASED 1782 0.1010
353 VASCULITIS 958 0.1001
354 LIVER INJURY 1600 0.0999
355 OFF LABEL USE 60438 0.0997
356 LIGAMENT RUPTURE 368 0.0990
357 NO THERAPEUTIC RESPONSE 1208 0.0989
358 DRUG HYPERSENSITIVITY 16309 0.0980
359 DRUG ERUPTION 1363 0.0978
360 HYPERCHOLESTEROLAEMIA 662 0.0973
361 SKIN LACERATION 778 0.0970
362 INFLAMMATORY BOWEL DISEASE 814 0.0964
363 SKIN LESION 2126 0.0961
364 MUSCULOSKELETAL DISCOMFORT 1367 0.0961
365 ABDOMINAL DISCOMFORT 12943 0.0956
366 SINUS DISORDER 1562 0.0954
367 DRUG INEFFECTIVE 103581 0.0953
368 BLOOD PRESSURE SYSTOLIC INCREASED 1541 0.0953
369 GASTROINTESTINAL DISORDER 5897 0.0952
370 TOOTH FRACTURE 892 0.0950
371 INTERVERTEBRAL DISC PROTRUSION 1796 0.0950
372 ENDOMETRIOSIS 377 0.0948
373 TOOTHACHE 1422 0.0948
374 SCRATCH 684 0.0947
375 INJECTION SITE INJURY 318 0.0945
376 RASH PRURITIC 4040 0.0941
377 SPUTUM DISCOLOURED 713 0.0941
378 SKIN HAEMORRHAGE 918 0.0937
379 CATARACT OPERATION 452 0.0934
380 PRODUCT DISTRIBUTION ISSUE 335 0.0931
381 DEFORMITY 787 0.0929
382 FUNGAL INFECTION 2546 0.0929
383 NIGHT SWEATS 2354 0.0927
384 LYMPHADENOPATHY 2716 0.0925
385 ALOPECIA 15377 0.0922
386 PURULENT DISCHARGE 341 0.0920
387 ROTATOR CUFF SYNDROME 1011 0.0916
388 PRODUCTIVE COUGH 3314 0.0916
389 DRUG DOSE OMISSION 15156 0.0914
390 ORAL CANDIDIASIS 924 0.0908
391 PROCTALGIA 486 0.0907
392 STOMATITIS 4384 0.0900
393 FOOD POISONING 361 0.0899
394 HEART RATE IRREGULAR 1806 0.0897
395 LOWER LIMB FRACTURE 1311 0.0897
396 RASH ERYTHEMATOUS 3071 0.0892
397 PYELONEPHRITIS 624 0.0890
398 INTERVERTEBRAL DISC DISORDER 335 0.0890
399 INTERVERTEBRAL DISC DEGENERATION 734 0.0886
400 SQUAMOUS CELL CARCINOMA OF SKIN 411 0.0880
401 ACCIDENT 841 0.0878
402 DISABILITY 1413 0.0877
403 DERMATITIS ALLERGIC 838 0.0877
404 HYPERKERATOSIS 400 0.0874
405 INJURY ASSOCIATED WITH DEVICE 1313 0.0870
406 GINGIVITIS 400 0.0864
407 LUNG INFECTION 1344 0.0862
408 PNEUMOCYSTIS JIROVECII PNEUMONIA 638 0.0860
409 PRURITUS GENERALISED 1858 0.0857
410 UMBILICAL HERNIA 333 0.0857
411 SNEEZING 1495 0.0854
412 TOOTH DISORDER 1639 0.0853
413 NERVE COMPRESSION 647 0.0853
414 HEPATIC STEATOSIS 1287 0.0845
415 OBESITY 1039 0.0844
416 TOOTH EXTRACTION 894 0.0840
417 BEDRIDDEN 929 0.0839
418 EYE INFLAMMATION 587 0.0839
419 BREAST MASS 472 0.0835
420 LIMB INJURY 1798 0.0835
421 BACTERIAL INFECTION 1216 0.0834
422 PREMATURE LABOUR 443 0.0834
423 BACK INJURY 677 0.0831
424 MENINGITIS 455 0.0831
425 SKIN WARM 399 0.0830
426 ILL-DEFINED DISORDER 3951 0.0829
427 NEEDLE ISSUE 1603 0.0828
428 COLITIS 2354 0.0826
429 SCAB 757 0.0825
430 SKIN REACTION 939 0.0825
431 CAESAREAN SECTION 875 0.0820
432 EAR DISORDER 318 0.0818
