Tumor Necrosis Factor Blocker [EPC]

Tumor Necrosis Factor Blocker [EPC] was reported 749214 times

Drugs of the Tumor Necrosis Factor Blocker [EPC] class are most commonly taken among patients reporting these side effects:

# Drug class Count Frequency
0 INJECTION SITE RECALL REACTION 481 0.9796
1 HUMAN ANTICHIMERIC ANTIBODY POSITIVE 282 0.9758
2 ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY POSITIVE 1266 0.8934
3 RHEUMATOID FACTOR POSITIVE 1629 0.8414
4 RED BLOOD CELL SEDIMENTATION RATE ABNORMAL 1404 0.8412
5 C-REACTIVE PROTEIN ABNORMAL 2175 0.7818
6 INJECTION SITE MACULE 468 0.7312
7 PEMPHIGUS 2855 0.7023
8 SYNOVITIS 5972 0.6722
9 HAND DEFORMITY 3234 0.6391
10 INJECTION SITE WARMTH 10401 0.6314
11 GRANULOMA SKIN 324 0.6291
12 RHEUMATIC FEVER 291 0.6165
13 JOINT DESTRUCTION 659 0.5975
14 JUVENILE IDIOPATHIC ARTHRITIS 873 0.5963
15 RHEUMATOID ARTHRITIS 41339 0.5790
16 DRUG SPECIFIC ANTIBODY 433 0.5653
17 BONE EROSION 1110 0.5439
18 RHEUMATOID NODULE 1029 0.5234
19 CONTRAINDICATED PRODUCT ADMINISTERED 7697 0.5040
20 ANKYLOSING SPONDYLITIS 2990 0.5037
21 BLOOD IRON ABNORMAL 324 0.4954
22 BODY HEIGHT BELOW NORMAL 286 0.4823
23 INJECTION SITE SWELLING 23525 0.4802
24 INJECTION SITE PRURITUS 22046 0.4758
25 ENTHESOPATHY 404 0.4703
26 LUPUS-LIKE SYNDROME 2701 0.4696
27 INJECTION SITE ERYTHEMA 41224 0.4641
28 INJECTION SITE HAEMATOMA 6203 0.4626
29 FINGER DEFORMITY 1386 0.4603
30 JOINT ARTHROPLASTY 548 0.4360
31 ARTHRODESIS 306 0.4221
32 INJECTION SITE REACTION 20638 0.4194
33 PSORIATIC ARTHROPATHY 8236 0.4138
34 INJECTION SITE INDURATION 3964 0.3952
35 SHOULDER ARTHROPLASTY 547 0.3899
36 INJECTION SITE DISCOLOURATION 3333 0.3895
37 FAECAL CALPROTECTIN INCREASED 429 0.3830
38 INJECTION SITE RASH 7227 0.3818
39 DISSEMINATED TUBERCULOSIS 671 0.3772
40 TRANSPLANT DYSFUNCTION 457 0.3758
41 INTESTINAL RESECTION 1332 0.3694
42 INJECTION SITE IRRITATION 3407 0.3679
43 BLOOD PARATHYROID HORMONE DECREASED 377 0.3597
44 INJECTION SITE URTICARIA 5271 0.3559
45 SLEEP DISORDER DUE TO GENERAL MEDICAL CONDITION, INSOMNIA TYPE 732 0.3524
46 RHEUMATOID LUNG 229 0.3480
47 PUSTULAR PSORIASIS 819 0.3418
48 DRUG LEVEL BELOW THERAPEUTIC 995 0.3376
49 LATENT TUBERCULOSIS 420 0.3376
50 RED BLOOD CELL SEDIMENTATION RATE INCREASED 2434 0.3348
51 HISTOPLASMOSIS 425 0.3333
52 DRUG SPECIFIC ANTIBODY PRESENT 1160 0.3326
53 INFUSION RELATED REACTION 11826 0.3317
54 GRIP STRENGTH DECREASED 1398 0.3304
55 JOINT WARMTH 293 0.3292
56 MYCOBACTERIUM TUBERCULOSIS COMPLEX TEST POSITIVE 514 0.3274
57 TUBERCULIN TEST POSITIVE 729 0.3252
58 KNEE ARTHROPLASTY 3714 0.3217
59 PULMONARY TUBERCULOSIS 1056 0.3216
60 SKIN PLAQUE 1624 0.3215
61 TUBERCULOSIS 2793 0.3208
62 RHEUMATOID FACTOR INCREASED 272 0.3196
63 THERAPEUTIC PRODUCT EFFECT DECREASED 5787 0.3175
64 IRITIS 682 0.3165
65 DRUG TOLERANCE DECREASED 385 0.3143
66 PSORIASIS 26733 0.3126
67 HISTOPLASMOSIS DISSEMINATED 243 0.3107
68 PANNICULITIS 470 0.3106
69 SYSTEMIC LUPUS ERYTHEMATOSUS 5414 0.3103
70 INJECTION SITE HYPERSENSITIVITY 479 0.3082
71 SCLERITIS 282 0.3055
72 RUBBER SENSITIVITY 267 0.3038
73 INJECTION SITE PAIN 56742 0.3035
74 INJECTION SITE DISCOMFORT 1772 0.3026
75 FOOT OPERATION 875 0.3006
76 CROHN'S DISEASE 2057 0.2999
77 DUODENAL ULCER PERFORATION 446 0.2997
78 FOETAL MALFORMATION 249 0.2916
79 SACROILIITIS 336 0.2912
80 FEAR OF INJECTION 1011 0.2899
81 TENOSYNOVITIS 544 0.2887
82 DEMYELINATION 860 0.2876
83 PNEUMONIA LEGIONELLA 318 0.2852
84 COLECTOMY 990 0.2851
85 ANTIBODY TEST POSITIVE 390 0.2828
86 PARANASAL SINUS HYPERSECRETION 840 0.2809
87 JOINT STIFFNESS 4993 0.2773
88 FOOT DEFORMITY 2048 0.2772
89 JOINT SWELLING 20523 0.2771
90 LIMB DEFORMITY 331 0.2720
91 INJECTION SITE BRUISING 13964 0.2668
92 HIP ARTHROPLASTY 2262 0.2638
93 JOINT EFFUSION 1289 0.2581
94 PYODERMA GANGRENOSUM 481 0.2575
95 ARTHROPATHY 9090 0.2551
96 JOINT LOCK 510 0.2530
97 POLYARTHRITIS 803 0.2527
98 BODY TEMPERATURE FLUCTUATION 369 0.2519
99 DERMATITIS PSORIASIFORM 298 0.2496
100 INTESTINAL OPERATION 232 0.2492
101 INJECTION SITE INFLAMMATION 796 0.2487
102 UVEITIS 1723 0.2429
103 NODULE 2081 0.2428
104 INJECTION SITE VESICLES 857 0.2415
105 DRUG EFFECT INCOMPLETE 8647 0.2366
106 ILEOSTOMY 309 0.2353
