MALIGNANT NEOPLASM PROGRESSION

MALIGNANT NEOPLASM PROGRESSION was reported 67429 times

MALIGNANT NEOPLASM PROGRESSION is most prevalent among patients taking these drug classes:

# Drug class Count Frequency
0 Vascular Endothelial Growth Factor Receptor 2 Antagonist [EPC] 584 0.1390
1 Estrogen Receptor Antagonist [EPC] 2397 0.1238
2 Programmed Death Receptor-1 Blocking Antibody [EPC] 12302 0.1141
3 CTLA-4-directed Blocking Antibody [EPC] 2715 0.0941
4 Catecholamine Synthesis Inhibitor [EPC] 3 0.0882
5 Androgen Receptor Inhibitor [EPC] 5018 0.0851
6 Poly(ADP-Ribose) Polymerase Inhibitor [EPC] 1689 0.0790
7 Programmed Death Ligand-1 Blocker [EPC] 590 0.0743
8 Aromatase Inhibitor [EPC] 3960 0.0517
9 SLAMF7-directed Immunostimulatory Antibody [EPC] 211 0.0515
10 Somatostatin Analog [EPC] 171 0.0460
11 Metal Chelator [EPC] 1 0.0385
12 Microtubule Inhibitor [EPC] 3929 0.0380
13 Kinase Inhibitor [EPC] 12976 0.0374
14 Lymphocyte Growth Factor [EPC] 31 0.0363
15 Platinum-based Drug [EPC] 5527 0.0337
16 Adrenal Steroid Synthesis Inhibitor [EPC] 15 0.0336
17 Topoisomerase Inhibitor [EPC] 1343 0.0283
18 Epidermal Growth Factor Receptor Antagonist [EPC] 998 0.0279
19 Nucleoside Metabolic Inhibitor [EPC] 5187 0.0264
20 Actinomycin [EPC] 55 0.0259
21 CD30-directed Immunoconjugate [EPC] 128 0.0225
22 Farnesyltransferase Inhibitor [EPC] 1 0.0217
23 Histone Deacetylase Inhibitor [EPC] 50 0.0201
24 Alkylating Drug [EPC] 3039 0.0183
25 CD33-directed Immunoconjugate [EPC] 51 0.0176
26 HER2/neu Receptor Antagonist [EPC] 821 0.0169
27 Cannabinoid [EPC] 119 0.0168
28 Inactivated Influenza B Virus Vaccine [EPC] 1 0.0161
29 Phenothiazine [EPC] 279 0.0146
30 Vascular Endothelial Growth Factor Inhibitor [EPC] 1870 0.0143
31 Serotonin-3 Receptor Antagonist [EPC] 903 0.0115
32 Opioid Agonist [EPC] 2534 0.0113
33 Substance P/Neurokinin-1 Receptor Antagonist [EPC] 138 0.0100
34 Osmotic Diuretic [EPC] 35 0.0098
35 Stimulant Laxative [EPC] 91 0.0098
36 Aldehyde Dehydrogenase Inhibitor [EPC] 7 0.0097
37 Hematopoietic Stem Cell Mobilizer [EPC] 10 0.0096
38 Antifibrinolytic Agent [EPC] 56 0.0094
39 Iron Chelator [EPC] 235 0.0094
40 RANK Ligand Inhibitor [EPC] 1388 0.0087
41 Lipid Emulsion [EPC] 13 0.0081
42 Tricyclic Antidepressant [EPC] 3 0.0079
43 Interleukin-6 Antagonist [EPC] 2 0.0076
44 Chloride Channel Activator [EPC] 56 0.0076
45 CD22-directed Immunoconjugate [EPC] 12 0.0075
46 Non-narcotic Antitussive [EPC] 102 0.0075
47 Live Attenuated Bacillus Calmette-Guerin Immunotherapy [EPC] 10 0.0074
48 Ester Local Anesthetic [EPC] 3 0.0074
49 Proteasome Inhibitor [EPC] 570 0.0071
50 Polyene Antifungal [EPC] 220 0.0071
51 Sulfonamide Antibacterial [EPC] 19 0.0068
52 Lincosamide Antibacterial [EPC] 141 0.0065
53 Chemokine Receptor Type 4 Interaction [EPC] 4 0.0062
54 Aluminum Complex [EPC] 109 0.0062
