OFF LABEL USE

OFF LABEL USE was reported 835576 times

OFF LABEL USE is most prevalent among patients taking these drug classes:

# Drug class Count Frequency
0 Autologous Cultured Cell [EPC] 244 0.5434
1 Interferon gamma Blocker [EPC] 80 0.4348
2 Adrenal Steroid Synthesis Inhibitor [EPC] 363 0.3797
3 Interleukin-1 Receptor Antagonist [EPC] 5068 0.3138
4 Antileishmanial [EPC] 116 0.3118
5 Lead Chelator [EPC] 23 0.2840
6 Isocitrate Dehydrogenase 1 Inhibitor [EPC] 659 0.2803
7 Antidiarrheal [EPC] 62 0.2707
8 Colony Stimulating Factor-1 Receptor Blocker [EPC] 30 0.2679
9 Melanocortin 4 Receptor Agonist [EPC] 68 0.2586
10 Carboxypeptidase [EPC] 86 0.2464
11 Human Immunoglobulin G [EPC] 4482 0.2228
12 Cytomegalovirus DNA Terminase Complex Inhibitor [EPC] 657 0.2204
13 Interleukin-6 Antagonist [EPC] 128 0.2148
14 Carbamoyl Phosphate Synthetase 1 Activator [EPC] 151 0.2060
15 Anthrax Protective Antigen-directed Antibody [EPC] 1 0.2000
16 Growth Hormone Secretagogue Receptor Agonist [EPC] 1 0.2000
17 Lipoglycopeptide Antibacterial [EPC] 174 0.1927
18 Acetylcholine Release Inhibitor [EPC] 17847 0.1865
19 Sodium Channel Blocker [EPC] 177 0.1855
20 RANK Ligand Inhibitor [EPC] 36585 0.1847
21 Catecholamine Synthesis Inhibitor [EPC] 14 0.1842
22 Estrogen Agonist/Antagonist [EPC] 452 0.1741
23 SARS-CoV-2 Nucleotide Analog RNA Polymerase Inhibitor [EPC] 2229 0.1692
24 Polyene Antimicrobial [EPC] 63 0.1654
25 Ileal Bile Acid Transporter Inhibitor [EPC] 50 0.1629
26 Bispecific HER2-directed Antibody [EPC] 7 0.1591
27 Menin Inhibitor [EPC] 3 0.1579
28 Interleukin-6 Receptor Antagonist [EPC] 20629 0.1561
29 Vesicular Monoamine Transporter 2 Inhibitor [EPC] 1126 0.1550
30 Interferon alfa-2b [EPC] 253 0.1510
31 Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor [EPC] 3222 0.1499
32 Aminosalicylate [EPC] 19471 0.1496
33 Endoglycosidase [EPC] 1416 0.1482
34 Tetracycline-class Antibacterial [EPC] 1088 0.1456
35 Purine Antimetabolite [EPC] 13409 0.1406
36 Methylating Agent [EPC] 144 0.1390
37 CD30-directed Immunoconjugate [EPC] 1325 0.1332
38 Human Blood Coagulation Factor [EPC] 43 0.1327
39 Glycolipid Disialoganglioside-directed Antibody [EPC] 133 0.1309
40 Dihydrofolate Reductase Inhibitor Antimalarial [EPC] 159 0.1284
41 Actinomycin [EPC] 278 0.1281
42 Anti-IgE [EPC] 10297 0.1253
43 Interleukin-12 Antagonist [EPC] 12524 0.1245
44 mu-Opioid Receptor Agonist [EPC] 361 0.1244
45 Cytolytic Agent [EPC] 286 0.1235
46 Complement C5 Inhibitor [EPC] 10 0.1235
47 Interferon gamma [EPC] 170 0.1226
48 Anthelmintic [EPC] 348 0.1225
49 Guanylate Cyclase-C Agonist [EPC] 3330 0.1216
50 Somatostatin Analog [EPC] 797 0.1208