107 PERICARDITIS 1563 0.2328
108 CHONDROPATHY 504 0.2328
109 RESPIRATORY TRACT CONGESTION 2459 0.2316
110 ILEAL STENOSIS 257 0.2313
111 OPEN WOUND 259 0.2313
112 DECREASED IMMUNE RESPONSIVENESS 1215 0.2310
113 LOWER RESPIRATORY TRACT INFECTION 6155 0.2273
114 JOINT RANGE OF MOTION DECREASED 1677 0.2273
115 PHARYNGITIS STREPTOCOCCAL 1534 0.2267
116 MATERNAL EXPOSURE DURING BREAST FEEDING 252 0.2238
117 ANAL ABSCESS 705 0.2237
118 ANTINUCLEAR ANTIBODY POSITIVE 585 0.2228
119 SINUSITIS 15077 0.2219
120 PNEUMOCYSTIS JIROVECI PNEUMONIA 491 0.2199
121 FISTULA 1506 0.2155
122 BASAL CELL CARCINOMA 2257 0.2144
123 FINE MOTOR SKILL DYSFUNCTION 361 0.2130
124 ARTHRITIS BACTERIAL 597 0.2116
125 HELICOBACTER INFECTION 744 0.2111
126 INCORRECT PRODUCT STORAGE 2777 0.2110
127 DRUG INTOLERANCE 12238 0.2108
128 INTESTINAL STENOSIS 623 0.2102
129 LIMB OPERATION 544 0.2099
130 ARTHRITIS INFECTIVE 641 0.2095
131 MUSCULOSKELETAL STIFFNESS 12052 0.2085
132 FOLLICULITIS 638 0.2082
133 GLOSSODYNIA 2518 0.2069
134 ARTHROPOD BITE 1020 0.2067
135 SINUS CONGESTION 1948 0.2061
136 SPINAL FUSION SURGERY 503 0.2059
137 ANAL FISTULA 692 0.2059
138 RECTAL ABSCESS 229 0.2056
139 SENSITIVITY TO WEATHER CHANGE 586 0.2055
140 THERAPEUTIC RESPONSE DECREASED 8185 0.2048
141 BLOOD PRESSURE FLUCTUATION 3294 0.2045
142 TOOTH INFECTION 1749 0.2045
143 NON-HODGKIN'S LYMPHOMA 268 0.2043
144 ONYCHOMYCOSIS 512 0.2035
145 TREATMENT FAILURE 10018 0.2022
146 LOCAL SWELLING 3519 0.2013
147 SARCOIDOSIS 652 0.1949
148 LYMPHOMA 1993 0.1947
149 ANIMAL BITE 326 0.1929
150 POST PROCEDURAL INFECTION 955 0.1928
151 WOUND 2777 0.1910
152 TONSILLITIS 661 0.1891
153 SYNOVIAL CYST 614 0.1887
154 RHEUMATIC DISORDER 229 0.1879
155 COLITIS ULCERATIVE 3940 0.1864
156 IRIDOCYCLITIS 329 0.1849
157 SHOULDER OPERATION 394 0.1844
158 JOINT CREPITATION 366 0.1840
159 INFECTIOUS MONONUCLEOSIS 300 0.1834
160 KNEE OPERATION 929 0.1812
161 INJECTION SITE HAEMORRHAGE 9036 0.1810
162 EAR INFECTION 2855 0.1797
163 MOBILITY DECREASED 8367 0.1791
164 HERPES ZOSTER 7034 0.1789
165 BRONCHITIS CHRONIC 349 0.1788
166 ARTHRALGIA 45922 0.1780
167 ANAL FISSURE 450 0.1779
168 PHARYNGITIS 1602 0.1776
169 SINUS HEADACHE 841 0.1770
170 TOOTH ABSCESS 1363 0.1763
171 FURUNCLE 990 0.1762
172 ARTHRITIS 9102 0.1758
173 DRUG EFFECT DECREASED 9425 0.1743
174 SKIN CANCER 1928 0.1733
175 ENDODONTIC PROCEDURE 310 0.1717
176 LYMPHOPROLIFERATIVE DISORDER 320 0.1701
177 LOCALISED INFECTION 2738 0.1686
178 FIBROMYALGIA 2544 0.1681
179 THERAPEUTIC RESPONSE DELAYED 331 0.1681
180 INFECTION SUSCEPTIBILITY INCREASED 228 0.1675
181 NASOPHARYNGITIS 19603 0.1674
182 B-CELL LYMPHOMA 429 0.1665
183 LOSS OF PERSONAL INDEPENDENCE IN DAILY ACTIVITIES 3697 0.1658
184 INFLAMMATION 4937 0.1658
185 ERYTHEMA NODOSUM 355 0.1653
186 SERUM SICKNESS 338 0.1653
187 VIRAL UPPER RESPIRATORY TRACT INFECTION 663 0.1641
188 DENGUE FEVER 231 0.1636
189 MUSCULOSKELETAL DISORDER 2278 0.1635
190 VARICELLA 290 0.1630
191 INJECTION SITE EXTRAVASATION 1662 0.1628
192 VULVOVAGINAL MYCOTIC INFECTION 485 0.1628
193 MUSCULOSKELETAL PAIN 7358 0.1622
194 INCREASED TENDENCY TO BRUISE 1110 0.1612
195 SURGERY 5366 0.1610
196 IMMUNOSUPPRESSION 787 0.1598
197 UPPER RESPIRATORY TRACT INFECTION 5011 0.1596
198 MALIGNANT MELANOMA 1502 0.1596
199 INFLAMMATORY MARKER INCREASED 405 0.1592
200 UPPER RESPIRATORY TRACT CONGESTION 336 0.1583
201 HIP SURGERY 425 0.1577
202 CUTANEOUS LUPUS ERYTHEMATOSUS 234 0.1569
203 C-REACTIVE PROTEIN INCREASED 3542 0.1560
204 INJECTION SITE MASS 3616 0.1559
205 MUCOUS STOOLS 361 0.1556
206 LYME DISEASE 336 0.1528
207 SPINAL OPERATION 820 0.1515
208 WOUND INFECTION 913 0.1505
209 SQUAMOUS CELL CARCINOMA 987 0.1504
210 ABSCESS 1581 0.1497
211 NECK MASS 288 0.1495
212 OSTEOARTHRITIS 4187 0.1475
213 PNEUMONIA VIRAL 291 0.1473
214 STREPTOCOCCAL INFECTION 524 0.1473
215 MUSCLE INJURY 391 0.1471
216 IMPAIRED HEALING 3127 0.1469
217 SUBCUTANEOUS ABSCESS 515 0.1464
218 EXOSTOSIS 907 0.1451
219 BRONCHITIS 7935 0.1438
220 DIVERTICULITIS 2692 0.1434
221 EAR CONGESTION 254 0.1417
222 ACCIDENTAL EXPOSURE TO PRODUCT 5687 0.1410
223 DRUG LEVEL ABOVE THERAPEUTIC 338 0.1408
224 THERAPEUTIC RESPONSE SHORTENED 1146 0.1408
225 SKIN PAPILLOMA 394 0.1402
226 THERAPY NON-RESPONDER 2940 0.1402