55 Osmotic Laxative [EPC] 986 0.0062
56 Anticholinergic [EPC] 74 0.0060
57 Vitamin K [EPC] 37 0.0060
58 Echinocandin Antifungal [EPC] 28 0.0059
59 Calcium [EPC] 626 0.0057
60 Bile Acid [EPC] 65 0.0057
61 Corticosteroid [EPC] 4933 0.0057
62 CD20-directed Cytolytic Antibody [EPC] 874 0.0056
63 Standardized Chemical Allergen [EPC] 62 0.0055
64 Erythropoiesis-stimulating Agent [EPC] 395 0.0055
65 Non-Standardized Plant Allergenic Extract [EPC] 50 0.0055
66 Phosphate Binder [EPC] 627 0.0055
67 Bile Acid Sequestrant [EPC] 43 0.0054
68 Benzodiazepine Antagonist [EPC] 3 0.0054
69 Gonadotropin Releasing Hormone Receptor Antagonist [EPC] 5 0.0053
70 Blood Viscosity Reducer [EPC] 15 0.0052
71 BCL-2 Inhibitor [EPC] 129 0.0051
72 Prostaglandin E1 Analog [EPC] 74 0.0051
73 Dihydropyridine Calcium Channel Blocker [EPC] 1172 0.0051
74 Calcitonin [EPC] 14 0.0051
75 Azole Antifungal [EPC] 540 0.0050
76 Non-Standardized Food Allergenic Extract [EPC] 73 0.0050
77 Xanthine Oxidase Inhibitor [EPC] 617 0.0049
78 Leukocyte Growth Factor [EPC] 481 0.0048
79 Vasopressin V2 Receptor Antagonist [EPC] 37 0.0048
80 Loop Diuretic [EPC] 1590 0.0047
81 Non-Standardized Chemical Allergen [EPC] 37 0.0047
82 Lipid-based Polyene Antifungal [EPC] 53 0.0046
83 Expectorant [EPC] 614 0.0046
84 Typical Antipsychotic [EPC] 82 0.0045
85 Dihydrofolate Reductase Inhibitor Antibacterial [EPC] 306 0.0045
86 Vitamin A [EPC] 22 0.0045
87 Glycopeptide Antibacterial [EPC] 188 0.0044
88 Antihypoglycemic Agent [EPC] 11 0.0044
89 Antidote [EPC] 35 0.0043
90 Vitamin D3 Analog [EPC] 78 0.0043
91 Methylxanthine [EPC] 735 0.0043
92 Sigma-1 Agonist [EPC] 11 0.0043
93 Carboxypeptidase [EPC] 1 0.0043
94 Thyroid Stimulating Hormone [EPC] 3 0.0042
95 Proton Pump Inhibitor [EPC] 1822 0.0042
96 Monobactam Antibacterial [EPC] 8 0.0041
97 Amide Local Anesthetic [EPC] 230 0.0041
98 5-alpha Reductase Inhibitor [EPC] 224 0.0041
99 l-Thyroxine [EPC] 513 0.0041
100 Aldosterone Antagonist [EPC] 418 0.0040
101 alpha-Glucosidase Inhibitor [EPC] 14 0.0040
102 Vitamin B12 [EPC] 803 0.0040
103 4-Hydroxyphenyl-Pyruvate Dioxygenase Inhibitor [EPC] 3 0.0040
104 Benzodiazepine [EPC] 2172 0.0039
105 Non-Standardized Insect Allergenic Extract [EPC] 15 0.0039
106 Melatonin Receptor Agonist [EPC] 40 0.0039
107 Vitamin C [EPC] 762 0.0038
108 RNA Synthetase Inhibitor Antibacterial [EPC] 28 0.0038
109 Quinolone Antimicrobial [EPC] 367 0.0038
110 Angiotensin Converting Enzyme Inhibitor [EPC] 417 0.0038
111 Vitamin D [EPC] 686 0.0037
112 Standardized Insect Venom Allergenic Extract [EPC] 17 0.0037
113 Central Nervous System Stimulant [EPC] 708 0.0037
114 Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor [EPC] 276 0.0037
115 Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC] 281 0.0036
116 Provitamin D2 Compound [EPC] 949 0.0036