51 Lymphocyte Activation Gene-3 Blocker [EPC] 52 0.1190
52 Lipid-based Polyene Antifungal [EPC] 2350 0.1161
53 Antirheumatic Agent [EPC] 12034 0.1160
54 Sulfone [EPC] 1190 0.1143
55 Antiseptic [EPC] 466 0.1135
56 Aldehyde Dehydrogenase Inhibitor [EPC] 124 0.1123
57 BCL-2 Inhibitor [EPC] 6655 0.1116
58 Topoisomerase Inhibitor [EPC] 8275 0.1103
59 Janus Kinase Inhibitor [EPC] 17733 0.1098
60 Hemoglobin S Polymerization Inhibitor [EPC] 2416 0.1084
61 Antimetabolite Immunosuppressant [EPC] 2147 0.1076
62 Echinocandin Antifungal [EPC] 823 0.1061
63 Noncompetitive AMPA Glutamate Receptor Antagonist [EPC] 772 0.1051
64 Antithrombin-directed RNA Interaction [EPC] 3 0.1034
65 Penem Antibacterial [EPC] 3357 0.1027
66 Classical Complement Pathway Inhibitor [EPC] 27 0.1019
67 Vasoconstrictor [EPC] 29 0.1018
68 Nucleoside Analog Antifungal [EPC] 129 0.0972
69 Histamine-1 Receptor Antagonist [EPC] 7808 0.0968
70 Medium-chain Triglyceride [EPC] 50 0.0962
71 CD19-directed Cytolytic Antibody [EPC] 50 0.0960
72 Selective T Cell Costimulation Blocker [EPC] 428 0.0938
73 Lipid Emulsion [EPC] 473 0.0938
74 Vascular Endothelial Growth Factor Inhibitor [EPC] 16711 0.0930
75 Bile Acid Sequestrant [EPC] 1083 0.0918
76 Corticosteroid [EPC] 115026 0.0912
77 Alkylating Drug [EPC] 21686 0.0912
78 Pyruvate Kinase Activator [EPC] 72 0.0907
79 Selective T Cell Costimulation Modulator [EPC] 11951 0.0883
80 Integrin Receptor Antagonist [EPC] 23002 0.0872
81 Oxazolidinone Antibacterial [EPC] 2519 0.0872
82 Calcineurin Inhibitor Immunosuppressant [EPC] 20305 0.0862
83 Cannabinoid [EPC] 849 0.0860
84 Bispecific CD20-directed CD3 T Cell Engager [EPC] 276 0.0859
85 Central Nervous System Stimulant [EPC] 10329 0.0856
86 CD52-directed Cytolytic Antibody [EPC] 1626 0.0851
87 Calcium [EPC] 12309 0.0846
88 Interleukin-2 Receptor Blocking Antibody [EPC] 965 0.0840
89 Alkaloid [EPC] 2140 0.0832
90 Benzodiazepine Antagonist [EPC] 69 0.0829
91 Hematopoietic Stem Cell Mobilizer [EPC] 120 0.0829
92 Antiprotozoal [EPC] 838 0.0827
93 Stimulant Laxative [EPC] 1145 0.0823
94 CD38-directed Cytolytic Antibody [EPC] 3785 0.0820
95 Vitamin K [EPC] 678 0.0820
96 Prostacycline [EPC] 73 0.0818
97 Thrombopoietin Receptor Agonist [EPC] 1199 0.0818
98 Progesterone [EPC] 1839 0.0817
99 Folate Analog Metabolic Inhibitor [EPC] 35053 0.0815
100 Anticholinergic [EPC] 1408 0.0803
101 Polyene Antifungal [EPC] 3748 0.0801
102 Tumor Necrosis Factor Blocker [EPC] 78162 0.0799
103 Antiparasitic [EPC] 484 0.0794
104 Complement Inhibitor [EPC] 5256 0.0791
105 Antimalarial [EPC] 790 0.0790
106 Pediculicide [EPC] 489 0.0781
107 Bile Acid [EPC] 1700 0.0781
108 Ergot Derivative [EPC] 370 0.0777
109 Inhalation Diagnostic Agent [EPC] 1 0.0769