227 WHEELCHAIR USER 425 0.1396
228 DRUG LEVEL DECREASED 781 0.1389
229 BURSITIS 976 0.1386
230 CYST 1169 0.1382
231 SWELLING 8151 0.1372
232 THERAPEUTIC PRODUCT EFFECT INCOMPLETE 4014 0.1371
233 TYPE IV HYPERSENSITIVITY REACTION 234 0.1367
234 ABSCESS LIMB 377 0.1356
235 INFECTION 12087 0.1351
236 INFLUENZA 9350 0.1337
237 WALKING AID USER 562 0.1333
238 ONYCHOMADESIS 288 0.1333
239 LUNG ADENOCARCINOMA 268 0.1329
240 ADVERSE REACTION 1239 0.1329
241 EYE INFECTION 890 0.1323
242 TENDERNESS 989 0.1322
243 FREQUENT BOWEL MOVEMENTS 1939 0.1321
244 CONDITION AGGRAVATED 22350 0.1318
245 IMMUNE SYSTEM DISORDER 1130 0.1316
246 SKIN INFECTION 916 0.1314
247 POSTOPERATIVE WOUND INFECTION 568 0.1313
248 MACULE 241 0.1302
249 LACERATION 1228 0.1301
250 THYROID NEOPLASM 318 0.1290
251 POOR VENOUS ACCESS 680 0.1289
252 SPINAL PAIN 941 0.1279
253 OROPHARYNGEAL PAIN 7727 0.1277
254 INJECTION SITE INJURY 296 0.1276
255 PULMONARY FIBROSIS 1530 0.1276
256 LIVER FUNCTION TEST INCREASED 1479 0.1274
257 NAIL DISORDER 658 0.1267
258 IMMOBILE 393 0.1266
259 ORAL INFECTION 342 0.1260
260 GALLBLADDER OPERATION 321 0.1247
261 LARYNGITIS 880 0.1246
262 KIDNEY INFECTION 1603 0.1239
263 HEPATIC ENZYME INCREASED 5236 0.1239
264 CARPAL TUNNEL SYNDROME 1192 0.1238
265 LUNG NEOPLASM 438 0.1238
266 EAR PAIN 1616 0.1238
267 STAPHYLOCOCCAL INFECTION 3082 0.1238
268 PERIPHERAL SWELLING 11308 0.1234
269 DRUG DOSE OMISSION BY DEVICE 604 0.1231
270 ABDOMINAL ABSCESS 371 0.1231
271 PULMONARY MASS 1160 0.1229
272 SECRETION DISCHARGE 876 0.1226
273 PAIN IN EXTREMITY 25694 0.1213
274 FUNGAL SKIN INFECTION 319 0.1208
275 HERPES VIRUS INFECTION 485 0.1207
276 SPONDYLITIS 250 0.1204
277 SKIN ULCER 2183 0.1201
278 APPARENT DEATH 425 0.1194
279 PHARYNGOLARYNGEAL PAIN 634 0.1192
280 RECTAL CANCER 250 0.1190
281 MATERNAL EXPOSURE BEFORE PREGNANCY 441 0.1186
282 SKIN MASS 486 0.1186
283 HEPATIC ENZYME ABNORMAL 388 0.1184
284 EYE OPERATION 263 0.1180
285 JOINT DISLOCATION 833 0.1176
286 RESPIRATORY TRACT INFECTION 1918 0.1175
287 JOINT INJURY 1662 0.1168
288 ORAL HERPES 1379 0.1166
289 SCIATICA 1087 0.1161
290 MENISCUS INJURY 481 0.1155
291 BRONCHIECTASIS 431 0.1149
292 HYSTERECTOMY 657 0.1144
293 GASTROENTERITIS VIRAL 1335 0.1143
294 RHINORRHOEA 4600 0.1142
295 SCRATCH 625 0.1140
296 SKIN HAEMORRHAGE 855 0.1135
297 PLEURISY 535 0.1130
298 MELANOCYTIC NAEVUS 334 0.1125
299 NECK PAIN 4332 0.1122
300 CLOSTRIDIUM DIFFICILE INFECTION 1498 0.1119
301 CELLULITIS 4013 0.1102
302 COLITIS MICROSCOPIC 278 0.1095
303 INCREASED UPPER AIRWAY SECRETION 484 0.1090
304 OVARIAN CYST 858 0.1090
305 INJURY ASSOCIATED WITH DEVICE 1084 0.1089
306 THERAPY INTERRUPTED 1008 0.1088
307 NASAL CONGESTION 3857 0.1086
308 NEPHROLITHIASIS 3176 0.1081
309 GASTRIC INFECTION 268 0.1079
310 GASTROINTESTINAL INFECTION 617 0.1076
311 MASS 1086 0.1073
312 ERYSIPELAS 383 0.1072
313 DIARRHOEA HAEMORRHAGIC 689 0.1064
314 DRUG DELIVERY SYSTEM MALFUNCTION 258 0.1052
315 SINUS DISORDER 1392 0.1050
316 PAIN 40809 0.1050
317 SPINAL COLUMN STENOSIS 494 0.1039
318 SKIN LACERATION 584 0.1033
319 RASH PUSTULAR 629 0.1031
320 DRUG EFFECT DELAYED 468 0.1029
321 VAGINAL INFECTION 340 0.1028
322 PRODUCT USE ISSUE 11642 0.1024
323 TOOTH FRACTURE 810 0.1024
324 VASCULITIS 782 0.1017
325 VIRAL INFECTION 2212 0.1017
326 HIDRADENITIS 272 0.1012
327 INTENTIONAL PRODUCT USE ISSUE 4476 0.1011
328 TRIGGER FINGER 255 0.1010
329 CYSTITIS 2344 0.1010
330 MOUTH ULCERATION 1390 0.1010
331 LIGAMENT RUPTURE 313 0.1000
332 TOOTHACHE 1266 0.0998
333 CERVIX CARCINOMA 236 0.0998
334 APHTHOUS ULCER 360 0.0997
335 SPINAL DISORDER 657 0.0989
336 DIFFUSE LARGE B-CELL LYMPHOMA 379 0.0988
337 NO THERAPEUTIC RESPONSE 1197 0.0980
338 SNEEZING 1356 0.0980
339 GRANULOMA 235 0.0980
340 HAEMATOCHEZIA 3247 0.0975
341 MUSCULOSKELETAL DISCOMFORT 1123 0.0973
342 DEVICE MALFUNCTION 3435 0.0969
343 PRODUCTIVE COUGH 2788 0.0968
344 SPUTUM DISCOLOURED 595 0.0965
345 SKIN NECROSIS 378 0.0963
346 DRUG INEFFECTIVE 83784 0.0958
347 RASH PRURITIC 3378 0.0958
348 GASTROINTESTINAL INFLAMMATION 468 0.0957
349 GAIT INABILITY 1420 0.0952
350 FUNGAL INFECTION 2137 0.0951
351 LYMPHADENOPATHY 2306 0.0950
352 INTERVERTEBRAL DISC DISORDER 315 0.0947
353 SKIN LESION 1685 0.0946