433 FOOT FRACTURE 1322 0.0818
434 URINARY TRACT INFECTION 11209 0.0818
435 STRESS 4747 0.0817
436 BLOOD IRON DECREASED 731 0.0817
437 OSTEOMYELITIS 1282 0.0810
438 ADVERSE DRUG REACTION 5474 0.0809
439 GASTROINTESTINAL PAIN 702 0.0807
440 FAECES SOFT 394 0.0807
441 DIFFUSE LARGE B-CELL LYMPHOMA 434 0.0805
442 COUGH 17963 0.0804
443 HAND FRACTURE 473 0.0803
444 TENDON DISORDER 444 0.0802
445 VARICOSE VEIN 349 0.0797
446 UNEVALUABLE EVENT 5286 0.0797
447 GESTATIONAL DIABETES 313 0.0797
448 APPENDICITIS 582 0.0793
449 LIMB DISCOMFORT 2024 0.0789
450 LIGAMENT SPRAIN 624 0.0788
451 PRODUCT STORAGE ERROR 4065 0.0788
452 BACK PAIN 15367 0.0788
453 UPPER-AIRWAY COUGH SYNDROME 504 0.0786
454 COLON CANCER 979 0.0784
455 ADRENAL INSUFFICIENCY 652 0.0782
456 STAPHYLOCOCCAL SEPSIS 340 0.0781
457 EPSTEIN-BARR VIRUS INFECTION 388 0.0781
458 LIP DRY 439 0.0779
459 LIVE BIRTH 457 0.0779
460 WEIGHT INCREASED 14189 0.0778
461 LUNG DISORDER 3030 0.0776
462 LIVER DISORDER 2778 0.0775
463 HEPATIC CIRRHOSIS 1133 0.0773
464 DEVICE MALFUNCTION 3784 0.0773
465 HERNIA 1190 0.0771
466 PAPULE 407 0.0770
467 INJECTION SITE NODULE 720 0.0763
468 DEVICE ISSUE 4807 0.0761
469 PNEUMONIA 19690 0.0760
470 CATARACT 3533 0.0758
471 SKIN DISORDER 2025 0.0757
472 BOWEL MOVEMENT IRREGULARITY 444 0.0757
473 TENDONITIS 1015 0.0754
474 UPPER LIMB FRACTURE 1315 0.0754
475 DRUG TOLERANCE 316 0.0753
476 FOOD ALLERGY 373 0.0753
477 RESPIRATORY DISORDER 1858 0.0751
478 COVID-19 9713 0.0751
479 LIVER FUNCTION TEST ABNORMAL 1982 0.0749
480 GROIN PAIN 562 0.0749
481 AUTOIMMUNE HEPATITIS 408 0.0745
482 BREAST CANCER STAGE III 338 0.0744
483 COELIAC DISEASE 573 0.0739
484 BLOOD CHOLESTEROL INCREASED 2802 0.0737
485 URTICARIA 9749 0.0737
486 RASH 25327 0.0735
487 VEIN DISORDER 319 0.0732
488 PULMONARY TOXICITY 375 0.0730
489 TONGUE DISORDER 475 0.0730
490 MALAISE 27299 0.0728
491 CHOLECYSTECTOMY 675 0.0728
492 PRODUCT AVAILABILITY ISSUE 920 0.0728
493 SEASONAL ALLERGY 751 0.0725
494 WRIST FRACTURE 725 0.0723
495 SMALL INTESTINAL OBSTRUCTION 716 0.0723
496 SPINAL OSTEOARTHRITIS 546 0.0722
497 PULMONARY CONGESTION 770 0.0719
498 INTERSTITIAL LUNG DISEASE 2743 0.0716
499 PNEUMONIA BACTERIAL 481 0.0716
500 INTESTINAL OBSTRUCTION 2086 0.0716
501 ENTERITIS 345 0.0715
502 ADVERSE EVENT 5451 0.0714
503 TRANSPLANT REJECTION 462 0.0713
504 HYPERCALCAEMIA 725 0.0712
505 INTESTINAL PERFORATION 655 0.0711
506 INGUINAL HERNIA 365 0.0709
507 NERVE INJURY 679 0.0709
508 DEVICE FAILURE 855 0.0707
509 GASTROENTERITIS 852 0.0707
510 IMPAIRED WORK ABILITY 1328 0.0707
511 OPTIC NEURITIS 553 0.0707
512 TYPE 2 DIABETES MELLITUS 1945 0.0706
513 FEELING HOT 3673 0.0705