110 Lipopeptide Antibacterial [EPC] 673 0.0763
111 Photoactivated Radical Generator [EPC] 57 0.0762
112 CD22-directed Immunoconjugate [EPC] 218 0.0760
113 Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC] 150 0.0760
114 Substance P/Neurokinin-1 Receptor Antagonist [EPC] 1437 0.0750
115 Hydrolytic Lysosomal Cholesteryl Ester-specific Enzyme [EPC] 48 0.0747
116 Proteasome Inhibitor [EPC] 8301 0.0743
117 Rifamycin Antimycobacterial [EPC] 246 0.0738
118 Prostaglandin E1 Analog [EPC] 1209 0.0738
119 Ectoparasiticide [EPC] 183 0.0732
120 Antifibrinolytic Agent [EPC] 678 0.0730
121 Oxaborole Antifungal [EPC] 4 0.0727
122 Cytomegalovirus pUL97 Kinase Inhibitor [EPC] 169 0.0725
123 RNA Synthetase Inhibitor Antibacterial [EPC] 945 0.0724
124 Osmotic Diuretic [EPC] 365 0.0720
125 Monobactam Antibacterial [EPC] 190 0.0720
126 Copper-containing Intrauterine Device [EPC] 3688 0.0718
127 Surfactant [EPC] 81 0.0717
128 Thyroid Stimulating Hormone [EPC] 72 0.0714
129 Glycopeptide Antibacterial [EPC] 4513 0.0710
130 HER2/neu Receptor Antagonist [EPC] 5403 0.0706
131 Carnitine Analog [EPC] 292 0.0705
132 Parenteral Iron Replacement [EPC] 929 0.0705
133 Hydrolytic Lysosomal Glycogen-specific Enzyme [EPC] 224 0.0703
134 Kinase Inhibitor [EPC] 38131 0.0703
135 Sulfonamide Antibacterial [EPC] 272 0.0702
136 Interleukin-23 Antagonist [EPC] 14835 0.0700
137 Erythroid Maturation Agent [EPC] 160 0.0695
138 Amide Local Anesthetic [EPC] 5958 0.0692
139 Tetracycline-class Drug [EPC] 4656 0.0690
140 Lymphocyte Growth Factor [EPC] 83 0.0689
141 Azole Antifungal [EPC] 10424 0.0686
142 Cholinergic Muscarinic Agonist [EPC] 119 0.0684
143 Rifamycin Antibacterial [EPC] 2310 0.0673
144 Anti-coagulant [EPC] 240 0.0670
145 Dopamine and Norepinephrine Reuptake Inhibitor [EPC] 247 0.0669
146 Small Interfering RNA [EPC] 3 0.0667
147 Expectorant [EPC] 13381 0.0663
148 Platinum-based Drug [EPC] 17163 0.0660
149 CD123 Interaction [EPC] 32 0.0648
150 beta3-Adrenergic Agonist [EPC] 2886 0.0647
151 Tissue Factor Pathway Inhibitor Antagonist [EPC] 2 0.0645
152 Potassium Binder [EPC] 963 0.0645
153 Vitamin B12 [EPC] 20414 0.0642
154 Serotonin and Norepinephrine Reuptake Inhibitor [EPC] 217 0.0642
155 Nitroimidazole Antimicrobial [EPC] 4143 0.0642
156 Pyrethroid [EPC] 110 0.0640
157 Enzyme Stabilizer [EPC] 72 0.0639
158 alpha-1 Adrenergic Agonist [EPC] 274 0.0639
159 Vitamin D [EPC] 18906 0.0638
160 Oxytocic [EPC] 187 0.0638
161 Serotonin-3 Receptor Antagonist [EPC] 8156 0.0633
162 Osmotic Laxative [EPC] 17934 0.0633
163 Non-Standardized Plant Allergenic Extract [EPC] 1079 0.0627
164 Interleukin-17 Receptor A Antagonist [EPC] 121 0.0624