354 SQUAMOUS CELL CARCINOMA OF SKIN 351 0.0944
355 HYPERKERATOSIS 357 0.0938
356 CONTUSION 6041 0.0931
357 ROTATOR CUFF SYNDROME 877 0.0923
358 INCORRECT DOSE ADMINISTERED BY DEVICE 770 0.0922
359 INTERVERTEBRAL DISC PROTRUSION 1504 0.0921
360 DRUG ERUPTION 1053 0.0920
361 UPPER-AIRWAY COUGH SYNDROME 455 0.0920
362 ULCER 1018 0.0919
363 DISABILITY 1189 0.0919
364 NERVE COMPRESSION 573 0.0917
365 DRUG DOSE OMISSION 15169 0.0914
366 RASH ERYTHEMATOUS 2595 0.0913
367 RHINITIS 487 0.0906
368 DRUG HYPERSENSITIVITY 12854 0.0900
369 BODY TEMPERATURE DECREASED 627 0.0895
370 DEVICE ISSUE 4131 0.0890
371 INSURANCE ISSUE 294 0.0886
372 BREAST MASS 420 0.0879
373 INTERVERTEBRAL DISC DEGENERATION 631 0.0876
374 ACCIDENT 668 0.0875
375 DERMATITIS ALLERGIC 675 0.0874
376 PYELONEPHRITIS 509 0.0871
377 ADVERSE DRUG REACTION 4289 0.0870
378 COLON CANCER 851 0.0869
379 PNEUMOCYSTIS JIROVECII PNEUMONIA 489 0.0868
380 PAPULE 332 0.0867
381 HYPERSENSITIVITY 10956 0.0866
382 INJECTION SITE PAPULE 260 0.0865
383 INFUSION SITE EXTRAVASATION 335 0.0864
384 PURULENT DISCHARGE 275 0.0855
385 PRURITUS GENERALISED 1856 0.0854
386 LUNG INFECTION 1338 0.0852
387 SKIN WARM 350 0.0849
388 DEFORMITY 582 0.0848
389 SCAB 644 0.0843
390 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 9170 0.0842
391 ADRENAL INSUFFICIENCY 522 0.0840
392 SEASONAL ALLERGY 623 0.0840
393 TOOTH DISORDER 1360 0.0839
394 INJECTION SITE NODULE 701 0.0835
395 COUGH 14728 0.0835
396 DISCOMFORT 2746 0.0834
397 BODY TEMPERATURE INCREASED 1225 0.0832
398 CATARACT OPERATION 350 0.0831
399 GINGIVITIS 325 0.0830
400 EYE INFLAMMATION 424 0.0828
401 TRANSPLANT REJECTION 446 0.0825
402 LIMB INJURY 1369 0.0823
403 FOOD POISONING 249 0.0822
404 UNEVALUABLE EVENT 4594 0.0821
405 MATERNAL EXPOSURE DURING PREGNANCY 3723 0.0820
406 HEART RATE IRREGULAR 1416 0.0817
407 URINARY TRACT INFECTION 9025 0.0817
408 VARICOSE VEIN 303 0.0816
409 ORAL CANDIDIASIS 694 0.0812
410 STAPHYLOCOCCAL SEPSIS 309 0.0811
411 PREMATURE LABOUR 389 0.0811
412 LIMB DISCOMFORT 1630 0.0810
413 IMMUNODEFICIENCY 623 0.0808
414 ORGANISING PNEUMONIA 229 0.0807
415 SKIN ATROPHY 306 0.0805
416 HEPATIC STEATOSIS 1036 0.0800
417 BEDRIDDEN 740 0.0798
418 BLOOD IRON DECREASED 540 0.0798
419 TOOTH EXTRACTION 721 0.0797
420 EAR DISORDER 252 0.0794
421 BLOOD TEST ABNORMAL 646 0.0794
422 NEEDLE ISSUE 981 0.0793
423 WOUND SECRETION 239 0.0792
424 OFF LABEL USE 32905 0.0790
425 MENINGITIS 369 0.0789
426 BACTERIAL INFECTION 919 0.0787
427 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 4767 0.0785
428 SKIN DISORDER 1596 0.0783
429 TENDON DISORDER 375 0.0782
430 FOOT FRACTURE 1051 0.0781
431 IRRITABLE BOWEL SYNDROME 944 0.0779
432 LIGAMENT SPRAIN 488 0.0774
433 CLOSTRIDIAL INFECTION 236 0.0773
434 UMBILICAL HERNIA 254 0.0773
435 BACK PAIN 12495 0.0771
436 PRODUCT STORAGE ERROR 1972 0.0770
437 ILL-DEFINED DISORDER 2051 0.0769
438 SKIN FISSURES 684 0.0765
439 NIGHT SWEATS 1595 0.0763
440 EPSTEIN-BARR VIRUS INFECTION 314 0.0762
441 STRESS 3521 0.0760
442 SKIN REACTION 738 0.0760
443 GROIN PAIN 489 0.0760
444 LIVER FUNCTION TEST ABNORMAL 1868 0.0759
445 UPPER LIMB FRACTURE 1107 0.0751
446 DENTAL CARIES 613 0.0751
447 APPENDICITIS 439 0.0750
448 CATARACT 2800 0.0749
449 GUILLAIN-BARRE SYNDROME 232 0.0746
450 PNEUMONIA 16012 0.0744
451 AUTOIMMUNE HEPATITIS 335 0.0742
452 HERNIA 915 0.0742
453 LOWER LIMB FRACTURE 874 0.0740
454 GASTROINTESTINAL PAIN 519 0.0739
455 ALOPECIA 10310 0.0738
456 HAND FRACTURE 350 0.0738
457 ABDOMINAL DISCOMFORT 7865 0.0737
458 ABDOMINAL HERNIA 248 0.0735
459 OSTEOMYELITIS 1023 0.0734
460 COLITIS 1642 0.0732
461 LUNG DISORDER 2367 0.0732
462 BRONCHOPNEUMONIA 250 0.0728
463 INTERSTITIAL LUNG DISEASE 2278 0.0728
464 BACK INJURY 490 0.0727
465 WRIST FRACTURE 605 0.0722
466 FEELING HOT 3042 0.0720
467 CHOLECYSTECTOMY 567 0.0714
468 ANKLE FRACTURE 777 0.0711
469 NERVE INJURY 572 0.0707
470 SKIN DISCOLOURATION 2260 0.0699
471 EAR DISCOMFORT 472 0.0699
472 BONE DISORDER 1005 0.0698
473 ENDOMETRIOSIS 230 0.0697
474 UNDERDOSE 3506 0.0694
475 THERAPY CESSATION 2241 0.0694
476 HEART RATE DECREASED 1619 0.0694
477 PNEUMONIA BACTERIAL 324 0.0692
478 MULTIPLE ALLERGIES 324 0.0690
479 URTICARIA 7595 0.0690