117 Glinide [EPC] 30 0.0036
118 Antiseptic [EPC] 11 0.0036
119 Tetracycline-class Drug [EPC] 143 0.0035
120 alpha-Adrenergic Blocker [EPC] 366 0.0034
121 CD52-directed Cytolytic Antibody [EPC] 52 0.0033
122 beta-Adrenergic Blocker [EPC] 768 0.0033
123 Antiarrhythmic [EPC] 221 0.0033
124 Sulfonylurea [EPC] 412 0.0033
125 Potassium-sparing Diuretic [EPC] 53 0.0033
126 Histamine-2 Receptor Antagonist [EPC] 878 0.0032
127 Platelet Aggregation Inhibitor [EPC] 1864 0.0032
128 Sclerosing Agent [EPC] 1 0.0032
129 Nitroimidazole Antimicrobial [EPC] 157 0.0031
130 Thiazide Diuretic [EPC] 554 0.0031
131 Orexin Receptor Antagonist [EPC] 35 0.0031
132 Thiazide-like Diuretic [EPC] 92 0.0031
133 Nonsteroidal Anti-inflammatory Drug [EPC] 2992 0.0030
134 HMG-CoA Reductase Inhibitor [EPC] 956 0.0029
135 Cholinergic Muscarinic Antagonist [EPC] 88 0.0029
136 Ergot Derivative [EPC] 10 0.0029
137 Cardiac Glycoside [EPC] 183 0.0029
138 Folate Analog Metabolic Inhibitor [EPC] 873 0.0028
139 Thyroid Hormone Synthesis Inhibitor [EPC] 15 0.0028
140 Nitrofuran Antibacterial [EPC] 52 0.0028
141 Photoenhancer [EPC] 4 0.0028
142 Progestin Antagonist [EPC] 9 0.0028
143 Mucocutaneous Epithelial Cell Growth Factor [EPC] 1 0.0027
144 Carnitine Analog [EPC] 5 0.0026
145 Anti-epileptic Agent [EPC] 1108 0.0025
146 Nitrate Vasodilator [EPC] 183 0.0025
147 Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor [EPC] 32 0.0025
148 Parenteral Iron Replacement [EPC] 22 0.0025
149 Humanized Monoclonal Antibody Fragment [EPC] 3 0.0024
150 Angiotensin 2 Receptor Blocker [EPC] 574 0.0024
151 Interferon gamma [EPC] 3 0.0024
152 Penem Antibacterial [EPC] 3 0.0023
153 Peroxisome Proliferator Receptor alpha Agonist [EPC] 147 0.0023
154 Hedgehog Pathway Inhibitor [EPC] 16 0.0023
155 Central alpha-2 Adrenergic Agonist [EPC] 99 0.0022
156 Plasma Volume Expander [EPC] 1 0.0022
157 Histamine-1 Receptor Antagonist [EPC] 69 0.0022
158 Factor Xa Inhibitor [EPC] 693 0.0022
159 Tetracycline-class Antibacterial [EPC] 9 0.0021
160 Calcineurin Inhibitor Immunosuppressant [EPC] 157 0.0021
161 Thalidomide Analog [EPC] 721 0.0020
162 Antimalarial [EPC] 12 0.0020
163 Insulin Analog [EPC] 712 0.0020
164 Sulfone [EPC] 14 0.0020
165 Asparagine-specific Enzyme [EPC] 18 0.0020
166 Dipeptidyl Peptidase 4 Inhibitor [EPC] 27 0.0020
167 Bismuth [EPC] 8 0.0019
168 CD38-directed Cytolytic Antibody [EPC] 39 0.0019
169 Dietary Cholesterol Absorption Inhibitor [EPC] 114 0.0019
170 Interleukin-6 Receptor Antagonist [EPC] 141 0.0019
171 Glycolipid Disialoganglioside-directed Antibody [EPC] 1 0.0019
172 Barbiturate [EPC] 20 0.0019
173 Macrolide Antimicrobial [EPC] 97 0.0018
174 Oxazolidinone Antibacterial [EPC] 34 0.0018
175 Insulin [EPC] 80 0.0018
176 Lipopeptide Antibacterial [EPC] 18 0.0018
177 Thrombopoietin Receptor Agonist [EPC] 21 0.0018