165 Thyroid Hormone Synthesis Inhibitor [EPC] 574 0.0618
166 Interleukin-5 Antagonist [EPC] 3016 0.0617
167 Vasopressin V2 Receptor Antagonist [EPC] 850 0.0611
168 Programmed Death Receptor-1 Blocking Antibody [EPC] 14180 0.0610
169 Atypical Antipsychotic [EPC] 32111 0.0604
170 Serotonin-4 Receptor Agonist [EPC] 35 0.0603
171 Nuclear Export Inhibitor [EPC] 504 0.0603
172 Antiarrhythmic [EPC] 5907 0.0601
173 Blood Viscosity Reducer [EPC] 254 0.0599
174 5-Lipoxygenase Inhibitor [EPC] 38 0.0597
175 Vasopressin Receptor Agonist [EPC] 17 0.0592
176 Central alpha-2 Adrenergic Agonist [EPC] 3265 0.0590
177 Plasma Kallikrein Inhibitor [EPC] 284 0.0588
178 Human Immunoglobulin [EPC] 3 0.0588
179 Angiopoietin-like 3 Inhibitor [EPC] 13 0.0583
180 Complement 5a Receptor Antagonist [EPC] 332 0.0583
181 Typical Antipsychotic [EPC] 1412 0.0579
182 Neurokinin 3 Receptor Antagonist [EPC] 112 0.0578
183 Macrolide Antibacterial [EPC] 132 0.0565
184 Carbonic Anhydrase Inhibitor [EPC] 1101 0.0560
185 Aluminum Complex [EPC] 1309 0.0559
186 Vitamin D3 Analog [EPC] 1107 0.0558
187 Interleukin-36 Receptor Antagonist [EPC] 19 0.0554
188 Nucleoside Metabolic Inhibitor [EPC] 14685 0.0553
189 Antimycobacterial [EPC] 1040 0.0553
190 Amino Acid Hypertonic Solution [EPC] 7 0.0551
191 Anthracycline Topoisomerase Inhibitor [EPC] 118 0.0547
192 CTLA-4-directed Blocking Antibody [EPC] 2489 0.0542
193 Epidermal Growth Factor Receptor Antagonist [EPC] 2444 0.0541
194 Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor [EPC] 6036 0.0539
195 Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC] 6145 0.0538
196 Catecholamine [EPC] 4181 0.0533
197 Ester Local Anesthetic [EPC] 2545 0.0533
198 Angiotensin Converting Enzyme Inhibitor [EPC] 7066 0.0533
199 Phenothiazine [EPC] 1547 0.0530
200 CD4-directed Blocking Antibody [EPC] 28 0.0528
201 Leptin Analog [EPC] 65 0.0527
202 Dopamine-2 Receptor Antagonist [EPC] 393 0.0526
203 Fluoroquinolone Antibacterial [EPC] 6423 0.0509
204 4-Hydroxyphenyl-Pyruvate Dioxygenase Inhibitor [EPC] 48 0.0509
205 Estrogen [EPC] 9396 0.0505
206 Opioid Agonist [EPC] 13469 0.0501
207 Leukocyte Growth Factor [EPC] 6995 0.0499
208 Arteriolar Vasodilator [EPC] 3672 0.0498
209 Recombinant Human Deoxyribonuclease 1 [EPC] 953 0.0492
210 Mucocutaneous Epithelial Cell Growth Factor [EPC] 19 0.0490
211 Serotonin-1b and Serotonin-1d Receptor Agonist [EPC] 1183 0.0488
212 GLP-1 Receptor Agonist [EPC] 19946 0.0487
213 Histone Deacetylase Inhibitor [EPC] 178 0.0486
214 Orthopoxvirus VP37 Envelope Wrapping Protein Inhibitor [EPC] 5 0.0485
215 Macrolide Antimicrobial [EPC] 2486 0.0485
216 Nonergot Dopamine Agonist [EPC] 1389 0.0484