480 EYE DISORDER 1494 0.0689
481 CANDIDA INFECTION 678 0.0689
482 PULMONARY CONGESTION 637 0.0689
483 GASTROINTESTINAL DISORDER 3312 0.0684
484 VEIN DISORDER 249 0.0684
485 NEOPLASM MALIGNANT 2830 0.0683
486 MUSCULOSKELETAL CHEST PAIN 732 0.0682
487 ENCEPHALITIS 305 0.0681
488 ONYCHOCLASIS 300 0.0681
489 GESTATIONAL DIABETES 229 0.0681
490 THYROID CANCER 457 0.0677
491 NEOPLASM 483 0.0677
492 RESPIRATORY DISORDER 1408 0.0676
493 APHONIA 602 0.0674
494 LUNG NEOPLASM MALIGNANT 1622 0.0674
495 CYTOMEGALOVIRUS INFECTION 750 0.0673
496 BLISTER 2412 0.0672
497 GAIT DISTURBANCE 9125 0.0671
498 DRY EYE 1624 0.0669
499 HERPES SIMPLEX 301 0.0667
500 BACK DISORDER 757 0.0667
501 OSTEOPOROSIS 1900 0.0664
502 PELVIC FRACTURE 355 0.0663
503 LIVER DISORDER 1961 0.0661
504 RASH 18314 0.0661
505 FOOD ALLERGY 245 0.0660
506 AUTOIMMUNE DISORDER 282 0.0660
507 ADVERSE EVENT 4278 0.0659
508 RASH PAPULAR 1128 0.0659
509 MALAISE 21083 0.0659
510 ABNORMAL LOSS OF WEIGHT 327 0.0658
511 INFLAMMATORY BOWEL DISEASE 501 0.0657
512 CAESAREAN SECTION 630 0.0657
513 INGUINAL HERNIA 285 0.0656
514 PRODUCT PRESCRIBING ISSUE 260 0.0655
515 PULMONARY THROMBOSIS 454 0.0653
516 IMPAIRED WORK ABILITY 1072 0.0651
517 INTENTIONAL PRODUCT MISUSE 3815 0.0651
518 OPTIC NEURITIS 441 0.0649
519 TENDONITIS 760 0.0649
520 THROAT IRRITATION 1885 0.0646
521 GLAUCOMA 874 0.0646
522 ESCHERICHIA INFECTION 333 0.0644
523 SPINAL OSTEOARTHRITIS 422 0.0643
524 WEIGHT FLUCTUATION 359 0.0642
525 BREAST CANCER 3386 0.0642
526 HEPATIC CIRRHOSIS 780 0.0639
527 ANAPHYLACTIC REACTION 2183 0.0638
528 SMALL INTESTINAL OBSTRUCTION 542 0.0638
529 HYPOAESTHESIA 6764 0.0637
530 CANDIDIASIS 256 0.0637
531 BLOOD PRESSURE DIASTOLIC DECREASED 286 0.0635
532 INTENTIONAL DOSE OMISSION 391 0.0632
533 MUSCLE STRAIN 379 0.0630
534 ABASIA 1552 0.0627
535 GASTROENTERITIS 650 0.0624
536 DEVICE FAILURE 591 0.0623
537 POLYP 280 0.0621
538 HYPOKINESIA 646 0.0621
539 THYROID DISORDER 633 0.0620
540 INTESTINAL PERFORATION 488 0.0619
541 ECZEMA 1058 0.0619
542 INFLUENZA LIKE ILLNESS 3917 0.0615
543 ERYTHEMA 8924 0.0614
544 PROCTALGIA 270 0.0614
545 OEDEMA PERIPHERAL 5876 0.0611
546 OSTEOPENIA 624 0.0610
547 PHOTOSENSITIVITY REACTION 705 0.0608
548 PYREXIA 14485 0.0608
549 STOMATITIS 2324 0.0604
550 OBESITY 624 0.0603
551 TENDON RUPTURE 574 0.0602
552 INTESTINAL OBSTRUCTION 1435 0.0600
553 RASH GENERALISED 1557 0.0598
554 HEADACHE 25998 0.0596
555 CONJUNCTIVITIS 614 0.0596
556 BRAIN NEOPLASM 352 0.0596
557 RASH MACULAR 1339 0.0594
558 DERMATITIS CONTACT 442 0.0594
559 TONGUE DISORDER 341 0.0594
560 FATIGUE 29882 0.0594
561 SCAR 750 0.0593
562 HYPERCHOLESTEROLAEMIA 344 0.0591
563 CONCUSSION 302 0.0590
564 HYPERCALCAEMIA 502 0.0590
565 FACIAL PAIN 350 0.0589
566 HYPERAESTHESIA 368 0.0584
567 IRON DEFICIENCY ANAEMIA 379 0.0583
568 CHILLS 4702 0.0582
569 UTERINE LEIOMYOMA 317 0.0582
570 THERMAL BURN 302 0.0582
571 BLOOD DISORDER 323 0.0579
572 VITAMIN D DECREASED 353 0.0578
573 ORAL DISORDER 301 0.0577
574 FEELING OF BODY TEMPERATURE CHANGE 248 0.0577
575 CHEST DISCOMFORT 3899 0.0575
576 COELIAC DISEASE 388 0.0573
577 OVARIAN CANCER 341 0.0567
578 PREGNANCY 957 0.0566
579 CARDIAC OPERATION 302 0.0562
580 PALLOR 997 0.0557
581 LEUKAEMIA 318 0.0554
582 SKIN SWELLING 249 0.0553
583 SCOLIOSIS 239 0.0552
584 POST PROCEDURAL COMPLICATION 787 0.0552
585 EXPOSURE DURING PREGNANCY 2127 0.0550
586 EMPHYSEMA 422 0.0549
587 HYPOACUSIS 1384 0.0549
588 SPINAL FRACTURE 706 0.0544
589 UTERINE CANCER 263 0.0542
590 ROAD TRAFFIC ACCIDENT 1617 0.0542
591 MIGRAINE 3276 0.0540
592 PAIN IN JAW 1145 0.0537
593 THROAT TIGHTNESS 1018 0.0537
594 DISEASE RECURRENCE 859 0.0536
595 SPINAL COMPRESSION FRACTURE 341 0.0534
596 PRURITUS 11827 0.0534
597 HEAD DISCOMFORT 578 0.0532
598 INAPPROPRIATE SCHEDULE OF DRUG ADMINISTRATION 3787 0.0530
599 DIABETES MELLITUS 3009 0.0530
600 VITAMIN D DEFICIENCY 348 0.0530
601 ABDOMINAL PAIN 8461 0.0530
602 DIVERTICULUM 327 0.0529
603 PARAESTHESIA 5937 0.0528
604 LARGE INTESTINE PERFORATION 262 0.0527
605 ABORTION SPONTANEOUS 1587 0.0525
606 GINGIVAL PAIN 296 0.0525
607 SUNBURN 300 0.0524
608 PRODUCT DOSE OMISSION 3540 0.0524
609 IMPAIRED GASTRIC EMPTYING 266 0.0523
610 HEARING IMPAIRED 314 0.0523