514 SKIN ATROPHY 327 0.0704
515 MACULAR DEGENERATION 675 0.0704
516 EAR DISCOMFORT 580 0.0703
517 OSTEOPOROSIS 2460 0.0702
518 DENTAL CARIES 661 0.0702
519 BLOOD TEST ABNORMAL 778 0.0701
520 ABNORMAL LOSS OF WEIGHT 389 0.0701
521 SARS-COV-2 TEST POSITIVE 772 0.0701
522 ANKLE FRACTURE 910 0.0696
523 RECTAL HAEMORRHAGE 2546 0.0694
524 CANDIDA INFECTION 887 0.0694
525 ILLNESS 3681 0.0693
526 EXPOSURE DURING PREGNANCY 3397 0.0693
527 HERPES SIMPLEX 359 0.0690
528 MUSCULOSKELETAL CHEST PAIN 885 0.0690
529 GAIT DISTURBANCE 11116 0.0685
530 NEOPLASM MALIGNANT 3655 0.0684
531 CYTOMEGALOVIRUS INFECTION 923 0.0684
532 PREGNANCY 1253 0.0683
533 NEOPLASM 633 0.0682
534 PYREXIA 19555 0.0680
535 BONE DISORDER 1115 0.0678
536 CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR 1561 0.0676
537 INCORRECT DOSE ADMINISTERED BY DEVICE 1007 0.0674
538 ANAPHYLACTIC REACTION 2850 0.0674
539 UNDERDOSE 3997 0.0669
540 MULTIPLE ALLERGIES 408 0.0667
541 ENCEPHALITIS 361 0.0665
542 HYPOAESTHESIA 8355 0.0665
543 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 10247 0.0661
544 EYE DISORDER 1759 0.0661
545 GLAUCOMA 1065 0.0660
546 APHONIA 729 0.0659
547 ROAD TRAFFIC ACCIDENT 2266 0.0656
548 ERYTHEMA 11149 0.0654
549 SKIN DISCOLOURATION 2518 0.0653
550 SKIN FISSURES 773 0.0653
551 THERAPY CESSATION 2621 0.0652
552 ABDOMINAL PAIN 12445 0.0649
553 IRON DEFICIENCY ANAEMIA 489 0.0648
554 THROAT IRRITATION 2327 0.0647
555 CONCUSSION 404 0.0646
556 GENERAL PHYSICAL HEALTH DETERIORATION 5571 0.0645
557 MUSCLE STRAIN 468 0.0643
558 ESCHERICHIA INFECTION 411 0.0643
559 HYPOKINESIA 802 0.0642
560 FATIGUE 40529 0.0642
561 RASH PAPULAR 1249 0.0640
562 DRUG DOSE OMISSION BY DEVICE 1773 0.0639
563 POLYP 349 0.0636
564 PELVIC FRACTURE 404 0.0632
565 INFLUENZA LIKE ILLNESS 4554 0.0632
566 BACK DISORDER 862 0.0631
567 VITAMIN D DECREASED 458 0.0628
568 ABASIA 1550 0.0626
569 TENDON RUPTURE 672 0.0625
570 HEADACHE 32341 0.0618
571 BLOOD PRESSURE INCREASED 7862 0.0615
572 OEDEMA PERIPHERAL 6610 0.0614
573 INTENTIONAL PRODUCT MISUSE 4373 0.0610
574 ECZEMA 1549 0.0606
575 PRURITUS 16931 0.0606
576 HEPATITIS 1271 0.0603
577 THYROID DISORDER 759 0.0603
578 PULMONARY THROMBOSIS 532 0.0602
579 RASH GENERALISED 1560 0.0601
580 WEIGHT DECREASED 13841 0.0599
581 UTERINE LEIOMYOMA 370 0.0598
582 ABORTION SPONTANEOUS 2055 0.0595
583 GINGIVAL PAIN 393 0.0594
584 PHOTOSENSITIVITY REACTION 824 0.0594
585 CONJUNCTIVITIS 810 0.0593
586 ONYCHOCLASIS 330 0.0590
587 CHILLS 5795 0.0588
588 HEAD DISCOMFORT 806 0.0582
589 CHEST DISCOMFORT 4795 0.0581
590 HYPERTENSION 10144 0.0581
591 SCAR 847 0.0580
592 MIGRAINE 4383 0.0579
593 RASH MACULAR 1596 0.0578