217 Antihypoglycemic Agent [EPC] 197 0.0481
218 Photoenhancer [EPC] 186 0.0479
219 Cholinergic Muscarinic Antagonist [EPC] 1828 0.0478
220 Anti-epileptic Agent [EPC] 11076 0.0477
221 Erythropoiesis-stimulating Agent [EPC] 2527 0.0476
222 Methylxanthine [EPC] 4249 0.0475
223 Nonsteroidal Anti-inflammatory Drug [EPC] 60059 0.0472
224 Leukotriene Receptor Antagonist [EPC] 1270 0.0472
225 Iron Chelator [EPC] 1356 0.0472
226 Non-Standardized Fungal Allergenic Extract [EPC] 94 0.0471
227 CD33-directed Immunoconjugate [EPC] 168 0.0466
228 Mood Stabilizer [EPC] 9952 0.0465
229 Benzodiazepine [EPC] 32404 0.0464
230 Non-Standardized Insect Allergenic Extract [EPC] 266 0.0462
231 Non-Standardized Chemical Allergen [EPC] 4929 0.0460
232 Tubulin Inhibiting Agent [EPC] 13 0.0456
233 Bismuth [EPC] 259 0.0456
234 Diagnostic Dye [EPC] 8 0.0455
235 Microtubule Inhibitor [EPC] 7174 0.0453
236 Androgen [EPC] 2036 0.0452
237 Insulin-like Growth Factor-1 Receptor Inhibitor [EPC] 240 0.0451
238 Poly(ADP-Ribose) Polymerase Inhibitor [EPC] 904 0.0450
239 Nitrofuran Antibacterial [EPC] 1107 0.0450
240 Thalidomide Analog [EPC] 22597 0.0445
241 Melanin Synthesis Inhibitor [EPC] 49 0.0442
242 Dihydropyridine Calcium Channel Blocker [EPC] 14224 0.0441
243 Quinolone Antimicrobial [EPC] 422 0.0440
244 Recombinant Human Nerve Growth Factor [EPC] 524 0.0437
245 Thiazide-like Diuretic [EPC] 1868 0.0437
246 Dipeptidyl Peptidase 4 Inhibitor [EPC] 1354 0.0437
247 Hedgehog Pathway Inhibitor [EPC] 403 0.0436
248 General Anesthetic [EPC] 1823 0.0436
249 Opioid Antagonist [EPC] 39 0.0432
250 gamma-Aminobutyric Acid-ergic Agonist [EPC] 3771 0.0432
251 Gamma Secretase Inhibitor [EPC] 34 0.0431
252 Xanthine Oxidase Inhibitor [EPC] 7162 0.0425
253 Proton Pump Inhibitor [EPC] 24099 0.0423
254 Sclerosing Agent [EPC] 18 0.0423
255 Peroxisome Proliferator-activated Receptor Agonist [EPC] 26 0.0422
256 Tyrosine Kinase 2 Inhibitor [EPC] 113 0.0419
257 Aldosterone Antagonist [EPC] 6236 0.0418
258 CCR5 Co-receptor Antagonist [EPC] 94 0.0415
259 Standardized Insect Venom Allergenic Extract [EPC] 295 0.0413
260 Phenylalanine Metabolizing Enzyme [EPC] 322 0.0406
261 Plasma Volume Expander [EPC] 119 0.0402
262 Glucosylceramide Synthase Inhibitor [EPC] 106 0.0402
263 Sodium-Glucose Cotransporter 2 Inhibitor [EPC] 3910 0.0399
264 Non-narcotic Antitussive [EPC] 633 0.0397
265 alpha-Hydroxy Acid [EPC] 80 0.0397
266 Progestin Antagonist [EPC] 183 0.0396
267 Factor Xa Inhibitor [EPC] 10581 0.0394
268 Serotonin Reuptake Inhibitor [EPC] 3457 0.0393
269 Phosphodiesterase 4 Inhibitor [EPC] 6296 0.0391
270 Insulin Analog [EPC] 17892 0.0391
271 Complement Factor D Inhibitor [EPC] 9 0.0390