178 Antiprotozoal [EPC] 14 0.0018
179 Radiographic Contrast Agent [EPC] 29 0.0018
180 alpha-Hydroxy Acid [EPC] 2 0.0018
181 Non-Standardized Fungal Allergenic Extract [EPC] 2 0.0017
182 Phosphodiesterase 3 Inhibitor [EPC] 8 0.0017
183 Adrenocorticotropic Hormone [EPC] 2 0.0017
184 Vitamin D Analog [EPC] 6 0.0017
185 Muscle Relaxant [EPC] 55 0.0017
186 Nucleoside Analog Antiviral [EPC] 150 0.0017
187 Cephalosporin Antibacterial [EPC] 10 0.0016
188 Alkaloid [EPC] 30 0.0016
189 Prostaglandin Analog [EPC] 112 0.0016
190 beta3-Adrenergic Agonist [EPC] 38 0.0015
191 Janus Kinase Inhibitor [EPC] 66 0.0015
192 Pleuromutilin Antibacterial [EPC] 1 0.0014
193 beta Lactamase Inhibitor [EPC] 5 0.0014
194 Nucleoside Analog Antifungal [EPC] 1 0.0014
195 Aminoglycoside Antibacterial [EPC] 41 0.0013
196 Immunoglobulin G [EPC] 8 0.0013
197 Methylating Agent [EPC] 1 0.0013
198 Selective T Cell Costimulation Modulator [EPC] 121 0.0013
199 Androgen [EPC] 50 0.0013
200 Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC] 56 0.0013
201 Mood Stabilizer [EPC] 210 0.0013
202 Adenosine Receptor Agonist [EPC] 7 0.0012
203 Purine Antimetabolite [EPC] 76 0.0012
204 Leukotriene Receptor Antagonist [EPC] 17 0.0012
205 Serotonin and Norepinephrine Reuptake Inhibitor [EPC] 2 0.0011
206 gamma-Aminobutyric Acid-ergic Agonist [EPC] 73 0.0011
207 Carbonic Anhydrase Inhibitor [EPC] 16 0.0011
208 Sodium-Glucose Cotransporter 2 Inhibitor [EPC] 32 0.0011
209 Catecholamine [EPC] 52 0.0011
210 Dopamine-2 Receptor Antagonist [EPC] 5 0.0010
211 Sympathomimetic-like Agent [EPC] 28 0.0010
212 Nicotinic Acid [EPC] 44 0.0010
213 Antimycobacterial [EPC] 14 0.0010
214 Oxytocic [EPC] 2 0.0010
215 Rifamycin Antibacterial [EPC] 19 0.0010
216 Antiparasitic [EPC] 4 0.0010
217 Pediculicide [EPC] 4 0.0009
218 alpha-Adrenergic Agonist [EPC] 40 0.0009
219 Cytomegalovirus DNA Terminase Complex Inhibitor [EPC] 1 0.0009
220 Radioactive Diagnostic Agent [EPC] 1 0.0009
221 Interferon alpha [EPC] 51 0.0009
222 Gadolinium-based Contrast Agent [EPC] 3 0.0009
223 Guanylate Cyclase-C Agonist [EPC] 15 0.0008
224 Antimetabolite Immunosuppressant [EPC] 7 0.0008
225 Progesterone [EPC] 11 0.0008
226 Interleukin-2 Receptor Blocking Antibody [EPC] 6 0.0008
227 Protease Inhibitor [EPC] 30 0.0008
228 General Anesthetic [EPC] 23 0.0008
229 Anti-coagulant [EPC] 4 0.0008
230 Estrogen [EPC] 112 0.0007
231 Atypical Antipsychotic [EPC] 258 0.0007
232 Anti-anginal [EPC] 12 0.0007
233 Aromatic Amino Acid [EPC] 32 0.0007
234 Serotonin-1b and Serotonin-1d Receptor Agonist [EPC] 24 0.0007
235 Aromatic Amino Acid Decarboxylation Inhibitor [EPC] 28 0.0007
236 Cholinergic Nicotinic Agonist [EPC] 36 0.0007
237 Endoglycosidase [EPC] 1 0.0007
238 Cytochrome P450 3A Inhibitor [EPC] 33 0.0006
239 Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC] 64 0.0006