611 DYSPHONIA 2032 0.0521
612 WEIGHT INCREASED 7819 0.0521
613 RECTAL HAEMORRHAGE 1655 0.0520
614 HEPATITIS B 241 0.0518
615 PHARYNGEAL OEDEMA 772 0.0515
616 DRY THROAT 358 0.0513
617 COVID-19 1380 0.0506
618 ILLNESS 792 0.0505
619 RENAL CYST 299 0.0505
620 LABORATORY TEST ABNORMAL 989 0.0504
621 SENSORY LOSS 293 0.0503
622 GENERALISED ERYTHEMA 287 0.0501
623 RIB FRACTURE 707 0.0499
624 DEAFNESS 857 0.0492
625 SEPSIS 3841 0.0491
626 GASTRIC DISORDER 1446 0.0489
627 EYE DISCHARGE 293 0.0488
628 UROSEPSIS 304 0.0488
629 BURNING SENSATION 2454 0.0488
630 GALLBLADDER DISORDER 679 0.0487
631 BLOOD PRESSURE INCREASED 5073 0.0485
632 SLEEP DISORDER 2074 0.0485
633 FEELING COLD 949 0.0482
634 BLOOD PRESSURE ABNORMAL 570 0.0482
635 DYSSTASIA 984 0.0480
636 PRODUCT AVAILABILITY ISSUE 238 0.0479
637 FEEDING DISORDER 490 0.0477
638 BLOOD CHOLESTEROL INCREASED 1508 0.0472
639 PHOTOPHOBIA 565 0.0471
640 NEURALGIA 729 0.0466
641 HIP FRACTURE 1016 0.0466
642 WEIGHT DECREASED 8751 0.0465
643 HEPATITIS 840 0.0465
644 GENERAL PHYSICAL HEALTH DETERIORATION 3158 0.0465
645 HYPERTENSION 6652 0.0463
646 LACRIMATION INCREASED 829 0.0461
647 SLEEP DISORDER DUE TO A GENERAL MEDICAL CONDITION 235 0.0456
648 FLANK PAIN 296 0.0454
649 FACIAL PARALYSIS 238 0.0454
650 ACTIVITIES OF DAILY LIVING IMPAIRED 897 0.0452
651 ORAL PAIN 716 0.0452
652 SEPTIC SHOCK 1272 0.0449
653 DERMATITIS 576 0.0448
654 PLATELET COUNT INCREASED 385 0.0448
655 FALL 10304 0.0447
656 HAEMORRHOIDS 632 0.0446
657 SWELLING FACE 2057 0.0445
658 CHOLELITHIASIS 1085 0.0445
659 FEMUR FRACTURE 1086 0.0442
660 WHITE BLOOD CELL COUNT INCREASED 1263 0.0440
661 PNEUMOTHORAX 460 0.0437
662 PRODUCT DOSE OMISSION ISSUE 2107 0.0436
663 PREMATURE BABY 939 0.0433
664 GENERALISED OEDEMA 362 0.0433
665 MALNUTRITION 318 0.0432
666 GOUT 521 0.0424
667 FEELING ABNORMAL 7486 0.0423
668 MUSCULAR WEAKNESS 3389 0.0422
669 NASAL DISCOMFORT 245 0.0418
670 OCULAR HYPERAEMIA 1172 0.0417
671 DEVICE RELATED INFECTION 491 0.0416
672 INFARCTION 232 0.0416
673 GASTRIC ULCER 593 0.0415
674 NAUSEA 22450 0.0415
675 PNEUMONITIS 672 0.0414
676 CHEST PAIN 5665 0.0414
677 PRODUCT PRESCRIBING ERROR 405 0.0414
678 INCORRECT ROUTE OF PRODUCT ADMINISTRATION 287 0.0414
679 EYE SWELLING 1045 0.0411
680 EYE PRURITUS 716 0.0411
681 MYOSITIS 234 0.0410
682 HOSPITALISATION 3470 0.0408
683 VISUAL IMPAIRMENT 3134 0.0408
684 ASTHMA 2596 0.0408
685 MACULAR DEGENERATION 307 0.0406
686 BACTERAEMIA 293 0.0404
687 MOTOR DYSFUNCTION 286 0.0402
688 BLOOD URINE PRESENT 562 0.0402
689 GINGIVAL BLEEDING 362 0.0400
690 PREMATURE DELIVERY 420 0.0400
691 MENSTRUAL DISORDER 239 0.0399
692 ABDOMINAL PAIN UPPER 5516 0.0398
693 HEPATOTOXICITY 549 0.0397
694 BLOOD PRESSURE SYSTOLIC INCREASED 472 0.0397
695 HIATUS HERNIA 397 0.0396
696 DIARRHOEA 16287 0.0394
697 MUSCLE TIGHTNESS 465 0.0393
698 EYE PAIN 1298 0.0390
699 HYPERHIDROSIS 3632 0.0389
700 SKIN EXFOLIATION 2073 0.0388
701 PROSTATE CANCER 1245 0.0386
702 TEMPERATURE INTOLERANCE 247 0.0384
703 CHOLECYSTITIS 328 0.0383
704 SYRINGE ISSUE 269 0.0383
705 AORTIC ANEURYSM 229 0.0383
706 EATING DISORDER 565 0.0383
707 GENERAL SYMPTOM 232 0.0382
708 ANAPHYLACTIC SHOCK 635 0.0382
709 CHRONIC OBSTRUCTIVE PULMONARY DISEASE 1432 0.0381
710 BLADDER DISORDER 273 0.0381
711 NERVOUSNESS 1572 0.0379
712 RETINAL DETACHMENT 238 0.0379
713 FRACTURE 536 0.0378
714 HEPATITIS C 401 0.0378
715 MEMORY IMPAIRMENT 3578 0.0377
716 VOMITING 12044 0.0376
717 MUSCLE SPASMS 4882 0.0375
718 WHEEZING 1327 0.0371
719 PERIPHERAL COLDNESS 362 0.0370
720 CLOSTRIDIUM DIFFICILE COLITIS 272 0.0369
721 BRONCHOSPASM 396 0.0368
722 DYSPNOEA 14344 0.0367
723 COLD SWEAT 468 0.0366
724 SLUGGISHNESS 263 0.0366
725 BONE PAIN 1523 0.0366
726 LEUKOPENIA 1254 0.0365
727 GASTRITIS 691 0.0365
728 POOR QUALITY SLEEP 504 0.0364
729 WRONG TECHNIQUE IN DRUG USAGE PROCESS 1324 0.0364
730 FLUSHING 2868 0.0363
731 ORAL DISCOMFORT 362 0.0362
732 LUNG INFILTRATION 271 0.0362
733 RENAL PAIN 259 0.0361
734 EXTRA DOSE ADMINISTERED 627 0.0360
735 ASTHENIA 9304 0.0359
736 PARAESTHESIA ORAL 343 0.0357
737 PANCREATITIS 1394 0.0356
738 HOT FLUSH 1652 0.0355
739 LIVER INJURY 406 0.0354
740 MUSCLE SPASTICITY 334 0.0354
741 OXYGEN SATURATION DECREASED 1153 0.0353