272 Hypoxia-inducible Factor Inhibitor [EPC] 52 0.0387
273 Nitrate Vasodilator [EPC] 3329 0.0385
274 Cardiac Myosin Inhibitor [EPC] 164 0.0383
275 Vitamin B6 Analog [EPC] 13 0.0382
276 Cephalosporin Antibacterial [EPC] 318 0.0382
277 Adenosine Receptor Agonist [EPC] 273 0.0378
278 Allylamine Antifungal [EPC] 263 0.0377
279 Neonatal Fc Receptor Blocker [EPC] 187 0.0377
280 Calcitonin Gene-related Peptide Receptor Antagonist [EPC] 420 0.0373
281 Pyridone [EPC] 1488 0.0371
282 P2Y12 Platelet Inhibitor [EPC] 4292 0.0370
283 Nucleoside Analog Antiviral [EPC] 3127 0.0369
284 Loop Diuretic [EPC] 16162 0.0364
285 Platelet Aggregation Inhibitor [EPC] 20065 0.0361
286 beta Lactamase Inhibitor [EPC] 161 0.0361
287 Interleukin-17A Antagonist [EPC] 6965 0.0360
288 Chloride Channel Activator [EPC] 330 0.0357
289 Bispecific B Cell Maturation Antigen-directed CD3 T Cell Engager [EPC] 1 0.0357
290 Uric Acid-specific Enzyme [EPC] 122 0.0356
291 HMG-CoA Reductase Inhibitor [EPC] 15253 0.0356
292 Recombinant Human Growth Hormone [EPC] 767 0.0356
293 beta-Adrenergic Blocker [EPC] 10656 0.0355
294 Prostacycline Vasodilator [EPC] 4630 0.0349
295 alpha-Glucosidase Inhibitor [EPC] 164 0.0348
296 Adrenocorticotropic Hormone [EPC] 66 0.0346
297 Thiazide Diuretic [EPC] 7191 0.0345
298 B Lymphocyte Stimulator-specific Inhibitor [EPC] 1065 0.0345
299 Peroxisome Proliferator Receptor alpha Agonist [EPC] 2023 0.0343
300 alpha-Adrenergic Blocker [EPC] 4671 0.0343
301 Influenza A M2 Protein Inhibitor [EPC] 515 0.0342
302 Vascular Endothelial Growth Factor Receptor 2 Antagonist [EPC] 209 0.0342
303 5-alpha Reductase Inhibitor [EPC] 2732 0.0340
304 Estrogen Receptor Antagonist [EPC] 1318 0.0337
305 Phosphodiesterase 5 Inhibitor [EPC] 4418 0.0336
306 Nitrogen Binding Agent [EPC] 3 0.0333
307 Aryl Hydrocarbon Receptor Agonist [EPC] 56 0.0333
308 Programmed Death Ligand-1 Blocker [EPC] 750 0.0332
309 Muscle Relaxant [EPC] 1458 0.0327
310 Barbiturate [EPC] 379 0.0326
311 Non-Standardized Food Allergenic Extract [EPC] 2547 0.0322
312 Protease Inhibitor [EPC] 1439 0.0321
313 gamma-Aminobutyric Acid A Receptor Agonist [EPC] 50 0.0320
314 Prostacyclin Receptor Agonist [EPC] 801 0.0317
315 Paramagnetic Contrast Agent [EPC] 143 0.0316
316 Standardized Animal Hair Allergenic Extract [EPC] 26 0.0316
317 Gonadotropin [EPC] 60 0.0315
318 Antidote [EPC] 1960 0.0313
319 Non-Standardized House Dust Allergenic Extract [EPC] 22 0.0311
320 Standardized Pollen Allergenic Extract [EPC] 18 0.0308
321 Phosphodiesterase 3 Inhibitor [EPC] 221 0.0307
322 Glinide [EPC] 262 0.0304
323 Potassium-sparing Diuretic [EPC] 401 0.0304
324 CD3-directed Antibody [EPC] 15 0.0304
325 Benzothiazole [EPC] 63 0.0302