594 HAEMORRHOIDS 954 0.0578
595 DRY EYE 1918 0.0577
596 DIVERTICULUM 393 0.0577
597 SCOLIOSIS 306 0.0576
598 ORAL DISORDER 352 0.0574
599 DEVICE DIFFICULT TO USE 2168 0.0574
600 CARDIAC OPERATION 382 0.0572
601 THROAT TIGHTNESS 1284 0.0569
602 POST PROCEDURAL COMPLICATION 931 0.0569
603 DEVICE DEPLOYMENT ISSUE 424 0.0568
604 IMPAIRED GASTRIC EMPTYING 356 0.0567
605 SLEEP DISORDER 3086 0.0564
606 HYPERAESTHESIA 411 0.0561
607 PALLOR 1311 0.0560
608 THERMAL BURN 343 0.0560
609 FACIAL PAIN 411 0.0560
610 LARGE INTESTINE PERFORATION 324 0.0557
611 BRAIN NEOPLASM 412 0.0555
612 IMPAIRED QUALITY OF LIFE 564 0.0555
613 DIABETES MELLITUS 3678 0.0555
614 HEPATOTOXICITY 978 0.0554
615 SPINAL FRACTURE 878 0.0551
616 BLOOD DISORDER 371 0.0550
617 VITAMIN D DEFICIENCY 441 0.0549
618 PAIN IN JAW 1345 0.0549
619 DERMATITIS CONTACT 493 0.0546
620 EMPHYSEMA 474 0.0542
621 FRUSTRATION TOLERANCE DECREASED 333 0.0536
622 FLANK PAIN 418 0.0534
623 FEEDING DISORDER 746 0.0533
624 SPINAL COMPRESSION FRACTURE 407 0.0533
625 PRODUCT DOSE OMISSION 3535 0.0532
626 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 3784 0.0531
627 DYSSTASIA 1326 0.0531
628 UROSEPSIS 400 0.0530
629 GENERALISED OEDEMA 525 0.0528
630 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 609 0.0528
631 OSTEOPENIA 701 0.0528
632 GASTRIC DISORDER 1850 0.0527
633 LUNG NEOPLASM MALIGNANT 1927 0.0525
634 GALLBLADDER DISORDER 817 0.0523
635 HEARING IMPAIRED 314 0.0523
636 MUSCLE SPASTICITY 577 0.0522
637 RENAL CYST 358 0.0521
638 SENSORY LOSS 357 0.0521
639 RIB FRACTURE 886 0.0519
640 PARAESTHESIA 7021 0.0519
641 PHARYNGEAL OEDEMA 780 0.0514
642 SEPSIS 4741 0.0511
643 PHOTOPHOBIA 754 0.0507
644 ANAL INCONTINENCE 323 0.0503
645 THYROID CANCER 550 0.0503
646 PRODUCT PRESCRIBING ISSUE 434 0.0502
647 BRONCHOPULMONARY ASPERGILLOSIS 304 0.0501
648 SUNBURN 326 0.0501
649 ABNORMAL FAECES 330 0.0501
650 FEELING COLD 1171 0.0498
651 DEAFNESS 1059 0.0498
652 BURNING SENSATION 2940 0.0494
653 MALNUTRITION 434 0.0493
654 RESPIRATORY RATE INCREASED 359 0.0492
655 LEUKAEMIA 384 0.0488
656 PRODUCT DOSE OMISSION ISSUE 7407 0.0487
657 DRY THROAT 408 0.0485
658 OVARIAN CANCER 394 0.0485
659 DRUG-INDUCED LIVER INJURY 1015 0.0484
660 DYSPHONIA 2310 0.0484
661 PLATELET COUNT INCREASED 522 0.0483
662 PRESCRIBED OVERDOSE 760 0.0483
663 DERMATITIS 741 0.0478
664 LOW BIRTH WEIGHT BABY 315 0.0477
665 WHITE BLOOD CELL COUNT INCREASED 1573 0.0475
666 BLOOD PRESSURE ABNORMAL 727 0.0472
667 EYE DISCHARGE 361 0.0470
668 CHOLELITHIASIS 1294 0.0468
669 PREMATURE BABY 1204 0.0465
670 NEURALGIA 909 0.0465
671 LABORATORY TEST ABNORMAL 1121 0.0464
672 MYOSITIS 316 0.0463