240 Reducing and Complexing Thiol [EPC] 1 0.0006
241 Interleukin-5 Receptor alpha-directed Cytolytic Antibody [EPC] 4 0.0006
242 Phosphodiesterase 4 Inhibitor [EPC] 6 0.0005
243 CCR5 Co-receptor Antagonist [EPC] 1 0.0005
244 Cholinesterase Inhibitor [EPC] 7 0.0005
245 Complement Inhibitor [EPC] 23 0.0005
246 Skin Test Antigen [EPC] 1 0.0005
247 Copper-containing Intrauterine Device [EPC] 15 0.0005
248 Aminosalicylate [EPC] 43 0.0005
249 Catechol-O-Methyltransferase Inhibitor [EPC] 5 0.0005
250 Paramagnetic Contrast Agent [EPC] 2 0.0005
251 Human Platelet-derived Growth Factor [EPC] 1 0.0005
252 Phosphodiesterase 5 Inhibitor [EPC] 44 0.0005
253 Recombinant Human Nerve Growth Factor [EPC] 1 0.0004
254 P2Y12 Platelet Inhibitor [EPC] 10 0.0004
255 Vitamin D2 Analog [EPC] 6 0.0004
256 Partial Opioid Agonist [EPC] 30 0.0004
257 Estrogen Agonist/Antagonist [EPC] 1 0.0004
258 Arteriolar Vasodilator [EPC] 9 0.0004
259 Retinoid [EPC] 82 0.0004
260 Potassium Binder [EPC] 5 0.0004
261 Selective T Cell Costimulation Blocker [EPC] 1 0.0004
262 Recombinant Human Growth Hormone [EPC] 4 0.0004
263 Influenza A M2 Protein Inhibitor [EPC] 3 0.0003
264 Interleukin-1 Receptor Antagonist [EPC] 3 0.0003
265 Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor [EPC] 12 0.0003
266 Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor [EPC] 12 0.0002
267 Noncompetitive AMPA Glutamate Receptor Antagonist [EPC] 1 0.0002
268 Interleukin-5 Antagonist [EPC] 5 0.0002
269 GLP-1 Receptor Agonist [EPC] 42 0.0002
270 Anti-IgE [EPC] 8 0.0002
271 Hepatitis C Virus NS5A Inhibitor [EPC] 7 0.0002
272 Hydrolytic Lysosomal Neutral Glycosphingolipid-specific Enzyme [EPC] 1 0.0002
273 Pyridone [EPC] 4 0.0001
274 Tumor Necrosis Factor Blocker [EPC] 100 0.0001
275 B Lymphocyte Stimulator-specific Inhibitor [EPC] 2 0.0001
276 Parathyroid Hormone Analog [EPC] 13 0.0001
277 Prostacyclin Receptor Agonist [EPC] 2 0.0001
278 Prostacycline [EPC] 1 0.0001
279 Lymphocyte Function-Associated Antigen-1 Antagonist [EPC] 1 0.0001
280 Antirheumatic Agent [EPC] 7 0.0001
281 Endothelin Receptor Antagonist [EPC] 13 0.0001
282 Recombinant Human Deoxyribonuclease 1 [EPC] 1 0.0001
283 Interferon beta [EPC] 11 0.0001
284 Soluble Guanylate Cyclase Stimulator [EPC] 1 0.0000
285 Interleukin-12 Antagonist [EPC] 3 0.0000
286 Prostacycline Vasodilator [EPC] 4 0.0000
287 Integrin Receptor Antagonist [EPC] 9 0.0000
288 Interleukin-23 Antagonist [EPC] 3 0.0000
289 Intestinal Lipase Inhibitor [EPC] 1 0.0000
290 Interleukin-17A Antagonist [EPC] 5 0.0000
291 Interleukin-4 Receptor alpha Antagonist [EPC] 3 0.0000
292 Acetylcholine Release Inhibitor [EPC] 2 0.0000
293 Potassium Channel Blocker [EPC] 2 0.0000
294 Pyrimidine Synthesis Inhibitor [EPC] 1 0.0000
295 Progestin [EPC] 6 0.0000
296 PCSK9 Inhibitor [EPC] 2 0.0000