326 Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor [EPC] 1575 0.0301
327 Prostaglandin Analog [EPC] 2723 0.0301
328 Cholinesterase Inhibitor [EPC] 553 0.0299
329 Claudin 18.2-directed Cytolytic Antibody [EPC] 32 0.0297
330 Vitamin A [EPC] 1684 0.0297
331 Non-Standardized Pollen Allergenic Extract [EPC] 17 0.0297
332 Tricyclic Antidepressant [EPC] 14 0.0295
333 Dietary Cholesterol Absorption Inhibitor [EPC] 2581 0.0294
334 Histamine-2 Receptor Antagonist [EPC] 9241 0.0289
335 Interleukin-4 Receptor alpha Antagonist [EPC] 12593 0.0287
336 Sympathomimetic-like Agent [EPC] 903 0.0283
337 Anti-anginal [EPC] 285 0.0280
338 Nonsteroidal Mineralocorticoid-Receptor Antagonist [EPC] 73 0.0279
339 Asparagine-specific Enzyme [EPC] 356 0.0274
340 Monoamine Oxidase Inhibitor [EPC] 81 0.0271
341 Farnesyltransferase Inhibitor [EPC] 2 0.0263
342 Cardiac Glycoside [EPC] 1859 0.0263
343 Orexin Receptor Antagonist [EPC] 457 0.0258
344 Sulfonylurea [EPC] 3123 0.0258
345 CD19-directed Chimeric Antigen Receptor [EPC] 354 0.0256
346 Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC] 1347 0.0254
347 SLAMF7-directed Immunostimulatory Antibody [EPC] 129 0.0253
348 Cytochrome P450 3A Inhibitor [EPC] 1520 0.0253
349 Parathyroid Hormone-Related Peptide Analog [EPC] 611 0.0244
350 Cortisol Synthesis Inhibitor [EPC] 15 0.0244
351 Respiratory Syncytial Virus Anti-F Protein Monoclonal Antibody [EPC] 403 0.0240
352 Sigma-1 Agonist [EPC] 206 0.0240
353 Nicotinic Acid [EPC] 1469 0.0239
354 Catechol-O-Methyltransferase Inhibitor [EPC] 162 0.0235
355 Protease Activator [EPC] 1 0.0233
356 Partial Opioid Agonist [EPC] 2134 0.0232
357 PCSK9 Inhibitor [EPC] 4137 0.0229
358 Folate Analog [EPC] 1140 0.0229
359 Aromatic Amino Acid Decarboxylation Inhibitor [EPC] 625 0.0222
360 Survival of Motor Neuron 2 Splicing Modifier [EPC] 88 0.0222
361 Endothelin Receptor Antagonist [EPC] 4302 0.0220
362 Melatonin Receptor Agonist [EPC] 283 0.0217
363 Radiographic Contrast Agent [EPC] 526 0.0215
364 Type I Interferon Receptor Antagonist [EPC] 35 0.0214
365 l-Thyroxine [EPC] 1 0.0208
366 Adenosine Triphosphate-Citrate Lyase Inhibitor [EPC] 63 0.0208
367 Interleukin-5 Receptor alpha-directed Cytolytic Antibody [EPC] 390 0.0208
368 Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC] 2545 0.0206
369 Chemokine Receptor Type 4 Interaction [EPC] 26 0.0205
370 Androgen Receptor Inhibitor [EPC] 1465 0.0201
371 Bispecific gp100 Peptide-HLA-directed CD3 T Cell Engager [EPC] 11 0.0201
372 l-Triiodothyronine [EPC] 1 0.0200
373 Soluble Guanylate Cyclase Stimulator [EPC] 656 0.0200
374 Lymphocyte Function-Associated Antigen-1 Antagonist [EPC] 318 0.0199