742 HEART RATE INCREASED 2394 0.0352
743 SLEEP APNOEA SYNDROME 498 0.0352
744 EYE HAEMORRHAGE 342 0.0349
745 MUSCLE ATROPHY 283 0.0348
746 POLYNEUROPATHY 251 0.0348
747 TYPE 2 DIABETES MELLITUS 840 0.0347
748 DRUG PRESCRIBING ERROR 667 0.0346
749 THROMBOSIS 1952 0.0344
750 RENAL DISORDER 1100 0.0344
751 MYALGIA 4157 0.0343
752 TRANSAMINASES INCREASED 538 0.0339
753 DRUG-INDUCED LIVER INJURY 513 0.0336
754 INCORRECT DOSE ADMINISTERED 3709 0.0336
755 LIP SWELLING 782 0.0336
756 HYPERSOMNIA 659 0.0335
757 BREAST PAIN 275 0.0335
758 PLEURAL EFFUSION 1475 0.0335
759 PARALYSIS 347 0.0334
760 PERICARDIAL EFFUSION 514 0.0334
761 ABDOMINAL DISTENSION 2346 0.0333
762 VERTIGO 1467 0.0331
763 HYPOAESTHESIA ORAL 356 0.0330
764 SPLENOMEGALY 274 0.0330
765 DYSURIA 875 0.0328
766 DIZZINESS 11366 0.0327
767 CORONARY ARTERY OCCLUSION 368 0.0326
768 ACUTE RESPIRATORY DISTRESS SYNDROME 401 0.0324
769 DRY MOUTH 1780 0.0320
770 HYPOTHYROIDISM 638 0.0320
771 NEUROPATHY PERIPHERAL 1848 0.0319
772 BLOOD PRESSURE DECREASED 1469 0.0318
773 CYANOSIS 372 0.0317
774 WHITE BLOOD CELL COUNT DECREASED 2215 0.0316
775 PRESYNCOPE 524 0.0316
776 DRUG RESISTANCE 501 0.0316
777 ALANINE AMINOTRANSFERASE INCREASED 1442 0.0315
778 PALPITATIONS 2594 0.0315
779 ATELECTASIS 233 0.0312
780 EPISTAXIS 1690 0.0312
781 VISUAL ACUITY REDUCED 904 0.0312
782 PRODUCT DISPENSING ERROR 266 0.0311
783 ACNE 1837 0.0310
784 EYELID OEDEMA 304 0.0308
785 HEAD INJURY 669 0.0308
786 RED BLOOD CELL COUNT DECREASED 577 0.0308
787 SENSORY DISTURBANCE 385 0.0305
788 MICTURITION URGENCY 235 0.0304
789 BLINDNESS 814 0.0303
790 MOVEMENT DISORDER 695 0.0302
791 ABDOMINAL PAIN LOWER 559 0.0302
792 SWOLLEN TONGUE 701 0.0300
793 ASPARTATE AMINOTRANSFERASE INCREASED 1185 0.0298
794 HEPATOMEGALY 228 0.0298
795 BLOOD POTASSIUM DECREASED 627 0.0296
796 GASTROOESOPHAGEAL REFLUX DISEASE 1630 0.0296
797 INSOMNIA 5709 0.0295
798 PROCEDURAL PAIN 526 0.0292
799 VISION BLURRED 2713 0.0291
800 DEPRESSION 5043 0.0290
801 HAEMORRHAGE 2040 0.0290
802 TACHYCARDIA 1789 0.0290
803 BODY HEIGHT DECREASED 257 0.0290
804 DYSPEPSIA 1923 0.0288
805 POLLAKIURIA 831 0.0286
806 DIPLOPIA 504 0.0283
807 MULTI-ORGAN FAILURE 491 0.0283
808 METASTASES TO LIVER 322 0.0283
809 POST PROCEDURAL HAEMORRHAGE 252 0.0283
810 PAIN OF SKIN 564 0.0282
811 DEPRESSED MOOD 992 0.0281
812 NERVOUS SYSTEM DISORDER 704 0.0280
813 QUALITY OF LIFE DECREASED 263 0.0279
814 CARDIOMYOPATHY 305 0.0277
815 LOSS OF CONSCIOUSNESS 2589 0.0277
816 AMNESIA 1360 0.0276
817 HEPATIC FUNCTION ABNORMAL 650 0.0275
818 HAEMATOCRIT DECREASED 429 0.0274
819 MUSCLE TWITCHING 459 0.0272
820 GASTRIC CANCER 312 0.0272
821 PULMONARY EMBOLISM 2002 0.0272
822 CARDIAC DISORDER 1838 0.0270
823 TINNITUS 872 0.0269
824 DISSEMINATED INTRAVASCULAR COAGULATION 294 0.0268
825 TRANSIENT ISCHAEMIC ATTACK 701 0.0268
826 CRYING 773 0.0267
827 LETHARGY 1136 0.0267
828 CIRCUMSTANCE OR INFORMATION CAPABLE OF LEADING TO MEDICATION ERROR 382 0.0267
829 ATRIAL FIBRILLATION 1780 0.0267
830 RESTLESS LEGS SYNDROME 347 0.0265
831 PRODUCT USE IN UNAPPROVED INDICATION 2992 0.0265
832 DEEP VEIN THROMBOSIS 1396 0.0264
833 HYPOPHAGIA 447 0.0264
834 ANGINA PECTORIS 586 0.0263
835 DYSPNOEA EXERTIONAL 621 0.0262
836 BREAST CANCER FEMALE 431 0.0262
837 DEHYDRATION 2523 0.0261
838 DECREASED APPETITE 3875 0.0260
839 MULTIPLE SCLEROSIS 873 0.0260
840 TOOTH LOSS 374 0.0260
841 CARDIOMEGALY 264 0.0259
842 BLINDNESS UNILATERAL 254 0.0257
843 RENAL IMPAIRMENT 1375 0.0257
844 FACE OEDEMA 321 0.0255
845 DRY SKIN 2114 0.0254
846 SYNCOPE 1836 0.0254
847 PANCREATIC CARCINOMA 386 0.0251
848 ANAEMIA 3415 0.0251
849 HAEMOGLOBIN DECREASED 1845 0.0251
850 DRUG EXPOSURE DURING PREGNANCY 851 0.0250
851 INCREASED APPETITE 289 0.0250
852 DEMENTIA 418 0.0247
853 TREMOR 2988 0.0245
854 OEDEMA 901 0.0242
855 MYOCARDIAL INFARCTION 3563 0.0242
856 BLOOD GLUCOSE ABNORMAL 305 0.0241
857 DEVICE DIFFICULT TO USE 348 0.0240
858 HAEMATOMA 471 0.0237
859 PROTEINURIA 278 0.0236
860 FAECES DISCOLOURED 371 0.0234
861 PERITONITIS 370 0.0233
862 RETCHING 340 0.0232
863 DEVICE LEAKAGE 311 0.0232
864 FEAR 518 0.0231
865 ANXIETY 4742 0.0231
866 RESPIRATORY FAILURE 1217 0.0228
867 PANCREATITIS ACUTE 351 0.0228
868 MENORRHAGIA 450 0.0227