673 ABDOMINAL PAIN UPPER 7744 0.0462
674 FEMUR FRACTURE 1265 0.0462
675 BLOOD ALBUMIN DECREASED 306 0.0456
676 FALL 12578 0.0456
677 EATING DISORDER 823 0.0455
678 ACTIVITIES OF DAILY LIVING IMPAIRED 898 0.0453
679 SWELLING FACE 2448 0.0452
680 CHEST PAIN 7169 0.0452
681 HYPOACUSIS 1520 0.0448
682 HIP FRACTURE 1175 0.0446
683 SEPTIC SHOCK 1524 0.0445
684 WHEEZING 1992 0.0444
685 GASTRIC ULCER 724 0.0442
686 MUSCULAR WEAKNESS 4170 0.0442
687 THERAPY PARTIAL RESPONDER 329 0.0440
688 PARAESTHESIA ORAL 512 0.0440
689 ORAL PAIN 838 0.0439
690 BREAST CANCER 3837 0.0438
691 STENT PLACEMENT 305 0.0438
692 BACTERAEMIA 402 0.0438
693 OCULAR HYPERAEMIA 1540 0.0436
694 ASTHMA 3546 0.0434
695 NAUSEA 28093 0.0432
696 CLOSTRIDIUM DIFFICILE COLITIS 375 0.0431
697 FRACTURE 687 0.0431
698 GOUT 634 0.0428
699 PNEUMOTHORAX 551 0.0427
700 DIARRHOEA 21996 0.0427
701 RENAL PAIN 372 0.0424
702 LACRIMATION INCREASED 969 0.0424
703 BLOOD URINE PRESENT 692 0.0423
704 DEVICE RELATED INFECTION 569 0.0423
705 FEELING ABNORMAL 8828 0.0421
706 HIATUS HERNIA 473 0.0420
707 EYE SWELLING 1260 0.0417
708 HEART RATE INCREASED 3424 0.0417
709 PREMATURE DELIVERY 562 0.0413
710 MOTOR DYSFUNCTION 343 0.0412
711 POOR QUALITY SLEEP 700 0.0410
712 VOMITING 15590 0.0408
713 GINGIVAL BLEEDING 430 0.0406
714 DYSPNOEA 18990 0.0405
715 PANCREATITIS 1802 0.0405
716 EYE PAIN 1701 0.0404
717 TEMPERATURE INTOLERANCE 328 0.0404
718 PNEUMONITIS 834 0.0404
719 PRESCRIBED UNDERDOSE 641 0.0402
720 MUSCLE SPASMS 6187 0.0402
721 VISUAL IMPAIRMENT 3899 0.0402
722 COVID-19 PNEUMONIA 370 0.0401
723 SYRINGE ISSUE 477 0.0399
724 HYPERHIDROSIS 4378 0.0396
725 NERVOUSNESS 1850 0.0395
726 ABDOMINAL DISTENSION 3323 0.0394
727 GASTRITIS 872 0.0393
728 ANAPHYLACTIC SHOCK 790 0.0393
729 MOVEMENT DISORDER 1076 0.0393
730 FLUSHING 3510 0.0392
731 ASTHENIA 12158 0.0391
732 ALANINE AMINOTRANSFERASE INCREASED 2039 0.0390
733 HOSPITALISATION 4415 0.0389
734 BLADDER DISORDER 330 0.0387
735 PERIPHERAL COLDNESS 448 0.0386
736 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 1686 0.0386
737 PRESYNCOPE 761 0.0386
738 OEDEMA 1690 0.0386
739 CHOLECYSTITIS 376 0.0385
740 HEPATITIS C 434 0.0381
741 INCORRECT DOSE ADMINISTERED 5996 0.0381
742 LUNG INFILTRATION 308 0.0378
743 MEMORY IMPAIRMENT 4349 0.0377
744 OXYGEN SATURATION DECREASED 1620 0.0376
745 MYALGIA 5317 0.0375
746 COLD SWEAT 557 0.0374
747 DYSPEPSIA 2971 0.0372
748 SKIN EXFOLIATION 2385 0.0370
749 EYE PRURITUS 864 0.0369
750 BRONCHOSPASM 448 0.0367
751 INFUSION SITE PAIN 335 0.0365
752 SLEEP APNOEA SYNDROME 605 0.0365
753 BLOOD PRESSURE DECREASED 2012 0.0364
754 MUSCLE TIGHTNESS 502 0.0364
755 QUALITY OF LIFE DECREASED 407 0.0364