375 Calcitonin [EPC] 61 0.0198
376 Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator [EPC] 38 0.0195
377 Interferon alpha [EPC] 1043 0.0194
378 Hydrolytic Lysosomal Glucocerebroside-specific Enzyme [EPC] 137 0.0193
379 Semifluorinated Alkane [EPC] 30 0.0184
380 Sucrose-specific Enzyme [EPC] 3 0.0182
381 Aromatic Amino Acid [EPC] 1071 0.0182
382 Sphingosine 1-phosphate Receptor Modulator [EPC] 232 0.0173
383 Phosphate Binder [EPC] 51 0.0173
384 Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor [EPC] 407 0.0171
385 Potassium Channel Blocker [EPC] 1185 0.0166
386 Insulin [EPC] 835 0.0164
387 Radioactive Diagnostic Agent [EPC] 42 0.0158
388 Calcitonin Gene-related Peptide Antagonist [EPC] 134 0.0157
389 GLP-2 Analog [EPC] 202 0.0153
390 Selectin Blocker [EPC] 21 0.0152
391 Gadolinium-based Contrast Agent [EPC] 70 0.0146
392 Vitamin D Analog [EPC] 256 0.0143
393 Cholinergic Nicotinic Agonist [EPC] 859 0.0143
394 Hydrolytic Lysosomal Neutral Glycosphingolipid-specific Enzyme [EPC] 131 0.0141
395 Parathyroid Hormone Analog [EPC] 1473 0.0132
396 Hydrolytic Lysosomal Glycosaminoglycan-specific Enzyme [EPC] 219 0.0129
397 Live Attenuated Bacillus Calmette-Guerin Immunotherapy [EPC] 22 0.0126
398 Corticotropin-releasing Factor Type 1 Receptor Antagonist [EPC] 2 0.0123
399 Cyclooxygenase Inhibitor [EPC] 1 0.0122
400 Tissue-nonspecific Alkaline Phosphatase [EPC] 107 0.0114
401 Cystic Fibrosis Transmembrane Conductance Regulator Potentiator [EPC] 189 0.0113
402 Thymic Stromal Lymphopoietin Blocker [EPC] 64 0.0112
403 Neuraminidase Inhibitor [EPC] 30 0.0112
404 Progestin [EPC] 3107 0.0112
405 Gonadotropin Releasing Hormone Receptor Antagonist [EPC] 245 0.0102
406 Pyrimidine Synthesis Inhibitor [EPC] 409 0.0091
407 Humanized Monoclonal Antibody Fragment [EPC] 13 0.0091
408 Retinoid [EPC] 2219 0.0090
409 Interleukin-31 Receptor alpha Antagonist [EPC] 89 0.0090
410 Thyroid Hormone Receptor beta Agonist [EPC] 13 0.0085
411 Reducing and Complexing Thiol [EPC] 19 0.0079
412 Contrast Agent for Ultrasound Imaging [EPC] 58 0.0077
413 Hepatitis C Virus NS3/4A Protease Inhibitor [EPC] 118 0.0073
414 Interleukin-13 Antagonist [EPC] 50 0.0072
415 Cholecystokinin Analog [EPC] 1 0.0065
416 Antisense Oligonucleotide [EPC] 75 0.0065
417 Hepatitis C Virus NS5A Inhibitor [EPC] 303 0.0063
418 Vitamin D2 Analog [EPC] 86 0.0061
419 TRPM8 Thermoreceptor Agonist [EPC] 13 0.0048
420 Interferon beta [EPC] 887 0.0043
421 Radioligand Therapeutic Agent [EPC] 48 0.0039
422 Intestinal Lipase Inhibitor [EPC] 98 0.0038
423 Amyloid Beta-directed Antibody [EPC] 11 0.0033
424 Skin Test Antigen [EPC] 6 0.0023
425 Autologous Cellular Immunotherapy [EPC] 13 0.0023