869 ACUTE MYELOID LEUKAEMIA 238 0.0227
870 CEREBROVASCULAR ACCIDENT 2950 0.0226
871 DRUG INEFFECTIVE FOR UNAPPROVED INDICATION 673 0.0225
872 RESPIRATORY DISTRESS 459 0.0225
873 FLATULENCE 868 0.0224
874 MYELODYSPLASTIC SYNDROME 236 0.0224
875 THERAPEUTIC RESPONSE UNEXPECTED 736 0.0223
876 DYSPHAGIA 1440 0.0223
877 ARRHYTHMIA 787 0.0223
878 HAEMOPTYSIS 458 0.0223
879 BONE DENSITY DECREASED 505 0.0221
880 BALANCE DISORDER 1378 0.0221
881 PANIC ATTACK 578 0.0219
882 PULMONARY OEDEMA 697 0.0217
883 BLOOD COUNT ABNORMAL 349 0.0217
884 FEELING JITTERY 321 0.0217
885 MULTIPLE FRACTURES 232 0.0216
886 THIRST 244 0.0215
887 BLOOD POTASSIUM INCREASED 250 0.0214
888 FOETAL EXPOSURE DURING PREGNANCY 1146 0.0214
889 MOOD ALTERED 416 0.0212
890 RENAL FAILURE 2215 0.0211
891 CARDIOVASCULAR DISORDER 457 0.0209
892 MENTAL DISORDER 616 0.0207
893 FLUID RETENTION 753 0.0207
894 BLADDER CANCER 602 0.0205
895 CARDIAC FAILURE 1096 0.0198
896 CARDIAC FAILURE CONGESTIVE 1382 0.0198
897 SPEECH DISORDER 753 0.0197
898 BLOOD TRIGLYCERIDES INCREASED 270 0.0197
899 CHOKING 256 0.0196
900 URINARY INCONTINENCE 418 0.0196
901 MOOD SWINGS 489 0.0196
902 BLOOD SODIUM DECREASED 254 0.0195
903 BLOOD CREATININE INCREASED 919 0.0194
904 PANCYTOPENIA 728 0.0193
905 EMOTIONAL DISORDER 457 0.0191
906 ACUTE RESPIRATORY FAILURE 226 0.0191
907 RASH MACULO-PAPULAR 281 0.0191
908 EYE IRRITATION 611 0.0190
909 PELVIC PAIN 256 0.0189
910 DEVICE USE ERROR 387 0.0186
911 LEUKOCYTOSIS 236 0.0186
912 PLATELET COUNT DECREASED 1294 0.0185
913 ANGIOEDEMA 563 0.0184
914 RENAL CANCER 403 0.0184
915 CONSTIPATION 2514 0.0183
916 TREATMENT NONCOMPLIANCE 604 0.0183
917 DYSGEUSIA 968 0.0182
918 HEMIPARESIS 238 0.0181
919 HYPOTENSION 2494 0.0180
920 CORONARY ARTERY DISEASE 476 0.0180
921 SOMNOLENCE 2524 0.0179
922 INJURY 1008 0.0177
923 APHASIA 381 0.0173
924 HAEMATEMESIS 328 0.0173
925 HEPATIC FAILURE 390 0.0172
926 CHROMATURIA 284 0.0169
927 CEREBRAL INFARCTION 306 0.0169
928 SHOCK 258 0.0166
929 PULMONARY HYPERTENSION 257 0.0164
930 HAEMATURIA 427 0.0164
931 MULTIPLE ORGAN DYSFUNCTION SYNDROME 233 0.0162
932 ACUTE MYOCARDIAL INFARCTION 374 0.0161
933 THINKING ABNORMAL 235 0.0160
934 DRUG DISPENSING ERROR 244 0.0159
935 ASCITES 330 0.0159
936 CONFUSIONAL STATE 1796 0.0154
937 CONVULSION 879 0.0154
938 GAMMA-GLUTAMYLTRANSFERASE INCREASED 268 0.0153
939 COGNITIVE DISORDER 480 0.0152
940 EPILEPSY 295 0.0151
941 OSTEONECROSIS 400 0.0151
942 DRUG ADMINISTRATION ERROR 463 0.0151
943 JAUNDICE 321 0.0150
944 NEUTROPENIA 1161 0.0148
945 MENTAL IMPAIRMENT 256 0.0147
946 VAGINAL HAEMORRHAGE 503 0.0146
947 THROMBOCYTOPENIA 1070 0.0143
948 DISTURBANCE IN ATTENTION 551 0.0139
949 BLOOD ALKALINE PHOSPHATASE INCREASED 275 0.0138
950 SKIN IRRITATION 483 0.0137
951 CEREBRAL HAEMORRHAGE 359 0.0136
952 HYPOXIA 312 0.0134
953 MUCOSAL INFLAMMATION 236 0.0133
954 NO ADVERSE EVENT 1197 0.0133
955 COMA 447 0.0129
956 SEIZURE 855 0.0127
957 DEATH 7141 0.0127
958 INCORRECT ROUTE OF DRUG ADMINISTRATION 454 0.0127
959 MEDICATION ERROR 510 0.0127
960 DISORIENTATION 389 0.0127
961 BLOOD GLUCOSE DECREASED 463 0.0126
962 RENAL FAILURE ACUTE 534 0.0126
963 HYPOKALAEMIA 389 0.0125
964 IRRITABILITY 578 0.0124
965 DYSARTHRIA 343 0.0124
966 RESPIRATORY ARREST 283 0.0122
967 URINARY RETENTION 277 0.0120
968 ANGER 316 0.0119
969 DELIRIUM 265 0.0116
970 RESTLESSNESS 307 0.0116
971 SUICIDAL IDEATION 770 0.0114
972 DISEASE PROGRESSION 768 0.0112
973 BLOOD GLUCOSE INCREASED 1583 0.0112
974 NEUTROPHIL COUNT DECREASED 259 0.0109
975 DYSKINESIA 320 0.0109
976 BLOOD CREATINE PHOSPHOKINASE INCREASED 247 0.0107
977 GASTROINTESTINAL HAEMORRHAGE 738 0.0107
978 CARDIAC ARREST 646 0.0104
979 SKIN BURNING SENSATION 500 0.0092
980 DRUG INTERACTION 1032 0.0090
981 DEPRESSED LEVEL OF CONSCIOUSNESS 232 0.0083
982 CARDIO-RESPIRATORY ARREST 272 0.0083
983 AGITATION 453 0.0080
984 BRADYCARDIA 307 0.0079
985 HYPOGLYCAEMIA 284 0.0078
986 ACUTE KIDNEY INJURY 657 0.0069
987 HALLUCINATION 336 0.0068
988 HYPONATRAEMIA 258 0.0064
989 PRODUCT QUALITY ISSUE 693 0.0061
990 EMOTIONAL DISTRESS 383 0.0060
991 SUICIDE ATTEMPT 259 0.0060
992 CHRONIC KIDNEY DISEASE 352 0.0058
993 OVERDOSE 811 0.0058
994 DRUG DEPENDENCE 463 0.0051
995 TOXICITY TO VARIOUS AGENTS 541 0.0049