756 WRONG TECHNIQUE IN DRUG USAGE PROCESS 1324 0.0364
757 NEUTROPHIL COUNT INCREASED 315 0.0363
758 BONE PAIN 1784 0.0362
759 DRY MOUTH 2383 0.0362
760 ORAL DISCOMFORT 424 0.0362
761 TRANSAMINASES INCREASED 676 0.0362
762 ABDOMINAL PAIN LOWER 775 0.0361
763 THROMBOSIS 2466 0.0360
764 ACNE 2374 0.0356
765 DIZZINESS 14755 0.0356
766 EYE HAEMORRHAGE 408 0.0354
767 LEUKOPENIA 1435 0.0353
768 PLEURAL EFFUSION 1812 0.0353
769 VERTIGO 1819 0.0352
770 RENAL DISORDER 1366 0.0350
771 HOT FLUSH 2026 0.0350
772 DISEASE RECURRENCE 1220 0.0349
773 HYPOAESTHESIA ORAL 444 0.0349
774 PRODUCT PRESCRIBING ERROR 582 0.0349
775 LIP SWELLING 968 0.0348
776 PARALYSIS 423 0.0347
777 BLINDNESS 1138 0.0346
778 ASPARTATE AMINOTRANSFERASE INCREASED 1552 0.0343
779 INSOMNIA 7759 0.0343
780 MUSCLE ATROPHY 331 0.0342
781 DYSURIA 1073 0.0342
782 DRUG PRESCRIBING ERROR 655 0.0340
783 PERICARDIAL EFFUSION 635 0.0340
784 MICTURITION URGENCY 315 0.0340
785 POLYNEUROPATHY 314 0.0339
786 HAEMORRHAGE 2859 0.0338
787 SPLENOMEGALY 334 0.0337
788 HYPERSOMNIA 794 0.0337
789 DIPLOPIA 709 0.0335
790 HYPERTENSIVE CRISIS 317 0.0334
791 DRUG RESISTANCE 674 0.0333
792 PROCEDURAL PAIN 723 0.0332
793 RED BLOOD CELL COUNT DECREASED 787 0.0331
794 BREAST PAIN 310 0.0331
795 PALPITATIONS 3187 0.0326
796 SENSORY DISTURBANCE 466 0.0325
797 CYANOSIS 436 0.0325
798 CORONARY ARTERY OCCLUSION 400 0.0324
799 HEAD INJURY 836 0.0324
800 GASTROOESOPHAGEAL REFLUX DISEASE 2087 0.0321
801 PRODUCT USE IN UNAPPROVED INDICATION 5400 0.0321
802 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 1321 0.0319
803 DEPRESSION 6299 0.0317
804 TACHYCARDIA 2336 0.0317
805 HAEMATOCRIT DECREASED 556 0.0315
806 SWOLLEN TONGUE 844 0.0315
807 ACUTE RESPIRATORY DISTRESS SYNDROME 460 0.0313
808 EYELID OEDEMA 332 0.0311
809 DECREASED APPETITE 5744 0.0310
810 EPISTAXIS 1943 0.0309
811 PRODUCT DISPENSING ERROR 448 0.0305
812 BLINDNESS UNILATERAL 355 0.0305
813 TINNITUS 1166 0.0304
814 BLOOD POTASSIUM DECREASED 768 0.0303
815 AMNESIA 1707 0.0302
816 VISUAL ACUITY REDUCED 935 0.0301
817 DEPRESSED MOOD 1279 0.0300
818 NERVOUS SYSTEM DISORDER 830 0.0299
819 LOSS OF CONSCIOUSNESS 3228 0.0299
820 PAIN OF SKIN 689 0.0297
821 POLLAKIURIA 1029 0.0297
822 HYPOTHYROIDISM 745 0.0296
823 PULMONARY EMBOLISM 2456 0.0295
824 SYNCOPE 2501 0.0295
825 INJURY 1844 0.0293
826 DEEP VEIN THROMBOSIS 1698 0.0291
827 CONFUSIONAL STATE 3958 0.0290
828 CRYING 935 0.0290
829 NEUROPATHY PERIPHERAL 2128 0.0288
830 MULTI-ORGAN FAILURE 500 0.0288
831 DRUG LEVEL INCREASED 397 0.0288
832 ANGINA PECTORIS 730 0.0287
833 WHITE BLOOD CELL COUNT DECREASED 2547 0.0285
834 VISION BLURRED 3180 0.0284
835 LETHARGY 1392 0.0284
836 FLATULENCE 1308 0.0283
837 HAEMOGLOBIN DECREASED 2460 0.0282
838 CARDIAC DISORDER 2259 0.0281
839 CARDIOMYOPATHY 351 0.0278
840 EXTRA DOSE ADMINISTERED 674 0.0276
841 FAECES DISCOLOURED 507 0.0276
842 FACE OEDEMA 397 0.0275
843 DEHYDRATION 3098 0.0274
844 DYSPNOEA EXERTIONAL 808 0.0273
845 RESTLESS LEGS SYNDROME 421 0.0271
846 TRANSIENT ISCHAEMIC ATTACK 793 0.0268
847 ANAEMIA 4286 0.0267
848 DEMENTIA 569 0.0265
849 MUSCLE TWITCHING 523 0.0264
850 ANXIETY 6424 0.0264
851 ATRIAL FIBRILLATION 2124 0.0261
852 HYPOPHAGIA 529 0.0260
853 DISSEMINATED INTRAVASCULAR COAGULATION 314 0.0257
854 DRUG EXPOSURE DURING PREGNANCY 870 0.0256
855 INCREASED APPETITE 353 0.0255
856 DRY SKIN 2529 0.0255
857 METASTASES TO LIVER 359 0.0254
858 HAEMATOMA 578 0.0254
859 HEPATIC FUNCTION ABNORMAL 742 0.0254
860 RENAL IMPAIRMENT 1711 0.0253
861 MYOCARDIAL INFARCTION 4045 0.0252
862 MENTAL DISORDER 915 0.0252
863 MULTIPLE SCLEROSIS 1032 0.0251
864 TREMOR 3532 0.0249
865 FOETAL EXPOSURE DURING PREGNANCY 1619 0.0248
866 PERITONITIS 439 0.0246
867 PELVIC PAIN 374 0.0246
868 FEAR 604 0.0245
869 RETCHING 416 0.0240
870 PROTEINURIA 350 0.0239
871 CEREBROVASCULAR ACCIDENT 3513 0.0237
872 PANCREATITIS ACUTE 428 0.0237
873 RESPIRATORY FAILURE 1447 0.0236
874 HAEMATEMESIS 514 0.0236
875 RESPIRATORY DISTRESS 547 0.0234
876 FLUID RETENTION 1010 0.0234
877 BALANCE DISORDER 1723 0.0234
878 DYSPHAGIA 1775 0.0233
879 HAEMOPTYSIS 551 0.0233
880 ARRHYTHMIA 948 0.0231
881 DEVICE USE ERROR 576 0.0229
882 MENORRHAGIA 449 0.0228
883 PANIC ATTACK 690 0.0225
884 THERAPEUTIC RESPONSE UNEXPECTED 866 0.0224
885 CARDIOVASCULAR DISORDER 523 0.0224
886 CONSTIPATION 3760 0.0222
887 MULTIPLE FRACTURES 331 0.0221
888 TOOTH LOSS 403 0.0221
889 BONE DENSITY DECREASED 628 0.0220
890 RASH MACULO-PAPULAR 389 0.0219
891 FEELING JITTERY 364 0.0218
892 BLOOD COUNT ABNORMAL 335 0.0217
893 TUBULOINTERSTITIAL NEPHRITIS 330 0.0216
894 HAEMATURIA 642 0.0216
895 PULMONARY OEDEMA 814 0.0216
896 MOOD ALTERED 484 0.0214
897 HEMIPARESIS 316 0.0212
898 CARDIAC FAILURE CONGESTIVE 1592 0.0212
899 ASCITES 523 0.0212
900 TREATMENT NONCOMPLIANCE 871 0.0212
901 RENAL FAILURE 2522 0.0212
902 BLOOD CREATININE INCREASED 1183 0.0212
903 CARDIAC FAILURE 1412 0.0211
904 BLOOD GLUCOSE ABNORMAL 326 0.0210
905 SPEECH DISORDER 934 0.0210
906 MEDICATION ERROR 968 0.0209
907 URINARY INCONTINENCE 515 0.0206
908 LEUKOCYTOSIS 306 0.0206
909 DEVICE LEAKAGE 493 0.0204
910 BLOOD TRIGLYCERIDES INCREASED 310 0.0203
911 CHOKING 316 0.0202
912 PANCYTOPENIA 913 0.0202
913 EMOTIONAL DISORDER 534 0.0201
914 HYPOTENSION 3358 0.0201
915 SOMNOLENCE 3312 0.0198
916 MOOD SWINGS 551 0.0197
917 BREAST CANCER FEMALE 487 0.0197
918 BLOOD SODIUM DECREASED 305 0.0195
919 PROSTATE CANCER 1483 0.0193
920 CORONARY ARTERY DISEASE 544 0.0193
921 BLOOD ALKALINE PHOSPHATASE INCREASED 419 0.0191
922 ANGIOEDEMA 691 0.0190
923 EYE IRRITATION 754 0.0186
924 DELIRIUM 510 0.0184
925 GAMMA-GLUTAMYLTRANSFERASE INCREASED 360 0.0184
926 EPILEPSY 444 0.0184
927 CEREBRAL INFARCTION 380 0.0182
928 MULTIPLE ORGAN DYSFUNCTION SYNDROME 358 0.0181
929 SHOCK 330 0.0180
930 ACUTE MYOCARDIAL INFARCTION 467 0.0180
931 CHROMATURIA 347 0.0180
932 APHASIA 456 0.0177
933 HEPATIC FAILURE 452 0.0176
934 PANCREATIC CARCINOMA 453 0.0171
935 PLATELET COUNT DECREASED 1504 0.0171
936 DYSGEUSIA 1110 0.0170
937 OSTEONECROSIS 500 0.0166
938 MUCOSAL INFLAMMATION 344 0.0162
939 JAUNDICE 377 0.0159
940 VAGINAL HAEMORRHAGE 591 0.0156
941 COGNITIVE DISORDER 595 0.0155
942 CONVULSION 883 0.0154
943 MENTAL IMPAIRMENT 310 0.0152
944 COMA 610 0.0151
945 SKIN IRRITATION 600 0.0151
946 THROMBOCYTOPENIA 1368 0.0151
947 DRUG ADMINISTRATION ERROR 463 0.0151
948 CEREBRAL HAEMORRHAGE 455 0.0150
949 HYPOKALAEMIA 556 0.0149
950 AGEUSIA 309 0.0148
951 GASTRIC CANCER 352 0.0145
952 DISTURBANCE IN ATTENTION 649 0.0140
953 BLOOD GLUCOSE DECREASED 568 0.0136
954 HYPOXIA 378 0.0133
955 DEATH 9380 0.0133
956 SEIZURE 1159 0.0133
957 NEUTROPENIA 1396 0.0132
958 DISORIENTATION 457 0.0132
959 IRRITABILITY 681 0.0130
960 RENAL FAILURE ACUTE 547 0.0129
961 URINARY RETENTION 351 0.0128
962 INCORRECT ROUTE OF DRUG ADMINISTRATION 456 0.0127
963 DYSARTHRIA 403 0.0126
964 BLADDER CANCER 709 0.0123
965 RESTLESSNESS 385 0.0123
966 ANGER 363 0.0122
967 SUICIDAL IDEATION 930 0.0120
968 GASTROINTESTINAL HAEMORRHAGE 894 0.0119
969 WRONG TECHNIQUE IN DEVICE USAGE PROCESS 357 0.0119
970 BLOOD CREATINE PHOSPHOKINASE INCREASED 305 0.0118
971 NO ADVERSE EVENT 1410 0.0115
972 BLOOD GLUCOSE INCREASED 1872 0.0114
973 DISEASE PROGRESSION 1061 0.0114
974 SKIN BURNING SENSATION 685 0.0114
975 EXPIRED PRODUCT ADMINISTERED 311 0.0113
976 DYSKINESIA 383 0.0112
977 CARDIO-RESPIRATORY ARREST 408 0.0111
978 CARDIAC ARREST 761 0.0108
979 BRADYCARDIA 490 0.0107
980 RENAL CANCER 475 0.0102
981 DRUG INTERACTION 1346 0.0101
982 NEUTROPHIL COUNT DECREASED 315 0.0100
983 AGITATION 588 0.0092
984 HYPOGLYCAEMIA 348 0.0084
985 ACUTE KIDNEY INJURY 974 0.0081
986 OVERDOSE 1394 0.0075
987 CHRONIC KIDNEY DISEASE 512 0.0073
988 PRODUCT QUALITY ISSUE 890 0.0073
989 HYPONATRAEMIA 330 0.0070
990 PRODUCT SUBSTITUTION ISSUE 331 0.0067
991 HALLUCINATION 399 0.0067
992 SUICIDE ATTEMPT 329 0.0065
993 TOXICITY TO VARIOUS AGENTS 715 0.0054
994 EMOTIONAL DISTRESS 506 0.0045
995 DRUG DEPENDENCE 638 0.0042